ES8303426A1 - Un procedimiento para la preparacion de un compuesto de cefalosporina. - Google Patents
Un procedimiento para la preparacion de un compuesto de cefalosporina.Info
- Publication number
- ES8303426A1 ES8303426A1 ES510307A ES510307A ES8303426A1 ES 8303426 A1 ES8303426 A1 ES 8303426A1 ES 510307 A ES510307 A ES 510307A ES 510307 A ES510307 A ES 510307A ES 8303426 A1 ES8303426 A1 ES 8303426A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- procedure
- cephalosporin
- preparation
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE CEFALOSPORINA Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R PUEDE SER UNO DE VARIOS RADICALES; R ES HIDROGENO O ALQUILO C <- ; A Y A'' SON HIDROGENO, ARILO O ALQUILO C <- ; Y N VALE DE 0-3. CONSISTE EN LA REACCION DE UNA 3-YODOMETIL-CEFALOSPORINA DE FORMULA (II) CUYOS GRUPOS ACIDO Y AMINO ESTAN PROTEGIDOS, CON UN ACIDO PIRIDINHIDROXAMICO O UNO DE SUS DERIVADOS, DE FORMULA (III), EN LAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE APROTICO, EN CONDICIONES ANHIDRAS. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIBIOTICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/242,792 US4336253A (en) | 1981-03-11 | 1981-03-11 | Cephalosporin antibiotics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8303426A1 true ES8303426A1 (es) | 1983-02-01 |
| ES510307A0 ES510307A0 (es) | 1983-02-01 |
Family
ID=22916202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES510307A Granted ES510307A0 (es) | 1981-03-11 | 1982-03-10 | Un procedimiento para la preparacion de un compuesto de cefalosporina. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4336253A (es) |
| EP (1) | EP0060144A3 (es) |
| JP (1) | JPS57165393A (es) |
| KR (1) | KR830009119A (es) |
| AU (1) | AU8091182A (es) |
| BG (1) | BG36936A3 (es) |
| CA (1) | CA1177066A (es) |
| CS (1) | CS238620B2 (es) |
| DD (1) | DD201599A5 (es) |
| DK (1) | DK100982A (es) |
| ES (1) | ES510307A0 (es) |
| FI (1) | FI820806L (es) |
| GB (1) | GB2094309B (es) |
| GR (1) | GR74714B (es) |
| IL (1) | IL65185A0 (es) |
| NZ (1) | NZ199959A (es) |
| PH (1) | PH17022A (es) |
| PL (1) | PL130568B1 (es) |
| PT (1) | PT74558B (es) |
| RO (1) | RO82962B (es) |
| ZA (1) | ZA821525B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4443444A (en) * | 1980-08-11 | 1984-04-17 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
| DE3118732A1 (de) * | 1981-05-12 | 1982-12-02 | Hoechst Ag, 6000 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
| US4450270A (en) * | 1981-10-02 | 1984-05-22 | Eli Lilly And Company | Dioximino cephalosporin antibiotics |
| US4616081A (en) * | 1982-07-07 | 1986-10-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Cephalosporin compounds |
| DE3316797A1 (de) * | 1983-05-07 | 1984-11-08 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von cephemverbindungen |
| DE3316798A1 (de) * | 1983-05-07 | 1984-11-08 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von cephemverbindungen |
| DE3588014D1 (de) * | 1984-11-23 | 1995-06-01 | Biochemie Gmbh | Verfahren zur herstellung bissilylierter 3-iodmethylcephalosporinderivaten. |
| US4703118A (en) * | 1985-04-08 | 1987-10-27 | Eli Lilly And Company | Synthesis of 3-iodomethyl cephalosporins |
| US4714760A (en) * | 1985-08-20 | 1987-12-22 | Bristol-Myers Company | Cephalosporin intermediates |
| US4749522A (en) * | 1985-10-31 | 1988-06-07 | Angio-Medical Corporation | Supercritical fluid extraction of animal derived materials |
| US4868294A (en) * | 1986-07-11 | 1989-09-19 | Bristol-Myers Company | Process for preparing cephalosporin intermediates |
| US7847093B2 (en) * | 2003-04-16 | 2010-12-07 | Sandoz Ag | Processes for the preparations of cefepime |
| EP2218723A3 (en) | 2003-04-16 | 2010-11-17 | Sandoz AG | Processes for the preparations of cefepime |
| WO2006008749A1 (en) * | 2004-07-16 | 2006-01-26 | Hetero Drugs Limited | Process for preparing pure cephalosporine intermediates |
| PT3616695T (pt) | 2011-09-09 | 2024-11-18 | Merck Sharp & Dohme | Ceftolozano/tazobactam para tratar infeções intrapulmonares |
