PT90883A - Processo de preparacao de 2,3,4,5-tetra-hidro-ih-3-benzazepinas e de composicoes farmaceuticas que as contem - Google Patents

Processo de preparacao de 2,3,4,5-tetra-hidro-ih-3-benzazepinas e de composicoes farmaceuticas que as contem

Info

Publication number: PT90883A
Authority: PT; Portugal
Prior art keywords: bridge; benzazepines; tetrahydro; preparing; pharmaceutical compositions
Prior art date: 1988-06-15

Application number

PT90883A

Other languages

English (en)

Other versions

PT90883B (pt

Inventor

Peter Hongaard Andersen

Louis Brammer Hansen

Peter Faarup

Frederik Christian Gronvald

Erling Guddal

Erik Bardum Nielsen

Kristian Tage Hansen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-15

Filing date

1989-06-15

Publication date

1989-12-29

1989-06-15 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1989-12-29 Publication of PT90883A publication Critical patent/PT90883A/pt

1994-12-30 Publication of PT90883B publication Critical patent/PT90883B/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PT90883A 1988-06-15 1989-06-15 Processo de preparacao de 2,3,4,5-tetra-hidro-ih-3-benzazepinas e de composicoes farmaceuticas que as contem PT90883B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK325188A DK325188D0 (da)	1988-06-15	1988-06-15	Hidtil ukendte benzazepinderivater

Publications (2)

Publication Number	Publication Date
PT90883A true PT90883A (pt)	1989-12-29
PT90883B PT90883B (pt)	1994-12-30

Family

ID=8120790

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT90883A PT90883B (pt)	1988-06-15	1989-06-15	Processo de preparacao de 2,3,4,5-tetra-hidro-ih-3-benzazepinas e de composicoes farmaceuticas que as contem

Country Status (15)

Country	Link
US (2)	US5010074A (pt)
EP (1)	EP0347672B1 (pt)
JP (1)	JP2769718B2 (pt)
AT (1)	ATE102188T1 (pt)
AU (1)	AU622911B2 (pt)
CA (1)	CA1317938C (pt)
DE (1)	DE68913367T2 (pt)
DK (1)	DK325188D0 (pt)
ES (1)	ES2061794T3 (pt)
FI (1)	FI93354C (pt)
IE (1)	IE891932L (pt)
IL (1)	IL90533A (pt)
NO (1)	NO173865C (pt)
NZ (1)	NZ229521A (pt)
PT (1)	PT90883B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK67489D0 (da) *	1989-02-14	1989-02-14	Novo Industri As	Nye benzazepinderivater
US5158948A (en) *	1990-11-16	1992-10-27	Abbott Laboratories	Tetracyclic spirobenzazepine dopamine antagonists
US5470850A (en) *	1992-02-24	1995-11-28	Novo Nordisk A/S	2,3,4,5-tetrahydro-1H-3-benzazepines
DK23392D0 (da) *	1992-02-24	1992-02-24	Novo Nordisk As	Heterocykliske forbindelser, deres anvendelse og fremstilling
PL189822B1 (pl) *	1997-03-12	2005-09-30	Addex Pharmaceuticals Sa	Zastosowanie (+)-5-(2,3-dihydrobenzofuran-7-ylo)-7-hydroksy-3-metylo-8-nitro-2,3,4,5-tetrahydro-1H-3-benzazepiny lub jej farmaceutycznie dopuszczalnej soli do wytwarzania kompozycji farmaceutycznej
US6277844B1 (en)	1998-09-14	2001-08-21	Sydney Spector	Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
GB0130576D0 (en) *	2001-12-20	2002-02-06	Cenes Ltd	Dopamine D1 receptor agonist pro-drug compounds & derivatives
CN1688584A (zh) *	2002-08-29	2005-10-26	先灵公司	治疗肥胖和中枢神经系统疾病的选择性d1/d5受体拮抗剂
AU2003294909B2 (en)	2002-12-20	2007-05-17	Glaxo Group Limited	Benzazepine derivatives for the treatment of neurological disorders
JP2006526021A (ja) *	2003-05-22	2006-11-16	シェーリング　コーポレイション	肥満およびｃｎｓ障害を治療する選択的ｄ１／ｄ５レセプタアンタゴニストとしての５ｈ−ベンゾ［ｄ］ナフト［２，１−ｂ］アゼピン誘導体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA974989A (en) *	1968-03-11	1975-09-23	Wallace And Tiernan Inc.	Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US4210749A (en) *	1974-11-12	1980-07-01	Pennwalt Corporation	Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
ZA792044B (en) *	1978-05-08	1980-05-28	Scherico Ltd	Substituted 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof,and pharmaceutical compositions containing them
US4327023A (en) *	1980-01-31	1982-04-27	Smithkline Corporation	Intermediates for preparing 7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4284556A (en) *	1980-01-31	1981-08-18	Smithkline Corporation	7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
DK180485D0 (da) *	1985-04-22	1985-04-23	Novo Industri As	Nitrogenholdige forbindelser
WO1987004430A2 (en) *	1986-01-16	1987-07-30	Schering Corporation	Fused benzazepines
EP0244088A3 (en) *	1986-04-03	1989-03-15	Smithkline Beecham Corporation	1-phenyl-3-benzazepine compounds and medicaments containing these compounds for treating gastrointestinal motility disorders

