PT99713A - Processo para preparacao de derivados de acido biliatico e de composicoes farmaceuticas que os contem - Google Patents

Processo para preparacao de derivados de acido biliatico e de composicoes farmaceuticas que os contem

Info

Publication number: PT99713A
Authority: PT; Portugal
Prior art keywords: bile acid; dilivates; biliatic; preparing; acid
Prior art date: 1990-12-06

Application number

PT99713A

Other languages

English (en)

Other versions

PT99713B (pt

Inventor

Werner Kramer

Stefan Mullner

Gunther Wess

Horst Neubauer

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-06

Filing date

1991-12-06

Publication date

1992-10-30

1991-12-06 Application filed by Hoechst Ag filed Critical Hoechst Ag

1992-10-30 Publication of PT99713A publication Critical patent/PT99713A/pt

1999-05-31 Publication of PT99713B publication Critical patent/PT99713B/pt

Links

239000002253 acid Substances 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical class C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 abstract 3
239000003613 bile acid Substances 0.000 abstract 3
238000010521 absorption reaction Methods 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000003158 alcohol group Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
230000002860 competitive effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000003839 salts Chemical group 0.000 abstract 1
210000000813 small intestine Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Veterinary Medicine (AREA)
Obesity (AREA)
Engineering & Computer Science (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Motorcycle And Bicycle Frame (AREA)
Train Traffic Observation, Control, And Security (AREA)

PT99713A 1990-12-06 1991-12-06 Processo para preparacao de derivados de acido biliatico e de composicoes farmaceuticas que os contem PT99713B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4038833		1990-12-06

Publications (2)

Publication Number	Publication Date
PT99713A true PT99713A (pt)	1992-10-30
PT99713B PT99713B (pt)	1999-05-31

Family

ID=6419672

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT99713A PT99713B (pt)	1990-12-06	1991-12-06	Processo para preparacao de derivados de acido biliatico e de composicoes farmaceuticas que os contem

Country Status (23)

