[go: up one dir, main page]

IL78250A - 1,2-benzisoxazol-3-yl and 1,2-benzisothiazol-3-yl derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

1,2-benzisoxazol-3-yl and 1,2-benzisothiazol-3-yl derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL78250A
IL78250A IL78250A IL7825086A IL78250A IL 78250 A IL78250 A IL 78250A IL 78250 A IL78250 A IL 78250A IL 7825086 A IL7825086 A IL 7825086A IL 78250 A IL78250 A IL 78250A
Authority
IL
Israel
Prior art keywords
halo
alkyl
benzisothiazol
benzisoxazol
derivatives
Prior art date
Application number
IL78250A
Other versions
IL78250A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24880589&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL78250(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL78250A0 publication Critical patent/IL78250A0/en
Publication of IL78250A publication Critical patent/IL78250A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Piperidine derivs. of formula (I) and their pharmaceutically acceptable acid addn. salts are new. R = H or 1-6C alkyl; R1 and R2 = H, halo, OH, 1-6C alkoxy or 1-6C alkyl; X = O or S; Alk = 1-4C alkanediyl; Q = a gp. of formula (a) or (b); Y1 and Y2 = O or S; R3 = H, halo, 1-6C alkyl, 1-6C alkoxy, CF3, NO2, CN, OH, 2-11C alkenoyloxy, NH2, mono- or di(1-6C alkyl)amino, 2-11C alkanoylamino, benzyloxy or azido; R4 = H or halo, R5 = H or 1-6C alkyl; Z = S, CH2 or C(R6) = C(R7); R6 and R7 = H or 1-6C alkyl; A = CH2CH2, CH2CH2CH2 or C(R8)=C(R9); R8 and R9 = H, halo, NH2 or 1-6C alkyl. More specifically, R = H; R1 = H or halo; R2 = H, halo, OH or 1-6C alkoxy; R3 = H, halo or Me; Y1 = O; Z-A = SCH2CH2, S(CH2)3; S-CR8=CR9, CH=CH-CR8=CR9 or (CH2)4; R8 and R9 = H or Me. 2 Cpds. (I) including 3-(2-(4-(6-fluoro -1,2-benzioxazol-3-yl)-1 piperidinyl)ethyl)-6,7,8,9 -tetrahydro-2-methyl-4H -pyrido(1,2-a) pyrimidin-4-one (Ia) are specifically claimed.
IL78250A 1985-03-27 1986-03-25 1,2-benzisoxazol-3-yl and 1,2-benzisothiazol-3-yl derivatives,their preparation and pharmaceutical compositions containing them IL78250A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71706785A 1985-03-27 1985-03-27

Publications (2)

Publication Number Publication Date
IL78250A0 IL78250A0 (en) 1986-07-31
IL78250A true IL78250A (en) 1991-05-12

Family

ID=24880589

Family Applications (1)

Application Number Title Priority Date Filing Date
IL78250A IL78250A (en) 1985-03-27 1986-03-25 1,2-benzisoxazol-3-yl and 1,2-benzisothiazol-3-yl derivatives,their preparation and pharmaceutical compositions containing them

Country Status (13)

Country Link
KR (1) KR910000165B1 (en)
AT (1) ATE79379T1 (en)
DE (1) DE3686341T2 (en)
ES (1) ES8705881A1 (en)
FI (1) FI81800C (en)
GR (1) GR860800B (en)
HU (1) HU195793B (en)
IL (1) IL78250A (en)
NO (2) NO162765C (en)
NZ (1) NZ215462A (en)
PH (1) PH24016A (en)
PT (1) PT82254B (en)
ZA (1) ZA862279B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2050069B1 (en) * 1992-07-10 1994-12-16 Vita Invest Sa PROCEDURE FOR OBTAINING 3- (2- (4- (6-FLUORO-1,2-BENZISOXAZOL-3-IL) PIPERIDINO) ETIL) -2-METHYL-6,7,8,9-TETRAHIDRO-4H-PIRIDO (1,2-A) PIRIMIDIN-4-ONA.
ES2085234B1 (en) * 1994-02-24 1997-01-16 Vita Invest Sa ACTIVE AGENT ON THE CENTRAL NERVOUS SYSTEM, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT.
HUP0402163A2 (en) * 2004-10-25 2006-05-29 Richter Gedeon Vegyeszet Process for the preparation of risperidone