1988
- 1988-06-15 DK DK325188A patent/DK325188D0/da not_active Application Discontinuation
1989
- 1989-06-05 IL IL9053389A patent/IL90533A/en unknown
- 1989-06-09 ES ES89110490T patent/ES2061794T3/es not_active Expired - Lifetime
- 1989-06-09 EP EP89110490A patent/EP0347672B1/en not_active Expired - Lifetime
- 1989-06-09 AT AT89110490T patent/ATE102188T1/de not_active IP Right Cessation
- 1989-06-09 DE DE68913367T patent/DE68913367T2/de not_active Expired - Lifetime
- 1989-06-12 US US07/365,250 patent/US5010074A/en not_active Expired - Lifetime
- 1989-06-13 CA CA000602684A patent/CA1317938C/en not_active Expired - Lifetime
- 1989-06-13 NZ NZ229521A patent/NZ229521A/en unknown
- 1989-06-14 NO NO892476A patent/NO173865C/no not_active IP Right Cessation
- 1989-06-14 AU AU36359/89A patent/AU622911B2/en not_active Expired
- 1989-06-15 JP JP1150662A patent/JP2769718B2/ja not_active Expired - Lifetime
- 1989-06-15 PT PT90883A patent/PT90883B/pt not_active IP Right Cessation
- 1989-06-15 IE IE891932A patent/IE891932L/xx not_active IP Right Cessation
- 1989-06-15 FI FI892946A patent/FI93354C/fi active IP Right Grant
1990
- 1990-02-07 US US07/477,450 patent/US5025009A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2061794T3 (es)	1994-12-16
NZ229521A (en)	1991-12-23
IL90533A0 (en)	1990-01-18
PT90883B (pt)	1994-12-30
NO173865C (no)	1994-02-16
IE891932L (en)	1989-12-15
EP0347672B1 (en)	1994-03-02
NO173865B (no)	1993-11-08
EP0347672A1 (en)	1989-12-27
FI892946A (fi)	1989-12-16
JPH0240364A (ja)	1990-02-09
CA1317938C (en)	1993-05-18
NO892476D0 (no)	1989-06-14
FI93354C (fi)	1995-03-27
FI892946A0 (fi)	1989-06-15
US5010074A (en)	1991-04-23
DE68913367T2 (de)	1994-06-01
JP2769718B2 (ja)	1998-06-25
DK325188D0 (da)	1988-06-15
DE68913367D1 (de)	1994-04-07
US5025009A (en)	1991-06-18
FI93354B (fi)	1994-12-15
AU3635989A (en)	1989-12-21
AU622911B2 (en)	1992-04-30
NO892476L (no)	1989-12-18
IL90533A (en)	1994-05-30
ATE102188T1 (de)	1994-03-15

