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PT75820B - New process for the preparation of imidazo<4,5-c>-pyridine and of pharmaceutical compositions therewith - Google Patents

New process for the preparation of imidazo<4,5-c>-pyridine and of pharmaceutical compositions therewith

Info

Publication number
PT75820B
PT75820B PT75820A PT7582082A PT75820B PT 75820 B PT75820 B PT 75820B PT 75820 A PT75820 A PT 75820A PT 7582082 A PT7582082 A PT 7582082A PT 75820 B PT75820 B PT 75820B
Authority
PT
Portugal
Prior art keywords
imidazo
pyridine
preparation
pharmaceutical compositions
new process
Prior art date
Application number
PT75820A
Other languages
English (en)
Other versions
PT75820A (en
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of PT75820A publication Critical patent/PT75820A/pt
Publication of PT75820B publication Critical patent/PT75820B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT75820A 1981-11-10 1982-11-09 New process for the preparation of imidazo<4,5-c>-pyridine and of pharmaceutical compositions therewith PT75820B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8133930 1981-11-10
GB8133942 1981-11-10
GB8213846 1982-05-12

Publications (2)

Publication Number Publication Date
PT75820A PT75820A (en) 1982-12-01
PT75820B true PT75820B (en) 1986-06-11

Family

ID=27261362

Family Applications (1)

Application Number Title Priority Date Filing Date
PT75820A PT75820B (en) 1981-11-10 1982-11-09 New process for the preparation of imidazo<4,5-c>-pyridine and of pharmaceutical compositions therewith

Country Status (17)

Country Link
US (1) US4603139A (pt)
EP (1) EP0079083B1 (pt)
KR (1) KR890000022B1 (pt)
AR (1) AR241247A1 (pt)
AU (1) AU9030682A (pt)
DD (1) DD205904A5 (pt)
DK (1) DK161325C (pt)
ES (2) ES517193A0 (pt)
FI (1) FI79312C (pt)
GB (1) GB2113675B (pt)
GR (1) GR76746B (pt)
IE (1) IE56478B1 (pt)
IL (1) IL67206A0 (pt)
MC (1) MC1491A1 (pt)
NO (1) NO158100C (pt)
PH (1) PH22764A (pt)
PT (1) PT75820B (pt)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0072926B1 (de) * 1981-08-19 1986-09-24 MERCK PATENT GmbH 2-Aryl-imidazopyridine
RO86850B (ro) * 1982-05-03 1985-05-31 Eli Lilly And Company Procedeu pentru prepararea unor 2-fenilimidazo [4,5 c] piridine
US4758574A (en) * 1982-05-03 1988-07-19 Eli Lilly And Company 2-phenylimidazio (4,5-c) pyridines
US4904785A (en) * 1982-05-03 1990-02-27 Eli Lilly And Company 2-phenylimidazo[4,5-c]pyridines
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3324115A1 (de) * 1983-07-05 1985-01-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4515796A (en) * 1983-09-08 1985-05-07 Eli Lilly And Company Certain naphthalenyl imidazo compounds and their pharmaceutical use
US4533734A (en) * 1983-11-10 1985-08-06 Eli Lilly And Company Inotropic agents
DE3346602A1 (de) * 1983-12-23 1985-07-11 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazo(4,5-c)pyridin-one, deren herstellung und diese verbindungen enthaltende arzneimittel
DE3347290A1 (de) * 1983-12-28 1985-07-11 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 2-phenyl-imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
ZA851236B (en) * 1984-02-24 1986-09-24 Lilly Co Eli 2-arylimidazo 4,5-cpyridines
US4578387A (en) * 1984-03-05 1986-03-25 Eli Lilly And Company Inotropic agents
DE3445299A1 (de) * 1984-12-12 1986-06-19 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
IL78241A0 (en) * 1985-03-29 1986-07-31 Lilly Co Eli Synthesis of inotropic imidazo(4,5-c)pyridine
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4740599A (en) * 1986-10-03 1988-04-26 Eli Lilly And Company Synthesis of alkylsulfinyl substituted 2-phenylimidazo(4,5-c)pyridines
ZA889365B (en) * 1987-12-22 1990-08-29 Lilly Co Eli Hydrates of andinotropic agent
GB8822170D0 (en) * 1988-09-21 1988-10-26 Pfizer Ltd Therapeutic agents
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JP2000510134A (ja) * 1996-05-15 2000-08-08 ビイク グルデン ロンベルク ヒェーミッシェ ファブリーク ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規のイミダゾピリジン
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ATE340175T1 (de) * 2003-02-25 2006-10-15 Altana Pharma Ag Imidazo(4,5-böchinolinderivate und ihre verwendung als inhibitoren der induzierbaren no- synthase
KR20060087386A (ko) * 2005-01-28 2006-08-02 주식회사 대웅제약 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물
WO2007034277A1 (en) * 2005-09-19 2007-03-29 Pfizer Products Inc. Aryl substituted imidazo [4,5-c] pyridine compounds as c3a receptor antagonists
RU2539568C2 (ru) 2008-10-31 2015-01-20 Дженентек, Инк. Пиразолопиримидиновые соединения-ингибиторы jak и способы
UA110324C2 (en) 2009-07-02 2015-12-25 Genentech Inc Jak inhibitory compounds based on pyrazolo pyrimidine
BR112012002854B1 (pt) * 2009-08-10 2020-02-18 Samumed, Llc Composto ou sal farmaceuticamente aceitável, composição farmacêutica e uso dos mesmos
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CA2812087A1 (en) 2010-09-15 2012-03-22 F. Hoffmann-La Roche Ag Azabenzothiazole compounds, compositions and methods of use
WO2012066061A1 (en) 2010-11-19 2012-05-24 F. Hoffmann-La Roche Ag Pyrazolopyridines and pyrazolopyridines and their use as tyk2 inhibitors
CN109705097B (zh) 2011-09-14 2022-02-01 萨穆梅德有限公司 吲唑-3-羧酰胺及其作为WNT/β-CATENIN信号传导通路抑制剂的用途
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
DK2770994T3 (da) 2012-05-04 2019-11-11 Samumed Llc 1h-pyrazolo[3,4-b]pyridiner og terapeutiske anvendelser deraf
CN105120862A (zh) 2013-01-08 2015-12-02 萨穆梅德有限公司 Wnt信号途径的3-(苯并咪唑-2-基)-吲唑抑制剂及其治疗应用
EP2818472A1 (en) * 2013-06-27 2014-12-31 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators
MX2015017821A (es) * 2013-07-02 2016-04-15 Syngenta Participations Ag Heterociclos bi-o triciclicos activos como plaguicidas con sustituyentes que contienen azufre.
CN105431433B (zh) * 2013-07-02 2018-04-06 先正达参股股份有限公司 有杀有害生物活性的具有含硫取代基的二环或三环杂环
US11229208B2 (en) 2013-07-02 2022-01-25 Syngenta Participations Ag Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents
US10364243B2 (en) * 2014-02-17 2019-07-30 Bayer Cropscience Aktiengesellschaft 2-(het)aryl-substituted fused bicyclic heterocycle derivatives as pesticides
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WO2016040182A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
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WO2016040185A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
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WO2016040188A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040184A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016058928A1 (en) * 2014-10-14 2016-04-21 Syngenta Participations Ag Pesticidally active heterocyclic derivatives with sulphur containing substituents
JP6675404B2 (ja) * 2014-12-17 2020-04-01 シンジェンタ パーティシペーションズ アーゲー 硫黄含有置換基を有する殺有害生物的に活性な複素環式誘導体
ES2729984T3 (es) * 2014-12-31 2019-11-07 Syngenta Participations Ag Derivados policíclicos activos como plaguicida que contienen sustituyentes de azufre
UY36547A (es) * 2015-02-05 2016-06-01 Bayer Cropscience Ag Derivados heterocíclicos condensados bicíclicos sustituidos por 2-(het)arilo como pesticidas
WO2017023980A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
WO2017024010A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof
WO2017024026A1 (en) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-indol-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
WO2017023987A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
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US10206909B2 (en) 2015-08-03 2019-02-19 Samumed, Llc 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
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US10231956B2 (en) 2015-08-03 2019-03-19 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017024025A1 (en) 2015-08-03 2017-02-09 Sunil Kumar Kc 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
AU2016348639B2 (en) 2015-11-06 2022-09-08 Samumed, Llc Treatment of osteoarthritis
JP7010851B2 (ja) 2016-06-01 2022-02-10 バイオスプライス セラピューティクス インコーポレイテッド Ｎ－（５－（３－（７－（３－フルオロフェニル）－３Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－イル）－１Ｈ－インダゾール－５－イル）ピリジン－３－イル）－３－メチルブタンアミドを調製するための方法
WO2018075858A1 (en) 2016-10-21 2018-04-26 Samumed, Llc Methods of using indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors
WO2018085865A1 (en) 2016-11-07 2018-05-11 Samumed, Llc Single-dose, ready-to-use injectable formulations
PE20200341A1 (es) 2017-05-22 2020-02-14 Hoffmann La Roche Composiciones y compuestos terapeuticos y metodos para utilizarlos

