LT2739615T - Fenil-3-aza-biciklo[3.1.0]heks-3-il-metanonai ir jų panaudojimas kaip vaisto - Google Patents
Fenil-3-aza-biciklo[3.1.0]heks-3-il-metanonai ir jų panaudojimas kaip vaistoInfo
- Publication number
- LT2739615T LT2739615T LTEP12741022.3T LT12741022T LT2739615T LT 2739615 T LT2739615 T LT 2739615T LT 12741022 T LT12741022 T LT 12741022T LT 2739615 T LT2739615 T LT 2739615T
- Authority
- LT
- Lithuania
- Prior art keywords
- methanones
- aza
- bicyclo
- hex
- medicament
- Prior art date
Links
- PZWNQSJXMXNUAT-UHFFFAOYSA-N 3-azabicyclo[3.1.0]hexan-3-yl(phenyl)methanone Chemical class C1C2CC2CN1C(=O)C1=CC=CC=C1 PZWNQSJXMXNUAT-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11176468 | 2011-08-03 | ||
| PCT/EP2012/065140 WO2013017657A1 (en) | 2011-08-03 | 2012-08-02 | Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2739615T true LT2739615T (lt) | 2017-04-10 |
Family
ID=46598566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP12741022.3T LT2739615T (lt) | 2011-08-03 | 2012-08-02 | Fenil-3-aza-biciklo[3.1.0]heks-3-il-metanonai ir jų panaudojimas kaip vaisto |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US9012489B2 (lt) |
| EP (1) | EP2739615B1 (lt) |
| JP (1) | JP5850589B2 (lt) |
| KR (1) | KR101944686B1 (lt) |
| CN (2) | CN103797005B (lt) |
| AP (1) | AP2014007399A0 (lt) |
| AR (1) | AR087436A1 (lt) |
| AU (1) | AU2012292036C1 (lt) |
| BR (1) | BR112014001642B1 (lt) |
| CA (1) | CA2843805C (lt) |
| CL (1) | CL2014000246A1 (lt) |
| CO (1) | CO6870037A2 (lt) |
| CY (1) | CY1119326T1 (lt) |
| DK (1) | DK2739615T3 (lt) |
| EA (1) | EA024933B1 (lt) |
| EC (1) | ECSP14013221A (lt) |
| ES (1) | ES2623006T3 (lt) |
| GE (1) | GEP20166483B (lt) |
| HK (1) | HK1193100A1 (lt) |
| HR (1) | HRP20170695T1 (lt) |
| HU (1) | HUE033134T2 (lt) |
| IL (1) | IL229962A (lt) |
| LT (1) | LT2739615T (lt) |
| MA (1) | MA35286B1 (lt) |
| ME (1) | ME02672B (lt) |
| MX (1) | MX347828B (lt) |
| MY (1) | MY167396A (lt) |
| PE (1) | PE20141352A1 (lt) |
| PH (1) | PH12014500276A1 (lt) |
| PL (1) | PL2739615T3 (lt) |
| PT (1) | PT2739615T (lt) |
| RS (1) | RS55927B1 (lt) |
| SI (1) | SI2739615T1 (lt) |
| TN (1) | TN2014000044A1 (lt) |
| TW (1) | TWI543974B (lt) |
| UA (1) | UA114405C2 (lt) |
| UY (1) | UY34239A (lt) |
| WO (1) | WO2013017657A1 (lt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2950084C (en) | 2014-06-06 | 2022-04-19 | Basf Se | Use of substituted oxadiazoles for combating phytopathogenic fungi |
| BR112018009539B1 (pt) | 2015-11-13 | 2022-05-24 | Basf Se | Uso de compostos da fórmula i, compostos, mistura, composição agroquímica, uso dos compostos e método para combater fungos nocivos fitopatogênicos |
| AR106679A1 (es) | 2015-11-13 | 2018-02-07 | Basf Se | Oxadiazoles sustituidos para combatir hongos fitopatógenos |
