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PT2739615T - Fenil-3-aza-biciclo[3.1.0]hex-3-il-metanonas e a sua utilização como medicamento - Google Patents

Fenil-3-aza-biciclo[3.1.0]hex-3-il-metanonas e a sua utilização como medicamento

Info

Publication number
PT2739615T
PT2739615T PT127410223T PT12741022T PT2739615T PT 2739615 T PT2739615 T PT 2739615T PT 127410223 T PT127410223 T PT 127410223T PT 12741022 T PT12741022 T PT 12741022T PT 2739615 T PT2739615 T PT 2739615T
Authority
PT
Portugal
Prior art keywords
methanones
aza
hex
bicycle
phenyl
Prior art date
Application number
PT127410223T
Other languages
English (en)
Inventor
Giovannini Riccardo
Rosenbrock Holger
Mazzaferro Rocco
Bertani Barbara
Ferrara Marco
Lingard Iain
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PT2739615T publication Critical patent/PT2739615T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
PT127410223T 2011-08-03 2012-08-02 Fenil-3-aza-biciclo[3.1.0]hex-3-il-metanonas e a sua utilização como medicamento PT2739615T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11176468 2011-08-03

Publications (1)

Publication Number Publication Date
PT2739615T true PT2739615T (pt) 2017-06-09

Family

ID=46598566

Family Applications (1)

Application Number Title Priority Date Filing Date
PT127410223T PT2739615T (pt) 2011-08-03 2012-08-02 Fenil-3-aza-biciclo[3.1.0]hex-3-il-metanonas e a sua utilização como medicamento

Country Status (38)

Country Link
US (1) US9012489B2 (pt)
EP (1) EP2739615B1 (pt)
JP (1) JP5850589B2 (pt)
KR (1) KR101944686B1 (pt)
CN (2) CN103797005B (pt)
AP (1) AP2014007399A0 (pt)
AR (1) AR087436A1 (pt)
AU (1) AU2012292036C1 (pt)
BR (1) BR112014001642B1 (pt)
CA (1) CA2843805C (pt)
CL (1) CL2014000246A1 (pt)
CO (1) CO6870037A2 (pt)
CY (1) CY1119326T1 (pt)
DK (1) DK2739615T3 (pt)
EA (1) EA024933B1 (pt)
EC (1) ECSP14013221A (pt)
ES (1) ES2623006T3 (pt)
GE (1) GEP20166483B (pt)
HK (1) HK1193100A1 (pt)
HR (1) HRP20170695T1 (pt)
HU (1) HUE033134T2 (pt)
IL (1) IL229962A (pt)
LT (1) LT2739615T (pt)
MA (1) MA35286B1 (pt)
ME (1) ME02672B (pt)
MX (1) MX347828B (pt)
MY (1) MY167396A (pt)
PE (1) PE20141352A1 (pt)
PH (1) PH12014500276A1 (pt)
PL (1) PL2739615T3 (pt)
PT (1) PT2739615T (pt)
RS (1) RS55927B1 (pt)
SI (1) SI2739615T1 (pt)
TN (1) TN2014000044A1 (pt)
TW (1) TWI543974B (pt)
UA (1) UA114405C2 (pt)
UY (1) UY34239A (pt)
WO (1) WO2013017657A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2950084C (en) 2014-06-06 2022-04-19 Basf Se Use of substituted oxadiazoles for combating phytopathogenic fungi
BR112018009539B1 (pt) 2015-11-13 2022-05-24 Basf Se Uso de compostos da fórmula i, compostos, mistura, composição agroquímica, uso dos compostos e método para combater fungos nocivos fitopatogênicos
AR106679A1 (es) 2015-11-13 2018-02-07 Basf Se Oxadiazoles sustituidos para combatir hongos fitopatógenos
KR20180083419A (ko) 2015-11-19 2018-07-20 바스프 에스이 식물병원성 진균을 퇴치하기 위한 치환 옥사디아졸
WO2017178245A1 (en) 2016-04-11 2017-10-19 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
WO2018224455A1 (en) 2017-06-07 2018-12-13 Basf Se Substituted cyclopropyl derivatives
CR20210545A (es) * 2019-05-01 2021-12-23 Boehringer Ingelheim Int Formas sólidas de un inhibidor de glyt1
CN116212025A (zh) 2020-01-09 2023-06-06 迪斯克医药公司 治疗红细胞生成性原卟啉病、x连锁原卟啉病或先天性红细胞生成性卟啉病的方法
KR20230051247A (ko) 2020-08-13 2023-04-17 베링거 인겔하임 인터내셔날 게엠베하 정신분열병과 연관된 인지 손상의 치료
CN117567449A (zh) 2020-10-13 2024-02-20 勃林格殷格翰国际有限公司 再加工方法
EP4436564A1 (en) * 2021-11-24 2024-10-02 MapLight Therapeutics, Inc. Methods of treating neurological disorders
CN114957087A (zh) * 2022-04-13 2022-08-30 湖南复瑞生物医药技术有限责任公司 一种帕罗韦德中间体制备方法
WO2023237103A1 (zh) * 2022-06-10 2023-12-14 成都百裕制药股份有限公司 吡咯烷衍生物、药物组合物及其在医药上的应用
WO2024042043A1 (en) 2022-08-24 2024-02-29 Boehringer Ingelheim International Gmbh A scalable process for the preparation of a glyt-1 inhibitor
WO2024243600A2 (en) * 2023-05-25 2024-11-28 Maplight Therapeutics, Inc. Compositions for treating neurological disorders

