PT716600E - Composicoes para administracao topica contendo derivados do acido 3-benzoilfenilacetico para o tratamento de doencas inflamatorias oftalmicas - Google Patents
Composicoes para administracao topica contendo derivados do acido 3-benzoilfenilacetico para o tratamento de doencas inflamatorias oftalmicasInfo
- Publication number
- PT716600E PT716600E PT95923733T PT95923733T PT716600E PT 716600 E PT716600 E PT 716600E PT 95923733 T PT95923733 T PT 95923733T PT 95923733 T PT95923733 T PT 95923733T PT 716600 E PT716600 E PT 716600E
- Authority
- PT
- Portugal
- Prior art keywords
- treatment
- ophthalmic
- acid
- compositions
- benzoylphenylic
- Prior art date
Links
- 208000027866 inflammatory disease Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- -1 amide derivatives of 3-benzoylphenylacetic acid Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/254,090 US5475034A (en) | 1994-06-06 | 1994-06-06 | Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT716600E true PT716600E (pt) | 2002-09-30 |
Family
ID=22962892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT95923733T PT716600E (pt) | 1994-06-06 | 1995-06-06 | Composicoes para administracao topica contendo derivados do acido 3-benzoilfenilacetico para o tratamento de doencas inflamatorias oftalmicas |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5475034A (pt) |
| EP (1) | EP0716600B1 (pt) |
| JP (1) | JP2866744B2 (pt) |
| KR (1) | KR100194242B1 (pt) |
| CN (1) | CN1088992C (pt) |
| AT (1) | ATE215366T1 (pt) |
| CA (1) | CA2167524C (pt) |
| DE (1) | DE69526183T2 (pt) |
| DK (1) | DK0716600T3 (pt) |
| ES (1) | ES2171543T3 (pt) |
| HK (1) | HK1012554A1 (pt) |
| MX (1) | MX9600487A (pt) |
| PT (1) | PT716600E (pt) |
| TW (1) | TW425382B (pt) |
| WO (1) | WO1995033457A1 (pt) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5976566A (en) * | 1997-08-29 | 1999-11-02 | Macrochem Corporation | Non-steroidal antiinflammtory drug formulations for topical application to the skin |
| US6066671A (en) | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
| US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| US20030086899A1 (en) * | 2000-03-14 | 2003-05-08 | Jafari Masoud R. | Chondroitin sulfate containing viscoelastics for use in treating joints |
| AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
| AR030346A1 (es) | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes neurodegenerativos de la retina y cabeza de nervio optico |
| US6646003B2 (en) | 2001-04-02 | 2003-11-11 | Alcon, Inc. | Method of treating ocular inflammatory and angiogenesis-related disorders of the posterior segment of the eye using an amide derivative of flurbiprofen or ketorolac |
| US20040132773A1 (en) * | 2001-08-13 | 2004-07-08 | Gamache Daniel A | Method of treating neurodgenerative disorders of the retina and optic nerve head |
| BR0309747A (pt) * | 2002-05-03 | 2005-04-26 | Alcon Inc | Método para o tratamento de distúrbios vasculares mediados pelo fator de crescimento vascular endotelial |
| CN100341498C (zh) | 2003-01-21 | 2007-10-10 | 千寿制药株式会社 | 含有2－氨基－3－(4－溴苯甲酰基)苯乙酸的水成液制剂 |
| US20030187072A1 (en) * | 2003-02-14 | 2003-10-02 | Kapin Michael A. | Method of treating angiogenesis-related disorders |