| KR20180083419A (ko) | 2015-11-19 | 2018-07-20 | 바스프 에스이 | 식물병원성 진균을 퇴치하기 위한 치환 옥사디아졸 |
| WO2017178245A1 (en) | 2016-04-11 | 2017-10-19 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| WO2018224455A1 (en) | 2017-06-07 | 2018-12-13 | Basf Se | Substituted cyclopropyl derivatives |
| CR20210545A (es) * | 2019-05-01 | 2021-12-23 | Boehringer Ingelheim Int | Formas sólidas de un inhibidor de glyt1 |
| CN116212025A (zh) | 2020-01-09 | 2023-06-06 | 迪斯克医药公司 | 治疗红细胞生成性原卟啉病、x连锁原卟啉病或先天性红细胞生成性卟啉病的方法 |
| KR20230051247A (ko) | 2020-08-13 | 2023-04-17 | 베링거 인겔하임 인터내셔날 게엠베하 | 정신분열병과 연관된 인지 손상의 치료 |
| CN117567449A (zh) | 2020-10-13 | 2024-02-20 | 勃林格殷格翰国际有限公司 | 再加工方法 |
| EP4436564A1 (en) * | 2021-11-24 | 2024-10-02 | MapLight Therapeutics, Inc. | Methods of treating neurological disorders |
| CN114957087A (zh) * | 2022-04-13 | 2022-08-30 | 湖南复瑞生物医药技术有限责任公司 | 一种帕罗韦德中间体制备方法 |
| WO2023237103A1 (zh) * | 2022-06-10 | 2023-12-14 | 成都百裕制药股份有限公司 | 吡咯烷衍生物、药物组合物及其在医药上的应用 |
| WO2024042043A1 (en) | 2022-08-24 | 2024-02-29 | Boehringer Ingelheim International Gmbh | A scalable process for the preparation of a glyt-1 inhibitor |
| WO2024243600A2 (en) * | 2023-05-25 | 2024-11-28 | Maplight Therapeutics, Inc. | Compositions for treating neurological disorders |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006514978A (ja) | 2003-04-10 | 2006-05-18 | ランバクシー ラボラトリーズ リミテッド | ムスカリン受容体アンタゴニストである置換アザビシクロヘキサン誘導体 |
| JP4732354B2 (ja) * | 2003-10-14 | 2011-07-27 | ファイザー・プロダクツ・インク | グリシン輸送阻害薬としての二環式［３．１．０］誘導体 |
| DE102004035280A1 (de) | 2004-07-21 | 2006-03-16 | Robert Bosch Gmbh | Kraftstoffinjektor mit direkter mehrstufiger Einspritzventilgliedansteuerung |
| RU2007125380A (ru) * | 2005-01-06 | 2009-02-20 | Ф. Хоффманн-Ля Рош Аг (Ch) | Сульфанил-замещенные фенилметаноны в качестве ингибиторов переносчика глицина 1 (glyt-1) для лечения неврологических и психоневрологических заболеваний |
| BRPI0519794A2 (pt) * | 2005-01-07 | 2009-03-17 | Hoffmann La Roche | derivados de [4-(heteroaril)piperazin-1-il]-(fenil 2,5-substituìdo)metanona como inibidores de transportador de glicina 1 (glyt-1) para o tratamento de distúrbios neurológicos e neuropsiquiátricos |
| BRPI0607311A2 (pt) * | 2005-02-07 | 2009-08-25 | Hoffmann La Roche | fenil metanonas substituìdas com heterociclila como inibidores do transportador de glicina 1 |
| MX2008015932A (es) * | 2006-06-22 | 2009-01-13 | Hoffmann La Roche | Derivados de fenil-metanona sustituida. |
| PT2041088E (pt) | 2006-06-28 | 2014-03-26 | Amgen Inc | Inibidores do transportador-1 da glicina |
| CL2007003827A1 (es) * | 2006-12-28 | 2008-09-26 | Actelion Pharmaceuticals Ltd | Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras. |
| UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| JP2012514006A (ja) * | 2008-12-29 | 2012-06-21 | バンダービルト ユニバーシティ | ３．１．０二環式ＧｌｙＴ１阻害剤ならびにその作製および使用の方法 |