Also Published As

Publication number Publication date
GR860800B (en) 1986-07-21
HU195793B (en) 1988-07-28
NO162765C (en) 1990-02-14
HUT42461A (en) 1987-07-28
NO861230L (en) 1986-09-29
FI81800C (en) 1990-12-10
NO162765B (en) 1989-11-06
FI81800B (en) 1990-08-31
ZA862279B (en) 1987-11-25
PH24016A (en) 1990-02-09
FI861328A (en) 1986-09-28
FI861328A0 (en) 1986-03-26
PT82254B (en) 1988-04-21
KR860007247A (en) 1986-10-10
ATE79379T1 (en) 1992-08-15
IL78250A0 (en) 1986-07-31
ES8705881A1 (en) 1987-05-16
DE3686341D1 (en) 1992-09-17
NZ215462A (en) 1988-09-29
NO1994021I1 (en) 1994-11-03
DE3686341T2 (en) 1993-01-14
PT82254A (en) 1986-04-01
ES553419A0 (en) 1987-05-16
KR910000165B1 (en) 1991-01-21

Similar Documents

Publication Publication Date Title
ES2354407T3 (en) HETEROARILPIPERIDINAS AND PIPERAZINAS AND ITS USE AS ANTIPSYCHOTICS AND ANALGESICS.
NO2007017I2 (en) 3- [2- [4- (6-fluoro-1,2-benzoxazol-3-yl) -1-piperidinyl] ethyl] -6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4 H -pyridol] 1,2-a] pyrimidin-4-one (palperidone)
AU5816600A (en) Respiratory syncytial virus replication inhibitors
HU910706D0 (en) Process for producing new n-(4-piperidinyl)-(dihydro-benzofurane- or dihydro-2h-benzopyrane)-carboxamide derivatives and pharmaceutical preparatives containing said compounds
MXPA04003474A (en) Imidazo (4,3-e)-1,2,4-triazolo(1,5-c) pyrimidines as adenosine a2a receptor antagonists.
AR002746A1 (en) PIRIMIDINE-DERIVED COMPOUNDS CONDENSED WITH A HETERO-CYCLIC RING AND PHARMACEUTICAL COMPOSITION CONTAINING SUCH COMPOUNDS.
JP2003500404A5 (en)
GR3018472T3 (en) 1-Naphthyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them.
ZA885788B (en) 2-((4-piperidyl)methyl)-1,2,3,4-tetrahydro-9h-pyrido(3,4-b)indole derivatives,their preparation and their application in therapy
MY132062A (en) Apolipoprotein-b synthesis inhibitors
IL78250A0 (en) 1,2-benzisoxazol-3-yl and 1,2-benzisothiazol-3-yl derivatives,their preparation and pharmaceutical compositions containing them
JP2004508330A5 (en)
RU2459824C2 (en) New compounds for mental disorders, preparing and using them
FI882909A0 (en) Process for the preparation of therapeutically useful furanyl methyl substituted benzimidazole and imidazopyridine derivatives
NO801491L (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 1-PHENYL-2-AMINOETANOL DERIVATIVES
IL89185A (en) 5-halo-2-(omega-)(4-(2-pyrimidinyl)-1-piperazinyl(alkyl)thieno-(2.3-d)isothiazol-3(2h)-one 1,1-dioxides,their preparation and pharmaceutical compositions containing them
HUP0104873A2 (en) Refined process for the preparation of 3-{2-[4-(6-fluoro-1,2-benzizoxazol-3-yl)-1-piperidinyl]-ethyl}-6,7,8,9-tetrahydro-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one
RU2003106190A (en) METHOD FOR ALLERGY TREATMENT USING SUBSTITUTED PYRAZOLES
MX9703074A (en) Apolipoprotein-b synthesis inhibitors.
DE3474958D1 (en) 1-(aminoalkylphenyl and aminoalkylbenzyl)-indoles and indolines, a process for their preparation and their use as medicaments
PT78465A (en) 1-(aminoalkylphenyl and aminoalkylbenzyl) - indoles and indolines a process for their preparation and their use as medicaments
HUP9802855A2 (en) Cyclic amide derivatives, pharmaceutical compositions containing them, process for producing them and their use

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
KB Patent renewed