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PT82254B - PROCESS FOR THE PREPARATION OF NEW 1,2-BENZISOXAZOLE-3-ILO AND 1,2-BENZISOZYAZOLE-3-ILO DERIVATIVES - Google Patents

PROCESS FOR THE PREPARATION OF NEW 1,2-BENZISOXAZOLE-3-ILO AND 1,2-BENZISOZYAZOLE-3-ILO DERIVATIVES

Info

Publication number
PT82254B
PT82254B PT82254A PT8225486A PT82254B PT 82254 B PT82254 B PT 82254B PT 82254 A PT82254 A PT 82254A PT 8225486 A PT8225486 A PT 8225486A PT 82254 B PT82254 B PT 82254B
Authority
PT
Portugal
Prior art keywords
halo
alkyl
ilo
new
benzisozyazole
Prior art date
Application number
PT82254A
Other languages
Portuguese (pt)
Other versions
PT82254A (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24880589&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT82254(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PT82254A publication Critical patent/PT82254A/en
Publication of PT82254B publication Critical patent/PT82254B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Piperidine derivs. of formula (I) and their pharmaceutically acceptable acid addn. salts are new. R = H or 1-6C alkyl; R1 and R2 = H, halo, OH, 1-6C alkoxy or 1-6C alkyl; X = O or S; Alk = 1-4C alkanediyl; Q = a gp. of formula (a) or (b); Y1 and Y2 = O or S; R3 = H, halo, 1-6C alkyl, 1-6C alkoxy, CF3, NO2, CN, OH, 2-11C alkenoyloxy, NH2, mono- or di(1-6C alkyl)amino, 2-11C alkanoylamino, benzyloxy or azido; R4 = H or halo, R5 = H or 1-6C alkyl; Z = S, CH2 or C(R6) = C(R7); R6 and R7 = H or 1-6C alkyl; A = CH2CH2, CH2CH2CH2 or C(R8)=C(R9); R8 and R9 = H, halo, NH2 or 1-6C alkyl. More specifically, R = H; R1 = H or halo; R2 = H, halo, OH or 1-6C alkoxy; R3 = H, halo or Me; Y1 = O; Z-A = SCH2CH2, S(CH2)3; S-CR8=CR9, CH=CH-CR8=CR9 or (CH2)4; R8 and R9 = H or Me. 2 Cpds. (I) including 3-(2-(4-(6-fluoro -1,2-benzioxazol-3-yl)-1 piperidinyl)ethyl)-6,7,8,9 -tetrahydro-2-methyl-4H -pyrido(1,2-a) pyrimidin-4-one (Ia) are specifically claimed.
PT82254A 1985-03-27 1986-03-24 PROCESS FOR THE PREPARATION OF NEW 1,2-BENZISOXAZOLE-3-ILO AND 1,2-BENZISOZYAZOLE-3-ILO DERIVATIVES PT82254B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71706785A 1985-03-27 1985-03-27

Publications (2)

Publication Number Publication Date
PT82254A PT82254A (en) 1986-04-01
PT82254B true PT82254B (en) 1988-04-21

Family

ID=24880589

Family Applications (1)

Application Number Title Priority Date Filing Date
PT82254A PT82254B (en) 1985-03-27 1986-03-24 PROCESS FOR THE PREPARATION OF NEW 1,2-BENZISOXAZOLE-3-ILO AND 1,2-BENZISOZYAZOLE-3-ILO DERIVATIVES

Country Status (13)

Country Link
KR (1) KR910000165B1 (en)
AT (1) ATE79379T1 (en)
DE (1) DE3686341T2 (en)
ES (1) ES8705881A1 (en)
FI (1) FI81800C (en)
GR (1) GR860800B (en)
HU (1) HU195793B (en)
IL (1) IL78250A (en)
NO (2) NO162765C (en)
NZ (1) NZ215462A (en)
PH (1) PH24016A (en)
PT (1) PT82254B (en)
ZA (1) ZA862279B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2050069B1 (en) * 1992-07-10 1994-12-16 Vita Invest Sa PROCEDURE FOR OBTAINING 3- (2- (4- (6-FLUORO-1,2-BENZISOXAZOL-3-IL) PIPERIDINO) ETIL) -2-METHYL-6,7,8,9-TETRAHIDRO-4H-PIRIDO (1,2-A) PIRIMIDIN-4-ONA.
ES2085234B1 (en) * 1994-02-24 1997-01-16 Vita Invest Sa ACTIVE AGENT ON THE CENTRAL NERVOUS SYSTEM, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT.
HUP0402163A2 (en) * 2004-10-25 2006-05-29 Richter Gedeon Vegyeszet Process for the preparation of risperidone

Also Published As

Publication number Publication date
GR860800B (en) 1986-07-21
HU195793B (en) 1988-07-28
NO162765C (en) 1990-02-14
HUT42461A (en) 1987-07-28
NO861230L (en) 1986-09-29
FI81800C (en) 1990-12-10
NO162765B (en) 1989-11-06
FI81800B (en) 1990-08-31
ZA862279B (en) 1987-11-25
PH24016A (en) 1990-02-09
FI861328A (en) 1986-09-28
FI861328A0 (en) 1986-03-26
IL78250A (en) 1991-05-12
KR860007247A (en) 1986-10-10
ATE79379T1 (en) 1992-08-15
IL78250A0 (en) 1986-07-31
ES8705881A1 (en) 1987-05-16
DE3686341D1 (en) 1992-09-17
NZ215462A (en) 1988-09-29
NO1994021I1 (en) 1994-11-03
DE3686341T2 (en) 1993-01-14
PT82254A (en) 1986-04-01
ES553419A0 (en) 1987-05-16
KR910000165B1 (en) 1991-01-21

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