Country	Link
US (1)	US5250524A (pt)
EP (1)	EP0489423B1 (pt)
JP (1)	JP3237882B2 (pt)
KR (1)	KR100221690B1 (pt)
AT (1)	ATE144988T1 (pt)
AU (1)	AU649089B2 (pt)
CA (1)	CA2057099C (pt)
CZ (1)	CZ281075B6 (pt)
DE (1)	DE59108326D1 (pt)
DK (1)	DK0489423T3 (pt)
ES (1)	ES2096614T3 (pt)
FI (1)	FI106800B (pt)
GR (1)	GR3021572T3 (pt)
HR (1)	HRP940751B1 (pt)
HU (2)	HU213402B (pt)
IE (1)	IE914235A1 (pt)
IL (1)	IL100240A (pt)
NO (1)	NO304187B1 (pt)
NZ (1)	NZ240846A (pt)
PT (1)	PT99713B (pt)
SI (1)	SI9111899B (pt)
YU (1)	YU48636B (pt)
ZA (1)	ZA919605B (pt)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5795870A (en) *	1991-12-13	1998-08-18	Trustees Of Princeton University	Compositions and methods for cell transformation
EP0548793A3 (en) *	1991-12-20	1995-11-02	Hoechst Ag	Ethylenic-unsaturated bile acid derivatives, process for their production and preliminary processes therefor
EP0549967B1 (de) *	1991-12-20	1996-03-13	Hoechst Aktiengesellschaft	Polymere und Oligomere von Gallensäurederivaten, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
IT1258788B (it) *	1992-01-17	1996-02-29	Giuliani Spa	Derivati solforati di acidi biliari
EP0573848B1 (de) *	1992-06-12	1997-12-03	Hoechst Aktiengesellschaft	Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel
ATE152729T1 (de) *	1993-03-09	1997-05-15	Hoechst Ag	Verfahren zur herstellung von 3beta- aminocholansäurederivaten
ATE169930T1 (de) *	1993-03-10	1998-09-15	Magainin Pharma	Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittel
TW289020B (pt) *	1993-05-08	1996-10-21	Hoechst Sktiengesellschaft
EP0624593A3 (de) *	1993-05-08	1995-06-07	Hoechst Ag	Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel.
TW289021B (pt) *	1993-05-08	1996-10-21	Hoechst Ag
TW289757B (pt) *	1993-05-08	1996-11-01	Hoechst Ag
US5624963A (en) *	1993-06-02	1997-04-29	Geltex Pharmaceuticals, Inc.	Process for removing bile salts from a patient and compositions therefor
US5585470A (en) *	1994-06-23	1996-12-17	Transcell Technologies, Inc.	Process for the manufacture of 3-amino-substituted glycosylated bile acids
US5856535A (en) *	1994-08-18	1999-01-05	Magainin Pharmaceuticals, Inc.	Aminosterol ester compounds
US5840740A (en) *	1995-06-07	1998-11-24	Magainin Pharmaceuticals Inc.	Aminosterol compounds and a method of treating infection using the aminosterol compounds
DE4432708A1 (de) *	1994-09-14	1996-03-21	Hoechst Ag	Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
US5583239A (en) *	1995-05-30	1996-12-10	Lehigh University	Antimicrobial sterol conjugates
US5792635A (en) *	1995-06-07	1998-08-11	Magainin Pharmaceuticals, Inc.	Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
US5994336A (en) *	1995-06-07	1999-11-30	Magainin Pharmaceuticals Inc.	Method of inhibiting proliferation of cells by administering an aminosterol compound
US5763430A (en) *	1995-06-07	1998-06-09	Magainin Pharmaceuticals Inc.	Method of treating a viral infection by administering a steroid compound
US5874597A (en) *	1995-06-07	1999-02-23	Magainin Pharmaceuticals, Inc.	Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5840936A (en) *	1995-06-07	1998-11-24	Magainin Pharmaceuticals Inc.	Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE)
US5795885A (en) *	1995-06-07	1998-08-18	Magainin Pharmaceuticals Inc.	Method of inhibiting profileration of cells by administering an aminosterol compound
US6143738A (en) *	1995-06-07	2000-11-07	Magainin Pharmaceuticals, Inc.	Therapeutic uses for an aminosterol compound
US5847172A (en) *	1995-06-07	1998-12-08	Magainin Pharmaceuticals Inc.	Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5789244A (en) *	1996-01-08	1998-08-04	Canji, Inc.	Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems
US7002027B1 (en) *	1996-01-08	2006-02-21	Canji, Inc.	Compositions and methods for therapeutic use
US20040014709A1 (en) *	1996-01-08	2004-01-22	Canji, Inc.	Methods and compositions for interferon therapy
US6392069B2 (en) *	1996-01-08	2002-05-21	Canji, Inc.	Compositions for enhancing delivery of nucleic acids to cells
FR2743561B1 (fr) *	1996-01-15	1998-02-20	Fournier Sca Lab	Derives de steroides, procede de preparation et utilisation en therapeutique
US6596712B2 (en)	1996-04-26	2003-07-22	Genaera Corporation	Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities
JP2000510460A (ja) *	1996-04-26	2000-08-15	マゲイニン・ファーマシューティカルズ・インコーポレーテッド	スクアラミンを他の抗癌剤と併用する上皮性悪性腫瘍の治療
DE19633268A1 (de) *	1996-08-19	1998-02-26	Hoechst Ag	Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung
