PT96058A - Metodo para a solubilizacao e naturacao de somatotropinas utilizando uma concentracao baixa de ureia - Google Patents
Metodo para a solubilizacao e naturacao de somatotropinas utilizando uma concentracao baixa de ureiaInfo
- Publication number
- PT96058A PT96058A PT96058A PT9605890A PT96058A PT 96058 A PT96058 A PT 96058A PT 96058 A PT96058 A PT 96058A PT 9605890 A PT9605890 A PT 9605890A PT 96058 A PT96058 A PT 96058A
- Authority
- PT
- Portugal
- Prior art keywords
- naturation
- somatotropins
- solubilization
- urea
- low concentration
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title abstract 2
- 239000004202 carbamide Substances 0.000 title abstract 2
- 230000007928 solubilization Effects 0.000 title abstract 2
- 238000005063 solubilization Methods 0.000 title abstract 2
- 239000012670 alkaline solution Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Beans For Foods Or Fodder (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fertilizers (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44628089A | 1989-12-05 | 1989-12-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT96058A true PT96058A (pt) | 1991-09-30 |
| PT96058B PT96058B (pt) | 1998-07-31 |
Family
ID=23772005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96058A PT96058B (pt) | 1989-12-05 | 1990-12-03 | Metodo para a solubilizacao e naturacao de somatotropinas utilizando uma concentracao baixa de ureia |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0432419B1 (pt) |
| JP (1) | JPH03181500A (pt) |
| KR (1) | KR0160975B1 (pt) |
| AT (1) | ATE113060T1 (pt) |
| AU (1) | AU628695B2 (pt) |
| CA (1) | CA2031369A1 (pt) |
| DE (1) | DE69013475T2 (pt) |
| DK (1) | DK0432419T3 (pt) |
| ES (1) | ES2062253T3 (pt) |
| FI (1) | FI97296C (pt) |
| HU (1) | HU214249B (pt) |
| IE (1) | IE66142B1 (pt) |
| IL (1) | IL96124A (pt) |
| NZ (1) | NZ236141A (pt) |
| PT (1) | PT96058B (pt) |
| ZA (1) | ZA909745B (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994018227A2 (en) * | 1993-02-04 | 1994-08-18 | Denzyme Aps | Improved method for the refolding of proteins |
| US5912327A (en) * | 1996-09-30 | 1999-06-15 | Human Genome Sciences, Inc. | Method of purifying chemokines from inclusion bodies |
| US6632425B1 (en) | 1997-03-20 | 2003-10-14 | Human Genome Sciences, Inc. | Chemokine compositions |
| AU739394B2 (en) * | 1998-08-27 | 2001-10-11 | Lg Chemical Limited | Process for the preparation of active somatotropin from inclusion bodies |
| DE10044360A1 (de) | 2000-09-08 | 2002-03-21 | Merck Patent Gmbh | Verfahren zur Aufreinigung von rekombinanten als unlösliche Aggregate exprimierte Proteinen |
| WO2002057296A1 (en) * | 2001-01-16 | 2002-07-25 | Københavns Universitet | A method for refolding of proteins |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1267615A (en) * | 1984-08-27 | 1990-04-10 | Dan Hadary | Method for recovering purified growth hormones from genetically engineered microorganisms |
| AU612133B2 (en) * | 1987-02-20 | 1991-07-04 | Natinco Nv | Production of proteins in active forms |
| JPH01257491A (ja) * | 1988-04-08 | 1989-10-13 | Tosoh Corp | 不溶性融合異種蛋白質の処理方法 |
-
1990
- 1990-10-23 EP EP90120309A patent/EP0432419B1/en not_active Expired - Lifetime
- 1990-10-23 ES ES90120309T patent/ES2062253T3/es not_active Expired - Lifetime
- 1990-10-23 DK DK90120309.1T patent/DK0432419T3/da active
- 1990-10-23 AT AT90120309T patent/ATE113060T1/de not_active IP Right Cessation
- 1990-10-23 DE DE69013475T patent/DE69013475T2/de not_active Expired - Fee Related
- 1990-10-25 IL IL96124A patent/IL96124A/xx active IP Right Grant
- 1990-11-20 NZ NZ236141A patent/NZ236141A/xx unknown
- 1990-11-21 IE IE420490A patent/IE66142B1/en not_active IP Right Cessation
- 1990-11-27 KR KR1019900019285A patent/KR0160975B1/ko not_active Expired - Fee Related
- 1990-11-30 JP JP2331005A patent/JPH03181500A/ja active Pending
- 1990-12-03 CA CA002031369A patent/CA2031369A1/en not_active Abandoned
- 1990-12-03 PT PT96058A patent/PT96058B/pt not_active IP Right Cessation
- 1990-12-04 FI FI905985A patent/FI97296C/fi not_active IP Right Cessation
- 1990-12-04 ZA ZA909745A patent/ZA909745B/xx unknown
- 1990-12-04 AU AU67736/90A patent/AU628695B2/en not_active Ceased
- 1990-12-05 HU HU908077A patent/HU214249B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR0160975B1 (ko) | 1998-11-16 |
| IL96124A0 (en) | 1991-07-18 |
| CA2031369A1 (en) | 1991-06-06 |
| IL96124A (en) | 1998-06-15 |
| IE904204A1 (en) | 1991-06-05 |
| ATE113060T1 (de) | 1994-11-15 |
| AU628695B2 (en) | 1992-09-17 |
| EP0432419B1 (en) | 1994-10-19 |
| FI97296C (fi) | 1996-11-25 |
| HU214249B (hu) | 1998-03-02 |
| ZA909745B (en) | 1991-10-30 |
| IE66142B1 (en) | 1995-12-13 |
| DK0432419T3 (da) | 1994-11-14 |
| JPH03181500A (ja) | 1991-08-07 |
| DE69013475T2 (de) | 1995-05-04 |
| ES2062253T3 (es) | 1994-12-16 |
| EP0432419A1 (en) | 1991-06-19 |
| DE69013475D1 (de) | 1994-11-24 |
| HUT58762A (en) | 1992-03-30 |
| NZ236141A (en) | 1993-01-27 |
| FI905985A0 (fi) | 1990-12-04 |
| FI905985L (fi) | 1991-06-06 |
| HU908077D0 (en) | 1991-06-28 |
| PT96058B (pt) | 1998-07-31 |
| FI97296B (fi) | 1996-08-15 |
| AU6773690A (en) | 1991-06-13 |
| KR910012235A (ko) | 1991-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19910412 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19980416 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19991031 |