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PT2933333T - Molécula de ácido nucleico de cadeia simples para controlar a expressão génica - Google Patents

Molécula de ácido nucleico de cadeia simples para controlar a expressão génica

Info

Publication number
PT2933333T
PT2933333T PT151699337T PT15169933T PT2933333T PT 2933333 T PT2933333 T PT 2933333T PT 151699337 T PT151699337 T PT 151699337T PT 15169933 T PT15169933 T PT 15169933T PT 2933333 T PT2933333 T PT 2933333T
Authority
PT
Portugal
Prior art keywords
nucleic acid
acid molecule
gene expression
controlling gene
strand nucleic
Prior art date
Application number
PT151699337T
Other languages
English (en)
Inventor
Ohgi Tadaaki
Itoh Akihiro
Hayashi Hirotake
Shirohzu Hisao
Hamasaki Tomohiro
Suzuki Hiroshi
Original Assignee
Bonac Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bonac Corp filed Critical Bonac Corp
Publication of PT2933333T publication Critical patent/PT2933333T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT151699337T 2010-07-08 2011-07-08 Molécula de ácido nucleico de cadeia simples para controlar a expressão génica PT2933333T (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2010156122 2010-07-08
JP2010174915 2010-08-03
JP2010230806 2010-10-13
JP2010230808 2010-10-13
JP2010269824 2010-12-02
JP2010269823 2010-12-02

Publications (1)

Publication Number Publication Date
PT2933333T true PT2933333T (pt) 2018-04-24

Family

ID=45441339

Family Applications (2)

Application Number Title Priority Date Filing Date
PT151699337T PT2933333T (pt) 2010-07-08 2011-07-08 Molécula de ácido nucleico de cadeia simples para controlar a expressão génica
PT117461475T PT2431466E (pt) 2010-07-08 2011-07-08 Molécula de ácido nucleico de cadeia simples para controlar a expressão génica

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT117461475T PT2431466E (pt) 2010-07-08 2011-07-08 Molécula de ácido nucleico de cadeia simples para controlar a expressão génica

Country Status (17)

Country Link
EP (2) EP2431466B1 (pt)
JP (3) JP4968811B2 (pt)
KR (1) KR101849798B1 (pt)
CN (2) CN102918156B (pt)
AU (1) AU2011274854B2 (pt)
BR (1) BR112013000481A2 (pt)
CA (1) CA2804511C (pt)
DK (2) DK2933333T3 (pt)
ES (2) ES2550487T3 (pt)
HU (2) HUE026520T2 (pt)
MX (1) MX352568B (pt)
NZ (2) NZ704812A (pt)
PT (2) PT2933333T (pt)
RU (1) RU2628311C2 (pt)
SG (2) SG196779A1 (pt)
TW (2) TWI527901B (pt)
WO (1) WO2012005368A1 (pt)

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CN109810977A (zh) * 2012-05-26 2019-05-28 株式会社博纳克 具有递送功能的基因表达调控用单链核酸分子
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SG10201805087VA (en) 2013-12-27 2018-07-30 Bonac Corp Artificial match-type mirna for controlling gene expression and use therefor
JP6726105B2 (ja) 2014-12-15 2020-07-22 株式会社ボナック ＴＧＦ−β１発現抑制のための一本鎖核酸分子
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US20200038427A1 (en) 2017-03-31 2020-02-06 Bonac Corporation Cyclic nucleic acid molecule having gene expression control function
JPWO2018199338A1 (ja) * 2017-04-27 2020-03-12 国立大学法人広島大学 Ｂ型肝炎治療用核酸分子
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TWI830718B (zh) * 2018-02-09 2024-02-01 日商住友化學股份有限公司 核酸分子之製造方法
EP3778914A4 (en) * 2018-03-30 2022-01-19 Sumitomo Chemical Company, Ltd. Method for producing single-strand rna
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KR20210069628A (ko) * 2018-10-02 2021-06-11 도레이 카부시키가이샤 헤어핀형 단일쇄 rna 분자의 제조 방법
US20220088057A1 (en) 2019-01-25 2022-03-24 Kyorin Pharmaceutical Co., Ltd. Therapeutic agent for fibrosis
CN114502566B (zh) 2019-10-11 2025-02-11 住友化学株式会社 核酸寡聚物的制造方法
US12391716B2 (en) 2020-01-29 2025-08-19 Sumitomo Chemical Company, Limited Process of preparing nucleic acid oligomer
WO2021153047A1 (ja) 2020-01-29 2021-08-05 住友化学株式会社 核酸オリゴマーの製造方法
JP7613130B2 (ja) * 2020-03-25 2025-01-15 味の素株式会社 リガーゼ変異体
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Also Published As

Publication number Publication date
SG196779A1 (en) 2014-02-13
TW201217523A (en) 2012-05-01
MX352568B (es) 2017-11-29
EP2431466A4 (en) 2012-04-25
CA2804511A1 (en) 2012-01-12
ES2550487T3 (es) 2015-11-10
DK2431466T3 (en) 2016-01-11
RU2013105329A (ru) 2014-08-20
CN102918156A (zh) 2013-02-06
HK1181423A1 (zh) 2013-11-08
CN104818276B (zh) 2020-12-11
TW201627500A (zh) 2016-08-01
CN104818276A (zh) 2015-08-05
AU2011274854B2 (en) 2015-04-16
ES2670017T3 (es) 2018-05-29
HUE037500T2 (hu) 2018-08-28
BR112013000481A2 (pt) 2019-10-15
EP2933333A1 (en) 2015-10-21
SG186899A1 (en) 2013-02-28
KR101849798B1 (ko) 2018-04-17
DK2933333T3 (en) 2018-04-30
MX2013000315A (es) 2013-05-01
CN102918156B (zh) 2015-11-25
EP2431466B1 (en) 2015-10-07
JP6162182B2 (ja) 2017-07-12
PT2431466E (pt) 2016-01-08
JP2012130342A (ja) 2012-07-12
WO2012005368A1 (ja) 2012-01-12
JP5804642B2 (ja) 2015-11-04
EP2431466A1 (en) 2012-03-21
EP2933333B1 (en) 2018-02-21
JPWO2012005368A1 (ja) 2013-09-05
TWI527901B (zh) 2016-04-01
HUE026520T2 (en) 2016-06-28
TWI573870B (zh) 2017-03-11
RU2628311C2 (ru) 2017-08-15
AU2011274854A1 (en) 2013-02-14
NZ606232A (en) 2015-06-26
JP2015231381A (ja) 2015-12-24
CA2804511C (en) 2021-07-06
KR20130090792A (ko) 2013-08-14
NZ704812A (en) 2017-01-27
JP4968811B2 (ja) 2012-07-04

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