PT2231689T - Novos nucleósidos 7-deazapurina citostáticos - Google Patents
Novos nucleósidos 7-deazapurina citostáticosInfo
- Publication number
- PT2231689T PT2231689T PT97028427T PT09702842T PT2231689T PT 2231689 T PT2231689 T PT 2231689T PT 97028427 T PT97028427 T PT 97028427T PT 09702842 T PT09702842 T PT 09702842T PT 2231689 T PT2231689 T PT 2231689T
- Authority
- PT
- Portugal
- Prior art keywords
- deazapurine nucleosides
- novel cytostatic
- cytostatic
- novel
- deazapurine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
- H02J7/00—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
- H02J7/00032—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries characterised by data exchange
- H02J7/00036—Charger exchanging data with battery
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
- H02J7/00—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
- H02J7/00047—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries with provisions for charging different types of batteries
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Power Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2224708P | 2008-01-18 | 2008-01-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2231689T true PT2231689T (pt) | 2016-10-07 |
Family
ID=40434932
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT16174985T PT3133080T (pt) | 2008-01-18 | 2009-01-15 | Nucleósidos de 7-deazapurina citostáticos inovadores |
PT97028427T PT2231689T (pt) | 2008-01-18 | 2009-01-15 | Novos nucleósidos 7-deazapurina citostáticos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT16174985T PT3133080T (pt) | 2008-01-18 | 2009-01-15 | Nucleósidos de 7-deazapurina citostáticos inovadores |
Country Status (18)
Country | Link |
---|---|
US (1) | US8093226B2 (pt) |
EP (2) | EP2231689B1 (pt) |
JP (2) | JP5485172B2 (pt) |
CN (1) | CN101977923B (pt) |
AU (1) | AU2009204568B2 (pt) |
CA (1) | CA2711384C (pt) |
CY (2) | CY1118104T1 (pt) |
DK (2) | DK3133080T3 (pt) |
ES (2) | ES2693551T3 (pt) |
HR (2) | HRP20161344T1 (pt) |
HU (2) | HUE041598T2 (pt) |
LT (2) | LT2231689T (pt) |
NZ (1) | NZ586610A (pt) |
PL (2) | PL2231689T3 (pt) |
PT (2) | PT3133080T (pt) |
SI (2) | SI3133080T1 (pt) |
TR (1) | TR201815961T4 (pt) |
WO (1) | WO2009089804A1 (pt) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2543904T3 (es) | 2005-12-13 | 2015-08-25 | Incyte Corporation | Pirrolo[2,3-b]piridinas y pirrolo[2,3-b]pirimidinas sustituidas con heteroarilo como inhibidores de quinasas Janus |
EP4011883A1 (en) | 2007-06-13 | 2022-06-15 | Incyte Holdings Corporation | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3-cyclopentylpropanenitrile |
CL2009001884A1 (es) * | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco. |
DK2421879T3 (da) * | 2009-04-22 | 2013-11-25 | Acad Of Science Czech Republic | Nye 7-deazapurinnukleotider til terapeutiske anvendelser |
WO2010135650A1 (en) | 2009-05-22 | 2010-11-25 | Incyte Corporation | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS |
SI2432472T1 (sl) | 2009-05-22 | 2019-11-29 | Incyte Holdings Corp | 3-(4-(7H-pirolo(2,3-d)pirimidin-4-il)-1H-pirazol-1-il)oktan- ali heptan-nitril kot inhibitorji JAK |
TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
NZ602313A (en) | 2010-03-10 | 2014-08-29 | Incyte Corp | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
MY161078A (en) | 2010-05-21 | 2017-04-14 | Incyte Holdings Corp | Topical formulation for a jak inhibitor |
AU2011330730B2 (en) * | 2010-11-18 | 2016-02-18 | Kasina Laila Innova Pharmaceuticals Private Limited | Substituted 4-(selenophen-2(or 3)-ylamino)pyrimidine compounds and methods of use thereof |
JP5917545B2 (ja) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Jak阻害剤としてのシクロブチル置換ピロロピリジンおよびピロロピリミジン誘導体 |
US9034884B2 (en) | 2010-11-19 | 2015-05-19 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors |
CN103797010B (zh) | 2011-06-20 | 2016-02-24 | 因塞特控股公司 | 作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物 |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
TW201406761A (zh) | 2012-05-18 | 2014-02-16 | Incyte Corp | 做爲jak抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物 |
US10166191B2 (en) | 2012-11-15 | 2019-01-01 | Incyte Corporation | Sustained-release dosage forms of ruxolitinib |
UA121532C2 (uk) | 2013-03-06 | 2020-06-10 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки при отриманні інгібітора jak |
CN116036089A (zh) | 2013-08-07 | 2023-05-02 | 因赛特控股公司 | Jak1抑制剂的持续释放剂型 |
WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
JP6650074B2 (ja) | 2016-06-29 | 2020-02-19 | ウスタフ オルガニッケ ヘミエ アー ビオヘミエ アカデミエ ヴェド ツェーエル,ヴェー.ヴェー.イー | 治療に使用するための、置換チエノピロロピリミジンリボヌクレオシド |
CZ307334B6 (cs) | 2016-08-02 | 2018-06-13 | Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. | Substituované heteropentadieno-pyrrolopyrimidinové ribonukleosidy pro terapeutické použití |
WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
CR20200379A (es) | 2018-01-30 | 2021-03-05 | Incyte Corp | Procesos e intermedio para elaborar un inhibidor de jak campo técnico |
CZ308104B6 (cs) | 2018-03-12 | 2020-01-08 | Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v. v. i. | Pyridinopyrrolopyrimidinové ribonukleosidy pro terapeutické použití |
AU2019245420B2 (en) | 2018-03-30 | 2024-10-10 | Incyte Corporation | Treatment of hidradenitis suppurativa using JAK inhibitors |
EP3952874A4 (en) * | 2019-04-05 | 2022-12-28 | Prelude Therapeutics, Incorporated | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 |
PH12021553139A1 (en) * | 2019-06-18 | 2022-07-25 | Taiho Pharmaceutical Co Ltd | Novel carbonate compound having pyrrolopyrimidine skeleton or pharmaceutically acceptable salt thereof |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
CN112190590A (zh) * | 2020-11-06 | 2021-01-08 | 牡丹江医学院 | 一种治疗动脉粥样硬化的硒核苷及其药物组合物 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50125033A (pt) * | 1974-03-19 | 1975-10-01 | ||
IL108523A0 (en) | 1993-02-03 | 1994-05-30 | Gensia Inc | Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain |
JPH10158293A (ja) * | 1996-08-08 | 1998-06-16 | Rikagaku Kenkyusho | 3’−デオキシリボヌクレオチド誘導体 |
JP3489991B2 (ja) * | 1997-07-07 | 2004-01-26 | 理化学研究所 | 3’−デオキシリボヌクレオチド誘導体 |
JP3318579B2 (ja) * | 1997-07-07 | 2002-08-26 | 理化学研究所 | Dnaの塩基配列決定方法 |
CZ9901996A3 (cs) * | 1999-06-04 | 2001-01-17 | Ústav organické chemie a biochemie AV ČR | Nové 6-fenylpurinové 9-ß-D-ribonukleosidy s antineoplastickým účinkem, jejich použití k přípravě farmaceutických preparátů a farmaceutické přípravky, které je obsahují |
AU2002353165A1 (en) * | 2001-12-17 | 2003-06-30 | Ribapharm Inc. | Deazapurine nucleoside libraries and compounds |
CN1863813B (zh) * | 2003-08-27 | 2011-03-30 | 生物区科学管理控股有限公司 | 作为治疗剂的三环核苷或核苷酸 |
JP2008517912A (ja) * | 2004-10-21 | 2008-05-29 | メルク エンド カムパニー インコーポレーテッド | RNA依存性RNAウイルス感染治療用フッ素化ピロロ[2,3−d]ピリミジンヌクレオシド |
CN101043893A (zh) * | 2004-10-21 | 2007-09-26 | 默克公司 | 治疗RNA-依赖性RNA病毒感染的氟化吡咯并[2,3-d]嘧啶核苷 |
AR056327A1 (es) * | 2005-04-25 | 2007-10-03 | Genelabs Tech Inc | Compuestos de nucleosidos para el tratamiento de infecciones virales |
-
2009
- 2009-01-15 SI SI200931882T patent/SI3133080T1/sl unknown
- 2009-01-15 DK DK16174985.8T patent/DK3133080T3/en active
- 2009-01-15 HU HUE16174985A patent/HUE041598T2/hu unknown
- 2009-01-15 US US12/354,432 patent/US8093226B2/en active Active
- 2009-01-15 NZ NZ586610A patent/NZ586610A/xx unknown
- 2009-01-15 PT PT16174985T patent/PT3133080T/pt unknown
- 2009-01-15 EP EP09702842.7A patent/EP2231689B1/en active Active
- 2009-01-15 ES ES16174985.8T patent/ES2693551T3/es active Active
- 2009-01-15 TR TR2018/15961T patent/TR201815961T4/tr unknown
- 2009-01-15 JP JP2010542509A patent/JP5485172B2/ja active Active
- 2009-01-15 EP EP16174985.8A patent/EP3133080B1/en active Active
- 2009-01-15 AU AU2009204568A patent/AU2009204568B2/en active Active
- 2009-01-15 PT PT97028427T patent/PT2231689T/pt unknown
- 2009-01-15 LT LTEP09702842.7T patent/LT2231689T/lt unknown
- 2009-01-15 HU HUE09702842A patent/HUE030767T2/en unknown
- 2009-01-15 PL PL09702842T patent/PL2231689T3/pl unknown
- 2009-01-15 DK DK09702842.7T patent/DK2231689T3/en active
- 2009-01-15 ES ES09702842.7T patent/ES2598503T3/es active Active
- 2009-01-15 PL PL16174985T patent/PL3133080T3/pl unknown
- 2009-01-15 LT LTEP16174985.8T patent/LT3133080T/lt unknown
- 2009-01-15 CA CA2711384A patent/CA2711384C/en active Active
- 2009-01-15 SI SI200931535A patent/SI2231689T1/sl unknown
- 2009-01-15 CN CN200980109880.3A patent/CN101977923B/zh active Active
- 2009-01-15 WO PCT/CZ2009/000004 patent/WO2009089804A1/en active Application Filing
-
2013
- 2013-12-25 JP JP2013266910A patent/JP2014058567A/ja not_active Withdrawn
-
2016
- 2016-10-14 HR HRP20161344TT patent/HRP20161344T1/hr unknown
- 2016-10-19 CY CY20161101041T patent/CY1118104T1/el unknown
-
2018
- 2018-10-29 HR HRP20181774TT patent/HRP20181774T1/hr unknown
- 2018-10-30 CY CY20181101120T patent/CY1121364T1/el unknown
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