| RU2006101150A (ru) * | 2003-06-13 | 2006-06-10 | Алькон, Инк. (Ch) | Композиции нестероидных противовоспалительных средств для лечения патологического ангиогенеза глаз |
| PL1683526T3 (pl) * | 2003-11-14 | 2012-09-28 | Senju Pharma Co | Preparat wodnego roztworu zawierający antybiotyk aminoglikozydowy i bromfenak |
| US8748402B2 (en) | 2004-06-07 | 2014-06-10 | Bausch & Lomb Pharma Holdings Corp. | Ophthalmic formulations and uses thereof |
| US8372814B2 (en) | 2004-06-07 | 2013-02-12 | Ista Pharmaceuticals, Inc. | Ophthalmic formulations and uses thereof |
| TWI358290B (en) | 2004-12-02 | 2012-02-21 | Alcon Inc | Topical nepafenac formulations |
| MX2007014084A (es) * | 2005-05-10 | 2008-02-07 | Alcon Inc | Suspension oftalmica que comprende un farmaco oftalmico, una poloxamina y un agente ajustador de la tonicidad de glicol, el uso de dicha composicion para la fabricacion de un medicamento para tratar trastornos oftalmicos. |
| PT1885336E (pt) * | 2005-05-10 | 2009-05-07 | Alcon Inc | Formulações de suspensão compreendendo um princípio activo, um tensoactivo poloxâmero ou meroxapol e um glicol, sua utilização no fabrico de um medicamento para tratamento de distúrbios oftálmicos |
| AU2007208054A1 (en) * | 2006-01-25 | 2007-08-02 | Aciex Therapeutics, Inc. | Formulations and methods for treating dry eye |
| US20100130580A1 (en) * | 2006-01-25 | 2010-05-27 | Aciex Therapeutics, Inc. | Formulations and Methods for Treating Dry Eye |
| US20090010850A1 (en) * | 2007-05-24 | 2009-01-08 | Ousler Iii George W | Formulations and methods for treating dry eye |
| TW200812575A (en) * | 2006-04-28 | 2008-03-16 | Alcon Inc | Formulations containing amide derivatives of carboxylic acid NSAIDs for topical administration to the eye |
| US20080153819A1 (en) * | 2006-12-21 | 2008-06-26 | Bingaman David P | Methods for treating macular edema and pathologic ocular angiogenesis using a neuroprotective agent and a receptor tyrosine kinase inhibitor |
| US20080153818A1 (en) * | 2006-12-21 | 2008-06-26 | Bingaman David P | Methods for preventing inflammation during surgery |
| US20090105245A1 (en) * | 2006-12-21 | 2009-04-23 | Bingaman David P | Methods for treating macular edema and ocular angiogenesis using an anti-inflammatory agent and a receptor tyrosine kinase inhibitor |
| UY31058A1 (es) * | 2007-05-01 | 2008-10-31 | Alcon Res Ltd | Formulaciones de aminoacido n-halogenado con compuestos antiinflamatorios |
| MX354184B (es) | 2007-10-05 | 2018-02-16 | Acucela Inc | Compuestos alcoxi para el tratamiento de enfermedades. |
| US20100292289A1 (en) * | 2007-11-30 | 2010-11-18 | Ampla Pharmaceuticals Inc. | Treatment of metabolic syndrome with novel amides |
| US20090239909A1 (en) * | 2008-03-24 | 2009-09-24 | Ampla Pharmaceuticals Inc. | Treatment of metabolic syndrome with lactams |
| US8778999B2 (en) | 2009-03-05 | 2014-07-15 | Insite Vision Incorporated | Non-steroidal anti-inflammatory ophthalmic compositions |
| US20100234469A1 (en) * | 2009-03-12 | 2010-09-16 | Medichem, S.A. | New Crystals Of A Benzoylbenzeneacetamide Derivative |
| US10471027B2 (en) | 2009-07-02 | 2019-11-12 | Acucela, Inc. | Pharmacology of visual cycle modulators |
