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PT2231689T - Novos nucleósidos 7-deazapurina citostáticos - Google Patents

Novos nucleósidos 7-deazapurina citostáticos

Info

Publication number
PT2231689T
PT2231689T PT97028427T PT09702842T PT2231689T PT 2231689 T PT2231689 T PT 2231689T PT 97028427 T PT97028427 T PT 97028427T PT 09702842 T PT09702842 T PT 09702842T PT 2231689 T PT2231689 T PT 2231689T
Authority
PT
Portugal
Prior art keywords
deazapurine nucleosides
novel cytostatic
cytostatic
novel
deazapurine
Prior art date
Application number
PT97028427T
Other languages
English (en)
Inventor
Hocek Michal
Naus Petr
Original Assignee
Inst Of Organic Chemistry And Biochemistry Of The Acad Of Sciences Of The Czech Republic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Of Organic Chemistry And Biochemistry Of The Acad Of Sciences Of The Czech Republic filed Critical Inst Of Organic Chemistry And Biochemistry Of The Acad Of Sciences Of The Czech Republic
Publication of PT2231689T publication Critical patent/PT2231689T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14Pyrrolo-pyrimidine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • HELECTRICITY
    • H02GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02JCIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
    • H02J7/00032Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries characterised by data exchange
    • H02J7/00036Charger exchanging data with battery
    • HELECTRICITY
    • H02GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02JCIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
    • H02J7/00047Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries with provisions for charging different types of batteries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Power Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PT97028427T 2008-01-18 2009-01-15 Novos nucleósidos 7-deazapurina citostáticos PT2231689T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2224708P 2008-01-18 2008-01-18

Publications (1)

Publication Number Publication Date
PT2231689T true PT2231689T (pt) 2016-10-07

Family

ID=40434932

Family Applications (2)

Application Number Title Priority Date Filing Date
PT16174985T PT3133080T (pt) 2008-01-18 2009-01-15 Nucleósidos de 7-deazapurina citostáticos inovadores
PT97028427T PT2231689T (pt) 2008-01-18 2009-01-15 Novos nucleósidos 7-deazapurina citostáticos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT16174985T PT3133080T (pt) 2008-01-18 2009-01-15 Nucleósidos de 7-deazapurina citostáticos inovadores

Country Status (18)

Country Link
US (1) US8093226B2 (pt)
EP (2) EP2231689B1 (pt)
JP (2) JP5485172B2 (pt)
CN (1) CN101977923B (pt)
AU (1) AU2009204568B2 (pt)
CA (1) CA2711384C (pt)
CY (2) CY1118104T1 (pt)
DK (2) DK3133080T3 (pt)
ES (2) ES2693551T3 (pt)
HR (2) HRP20161344T1 (pt)
HU (2) HUE041598T2 (pt)
LT (2) LT2231689T (pt)
NZ (1) NZ586610A (pt)
PL (2) PL2231689T3 (pt)
PT (2) PT3133080T (pt)
SI (2) SI3133080T1 (pt)
TR (1) TR201815961T4 (pt)
WO (1) WO2009089804A1 (pt)

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EP4011883A1 (en) 2007-06-13 2022-06-15 Incyte Holdings Corporation Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3-cyclopentylpropanenitrile
CL2009001884A1 (es) * 2008-10-02 2010-05-14 Incyte Holdings Corp Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
DK2421879T3 (da) * 2009-04-22 2013-11-25 Acad Of Science Czech Republic Nye 7-deazapurinnukleotider til terapeutiske anvendelser
WO2010135650A1 (en) 2009-05-22 2010-11-25 Incyte Corporation N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS
SI2432472T1 (sl) 2009-05-22 2019-11-29 Incyte Holdings Corp 3-(4-(7H-pirolo(2,3-d)pirimidin-4-il)-1H-pirazol-1-il)oktan- ali heptan-nitril kot inhibitorji JAK
TW201113285A (en) 2009-09-01 2011-04-16 Incyte Corp Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
NZ602313A (en) 2010-03-10 2014-08-29 Incyte Corp Piperidin-4-yl azetidine derivatives as jak1 inhibitors
MY161078A (en) 2010-05-21 2017-04-14 Incyte Holdings Corp Topical formulation for a jak inhibitor
AU2011330730B2 (en) * 2010-11-18 2016-02-18 Kasina Laila Innova Pharmaceuticals Private Limited Substituted 4-(selenophen-2(or 3)-ylamino)pyrimidine compounds and methods of use thereof
JP5917545B2 (ja) 2010-11-19 2016-05-18 インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation Jak阻害剤としてのシクロブチル置換ピロロピリジンおよびピロロピリミジン誘導体
US9034884B2 (en) 2010-11-19 2015-05-19 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors
CN103797010B (zh) 2011-06-20 2016-02-24 因塞特控股公司 作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為jak抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
TW201406761A (zh) 2012-05-18 2014-02-16 Incyte Corp 做爲jak抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
US10166191B2 (en) 2012-11-15 2019-01-01 Incyte Corporation Sustained-release dosage forms of ruxolitinib
UA121532C2 (uk) 2013-03-06 2020-06-10 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки при отриманні інгібітора jak
CN116036089A (zh) 2013-08-07 2023-05-02 因赛特控股公司 Jak1抑制剂的持续释放剂型
WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
JP6650074B2 (ja) 2016-06-29 2020-02-19 ウスタフ オルガニッケ ヘミエ アー ビオヘミエ アカデミエ ヴェド ツェーエル,ヴェー.ヴェー.イー 治療に使用するための、置換チエノピロロピリミジンリボヌクレオシド
CZ307334B6 (cs) 2016-08-02 2018-06-13 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Substituované heteropentadieno-pyrrolopyrimidinové ribonukleosidy pro terapeutické použití
WO2019113487A1 (en) 2017-12-08 2019-06-13 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms
CR20200379A (es) 2018-01-30 2021-03-05 Incyte Corp Procesos e intermedio para elaborar un inhibidor de jak campo técnico
CZ308104B6 (cs) 2018-03-12 2020-01-08 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v. v. i. Pyridinopyrrolopyrimidinové ribonukleosidy pro terapeutické použití
AU2019245420B2 (en) 2018-03-30 2024-10-10 Incyte Corporation Treatment of hidradenitis suppurativa using JAK inhibitors
EP3952874A4 (en) * 2019-04-05 2022-12-28 Prelude Therapeutics, Incorporated SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5
PH12021553139A1 (en) * 2019-06-18 2022-07-25 Taiho Pharmaceutical Co Ltd Novel carbonate compound having pyrrolopyrimidine skeleton or pharmaceutically acceptable salt thereof
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
CN112190590A (zh) * 2020-11-06 2021-01-08 牡丹江医学院 一种治疗动脉粥样硬化的硒核苷及其药物组合物