US6262283B1 (en)	1996-12-06	2001-07-17	Magainin Pharmaceuticals Inc.	Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
ES2223091T3 (es) *	1997-04-04	2005-02-16	Aventis Pharma Deutschland Gmbh	Derivados de propanolamina hipolipidemicos.
DE19845403B4 (de) *	1998-10-02	2005-02-10	Aventis Pharma Deutschland Gmbh	Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19950686B4 (de) *	1999-10-21	2006-06-29	Martin-Luther-Universität Halle-Wittenberg	Multifunktionelle Spacer
US7074778B2 (en) *	1999-12-09	2006-07-11	Genaera Corporation	Asthma associated factors as targets for treating atopic allergies including asthma and related disorders
DK1274718T3 (da) *	2000-04-12	2007-02-12	Genaera Corp	En fremgangsmåde til forberedelse af 7.alpha.-hydroxy 3-aminosubstituerede steroler vee en ubeskyttet 7.alpha.-hydroxy gruppe
US8975246B2 (en)	2001-04-17	2015-03-10	Galmed Research And Development Ltd.	Bile acid or bile salt fatty acid conjugates
ES2745068T3 (es) *	2001-12-20	2020-02-27	Merck Sharp & Dohme	Composiciones de SYN3 y métodos
US7141559B2 (en)	2002-06-19	2006-11-28	Karo Bio Ab	Glucocorticoid receptor ligands for the treatment of metabolic disorders
DK1551860T3 (da) *	2002-06-19	2007-04-02	Karobio Ab	Glukokortikoid-receptorligander til behandling af stofskifteforstyrrelser
GB0307918D0 (en)	2003-04-05	2003-05-14	Astrazeneca Ab	Therapeutic use
US7355056B2 (en)	2003-06-04	2008-04-08	Canji, Inc.	Transfection agents
US7235678B2 (en) *	2004-03-30	2007-06-26	Council Of Scientific And Industrial Research	Bile acid derived steroidal dimers with novel amphiphilic topology having antifungal activity
US20050225942A1 (en) *	2004-04-07	2005-10-13	First International Computer Inc.	Plug-in cooling device
ES2318922B1 (es) *	2005-05-30	2010-02-12	Universidade De Santiago De Compostela	Nuevos dimeros derivados de acidos biliares funcionalizados en la posicion 3 del anillo a. metodo para la sintesis y aplicaciones.
ES2318927B1 (es) *	2005-08-25	2010-02-12	Universidade De Santiago De Compostela	Nuevos dimeros de acidos biliares funcionalizados en la posicion 24 de la cadena alquilica de la sal biliar. procedimientos para su obtencion y aplicaciones.
US7960439B1 (en)	2006-06-12	2011-06-14	Iowa State University Research Foundation, Inc.	Environmentally sensitive foldable oligomers
US7962543B2 (en) *	2007-06-01	2011-06-14	Advanced Micro Devices, Inc.	Division with rectangular multiplier supporting multiple precisions and operand types
KR101289199B1 (ko)	2008-08-28	2013-07-29	한양대학교 산학협력단	수용성기를 포함한 바일산 유도체 및 그의 응용
WO2012054092A1 (en) *	2010-01-22	2012-04-26	Trustees Of Dartmouth College	Lipid cofactors for facilitating propogation of prpsc
WO2011150286A2 (en)	2010-05-26	2011-12-01	Satiogen Pharmaceuticals,Inc.	Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
HRP20160993T1 (hr)	2010-11-04	2016-12-30	Albireo Ab	Inhibitori ibat za liječenje bolesti jetre
DK2637646T3 (en)	2010-11-08	2016-08-29	Albireo Ab	PHARMACEUTICAL COMBINATION CONTAINING AN IBAT inhibitor and a bile acid binder
KR20210131431A (ko)	2011-10-28	2021-11-02	샤이어 휴먼 지네틱 테라피즈 인크.	고담혈증 및 담즙 정체성 간 질환 치료용 담즙산 재순환 억제제
SG11201401849QA (en)	2011-10-28	2014-05-29	Lumena Pharmaceuticals Inc	Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
KR20160003664A (ko)	2013-03-15	2016-01-11	루메나 파마수티컬즈, 인코포레이티드	바렛 식도 및 위식도 역류 질환 치료용 담즙산 재순환 억제제
AU2014228850A1 (en)	2013-03-15	2015-10-29	Lumena Pharmaceuticals Llc	Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
JO3301B1 (ar)	2013-04-26	2018-09-16	Albireo Ab	تعديلات بلورية على إيلوبيكسيبات
KR102560954B1 (ko)	2014-06-25	2023-07-31	이에이 파마 가부시키가이샤	고형 제제 및 그의 착색 방지 또는 착색 감소 방법
EP3012252A1 (en)	2014-10-24	2016-04-27	Ferring BV	Crystal modifications of elobixibat
US10786529B2 (en)	2016-02-09	2020-09-29	Albireo Ab	Oral cholestyramine formulation and use thereof
US10441605B2 (en)	2016-02-09	2019-10-15	Albireo Ab	Oral cholestyramine formulation and use thereof
WO2017138878A1 (en)	2016-02-09	2017-08-17	Albireo Ab	Oral cholestyramine formulation and use thereof
US10441604B2 (en)	2016-02-09	2019-10-15	Albireo Ab	Cholestyramine pellets and methods for preparation thereof
WO2017138877A1 (en)	2016-02-09	2017-08-17	Albireo Ab	Oral cholestyramine formulation and use thereof
WO2019032027A1 (en)	2017-08-09	2019-02-14	Albireo Ab	CHOLESTYRAMINE TABLETS, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE
WO2019032026A1 (en)	2017-08-09	2019-02-14	Albireo Ab	CHOLESTYRAMINE GRANULES, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE
