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RO82679B - PROCEDEU DE PREPARARE A UNEI SUSPENSII DE BACAMPICILINA MICROîNCAPSULATA - Google Patents

PROCEDEU DE PREPARARE A UNEI SUSPENSII DE BACAMPICILINA MICROîNCAPSULATA

Info

Publication number
RO82679B
RO82679B RO104817A RO10481781A RO82679B RO 82679 B RO82679 B RO 82679B RO 104817 A RO104817 A RO 104817A RO 10481781 A RO10481781 A RO 10481781A RO 82679 B RO82679 B RO 82679B
Authority
RO
Romania
Prior art keywords
suspension
micropacked
becampicillin
preparing
weight
Prior art date
Application number
RO104817A
Other languages
English (en)
Other versions
RO82679A (ro
Inventor
Morgan Lee Beatty
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of RO82679A publication Critical patent/RO82679A/ro
Publication of RO82679B publication Critical patent/RO82679B/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Inventia se refera la un procedeu de preparare a unei suspensii de bacampicilina microîncapsulata prin care hidroclorura de b campicilina se acopera cu un învelis format dintr-un amestec de etilceluloza si hidroxipropilceluloza asociate într-un raport de 1,5:1......2:1, si dintr-un material de umplutura dintr-un polimer organic, greutatea învelisului reprezentînd circa 54% din greutatea miezului microcapsulele obtinute fiind apoi amestecate cu un vehicul de suspensie care determina în mediul apos de suspensie un pH cuprins între 7,2 si 8,2 suspensia obtinuta prezentînd un nivel maxim de ampicilina în serul sanguin de cel putin 6 mg/ml dupa administrare orala.
RO104817A 1980-08-22 1981-07-08 PROCEDEU DE PREPARARE A UNEI SUSPENSII DE BACAMPICILINA MICROîNCAPSULATA RO82679B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/180,537 US4321253A (en) 1980-08-22 1980-08-22 Suspension of microencapsulated bacampicillin acid addition salt for oral, especially pediatric, administration

Publications (2)

Publication Number Publication Date
RO82679A RO82679A (ro) 1984-05-23
RO82679B true RO82679B (ro) 1984-07-30

Family

ID=22660812

Family Applications (1)

Application Number Title Priority Date Filing Date
RO104817A RO82679B (ro) 1980-08-22 1981-07-08 PROCEDEU DE PREPARARE A UNEI SUSPENSII DE BACAMPICILINA MICROîNCAPSULATA

Country Status (41)

Country Link
US (1) US4321253A (ro)
JP (1) JPS5775986A (ro)
KR (1) KR860000513B1 (ro)
AR (1) AR227201A1 (ro)
AT (1) AT370994B (ro)
AU (1) AU529965B2 (ro)
BE (1) BE890028A (ro)
BG (1) BG42000A3 (ro)
CA (1) CA1137414A (ro)
CH (1) CH650674A5 (ro)
CS (1) CS225845B2 (ro)
DD (1) DD201644A5 (ro)
DE (1) DE3132614C2 (ro)
DK (1) DK158971C (ro)
DZ (1) DZ315A1 (ro)
ES (1) ES8303091A1 (ro)
FI (1) FI72647C (ro)
FR (1) FR2488798A1 (ro)
GB (1) GB2082539B (ro)
GR (1) GR74983B (ro)
HK (1) HK43786A (ro)
HU (1) HU188679B (ro)
IE (1) IE51506B1 (ro)
IL (1) IL63617A (ro)
IN (1) IN156538B (ro)
IT (1) IT1138161B (ro)
KE (1) KE3626A (ro)
LU (1) LU83572A1 (ro)
MX (1) MX5731A (ro)
MY (1) MY8600597A (ro)
NL (1) NL191978C (ro)
NO (1) NO154821C (ro)
NZ (1) NZ198106A (ro)
PH (1) PH17125A (ro)
PL (1) PL232141A1 (ro)
PT (1) PT73555B (ro)
RO (1) RO82679B (ro)
SE (1) SE448819B (ro)
SU (1) SU1364226A3 (ro)
YU (1) YU43985B (ro)
ZA (1) ZA815793B (ro)

