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PT641215E - Analogos de trombomodulina resistentes a proteases - Google Patents

Analogos de trombomodulina resistentes a proteases

Info

Publication number
PT641215E
PT641215E PT93905821T PT93905821T PT641215E PT 641215 E PT641215 E PT 641215E PT 93905821 T PT93905821 T PT 93905821T PT 93905821 T PT93905821 T PT 93905821T PT 641215 E PT641215 E PT 641215E
Authority
PT
Portugal
Prior art keywords
analogs
trombomodulin
protease resistant
methods
thrombomodulin
Prior art date
Application number
PT93905821T
Other languages
English (en)
Inventor
David Richard Light
William H Andrews
Jeffrey Homer Clarke
Robert Michael Wydro
Patricia Ann Young
Original Assignee
Paion Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paion Gmbh filed Critical Paion Gmbh
Publication of PT641215E publication Critical patent/PT641215E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Prostheses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT93905821T 1992-02-05 1993-02-05 Analogos de trombomodulina resistentes a proteases PT641215E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83057792A 1992-02-05 1992-02-05

Publications (1)

Publication Number Publication Date
PT641215E true PT641215E (pt) 2004-09-30

Family

ID=25257242

Family Applications (1)

Application Number Title Priority Date Filing Date
PT93905821T PT641215E (pt) 1992-02-05 1993-02-05 Analogos de trombomodulina resistentes a proteases

Country Status (9)

Country Link
EP (2) EP0641215B1 (pt)
JP (2) JP3517236B2 (pt)
AT (1) ATE264913T1 (pt)
AU (1) AU675422B2 (pt)
CA (1) CA2129370A1 (pt)
DE (1) DE69333491T2 (pt)
ES (1) ES2220905T3 (pt)
PT (1) PT641215E (pt)
WO (1) WO1993015755A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7060484B1 (en) 1993-11-12 2006-06-13 Gilead Sciences, Inc. Polypeptides and coagulation therapy
US6110721A (en) * 1993-11-12 2000-08-29 Gilead Sciences, Inc. Polypeptides and coagulation therapy
DE69433133T2 (de) * 1993-12-17 2004-04-01 Mochida Pharmaceutical Co. Ltd. Lösliches thrombomodulin enthaltende zubereitung
WO2003039586A1 (en) * 2001-11-09 2003-05-15 Novo Nordisk Health Care Ag Pharmaceutical composition comprising factor vii polypeptides and thrombomodulin polypeptides
EP1948216B1 (en) * 2005-10-13 2011-03-30 Eli Lilly And Company Treatment of acute renal failure with soluble thrombomodulin
AU2007305550B2 (en) 2006-10-06 2010-09-30 Asahi Kasei Pharma Corporation Agent for Therapy and/or Improvement of Disseminated Intravascular Coagulation
WO2008117735A1 (ja) 2007-03-23 2008-10-02 Asahi Kasei Pharma Corporation 高純度可溶性トロンボモジュリンの製造方法
EP2014296A1 (en) * 2007-07-10 2009-01-14 PAION Deutschland GmbH Novel strategies for increasing the reperfusion in obstructed blood vessel
AR067345A1 (es) * 2007-07-10 2009-10-07 Paion Deutschland Gmbh Uso de trombomodulina para la preparacion de un medicamento trombolitico
EP2120049A1 (de) 2008-05-14 2009-11-18 PAION Deutschland GmbH Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern
EP2320936A1 (en) * 2008-07-16 2011-05-18 PAION Deutschland GmbH Prevention and treatment of radiation injury
WO2010006635A1 (en) * 2008-07-16 2010-01-21 Paion Deutschland Gmbh Treatment of inflammatory bowel disease
JP2012529445A (ja) 2009-06-12 2012-11-22 パイオン ドイチュラント ゲーエムベーハー 線溶亢進を伴う凝固障害の処置
AU2011246021B2 (en) 2010-04-30 2014-03-13 Asahi Kasei Pharma Corporation High-purity soluble thrombomodulin and method for producing same
AU2010355558A1 (en) 2010-06-14 2013-01-24 Paion Deutschland Gmbh Treatment of coagulopathy with hyperfibrinolysis
AU2012337838B2 (en) 2011-11-15 2016-04-21 Asahi Kasei Pharma Corporation Medicament for therapeutic treatment and/or improvement of sepsis
JP2015522024A (ja) * 2012-06-29 2015-08-03 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 糖タンパク質の凝集を低下させるための方法
BR112021007460A2 (pt) 2018-10-22 2021-11-03 Asahi Kasei Pharma Corp Medicamento para tratamento terapêutico e/ou melhora de um paciente com sepse

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK299087D0 (da) * 1987-06-12 1987-06-12 Novo Industri As Proteins and derivatives thereof
JPH04505554A (ja) * 1989-02-17 1992-10-01 コドン 可溶性トロンボモジュリン類似体
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
CA2022713A1 (en) * 1989-08-11 1991-02-12 Nils U. Bang Human thrombomodulin derivatives
JPH03259084A (ja) * 1990-03-06 1991-11-19 Kowa Co トロンビン結合性物質の製造法
AU2317192A (en) * 1991-07-01 1993-02-11 Berlex Laboratories, Inc. Novel mutagenesis methods and compositions
AU4533093A (en) * 1992-06-10 1994-01-04 Michael John Morser Mutants of the epidermal growth factor domains of human thrombomodulin

Also Published As

Publication number Publication date
EP0641215B1 (en) 2004-04-21
AU675422B2 (en) 1997-02-06
ES2220905T3 (es) 2004-12-16
EP0641215A4 (en) 1995-11-29
CA2129370A1 (en) 1993-08-19
JP3517236B2 (ja) 2004-04-12
EP0641215A1 (en) 1995-03-08
ATE264913T1 (de) 2004-05-15
JPH07503849A (ja) 1995-04-27
AU3659393A (en) 1993-09-03
WO1993015755A1 (en) 1993-08-19
EP1449849A3 (en) 2006-01-25
DE69333491D1 (en) 2004-05-27
EP1449849A2 (en) 2004-08-25
JP2004105188A (ja) 2004-04-08
DE69333491T2 (de) 2005-03-31

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