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EP0072926B1 (de) * 1981-08-19 1986-09-24 MERCK PATENT GmbH 2-Aryl-imidazopyridine
RO86850B (ro) * 1982-05-03 1985-05-31 Eli Lilly And Company Procedeu pentru prepararea unor 2-fenilimidazo [4,5 c] piridine
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
NO158100C (no) 1988-07-13
IE822667L (en) 1983-05-10
FI79312C (fi) 1989-12-11
AR241247A1 (es) 1992-03-31
FI823846A0 (fi) 1982-11-09
NO158100B (no) 1988-04-05
FI823846L (fi) 1983-05-11
IE56478B1 (en) 1991-08-14
KR890000022B1 (ko) 1989-03-06
GR76746B (pt) 1984-08-30
AU9030682A (en) 1983-05-19
DK161325B (da) 1991-06-24
ES8503351A1 (es) 1985-02-16
ES8401486A1 (es) 1983-12-01
ES523083A0 (es) 1985-02-16
MC1491A1 (fr) 1983-09-12
US4603139A (en) 1986-07-29
GB2113675B (en) 1985-10-30
FI79312B (fi) 1989-08-31
DK161325C (da) 1991-12-02
PT75820A (en) 1982-12-01
PH22764A (en) 1988-12-12
GB2113675A (en) 1983-08-10
IL67206A0 (en) 1983-03-31
DK499582A (da) 1983-05-11
KR840002398A (ko) 1984-07-02
NO823732L (no) 1983-05-11
EP0079083A1 (en) 1983-05-18
DD205904A5 (de) 1984-01-11
EP0079083B1 (en) 1991-02-27
ES517193A0 (es) 1983-12-01

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