| US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
| US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| US20140274990A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Ceftolozane pharmaceutical compositions |
| CN110279698B (zh) | 2013-03-15 | 2022-10-28 | 默沙东有限责任公司 | 头孢特咯瓒抗生素组合物 |
| ES2800603T3 (es) | 2013-09-09 | 2021-01-04 | Merck Sharp & Dohme | Tratamiento de infecciones con ceftolozano/tazobactam en sujetos con insuficiencia renal |
| US8906898B1 (en) | 2013-09-27 | 2014-12-09 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3792047A (en) * | 1971-12-07 | 1974-02-12 | Glaxo Lab Ltd | N-(7,2'-thienylacetamidoceph-3-em-3-ylmethyl)-3"or 4"-n-hydroxyloweralkylcarbamoyl-pyridinium-4-carboxylates |
| DE2760123C2 (de) * | 1976-01-23 | 1986-04-30 | Roussel-Uclaf, Paris | 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
| JPS52125188A (en) | 1976-04-14 | 1977-10-20 | Takeda Chem Ind Ltd | Cephalosporin derivatives and their preparation |
| GR63088B (en) * | 1976-04-14 | 1979-08-09 | Takeda Chemical Industries Ltd | Preparation process of novel cephalosporins |
| JPS6011713B2 (ja) * | 1976-09-08 | 1985-03-27 | 武田薬品工業株式会社 | セフアロスポリン誘導体およびその製造法 |
| HU184631B (en) | 1978-05-26 | 1984-09-28 | Glaxo Group Ltd | Process for preparing cef-3-em-4-carboxylic acid derivatives with antiaiotic activity |
| GB2027692B (en) | 1978-05-26 | 1983-02-09 | Glaxo Group Ltd | Cephalosporin antibiotics |
| AR228726A1 (es) * | 1978-05-26 | 1983-04-15 | Glaxo Group Ltd | Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato |
| GB2043641B (en) | 1979-02-23 | 1983-07-20 | Glaxo Group Ltd | Cephalosporins |
| US4237128A (en) * | 1979-04-12 | 1980-12-02 | E. R. Squibb & Sons, Inc. | 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides |
-
1981
- 1981-03-11 US US06/242,792 patent/US4336253A/en not_active Expired - Fee Related
-
1982
- 1982-02-25 AU AU80911/82A patent/AU8091182A/en not_active Abandoned
- 1982-03-07 IL IL65185A patent/IL65185A0/xx unknown
- 1982-03-08 ZA ZA821525A patent/ZA821525B/xx unknown
- 1982-03-08 CA CA000397794A patent/CA1177066A/en not_active Expired
- 1982-03-09 PH PH26960A patent/PH17022A/en unknown
- 1982-03-09 DK DK100982A patent/DK100982A/da not_active Application Discontinuation
- 1982-03-09 GR GR67535A patent/GR74714B/el unknown
- 1982-03-09 NZ NZ199959A patent/NZ199959A/en unknown
- 1982-03-09 DD DD82238001A patent/DD201599A5/de unknown
- 1982-03-09 FI FI820806A patent/FI820806L/fi not_active Application Discontinuation
- 1982-03-10 KR KR1019820001027A patent/KR830009119A/ko not_active Ceased
- 1982-03-10 BG BG055737A patent/BG36936A3/xx unknown
- 1982-03-10 ES ES510307A patent/ES510307A0/es active Granted
- 1982-03-10 GB GB8207000A patent/GB2094309B/en not_active Expired
- 1982-03-10 EP EP82301216A patent/EP0060144A3/en not_active Ceased
- 1982-03-10 PT PT74558A patent/PT74558B/pt unknown
- 1982-03-11 JP JP57039277A patent/JPS57165393A/ja active Pending
- 1982-03-11 RO RO106875A patent/RO82962B/ro unknown
- 1982-03-11 PL PL1982235396A patent/PL130568B1/pl unknown
- 1982-03-11 CS CS821667A patent/CS238620B2/cs unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR830009119A (ko) | 1983-12-17 |
| DD201599A5 (de) | 1983-07-27 |
| JPS57165393A (en) | 1982-10-12 |
| ZA821525B (en) | 1983-03-30 |
| PT74558B (en) | 1984-11-27 |
| IL65185A0 (en) | 1982-05-31 |
| US4336253A (en) | 1982-06-22 |
| PH17022A (en) | 1984-05-11 |
| EP0060144A3 (en) | 1983-09-14 |
| PL130568B1 (en) | 1984-08-31 |
| ES510307A0 (es) | 1983-02-01 |
| PT74558A (en) | 1982-04-01 |
| FI820806A7 (fi) | 1982-09-12 |
| DK100982A (da) | 1982-09-12 |
| RO82962B (ro) | 1984-01-30 |
| GB2094309A (en) | 1982-09-15 |
| BG36936A3 (bg) | 1985-02-15 |
| FI820806L (fi) | 1982-09-12 |
| EP0060144A2 (en) | 1982-09-15 |
| RO82962A (ro) | 1984-01-14 |
| CA1177066A (en) | 1984-10-30 |
| PL235396A1 (es) | 1982-09-27 |
| CS238620B2 (en) | 1985-12-16 |
| GB2094309B (en) | 1985-03-27 |
| GR74714B (es) | 1984-07-06 |
| AU8091182A (en) | 1982-09-16 |
| NZ199959A (en) | 1985-08-16 |
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