WO2019148294A1 (en) *	2018-02-02	2019-08-08	Interface Biologics, Inc.	Dimeric dexamethasone prodrug compositions and uses thereof
US10793534B2 (en)	2018-06-05	2020-10-06	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
EP3802504B1 (en)	2018-06-05	2023-01-18	Albireo AB	Benzothia(di)azepine compounds and their use as bile acid modulators
US11801226B2 (en)	2018-06-20	2023-10-31	Albireo Ab	Pharmaceutical formulation of odevixibat
PE20210182A1 (es)	2018-06-20	2021-01-29	Albireo Ab	Modificaciones de cristales de odexibat
US11549878B2 (en)	2018-08-09	2023-01-10	Albireo Ab	In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US11007142B2 (en)	2018-08-09	2021-05-18	Albireo Ab	Oral cholestyramine formulation and use thereof
US10722457B2 (en)	2018-08-09	2020-07-28	Albireo Ab	Oral cholestyramine formulation and use thereof
US10975045B2 (en)	2019-02-06	2021-04-13	Aibireo AB	Benzothiazepine compounds and their use as bile acid modulators
US10941127B2 (en)	2019-02-06	2021-03-09	Albireo Ab	Benzothiadiazepine compounds and their use as bile acid modulators
FI3921028T3 (fi)	2019-02-06	2023-01-31		Bentsotiadiatsepiinin yhdisteet ja niiden käyttö sappihapon modulaattoreina
JP7504110B2 (ja)	2019-02-06	2024-06-21	アルビレオ・アクチボラグ	ベンゾチアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
US20220133738A1 (en)	2019-02-12	2022-05-05	Mirum Pharmaceuticals, Inc.	Genotype and dose-dependent response to an asbti in patients with bile salt export pump deficiency
CN116925168A (zh) *	2019-08-23	2023-10-24	深圳云合医药科技合伙企业(有限合伙)	胆汁酸衍生物及其组合物和应用
EP4069359B1 (en)	2019-12-04	2024-01-03	Albireo AB	Benzothia(di)azepine compounds and their use as bile acid modulators
JP7696897B2 (ja)	2019-12-04	2025-06-23	アルビレオ・アクチボラグ	ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
FI4069360T3 (fi)	2019-12-04	2024-02-20	Albireo Ab	Bentsotia(di)atsepiinin yhdisteet ja niiden käyttö sappihapon modulaattoreina
AR120683A1 (es)	2019-12-04	2022-03-09	Albireo Ab	Compuestos de benzoti(di)azepina y su uso como ácido biliar
WO2021110885A1 (en)	2019-12-04	2021-06-10	Albireo Ab	Benzothiadiazepine compounds and their use as bile acid modulators
TWI865673B (zh)	2019-12-04	2024-12-11	瑞典商艾爾比瑞歐公司	苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
AR120674A1 (es)	2019-12-04	2022-03-09	Albireo Ab	Compuestos de benzotiazepina y su uso como ácido biliar
US11014898B1 (en)	2020-12-04	2021-05-25	Albireo Ab	Benzothiazepine compounds and their use as bile acid modulators
WO2021110886A1 (en)	2019-12-04	2021-06-10	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
CN114761018A (zh)	2019-12-04	2022-07-15	阿尔比里奥公司	苯并硫杂二氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
CN115956083A (zh)	2020-05-01	2023-04-11	波纹疗法公司	异二聚体组合物及用于治疗眼部病症的方法
EP4188541B1 (en)	2020-08-03	2024-12-25	Albireo AB	Benzothia(di)azepine compounds and their use as bile acid modulators
WO2022029101A1 (en)	2020-08-03	2022-02-10	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
JP2023549226A (ja)	2020-11-12	2023-11-22	アルビレオエービー	進行性家族性肝内胆汁うっ滞症（ｐｆｉｃ）を処置するためのオデビキシバット
AU2021390172A1 (en)	2020-12-04	2023-06-22	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
TW202313579A (zh)	2021-06-03	2023-04-01	瑞典商艾爾比瑞歐公司	苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
WO2023216423A1 (zh) *	2022-05-13	2023-11-16	苏州慧疗生物医药科技有限公司	脂质化合物及其组合物，制备和用途
KR20250022025A (ko)	2022-06-09	2025-02-14	알비레오 에이비	간염 치료
AU2023304672A1 (en)	2022-07-05	2025-01-02	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
AU2023390975A1 (en)	2022-12-09	2025-06-05	Albireo Ab	Asbt inhibitors in the treatment of renal diseases
WO2025146507A1 (en)	2024-01-05	2025-07-10	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
WO2025146508A1 (en)	2024-01-05	2025-07-10	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4418059A (en) *	1981-07-20	1983-11-29	Montefiore Medical Center	Nucleoside ester compositions
IT1210874B (it) *	1982-04-15	1989-09-29	Istituto Chemioterapico	Sale di magnesio dell'acido chenodesossicolico e dell'acido ursodesossicolico, processo per lasua preparazione e composizioni terapeutiche che lo contengono come principio attivo.
ATE45284T1 (de) *	1985-05-15	1989-08-15	Ba Inpharm Bv	Wirkstoff-vorlaeufer enthaltende pharmazeutische zusammensetzungen, verfahren zu ihrer herstellung, verfahren zur herstellung von wirkstoff-vorlaeufer-verbindungen und die erhaltenen verbindungen.
DE3742798C2 (de) *	1987-12-17	1997-02-13	Freedom Chemical Co	Verfahren zur Herstellung des Magnesium-Doppelsalzes der Chenodesoxycholsäure und Ursodesoxycholsäure

