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RO82962B - Procedeu pentru prepararea unor derivati de cefalosporina - Google Patents

Procedeu pentru prepararea unor derivati de cefalosporina

Info

Publication number
RO82962B
RO82962B RO106875A RO10687582A RO82962B RO 82962 B RO82962 B RO 82962B RO 106875 A RO106875 A RO 106875A RO 10687582 A RO10687582 A RO 10687582A RO 82962 B RO82962 B RO 82962B
Authority
RO
Romania
Prior art keywords
carbon atoms
group
carboxylic acid
general formula
alkyl group
Prior art date
Application number
RO106875A
Other languages
English (en)
Other versions
RO82962A (ro
Inventor
William Henry
Walker Lunn
John Kevin Shadle
Original Assignee
Eli Lilly And Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co filed Critical Eli Lilly And Co
Publication of RO82962A publication Critical patent/RO82962A/ro
Publication of RO82962B publication Critical patent/RO82962B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati de cefalosporina cu formula generala I: (vezi formula) în care substituentul R reprezinta o grupa alchil cu 1...4 atomi de carbon sau o grupa cu formula II: (vezi formula) unde m este 0,1 sau 2 a si b sînt independent hidrogen sau alchil cu 1...3 atomi de carbon sau luati împreuna formeaza un inel carbociclic cu 3...6 membri si R' este hidrogen sau o grupa carboxiprotectoare, substituentul R1 reprezinta hidrogen sau o grupa alchil cu 1...4 atomi de carbon, n reprezinta 0,1,2 sau 3 substituentii A si A' reprezinta independent hidrogen, o grupa alil sau o grupa alchil cu 1...4 atomi de carbon, constînd din aceea ca 0 3-iodmetilcefalosporina cu formula generala II: (vezi formula) în care substituentul R are semnificatiile de mai sus, se trateaza cu un derivat de acid piridinhidroxamic cu formula generala III: (vezi formula) în care substituentii R1, n, A si A' au semnificatiile de mai sus în conditii anhidre, într-un solvent ales dintre acetonitril si propionitril, la temperatura camerei, gruparile de acid carboxilic din pozitia C4, acid carboxilic a functiei imino daca exista, amino în pozitia 2 a inelului sau acid carboxilic din acidul piridinhidroxamic fiind protejate în timpul reactiei, dupa care, eventual, grupele de protectie se îndeparteaza prin procedee în sine cunoscute si compusii cu formula I obtinuti pot fi transformati, daca se doreste, în saruri farmeceutic acceptabile.
RO106875A 1981-03-11 1982-03-11 Procedeu pentru prepararea unor derivati de cefalosporina RO82962B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/242,792 US4336253A (en) 1981-03-11 1981-03-11 Cephalosporin antibiotics

Publications (2)

Publication Number Publication Date
RO82962A RO82962A (ro) 1984-01-14
RO82962B true RO82962B (ro) 1984-01-30

Family

ID=22916202

Family Applications (1)

Application Number Title Priority Date Filing Date
RO106875A RO82962B (ro) 1981-03-11 1982-03-11 Procedeu pentru prepararea unor derivati de cefalosporina

Country Status (21)