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IL108523A0 (en) 1993-02-03 1994-05-30 Gensia Inc Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain
JPH10158293A (ja) * 1996-08-08 1998-06-16 Rikagaku Kenkyusho 3’−デオキシリボヌクレオチド誘導体
JP3489991B2 (ja) * 1997-07-07 2004-01-26 理化学研究所 3’−デオキシリボヌクレオチド誘導体
JP3318579B2 (ja) * 1997-07-07 2002-08-26 理化学研究所 Dnaの塩基配列決定方法
CZ9901996A3 (cs) * 1999-06-04 2001-01-17 Ústav organické chemie a biochemie AV ČR Nové 6-fenylpurinové 9-ß-D-ribonukleosidy s antineoplastickým účinkem, jejich použití k přípravě farmaceutických preparátů a farmaceutické přípravky, které je obsahují
AU2002353165A1 (en) * 2001-12-17 2003-06-30 Ribapharm Inc. Deazapurine nucleoside libraries and compounds
CN1863813B (zh) * 2003-08-27 2011-03-30 生物区科学管理控股有限公司 作为治疗剂的三环核苷或核苷酸
JP2008517912A (ja) * 2004-10-21 2008-05-29 メルク エンド カムパニー インコーポレーテッド RNA依存性RNAウイルス感染治療用フッ素化ピロロ[2,3−d]ピリミジンヌクレオシド
CN101043893A (zh) * 2004-10-21 2007-09-26 默克公司 治疗RNA-依赖性RNA病毒感染的氟化吡咯并[2,3-d]嘧啶核苷
AR056327A1 (es) * 2005-04-25 2007-10-03 Genelabs Tech Inc Compuestos de nucleosidos para el tratamiento de infecciones virales

Also Published As

Publication number Publication date
HRP20161344T1 (hr) 2016-11-18
HUE030767T2 (en) 2017-05-29
CA2711384C (en) 2016-07-26
EP3133080A1 (en) 2017-02-22
ES2693551T3 (es) 2018-12-12
EP2231689B1 (en) 2016-07-20
AU2009204568B2 (en) 2013-10-03
PL3133080T3 (pl) 2018-12-31
JP2011509949A (ja) 2011-03-31
JP2014058567A (ja) 2014-04-03
NZ586610A (en) 2012-08-31
DK2231689T3 (en) 2016-09-19
EP2231689A1 (en) 2010-09-29
EP3133080B1 (en) 2018-08-01
ES2598503T3 (es) 2017-01-27
SI2231689T1 (sl) 2016-11-30
CA2711384A1 (en) 2009-07-23
DK3133080T3 (en) 2018-11-26
HRP20181774T1 (hr) 2018-12-28
CN101977923B (zh) 2014-10-08
HUE041598T2 (hu) 2019-05-28
US8093226B2 (en) 2012-01-10
AU2009204568A1 (en) 2009-07-23
CN101977923A (zh) 2011-02-16
LT2231689T (lt) 2016-10-25
PT3133080T (pt) 2018-11-16
WO2009089804A1 (en) 2009-07-23
TR201815961T4 (tr) 2018-11-21
SI3133080T1 (sl) 2018-12-31
CY1121364T1 (el) 2020-05-29
CY1118104T1 (el) 2017-06-28
PL2231689T3 (pl) 2017-01-31
US20090203637A1 (en) 2009-08-13
JP5485172B2 (ja) 2014-05-07
LT3133080T (lt) 2018-11-12

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