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US4994260A (en) * 1982-05-28 1991-02-19 Astra Lakemedel Aktiebolag Pharmaceutical mixture
SE8203953D0 (sv) * 1982-06-24 1982-06-24 Astra Laekemedel Ab Pharmaceutical mixture
WO1984000004A1 (en) * 1982-06-14 1984-01-05 Key Pharma Sustained release aspirin
US4508702A (en) * 1982-06-14 1985-04-02 Key Pharmaceuticals, Inc. Sustained release aspirin
DE3382392D1 (de) * 1982-07-09 1991-10-02 Key Pharma Dosierungsart zur dauerhaften verabreichung von chinidin.
US4634587A (en) * 1982-07-09 1987-01-06 Key Pharmaceuticals, Inc. Sustained release quinidine dosage form
AU569277B2 (en) * 1983-03-03 1988-01-28 Dow Chemical Company, The Aqueuos dispersion of water-insoluble organophilic cellulose ether for sustained release of active agents
US4555399A (en) * 1983-11-18 1985-11-26 Key Pharmaceuticals, Inc. Aspirin tablet
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
SE8405611D0 (sv) * 1984-11-09 1984-11-09 Astra Laekemedel Ab Process for stabilization of bacampicillin hydrochloride
US4800087A (en) * 1986-11-24 1989-01-24 Mehta Atul M Taste-masked pharmaceutical compositions
GB8628359D0 (en) * 1986-11-27 1986-12-31 Zyma Sa Galenical formulation
US4853229A (en) * 1987-10-26 1989-08-01 Alza Corporation Method for adminstering tiny pills
US5084278A (en) * 1989-06-02 1992-01-28 Nortec Development Associates, Inc. Taste-masked pharmaceutical compositions
HU215958B (hu) * 1992-04-30 1999-03-29 Schering Corp. Eljárás stabil, hidratált, száraz ceftibuten porkészítmény előállítására perorális szuszpenziókhoz
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
US6270804B1 (en) * 1998-04-03 2001-08-07 Biovail Technologies Ltd. Sachet formulations
IN191482B (ro) * 1999-03-19 2003-12-06 Ranbaxy Lab Ltd
JP4711478B2 (ja) * 1999-08-13 2011-06-29 旭化成ケミカルズ株式会社 味がマスクされた薬物
US20050037086A1 (en) * 1999-11-19 2005-02-17 Zycos Inc., A Delaware Corporation Continuous-flow method for preparing microparticles
JP2003518485A (ja) 1999-12-23 2003-06-10 ファイザー・プロダクツ・インク 向上された薬物濃度を与える医薬組成物
EP1118333A1 (en) * 2000-01-18 2001-07-25 Eurand International S.P.A. Compositions with enhanced oral bioavailability
US6551617B1 (en) 2000-04-20 2003-04-22 Bristol-Myers Squibb Company Taste masking coating composition
DK1276470T3 (da) 2000-04-20 2007-06-18 Novartis Ag Smagskaskerende overtrækssammensætning
AU6815901A (en) * 2000-06-02 2001-12-17 Zycos Inc Delivery systems for bioactive agents
FR2822834B1 (fr) * 2001-04-02 2005-02-25 Flamel Tech Sa Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation
US20030096791A1 (en) * 2001-05-31 2003-05-22 Cima Labs Inc. Taste masking of highly water-soluble drugs
KR20030015655A (ko) * 2001-08-17 2003-02-25 한미약품공업 주식회사 항암제의 경구흡수율을 증가시키는 인단계 화합물의결정성 산부가염, 이의 제조방법 및 이를 함유하는 약학적조성물
US8101209B2 (en) * 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
FR2830447B1 (fr) * 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
DE60325709D1 (de) 2002-04-09 2009-02-26 Flamel Tech Sa Orale wässrige suspension, mikrokapseln enthaltend, zur kontrollierten freisetzung von wirkstoffen
PT1492531E (pt) * 2002-04-09 2008-12-10 Flamel Tech Sa Formulação farmacêutica oral sob a forma de suspensão aquosa de microcápsulas que permite a libertação modificada de amoxicilina
FR2842736B1 (fr) 2002-07-26 2005-07-22 Flamel Tech Sa Formulation pharmaceutique orale sous forme d'une pluralite de microcapsules permettant la liberation prolongee de principe(s) actif(s) peu soluble(s)
FR2842735B1 (fr) * 2002-07-26 2006-01-06 Flamel Tech Sa Microcapsules a liberation modifiee de principes actifs peu solubles pour l'administration per os
FR2843117B1 (fr) * 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
US7632521B2 (en) * 2003-07-15 2009-12-15 Eurand, Inc. Controlled release potassium chloride tablets
FR2860516B1 (fr) * 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
FR2862536B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
US7244765B2 (en) * 2004-06-25 2007-07-17 Cytokine Pharmasciences, Inc Guanylhydrazone salts, compositions, processes of making and methods of using
FR2885526B1 (fr) * 2005-05-13 2007-07-27 Flamel Technologies Sa Medicament oral a base d'inhibiteur de pompe a protons
EP3363442A4 (en) * 2015-10-13 2019-03-06 Techno Guard CO. LTD. PROTECTIVE COMPOSITION FOR STOMACH-DARM-SCHLEIMHAUT