Country Link
US (1) US4336253A (ro)
EP (1) EP0060144A3 (ro)
JP (1) JPS57165393A (ro)
KR (1) KR830009119A (ro)
AU (1) AU8091182A (ro)
BG (1) BG36936A3 (ro)
CA (1) CA1177066A (ro)
CS (1) CS238620B2 (ro)
DD (1) DD201599A5 (ro)
DK (1) DK100982A (ro)
ES (1) ES8303426A1 (ro)
FI (1) FI820806L (ro)
GB (1) GB2094309B (ro)
GR (1) GR74714B (ro)
IL (1) IL65185A0 (ro)
NZ (1) NZ199959A (ro)
PH (1) PH17022A (ro)
PL (1) PL130568B1 (ro)
PT (1) PT74558B (ro)
RO (1) RO82962B (ro)
ZA (1) ZA821525B (ro)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443444A (en) * 1980-08-11 1984-04-17 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
US4450270A (en) * 1981-10-02 1984-05-22 Eli Lilly And Company Dioximino cephalosporin antibiotics
US4616081A (en) * 1982-07-07 1986-10-07 Asahi Kasei Kogyo Kabushiki Kaisha Cephalosporin compounds
DE3316797A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
DE3316798A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
DE3588208D1 (de) * 1984-11-23 1999-04-08 Biochemie Gmbh Cephalosporinderivative
US4703118A (en) * 1985-04-08 1987-10-27 Eli Lilly And Company Synthesis of 3-iodomethyl cephalosporins
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
US4749522A (en) * 1985-10-31 1988-06-07 Angio-Medical Corporation Supercritical fluid extraction of animal derived materials
US4868294A (en) * 1986-07-11 1989-09-19 Bristol-Myers Company Process for preparing cephalosporin intermediates
EP1618114B1 (en) 2003-04-16 2010-07-14 Sandoz AG Processes for the preparations of cefepime
US7847093B2 (en) * 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime
US20070111980A1 (en) * 2004-07-16 2007-05-17 Bandi Parthasaradhi Reddy Process for preparing pure cephalosporine intermediates
RS66326B1 (sr) 2011-09-09 2025-01-31 Merck Sharp & Dohme Llc Ceftolozan/tazobaktam za lečenje intrapulmonalnih infekcija
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
NZ700372A (en) 2013-03-15 2016-01-29 Merck Sharp & Dohme Ceftolozane antibiotic compositions
US20140274990A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
US10376496B2 (en) 2013-09-09 2019-08-13 Merck, Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3792047A (en) * 1971-12-07 1974-02-12 Glaxo Lab Ltd N-(7,2'-thienylacetamidoceph-3-em-3-ylmethyl)-3"or 4"-n-hydroxyloweralkylcarbamoyl-pyridinium-4-carboxylates
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
JPS52125188A (en) 1976-04-14 1977-10-20 Takeda Chem Ind Ltd Cephalosporin derivatives and their preparation
GR63088B (en) * 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins
JPS6011713B2 (ja) * 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
GB2027692B (en) 1978-05-26 1983-02-09 Glaxo Group Ltd Cephalosporin antibiotics
BE876538A (fr) 1978-05-26 1979-11-26 Glaxo Group Ltd Procede de preparation de cephalosporines
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
FR2449692A1 (fr) 1979-02-23 1980-09-19 Glaxo Group Ltd Nouvelles cephalosporines qui exercent une activite contre les organismes gram-negatifs
US4237128A (en) * 1979-04-12 1980-12-02 E. R. Squibb & Sons, Inc. 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides

Also Published As

Publication number Publication date
DD201599A5 (de) 1983-07-27
GR74714B (ro) 1984-07-06
PL235396A1 (ro) 1982-09-27
PT74558A (en) 1982-04-01
KR830009119A (ko) 1983-12-17
ZA821525B (en) 1983-03-30
CS238620B2 (en) 1985-12-16
PH17022A (en) 1984-05-11
NZ199959A (en) 1985-08-16
EP0060144A3 (en) 1983-09-14
ES510307A0 (es) 1983-02-01
PL130568B1 (en) 1984-08-31
GB2094309B (en) 1985-03-27
GB2094309A (en) 1982-09-15
DK100982A (da) 1982-09-12
PT74558B (en) 1984-11-27
FI820806L (fi) 1982-09-12
BG36936A3 (en) 1985-02-15
IL65185A0 (en) 1982-05-31
ES8303426A1 (es) 1983-02-01
CA1177066A (en) 1984-10-30
EP0060144A2 (en) 1982-09-15
US4336253A (en) 1982-06-22
RO82962A (ro) 1984-01-14
JPS57165393A (en) 1982-10-12
AU8091182A (en) 1982-09-16

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