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FI93354C - Menetelmä uusien terapeuttisesti käyttökelpoisten 2,3,4,5-tetrahydro-1H-3-bentsoatsepiinijohdannaisten valmistamiseksi - Google Patents

Menetelmä uusien terapeuttisesti käyttökelpoisten 2,3,4,5-tetrahydro-1H-3-bentsoatsepiinijohdannaisten valmistamiseksi

Info

Publication number
FI93354C
FI93354C FI892946A FI892946A FI93354C FI 93354 C FI93354 C FI 93354C FI 892946 A FI892946 A FI 892946A FI 892946 A FI892946 A FI 892946A FI 93354 C FI93354 C FI 93354C
Authority
FI
Finland
Prior art keywords
bridge
tetrahydro
therapeutically useful
preparing new
benzazepine derivatives
Prior art date
Application number
FI892946A
Other languages
English (en)
Swedish (sv)
Other versions
FI892946A (fi
FI892946A0 (fi
FI93354B (fi
Inventor
Frederik Christian Groenwald
Peter Hoengaard Andersen
Peter Faarup
Erling Guddal
Kristian Tage Hansen
Louis Brammer Hansen
Erik Bardum Nielsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of FI892946A0 publication Critical patent/FI892946A0/fi
Publication of FI892946A publication Critical patent/FI892946A/fi
Application granted granted Critical
Publication of FI93354B publication Critical patent/FI93354B/fi
Publication of FI93354C publication Critical patent/FI93354C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI892946A 1988-06-15 1989-06-15 Menetelmä uusien terapeuttisesti käyttökelpoisten 2,3,4,5-tetrahydro-1H-3-bentsoatsepiinijohdannaisten valmistamiseksi FI93354C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK325188 1988-06-15
DK325188A DK325188D0 (da) 1988-06-15 1988-06-15 Hidtil ukendte benzazepinderivater

Publications (4)

Publication Number Publication Date
FI892946A0 FI892946A0 (fi) 1989-06-15
FI892946A FI892946A (fi) 1989-12-16
FI93354B FI93354B (fi) 1994-12-15
FI93354C true FI93354C (fi) 1995-03-27

Family

ID=8120790

Family Applications (1)

Application Number Title Priority Date Filing Date
FI892946A FI93354C (fi) 1988-06-15 1989-06-15 Menetelmä uusien terapeuttisesti käyttökelpoisten 2,3,4,5-tetrahydro-1H-3-bentsoatsepiinijohdannaisten valmistamiseksi

Country Status (15)

Country Link
US (2) US5010074A (fi)
EP (1) EP0347672B1 (fi)
JP (1) JP2769718B2 (fi)
AT (1) ATE102188T1 (fi)
AU (1) AU622911B2 (fi)
CA (1) CA1317938C (fi)
DE (1) DE68913367T2 (fi)
DK (1) DK325188D0 (fi)
ES (1) ES2061794T3 (fi)
FI (1) FI93354C (fi)
IE (1) IE891932L (fi)
IL (1) IL90533A (fi)
NO (1) NO173865C (fi)
NZ (1) NZ229521A (fi)
PT (1) PT90883B (fi)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK67489D0 (da) * 1989-02-14 1989-02-14 Novo Industri As Nye benzazepinderivater
US5158948A (en) * 1990-11-16 1992-10-27 Abbott Laboratories Tetracyclic spirobenzazepine dopamine antagonists
US5470850A (en) * 1992-02-24 1995-11-28 Novo Nordisk A/S 2,3,4,5-tetrahydro-1H-3-benzazepines
DK23392D0 (da) * 1992-02-24 1992-02-24 Novo Nordisk As Heterocykliske forbindelser, deres anvendelse og fremstilling
PL189822B1 (pl) * 1997-03-12 2005-09-30 Addex Pharmaceuticals Sa Zastosowanie (+)-5-(2,3-dihydrobenzofuran-7-ylo)-7-hydroksy-3-metylo-8-nitro-2,3,4,5-tetrahydro-1H-3-benzazepiny lub jej farmaceutycznie dopuszczalnej soli do wytwarzania kompozycji farmaceutycznej
US6277844B1 (en) 1998-09-14 2001-08-21 Sydney Spector Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
GB0130576D0 (en) * 2001-12-20 2002-02-06 Cenes Ltd Dopamine D1 receptor agonist pro-drug compounds & derivatives
CN1688584A (zh) * 2002-08-29 2005-10-26 先灵公司 治疗肥胖和中枢神经系统疾病的选择性d1/d5受体拮抗剂
AU2003294909B2 (en) 2002-12-20 2007-05-17 Glaxo Group Limited Benzazepine derivatives for the treatment of neurological disorders
JP2006526021A (ja) * 2003-05-22 2006-11-16 シェーリング　コーポレイション 肥満およびｃｎｓ障害を治療する選択的ｄ１／ｄ５レセプタアンタゴニストとしての５ｈ−ベンゾ［ｄ］ナフト［２，１−ｂ］アゼピン誘導体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA974989A (en) * 1968-03-11 1975-09-23 Wallace And Tiernan Inc. Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US4210749A (en) * 1974-11-12 1980-07-01 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
ZA792044B (en) * 1978-05-08 1980-05-28 Scherico Ltd Substituted 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof,and pharmaceutical compositions containing them
US4327023A (en) * 1980-01-31 1982-04-27 Smithkline Corporation Intermediates for preparing 7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4284556A (en) * 1980-01-31 1981-08-18 Smithkline Corporation 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
DK180485D0 (da) * 1985-04-22 1985-04-23 Novo Industri As Nitrogenholdige forbindelser
WO1987004430A2 (en) * 1986-01-16 1987-07-30 Schering Corporation Fused benzazepines
EP0244088A3 (en) * 1986-04-03 1989-03-15 Smithkline Beecham Corporation 1-phenyl-3-benzazepine compounds and medicaments containing these compounds for treating gastrointestinal motility disorders

Also Published As

Publication number Publication date
ES2061794T3 (es) 1994-12-16
NZ229521A (en) 1991-12-23
IL90533A0 (en) 1990-01-18
PT90883B (pt) 1994-12-30
NO173865C (no) 1994-02-16
IE891932L (en) 1989-12-15
PT90883A (pt) 1989-12-29
EP0347672B1 (en) 1994-03-02
NO173865B (no) 1993-11-08
EP0347672A1 (en) 1989-12-27
FI892946A (fi) 1989-12-16
JPH0240364A (ja) 1990-02-09
CA1317938C (en) 1993-05-18
NO892476D0 (no) 1989-06-14
FI892946A0 (fi) 1989-06-15
US5010074A (en) 1991-04-23
DE68913367T2 (de) 1994-06-01
JP2769718B2 (ja) 1998-06-25
DK325188D0 (da) 1988-06-15
DE68913367D1 (de) 1994-04-07
US5025009A (en) 1991-06-18
FI93354B (fi) 1994-12-15
AU3635989A (en) 1989-12-21
AU622911B2 (en) 1992-04-30
NO892476L (no) 1989-12-18
IL90533A (en) 1994-05-30
ATE102188T1 (de) 1994-03-15

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Legal Events

Date Code Title Description
BB Publication of examined application
FG Patent granted

Owner name: ADDEX PHARMACEUTICALS SA