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006514978A (ja) 2003-04-10 2006-05-18 ランバクシー ラボラトリーズ リミテッド ムスカリン受容体アンタゴニストである置換アザビシクロヘキサン誘導体
JP4732354B2 (ja) * 2003-10-14 2011-07-27 ファイザー・プロダクツ・インク グリシン輸送阻害薬としての二環式[3.1.0]誘導体
DE102004035280A1 (de) 2004-07-21 2006-03-16 Robert Bosch Gmbh Kraftstoffinjektor mit direkter mehrstufiger Einspritzventilgliedansteuerung
RU2007125380A (ru) * 2005-01-06 2009-02-20 Ф. Хоффманн-Ля Рош Аг (Ch) Сульфанил-замещенные фенилметаноны в качестве ингибиторов переносчика глицина 1 (glyt-1) для лечения неврологических и психоневрологических заболеваний
BRPI0519794A2 (pt) * 2005-01-07 2009-03-17 Hoffmann La Roche derivados de [4-(heteroaril)piperazin-1-il]-(fenil 2,5-substituìdo)metanona como inibidores de transportador de glicina 1 (glyt-1) para o tratamento de distúrbios neurológicos e neuropsiquiátricos
BRPI0607311A2 (pt) * 2005-02-07 2009-08-25 Hoffmann La Roche fenil metanonas substituìdas com heterociclila como inibidores do transportador de glicina 1
MX2008015932A (es) * 2006-06-22 2009-01-13 Hoffmann La Roche Derivados de fenil-metanona sustituida.
PT2041088E (pt) 2006-06-28 2014-03-26 Amgen Inc Inibidores do transportador-1 da glicina
CL2007003827A1 (es) * 2006-12-28 2008-09-26 Actelion Pharmaceuticals Ltd Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras.
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
JP2012514006A (ja) * 2008-12-29 2012-06-21 バンダービルト ユニバーシティ 3.1.0二環式GlyT1阻害剤ならびにその作製および使用の方法
PE20120500A1 (es) 2009-01-27 2012-05-04 Hoffmann La Roche Piperidinas sustituidas con heteroilamino y aroilamino como inhibidores de glyt-1

Also Published As

Publication number Publication date
EP2739615B1 (en) 2017-03-15
PH12014500276A1 (en) 2017-02-01
CA2843805C (en) 2021-03-23
UY34239A (es) 2013-02-28
CN105837562A (zh) 2016-08-10
PL2739615T3 (pl) 2017-08-31
BR112014001642A2 (pt) 2017-02-14
CL2014000246A1 (es) 2014-08-08
AU2012292036A1 (en) 2014-01-16
ME02672B (me) 2017-06-20
US9012489B2 (en) 2015-04-21
HRP20170695T1 (hr) 2017-07-28
WO2013017657A1 (en) 2013-02-07
RS55927B1 (sr) 2017-09-29
ES2623006T3 (es) 2017-07-10
AR087436A1 (es) 2014-03-26
LT2739615T (lt) 2017-04-10
MY167396A (en) 2018-08-16
CO6870037A2 (es) 2014-02-20
PE20141352A1 (es) 2014-10-12
CN105837562B (zh) 2020-01-17
TW201321364A (zh) 2013-06-01
GEP20166483B (en) 2016-05-25
KR20140051922A (ko) 2014-05-02
DK2739615T3 (en) 2017-05-08
IL229962A (en) 2016-09-29
HK1193100A1 (zh) 2014-09-12
KR101944686B1 (ko) 2019-02-01
HUE033134T2 (en) 2017-11-28
ECSP14013221A (es) 2014-03-31
CA2843805A1 (en) 2013-02-07
AP2014007399A0 (en) 2014-01-31
BR112014001642B1 (pt) 2022-03-22
CN103797005A (zh) 2014-05-14
EP2739615A1 (en) 2014-06-11
TWI543974B (zh) 2016-08-01
MA35286B1 (fr) 2014-07-03
NZ619258A (en) 2015-12-24
US20130197011A1 (en) 2013-08-01
JP5850589B2 (ja) 2016-02-03
JP2014524414A (ja) 2014-09-22
UA114405C2 (uk) 2017-06-12
AU2012292036B2 (en) 2016-10-06
EA201400183A1 (ru) 2014-06-30
MX347828B (es) 2017-05-15
MX2014001252A (es) 2014-05-13
EA024933B1 (ru) 2016-11-30
TN2014000044A1 (en) 2015-07-01
SI2739615T1 (sl) 2017-07-31
CN103797005B (zh) 2016-05-11
AU2012292036C1 (en) 2017-03-23
CY1119326T1 (el) 2018-02-14

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