Publication	Publication Date	Title
FI901530A0 (fi)	1990-03-27	Menetelmä immunomoduloivien atsaspiraanien valmistamiseksi
NO944644D0 (no)	1994-12-02	Fremstilling av 3,4,4-trisubstituert-piperidinyl-N-alkylkarboksylater og mellomprodukter
NO1998008I1 (no)	1998-02-05	Naratriptan
DK543787D0 (da)	1987-10-16	Antibakterielle midler
FI893751A (fi)	1990-02-11	Kemiska foereningar.
PT90883A (pt)	1989-12-29	Processo de preparacao de 2,3,4,5-tetra-hidro-ih-3-benzazepinas e de composicoes farmaceuticas que as contem
PT92180A (pt)	1990-05-31	Processo para a preparacao de novas mevalonolactonas do tipo tienopiridina e de composicoes farmaceuticas que as contem
HU912271D0 (en)	1991-12-30	Process for the production of bis/4-(2,6-dialkyl)phenol/-silane derivatives with antiatherosclerotic effect
PT91555A (pt)	1990-03-08	Processo de preparacao de derivados de dibenzo{2,3:6,7}-(oxepino ou tiepino){4,5-c}(piridina ou pirrol)e de composicoes farmaceuticas que os contem
NO893249L (no)	1990-02-14	Cykliske svovelinneholdende forbindelser.
DE3867652D1 (de)	1992-02-27	N-substituierte 3,4-dihydropyrimidinverbindungen als mittel zur behandlung von erkrankungen des kardiovaskularen systems.
DE69018659D1 (de)	1995-05-24	3- oder 4-substituierte Oxotremorin-Derivate.
BR9813775A (pt)	2000-10-10	Uso de um composto, processo para o tratamento de uma condição de cefaléia vascular, e, composição farmacêutica adequada para uso no tratamento de uma condição de cefaléia vascular.
PT94472A (pt)	1991-02-08	Processo para preparacao de acido (1,2,3,4-tetrahidro-9-acridinimino )-ciclohexano-carboxilico e seus derivados, bem como de composicoes farmaceuticas que os contem
PT99331B (pt)	2000-08-31	Processo para a preparacao de 3-difenilmetoxi-8-azabiciclo{3.2.1}octilalquil-tiazolidinomas e de composicoes farmaceuticas que as contem
PT82593B (pt)	1988-03-03	Processo de preparacao da oxadiazolil-imidazobenzodiazepina e das composicoes farmaceuticas que a contem
NO842345L (no)	1984-12-27	Heksahydropyrrolo(2,1-a)isoquinolin-derivater.
AU7589298A (en)	1999-01-19	5-{(heteroaryl)alkyl}-3-oxo-pyrido{1,2-(a)}benzimidazole-4-c arboxamide derivatives useful in treating central nervous system disorders
PT94298A (pt)	1991-02-08	Processo para a preparacao de derivados de 4, 5, 5a, 6-tetra-hidro-3h-isoxazolo{5,4,3-k1}acridinas e de composicoes farmaceuticas que os contem
ATE44144T1 (de)	1989-07-15	6h-dibenzo(b,e)(1,4)oxathiepin-verbindungen.

Legal Events

Date	Code	Title	Description
1994-12-30	FG3A	Patent granted, date of granting	Effective date: 19940603
2001-11-30	PC3A	Transfer or assignment	Free format text: 20010821 CENES LIMITED GB
2003-06-30	PC3A	Transfer or assignment	Free format text: ADDEX PHARMACEUTICALS, SA. CH Effective date: 20030505
2009-06-22	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20090615