1991
- 1991-12-04 NZ NZ240846A patent/NZ240846A/en unknown
- 1991-12-04 AT AT91120841T patent/ATE144988T1/de not_active IP Right Cessation
- 1991-12-04 FI FI915719A patent/FI106800B/fi active
- 1991-12-04 DE DE59108326T patent/DE59108326D1/de not_active Expired - Lifetime
- 1991-12-04 DK DK91120841.1T patent/DK0489423T3/da active
- 1991-12-04 EP EP91120841A patent/EP0489423B1/de not_active Expired - Lifetime
- 1991-12-04 ES ES91120841T patent/ES2096614T3/es not_active Expired - Lifetime
- 1991-12-04 IL IL10024091A patent/IL100240A/en not_active IP Right Cessation
- 1991-12-04 US US07/802,413 patent/US5250524A/en not_active Expired - Lifetime
- 1991-12-05 ZA ZA919605A patent/ZA919605B/xx unknown
- 1991-12-05 CZ CS913697A patent/CZ281075B6/cs not_active IP Right Cessation
- 1991-12-05 AU AU88849/91A patent/AU649089B2/en not_active Ceased
- 1991-12-05 NO NO914792A patent/NO304187B1/no not_active IP Right Cessation
- 1991-12-05 JP JP34837791A patent/JP3237882B2/ja not_active Expired - Lifetime
- 1991-12-05 HU HU913817A patent/HU213402B/hu not_active IP Right Cessation
- 1991-12-05 CA CA002057099A patent/CA2057099C/en not_active Expired - Lifetime
- 1991-12-05 IE IE423591A patent/IE914235A1/en not_active Application Discontinuation
- 1991-12-06 KR KR1019910022269A patent/KR100221690B1/ko not_active Expired - Fee Related
- 1991-12-06 SI SI9111899A patent/SI9111899B/sl unknown
- 1991-12-06 YU YU189991A patent/YU48636B/sh unknown
- 1991-12-06 PT PT99713A patent/PT99713B/pt active IP Right Grant
1994
- 1994-10-25 HR HR940751A patent/HRP940751B1/xx not_active IP Right Cessation
1995
- 1995-06-29 HU HU95P/P00553P patent/HU211900A9/hu unknown
1996
- 1996-11-07 GR GR960402941T patent/GR3021572T3/el unknown