| PE20120500A1 (es) | 2009-01-27 | 2012-05-04 | Hoffmann La Roche | Piperidinas sustituidas con heteroilamino y aroilamino como inhibidores de glyt-1 |
-
2012
- 2012-07-27 US US13/560,063 patent/US9012489B2/en active Active
- 2012-08-01 TW TW101127831A patent/TWI543974B/zh active
- 2012-08-02 RS RS20170472A patent/RS55927B1/sr unknown
- 2012-08-02 CA CA2843805A patent/CA2843805C/en active Active
- 2012-08-02 CN CN201280042794.7A patent/CN103797005B/zh active Active
- 2012-08-02 PE PE2014000158A patent/PE20141352A1/es active IP Right Grant
- 2012-08-02 CN CN201610214305.1A patent/CN105837562B/zh active Active
- 2012-08-02 SI SI201230968A patent/SI2739615T1/sl unknown
- 2012-08-02 PT PT127410223T patent/PT2739615T/pt unknown
- 2012-08-02 HU HUE12741022A patent/HUE033134T2/en unknown
- 2012-08-02 MX MX2014001252A patent/MX347828B/es active IP Right Grant
- 2012-08-02 MY MYPI2014000271A patent/MY167396A/en unknown
- 2012-08-02 DK DK12741022.3T patent/DK2739615T3/en active
- 2012-08-02 JP JP2014523332A patent/JP5850589B2/ja active Active
- 2012-08-02 UA UAA201402017A patent/UA114405C2/uk unknown
- 2012-08-02 LT LTEP12741022.3T patent/LT2739615T/lt unknown
- 2012-08-02 PL PL12741022T patent/PL2739615T3/pl unknown
- 2012-08-02 KR KR1020147002515A patent/KR101944686B1/ko active IP Right Grant
- 2012-08-02 ES ES12741022.3T patent/ES2623006T3/es active Active
- 2012-08-02 ME MEP-2017-92A patent/ME02672B/me unknown
- 2012-08-02 EP EP12741022.3A patent/EP2739615B1/en active Active
- 2012-08-02 BR BR112014001642-9A patent/BR112014001642B1/pt active IP Right Grant
- 2012-08-02 AP AP2014007399A patent/AP2014007399A0/xx unknown
- 2012-08-02 EA EA201400183A patent/EA024933B1/ru not_active IP Right Cessation
- 2012-08-02 GE GEAP201213402A patent/GEP20166483B/en unknown
- 2012-08-02 AU AU2012292036A patent/AU2012292036C1/en active Active
- 2012-08-02 AR ARP120102828 patent/AR087436A1/es active IP Right Grant
- 2012-08-02 PH PH1/2014/500276A patent/PH12014500276A1/en unknown
- 2012-08-02 WO PCT/EP2012/065140 patent/WO2013017657A1/en active Application Filing
- 2012-08-03 UY UY34239A patent/UY34239A/es unknown
-
2013
- 2013-12-17 IL IL229962A patent/IL229962A/en active IP Right Grant
-
2014
- 2014-01-31 CL CL2014000246A patent/CL2014000246A1/es unknown
- 2014-01-31 MA MA36719A patent/MA35286B1/fr unknown
- 2014-01-31 TN TNP2014000044A patent/TN2014000044A1/en unknown
- 2014-02-03 CO CO14022058A patent/CO6870037A2/es active IP Right Grant
- 2014-02-26 EC ECSP14013221 patent/ECSP14013221A/es unknown
- 2014-07-02 HK HK14106631.6A patent/HK1193100A1/zh unknown
-
2017
- 2017-05-10 HR HRP20170695TT patent/HRP20170695T1/hr unknown
- 2017-06-06 CY CY20171100591T patent/CY1119326T1/el unknown
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