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US3549746A (en) * 1967-11-02 1970-12-22 Bristol Myers Co Antibiotic composition
US3873521A (en) * 1970-09-17 1975-03-25 Astra Laekemedel Ab Esters of {60 -amino penicillins
ZA718014B (en) 1970-12-23 1972-08-30 Beecham Group Ltd Pharmaceutical formulations
US4016254A (en) * 1972-05-19 1977-04-05 Beecham Group Limited Pharmaceutical formulations
GB1455296A (en) * 1973-05-24 1976-11-10 Beecham Group Ltd Veterinary treatment
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US4127647A (en) * 1975-04-08 1978-11-28 Meiji Seika Kaisha, Ltd. Process for preparation of stable amorphous macrolide antibiotic solids
JPS5840529B2 (ja) * 1975-09-29 1983-09-06 明治製菓株式会社 ケイコウヨウセイザイノセイホウ
GB1561301A (en) * 1976-01-02 1980-02-20 Beecham Group Ltd Orally administrable pharmaceutical composition
ZA793934B (en) * 1978-08-04 1980-07-30 Beecham Group Ltd Powders
JPS57105316A (en) * 1980-12-23 1982-06-30 Hitachi Cable Ltd Method of fitting heat-shrinkable tube

Also Published As

Publication number Publication date
JPH0248525B2 (ro) 1990-10-25
ES504905A0 (es) 1983-02-01
FR2488798A1 (fr) 1982-02-26
US4321253A (en) 1982-03-23
KE3626A (en) 1986-05-16
PH17125A (en) 1984-06-01
SU1364226A3 (ru) 1987-12-30
IT1138161B (it) 1986-09-17
MX5731A (es) 1993-11-01
HK43786A (en) 1986-06-20
DD201644A5 (de) 1983-08-03
AU529965B2 (en) 1983-06-30
BE890028A (fr) 1982-02-22
NO812827L (no) 1982-02-23
IL63617A (en) 1984-11-30
CH650674A5 (fr) 1985-08-15
FR2488798B1 (ro) 1985-01-11
NL191978B (nl) 1996-08-01
NL191978C (nl) 1996-12-03
KR830005850A (ko) 1983-09-14
DK158971B (da) 1990-08-13
IN156538B (ro) 1985-08-31
MY8600597A (en) 1986-12-31
RO82679A (ro) 1984-05-23
ES8303091A1 (es) 1983-02-01
FI72647C (fi) 1987-07-10
DK158971C (da) 1991-01-07
NZ198106A (en) 1983-12-16
DZ315A1 (fr) 2004-09-13
DE3132614C2 (de) 1985-08-22
IE51506B1 (en) 1987-01-07
FI72647B (fi) 1987-03-31
HU188679B (en) 1986-05-28
GR74983B (ro) 1984-07-12
GB2082539B (en) 1984-01-18
AR227201A1 (es) 1982-09-30
JPS5775986A (en) 1982-05-12
KR860000513B1 (ko) 1986-05-02
NO154821C (no) 1987-01-07
PL232141A1 (ro) 1982-03-15
LU83572A1 (fr) 1982-04-14
PT73555B (en) 1983-07-14
NO154821B (no) 1986-09-22
NL8103902A (nl) 1982-03-16
DK372181A (da) 1982-02-23
GB2082539A (en) 1982-03-10
ATA362781A (de) 1982-10-15
FI812574L (fi) 1982-02-23
DE3132614A1 (de) 1982-05-19
SE8104974L (sv) 1982-02-23
AU7441681A (en) 1982-04-01
AT370994B (de) 1983-05-25
IL63617A0 (en) 1981-11-30
IE811911L (en) 1982-02-22
ZA815793B (en) 1982-08-25
SE448819B (sv) 1987-03-23
YU43985B (en) 1990-02-28
CA1137414A (en) 1982-12-14
CS225845B2 (en) 1984-02-13
IT8123587A0 (it) 1981-08-20
BG42000A3 (en) 1987-09-15
YU201781A (en) 1984-04-30
PT73555A (en) 1981-09-01

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