Also Published As

Publication number	Publication date
EP0489423A1 (de)	1992-06-10
HU211900A9 (en)	1996-01-29
AU649089B2 (en)	1994-05-12
NO304187B1 (no)	1998-11-09
FI915719L (fi)	1992-06-07
NO914792L (no)	1992-06-09
PT99713B (pt)	1999-05-31
YU189991A (sh)	1995-10-03
US5250524A (en)	1993-10-05
CA2057099A1 (en)	1992-06-07
YU48636B (sh)	1999-03-04
EP0489423B1 (de)	1996-11-06
NO914792D0 (no)	1991-12-05
DK0489423T3 (da)	1997-04-14
IL100240A0 (en)	1992-09-06
AU8884991A (en)	1992-06-11
ATE144988T1 (de)	1996-11-15
ES2096614T3 (es)	1997-03-16
ZA919605B (en)	1992-08-26
KR920012108A (ko)	1992-07-25
HU913817D0 (en)	1992-02-28
GR3021572T3 (en)	1997-02-28
IL100240A (en)	1995-10-31
CZ281075B6 (cs)	1996-06-12
DE59108326D1 (de)	1996-12-12
HRP940751B1 (en)	2000-12-31
NZ240846A (en)	1994-04-27
HU213402B (en)	1997-06-30
SI9111899B (sl)	2000-06-30
JPH05294988A (ja)	1993-11-09
FI106800B (fi)	2001-04-12
KR100221690B1 (ko)	1999-10-01
HUT62599A (en)	1993-05-28
SI9111899A (sl)	1998-04-30
JP3237882B2 (ja)	2001-12-10
CS369791A3 (en)	1992-06-17
FI915719A0 (fi)	1991-12-04
HRP940751A2 (en)	1997-04-30
IE914235A1 (en)	1992-06-17
CA2057099C (en)	2005-05-17

