PT3077368T - Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x - Google Patents

Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x

Info

Publication number: PT3077368T
Authority: PT; Portugal
Prior art keywords: ionic; purification; synthesis; contrast agents; alternative process
Prior art date: 2013-12-06

Application number

PT14814793T

Other languages

English (en)

Inventor

Haaland Torfinn

Askildsen Arne

Silalahi Sumihar

Martin Farbrot Alf

Dagny Saanum Inger

Kalleberg Rita

Original Assignee

Ge Healthcare As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-12-06

Filing date

2014-12-08

Publication date

2018-10-19

2014-12-08 Application filed by Ge Healthcare As filed Critical Ge Healthcare As

2018-10-19 Publication of PT3077368T publication Critical patent/PT3077368T/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PT14814793T 2013-12-06 2014-12-08 Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x PT3077368T (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201361912799P	2013-12-06	2013-12-06
US201461969951P	2014-03-25	2014-03-25

Publications (1)

Publication Number	Publication Date
PT3077368T true PT3077368T (pt)	2018-10-19

Family

ID=52117869

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT14814793T PT3077368T (pt)	2013-12-06	2014-12-08	Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x

Country Status (7)

Country	Link
US (2)	US9834504B2 (pt)
EP (1)	EP3077368B1 (pt)
JP (1)	JP6506758B2 (pt)
CN (1)	CN105873898B (pt)
ES (1)	ES2683143T3 (pt)
PT (1)	PT3077368T (pt)
WO (1)	WO2015082720A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT3077368T (pt)	2013-12-06	2018-10-19	Ge Healthcare As	Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x
CN105669488A (zh) *	2016-01-11	2016-06-15	浙江海洲制药有限公司	X-ct造影剂含碘中间体母液的预处理及中间体回收方法
GB202004773D0 (en) *	2020-03-31	2020-05-13	Ge Healthcare As	Continuous crystallisation method

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1548594A (en) *	1976-06-11	1979-07-18	Nyegaard & Co As	Triiodoisophthalic acid amides
CN1109272C (zh) *	1993-03-10	2003-05-21	株式会社亚玛托亚商会	彩色析象器
CN1078201C (zh) *	1995-11-20	2002-01-23	江苏省原子医学研究所	一种碘海醇的制备方法
GB9618055D0 (en) *	1996-08-29	1996-10-09	Nycomed Imaging As	Process
US5840967A (en) *	1996-08-29	1998-11-24	Nycomed Imaging As	Process for the preparation of contrast agents
GB9903109D0 (en)	1999-02-11	1999-04-07	Nycomed Imaging As	Process
US20030236407A1 (en) *	2002-02-28	2003-12-25	Schering Ag	Perfluoroalkyl group-containing micelle-forming triiodoaromatic compounds, process for their production and their use as contrast media
US20110021823A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Processing crude iodixanol mixture by nanofiltration
US20110021833A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
US20110021828A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Recovering unreacted intermediate from desalinated and desolventized dimerisation reaction mixture by ultrafiltration
EP2277859A1 (en) *	2009-07-21	2011-01-26	GE Healthcare AS	Acetylation using reduced concentration of acetic acid anhydride for synthesizing non-ionic X-ray contrast agents
EP2277851A1 (en) *	2009-07-21	2011-01-26	GE Healthcare AS	Acetylation using reduced volume of acetic acid anhydride for synthesizing non-ionic X-ray contrast agents
US7754920B1 (en) *	2009-07-21	2010-07-13	Ge Healthcare As	Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents
US20110021822A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
US20110021821A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
PT3077367T (pt) *	2013-12-06	2018-10-03	Ge Healthcare As	Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x
PT3077368T (pt) *	2013-12-06	2018-10-19	Ge Healthcare As	Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x

2014
- 2014-12-08 PT PT14814793T patent/PT3077368T/pt unknown
- 2014-12-08 ES ES14814793.7T patent/ES2683143T3/es active Active
- 2014-12-08 US US15/100,718 patent/US9834504B2/en active Active
- 2014-12-08 JP JP2016536191A patent/JP6506758B2/ja active Active
- 2014-12-08 WO PCT/EP2014/076891 patent/WO2015082720A1/en active Application Filing
- 2014-12-08 CN CN201480066348.9A patent/CN105873898B/zh active Active
- 2014-12-08 EP EP14814793.7A patent/EP3077368B1/en active Active
2017
- 2017-05-24 US US15/603,681 patent/US10011560B2/en active Active

Also Published As

Publication number	Publication date
CN105873898A (zh)	2016-08-17
US9834504B2 (en)	2017-12-05
JP6506758B2 (ja)	2019-04-24
CN105873898B (zh)	2019-06-25
EP3077368A1 (en)	2016-10-12
JP2016539142A (ja)	2016-12-15
US20160297749A1 (en)	2016-10-13
EP3077368B1 (en)	2018-07-11
WO2015082720A1 (en)	2015-06-11
US10011560B2 (en)	2018-07-03
ES2683143T3 (es)	2018-09-25
US20170253556A1 (en)	2017-09-07

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