| BR112012013503B8 (pt) | 2009-12-03 | 2021-05-25 | Alcon Res Llc | composição de suspensão oftálmica aquosa topicamente administrável, e método para manter sua viscosidade |
| WO2014207769A1 (en) | 2013-06-27 | 2014-12-31 | Mylan Laboratories Ltd | Process for the preparation of nepafenac |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1226344A (pt) * | 1967-07-31 | 1971-03-24 | ||
| CH577461A5 (pt) * | 1975-08-13 | 1976-07-15 | Robins Co Inc A H | |
| US4318949A (en) * | 1976-09-16 | 1982-03-09 | Toray Industries, Inc. | Composite nap sheet and process for preparing the same |
| US4313949A (en) * | 1979-09-26 | 1982-02-02 | A. H. Robins Company, Inc. | Method of producing an inhibitory effect on blood platelet aggregation |
| US4254146A (en) * | 1979-10-18 | 1981-03-03 | A. H. Robins Company, Inc. | 3-Benzoyl-2-nitrophenylacetic acids, metal salts, amides and esters |
| IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
| DE3026402A1 (de) * | 1980-07-11 | 1982-02-04 | Syntex Corp., Palo Alto, Calif. | Die verwendung analgetischer und nicht-hormonaler, entzuendungshemmender mittel bei der behandlung von mikrovaskulaeren erkrankungen |
| US4503073A (en) * | 1981-01-07 | 1985-03-05 | A. H. Robins Company, Incorporated | 2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids |
| IL64724A0 (en) * | 1981-02-17 | 1982-03-31 | Robins Co Inc A H | 2-amino-3-(halobenzoyl)-methylphenylacetic acids and esters and salts thereof and pharmaceutical compositions containing them |
| US4568695A (en) * | 1983-12-07 | 1986-02-04 | A. H. Robins Company, Incorporated | 2-Amino-3-benzoyl-phenethylalcohols and intermediates therefor |
| US4851443A (en) * | 1985-03-14 | 1989-07-25 | Smith Kline Dauelsberg, Gmbh | Carboxylic acid amides, compositions and medical use thereof |
| DE3668450D1 (de) * | 1985-03-14 | 1990-03-01 | Smithkline Dauelsberg | 5-aminosalicylsaeurederivate von nicht-steroidalen entzuendungshemmenden sauren. |
| US4683242A (en) * | 1985-10-28 | 1987-07-28 | A. H. Robins Company, Incorporated | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters |
| CA1325382C (en) * | 1988-01-27 | 1993-12-21 | Takahiro Ogawa | Locally administrable therapeutic composition for inflammatory disease |
-
1994
- 1994-06-06 US US08/254,090 patent/US5475034A/en not_active Expired - Lifetime
-
1995
- 1995-06-06 AT AT95923733T patent/ATE215366T1/de active
- 1995-06-06 MX MX9600487A patent/MX9600487A/es unknown
- 1995-06-06 PT PT95923733T patent/PT716600E/pt unknown
- 1995-06-06 CA CA002167524A patent/CA2167524C/en not_active Expired - Lifetime
- 1995-06-06 DE DE69526183T patent/DE69526183T2/de not_active Expired - Lifetime
- 1995-06-06 DK DK95923733T patent/DK0716600T3/da active
- 1995-06-06 JP JP8501284A patent/JP2866744B2/ja not_active Expired - Lifetime
- 1995-06-06 WO PCT/US1995/007187 patent/WO1995033457A1/en active IP Right Grant
- 1995-06-06 KR KR1019960700563A patent/KR100194242B1/ko not_active IP Right Cessation
- 1995-06-06 CN CN95190521A patent/CN1088992C/zh not_active Expired - Lifetime
- 1995-06-06 TW TW084105686A patent/TW425382B/zh not_active IP Right Cessation
- 1995-06-06 ES ES95923733T patent/ES2171543T3/es not_active Expired - Lifetime
- 1995-06-06 EP EP95923733A patent/EP0716600B1/en not_active Expired - Lifetime
-
1998
