RO85262B - Procedeu pentru prepararea unor 3-benzazepine - Google Patents
Procedeu pentru prepararea unor 3-benzazepineInfo
- Publication number
- RO85262B RO85262B RO109135A RO10913582A RO85262B RO 85262 B RO85262 B RO 85262B RO 109135 A RO109135 A RO 109135A RO 10913582 A RO10913582 A RO 10913582A RO 85262 B RO85262 B RO 85262B
- Authority
- RO
- Romania
- Prior art keywords
- benzazepines
- general formula
- preparing
- formula
- cyclized
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Inventia se refera la u procedeu pentru prepararea unor 3-benzazepine cu formula generala I: (vezi formula) în care R reprezinta o grupare alchil cu 1...3 atomi de carbon sai alil si X reprezinta un atom de halogen constînd în aceea ca un compus cu formula generala II: (vezi formula) în care R si X au semnificatiile de mai sus si Z reprezinta clor sau brom, se ciclizeaza în prezenta de clorura de aluminiu topita si clorura de amoniu, la o temperatura cuprinsa între 140...175 degree C, dupa care produsul cu formula I obtinut poate fi transformat, prin metode cunoscute, într-o stare de aditie acida acceptabila farmaceutic.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32524981A | 1981-11-27 | 1981-11-27 | |
| US06/398,015 US4465677A (en) | 1982-07-14 | 1982-07-14 | Pharmaceutical compositions and method of producing alpha2 antagonism |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO85262A RO85262A (ro) | 1984-09-29 |
| RO85262B true RO85262B (ro) | 1984-10-30 |
Family
ID=26984843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO109135A RO85262B (ro) | 1981-11-27 | 1982-11-25 | Procedeu pentru prepararea unor 3-benzazepine |
Country Status (18)
| Country | Link |
|---|---|
| AU (1) | AU555672B2 (ro) |
| CA (1) | CA1214165A (ro) |
| DD (1) | DD205896A5 (ro) |
| DK (1) | DK493182A (ro) |
| EG (1) | EG16524A (ro) |
| ES (1) | ES517697A0 (ro) |
| FI (1) | FI823715L (ro) |
| GR (1) | GR77702B (ro) |
| IE (1) | IE53962B1 (ro) |
| IL (1) | IL67092A (ro) |
| NO (1) | NO158537C (ro) |
| NZ (1) | NZ202245A (ro) |
| PH (1) | PH18471A (ro) |
| PL (1) | PL136452B1 (ro) |
| PT (1) | PT75838B (ro) |
| RO (1) | RO85262B (ro) |
| YU (1) | YU265782A (ro) |
| ZW (1) | ZW23382A1 (ro) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4541954A (en) * | 1984-09-05 | 1985-09-17 | Smithkline Beckman Corporation | Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine |
-
1982
- 1982-10-14 IE IE248682A patent/IE53962B1/en unknown
- 1982-10-21 NZ NZ20224582A patent/NZ202245A/en unknown
- 1982-10-22 CA CA000414027A patent/CA1214165A/en not_active Expired
- 1982-10-27 IL IL67092A patent/IL67092A/xx unknown
- 1982-10-29 GR GR69668A patent/GR77702B/el unknown
- 1982-11-01 ZW ZW23382A patent/ZW23382A1/xx unknown
- 1982-11-01 FI FI823715A patent/FI823715L/fi not_active Application Discontinuation
- 1982-11-02 PH PH28081A patent/PH18471A/en unknown
- 1982-11-04 AU AU90172/82A patent/AU555672B2/en not_active Ceased
- 1982-11-05 DK DK493182A patent/DK493182A/da not_active Application Discontinuation
- 1982-11-12 PT PT7583882A patent/PT75838B/pt unknown
- 1982-11-24 EG EG69582A patent/EG16524A/xx active
- 1982-11-25 RO RO109135A patent/RO85262B/ro unknown
- 1982-11-26 YU YU265782A patent/YU265782A/xx unknown
- 1982-11-26 PL PL23924482A patent/PL136452B1/pl unknown
- 1982-11-26 NO NO823990A patent/NO158537C/no unknown
- 1982-11-26 ES ES517697A patent/ES517697A0/es active Granted
- 1982-11-29 DD DD24531382A patent/DD205896A5/de unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH18471A (en) | 1985-07-18 |
| DD205896A5 (de) | 1984-01-11 |
| NO158537B (no) | 1988-06-20 |
| FI823715A0 (fi) | 1982-11-01 |
| IE53962B1 (en) | 1989-04-26 |
| DK493182A (da) | 1983-05-28 |
| IL67092A (en) | 1987-09-16 |
| NO823990L (no) | 1983-05-30 |
| PL239244A1 (en) | 1984-01-02 |
| RO85262A (ro) | 1984-09-29 |
| ZW23382A1 (en) | 1983-01-26 |
| PL136452B1 (en) | 1986-02-28 |
| FI823715L (fi) | 1983-05-28 |
| NZ202245A (en) | 1985-09-13 |
| AU555672B2 (en) | 1986-10-02 |
| ES8405769A1 (es) | 1984-06-16 |
| AU9017282A (en) | 1983-06-02 |
| ES517697A0 (es) | 1984-06-16 |
| IL67092A0 (en) | 1983-02-23 |
| EG16524A (en) | 1989-06-30 |
| CA1214165A (en) | 1986-11-18 |
| PT75838A (en) | 1982-12-01 |
| NO158537C (no) | 1988-09-28 |
| PT75838B (en) | 1985-11-12 |
| GR77702B (ro) | 1984-09-25 |
| IE822486L (en) | 1983-05-27 |
| YU265782A (en) | 1984-12-31 |
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