Publication	Publication Date	Title
PT99713A (pt)	1992-10-30	Processo para preparacao de derivados de acido biliatico e de composicoes farmaceuticas que os contem
PT87929A (pt)	1989-06-30	Processo para a preparacao de derivados de acido 3-desmetil-mevalonico e de composicoes farmaceuticas que os contem
PT99267A (pt)	1992-08-31	Processo para a preparacao de novos derivados de mercaptoacetilamida e de composicoes farmaceuticas que os contem
PT98102A (pt)	1992-03-31	Processo de preparacao de misturas de polissacaridos de baixo peso molecular e de composicoes farmaceuticas que as contem
PT91053A (pt)	1990-02-08	Processo para a preparacao de derivados de acido difosfonico e de composicoes farmaceuticas que os contem
PT91766A (pt)	1990-03-30	Processo para a preparacao de derivados do acido 3,5-dihidroxihept-6-ina-carboxilico substituidos na posicao, de seus compostos intermedios e de composicoes farmaceuticas que os contem
PT91287A (pt)	1990-02-08	Processo de preparacao de derivados do acido indazol-3-carboxilico e de composicoes farmaceuticas que os contem
PT93246A (pt)	1990-08-31	Processo para a preparacao de compostos pirrolicos substituidos e de composicoes farmaceuticas que os contem
PT87261A (pt)	1988-05-01	Processo de preparacao de heparinas de baixo peso molecular,com estrutura regular e de composicoes farmaceuticas que as contem
PT95299A (pt)	1991-05-22	Processo para preparacao de derivados do acido biliar e de composicoes farmaceuticas que os contem
IT1206078B (it)	1989-04-14	Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
ATE25525T1 (de)	1987-03-15	N-glycosylierte carbonsaeureamid-derivate, verfahren zu ihrer herstellung sowie ihre verwendung zur beeinflussung der koerpereigenen abwehr.
PT97826A (pt)	1992-04-30	Processo para a preparacao de purificacao de uma proteina a partir de uma planta com um efeito inibidor num patogenio ou peste e de composicoes anti-fungos que as contem
PT84823B (pt)	1989-12-29	Processo para a preparacao de novos derivados de imidazois 1-substituidos com accao inibidora da dopamina-beta-hidroxilase e de composicoes farmaceuticas que os contem
PT82987B (pt)	1988-07-01	Processo para a preparacao de novos de derivados de acidos carboxilicos bem como de composicoes farmaceuticas que os contem
MX9205916A (es)	1993-06-01	Derivados de acido ciclohexanoacetico, proceso para su preparacion y composicion farmaceutica que los comprende
PT90362A (pt)	1989-11-10	Metodo para o tratamento de doencas muco-epiteliais e da pele em mamiferos que utiliza acidos 4-quinolinocarboxilicos e seus derivados e processo para a preparacao de composicoes farmaceuticas que contem os mesmos compostos
PT88679A (pt)	1989-07-31	Processo para a preparacao de derivados de aminoacidos e de composicoes farmaceuticas que os contem
PT82512B (pt)	1988-03-03	Processo para a preparacao de derivados de quinolilglicinamidas com actividade psicotropica e de composicoes farmaceuticas que os contem
PT87930A (pt)	1989-06-30	Processo para a preparacao de derivados de acido 3-desmetil-4-fluor-mevalonico e de composicoes farmaceuticas que os contem
PT88335A (pt)	1989-06-30	Processo para a preparacao de derivados do acido 1,4-dihidro-4-oxo-3-quinolinocarboxilico e de composicoes farmaceuticas que os contem
PT91362A (pt)	1990-03-08	Processo para a preparacao de novos acidos 6-fluor-3,5-di-hidroxi-carboxilicos e seus derivados, e de composicoes farmaceuticas que os contem e de produtos intermediarios
PT94078A (pt)	1991-01-08	Processo para a preparacao de derivados de acido butenoico e de composicoes farmaceuticas que os contem
PT88288A (pt)	1989-09-14	Processo de preparacao de acidos omega-arilsulfonamidoalcanoicos e de composicoes farmaceuticas que os contem
PT92388A (pt)	1990-05-31	Processo para a preparacao de derivados de aminodiol inibidores de renina e de composicoes farmaceuticas que os contem

Legal Events

Date	Code	Title	Description
1992-10-30	BB1A	Laying open of patent application	Effective date: 19920617
1999-05-31	FG3A	Patent granted, date of granting	Effective date: 19990211