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PT2948183T - Conjugados anticorpo-fármaco de duocarmicina para utilização no tratamento de cancro do endométrio - Google Patents

Conjugados anticorpo-fármaco de duocarmicina para utilização no tratamento de cancro do endométrio

Info

Publication number
PT2948183T
PT2948183T PT157002114T PT15700211T PT2948183T PT 2948183 T PT2948183 T PT 2948183T PT 157002114 T PT157002114 T PT 157002114T PT 15700211 T PT15700211 T PT 15700211T PT 2948183 T PT2948183 T PT 2948183T
Authority
PT
Portugal
Prior art keywords
treatment
endometrial cancer
duocarmycin
adcs
duocarmycin adcs
Prior art date
Application number
PT157002114T
Other languages
English (en)
Inventor
Johannes Goedings Peter
davide santin Alessandro
Original Assignee
Univ Yale
Synthon Biopharmaceuticals Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale, Synthon Biopharmaceuticals Bv filed Critical Univ Yale
Publication of PT2948183T publication Critical patent/PT2948183T/pt

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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
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  • Organic Chemistry (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
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  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PT157002114T 2014-01-10 2015-01-09 Conjugados anticorpo-fármaco de duocarmicina para utilização no tratamento de cancro do endométrio PT2948183T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14150791 2014-01-10

Publications (1)

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PT2948183T true PT2948183T (pt) 2016-07-13

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PT157002114T PT2948183T (pt) 2014-01-10 2015-01-09 Conjugados anticorpo-fármaco de duocarmicina para utilização no tratamento de cancro do endométrio

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Country Link
US (2) US9427480B2 (pt)
EP (1) EP2948183B1 (pt)
JP (1) JP6224268B2 (pt)
KR (2) KR20220045075A (pt)
CN (1) CN105899237B (pt)
AU (1) AU2015205588B2 (pt)
CA (1) CA2935430C (pt)
CL (1) CL2016001743A1 (pt)
CY (1) CY1117712T1 (pt)
DK (1) DK2948183T3 (pt)
ES (1) ES2578831T3 (pt)
HR (1) HRP20160797T1 (pt)
HU (1) HUE029672T2 (pt)
MX (1) MX368234B (pt)
MY (1) MY189713A (pt)
PL (1) PL2948183T3 (pt)
PT (1) PT2948183T (pt)
RU (1) RU2686085C2 (pt)
SG (1) SG11201605597VA (pt)
WO (1) WO2015104373A2 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
MX2011004625A (es) 2008-11-03 2011-07-20 Syntarga Bv Analogos cc-1065 novedosos y sus conjugados.
AU2011243294C1 (en) 2010-04-21 2015-12-03 Syntarga B.V. Novel conjugates of CC-1065 analogs and bifunctional linkers
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PT2948183T (pt) 2014-01-10 2016-07-13 Univ Yale Conjugados anticorpo-fármaco de duocarmicina para utilização no tratamento de cancro do endométrio
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