- 1998-12-17 HK HK98113825A patent/HK1012554A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08510479A (ja) | 1996-11-05 |
| ES2171543T3 (es) | 2002-09-16 |
| ATE215366T1 (de) | 2002-04-15 |
| CN1129397A (zh) | 1996-08-21 |
| CA2167524C (en) | 2002-08-13 |
| JP2866744B2 (ja) | 1999-03-08 |
| AU2818495A (en) | 1996-01-04 |
| DK0716600T3 (da) | 2002-06-24 |
| CA2167524A1 (en) | 1995-12-14 |
| AU689277B2 (en) | 1998-03-26 |
| HK1012554A1 (en) | 1999-08-06 |
| WO1995033457A1 (en) | 1995-12-14 |
| DE69526183T2 (de) | 2002-09-26 |
| MX9600487A (es) | 1997-06-28 |
| EP0716600B1 (en) | 2002-04-03 |
| US5475034A (en) | 1995-12-12 |
| KR100194242B1 (ko) | 1999-06-15 |
| CN1088992C (zh) | 2002-08-14 |
| EP0716600A1 (en) | 1996-06-19 |
| DE69526183D1 (de) | 2002-05-08 |
| KR960703580A (ko) | 1996-08-31 |
| TW425382B (en) | 2001-03-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT716600E (pt) | Composicoes para administracao topica contendo derivados do acido 3-benzoilfenilacetico para o tratamento de doencas inflamatorias oftalmicas | |
| HUP0100815A2 (hu) | Neurológiai és neuropszichiátriai rendellenességek kezelésére szolgáló gyógyszerkészítmények | |
| TW262461B (pt) | ||
| NZ331163A (en) | Composition comprising interleukin-1 inhibitor and hydrogel ester (hyaluronan) for treating inflammatory diseases | |
| DK0713701T3 (da) | 2-Brommelatonin til behandling af søvnforstyrrelser | |
| EE9700172A (et) | Raku adhesiooni inhibiitorid | |
| DE69625691D1 (de) | Verabreichung von peptidylheterocyclen zur behandlung von thrombin in zusammenhang stehenden krankheiten | |
| CA2120367A1 (en) | Compositions and use of pharmaceutical compositions in the treatment of symptoms of disorders related to chronic inflammatory diseases and etiologically related symptomology | |
| SE8804036L (sv) | Ny anvaendning av 11,28-dioxa-4-azatricklo (22.3.1.04.9)-oktakos-18-en-derivat och farmaceutiska kompositioner innehaallande desamma | |
| EP1007556A4 (en) | TROPONIN SUB-UNITS AND FRAGMENTS FOR USE AS INHIBITORS OF ANGIOGENESIS | |
| MC2078A1 (fr) | Emploi d'alezastine comme matiere active contre le psoriasis et des maladies inflammatoires | |
| EP0226223A3 (en) | Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity | |
| IT1263013B (it) | Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee. | |
| IE802589L (en) | Anti-inflammatory pharmaceutical composition containing¹rosmarinic acid | |
| UA42719C2 (uk) | Сполуки, композиції та способи, які інгібують протеази, для лікування та профілактики імуномедіаторних запальних хвороб | |
| AU2068895A (en) | Dl- di- or tri-hydroxyphenylglycine alkyl esters for the treatment of inflammatory and allergic conditions | |
| TR199900725T2 (xx) | Hidroksamik asit t�revleri | |
| ATE97812T1 (de) | Therapeutische verwendung des isopropylesterderivates von monosialogangliosiden bei erkrankungen des nervensystems, begleitet von entzuendungen. | |
| NO974551D0 (no) | Bruk av sulbutiamin for å fremskaffe farmasöytiske sammensetninger nyttige i behandling av visse psykomotoriske- og psyko-intellektuelle sykdommer | |
| CA2073673A1 (en) | Esters of 2-arylmethyl-1-naphthol derivatives as 5-lipoxygenase inhibitors | |
| MY110416A (en) | Composition for the treatment of schizophrenia. |