PT1948816E - Processos melhorados de focalização - Google Patents
Processos melhorados de focalização Download PDFInfo
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- PT1948816E PT1948816E PT06817236T PT06817236T PT1948816E PT 1948816 E PT1948816 E PT 1948816E PT 06817236 T PT06817236 T PT 06817236T PT 06817236 T PT06817236 T PT 06817236T PT 1948816 E PT1948816 E PT 1948816E
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- dna
- amplicons
- beads
- homo sapiens
- pcr
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
- G01R31/327—Testing of circuit interrupters, switches or circuit-breakers
- G01R31/3277—Testing of circuit interrupters, switches or circuit-breakers of low voltage devices, e.g. domestic or industrial devices, such as motor protections, relays, rotation switches
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
- G01R31/50—Testing of electric apparatus, lines, cables or components for short-circuits, continuity, leakage current or incorrect line connections
- G01R31/52—Testing for short-circuits, leakage current or ground faults
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02H—EMERGENCY PROTECTIVE CIRCUIT ARRANGEMENTS
- H02H1/00—Details of emergency protective circuit arrangements
- H02H1/0007—Details of emergency protective circuit arrangements concerning the detecting means
- H02H1/0015—Using arc detectors
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02H—EMERGENCY PROTECTIVE CIRCUIT ARRANGEMENTS
- H02H3/00—Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition with or without subsequent reconnection ; integrated protection
- H02H3/26—Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition with or without subsequent reconnection ; integrated protection responsive to difference between voltages or between currents; responsive to phase angle between voltages or between currents
- H02H3/32—Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition with or without subsequent reconnection ; integrated protection responsive to difference between voltages or between currents; responsive to phase angle between voltages or between currents involving comparison of the voltage or current values at corresponding points in different conductors of a single system, e.g. of currents in go and return conductors
- H02H3/33—Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition with or without subsequent reconnection ; integrated protection responsive to difference between voltages or between currents; responsive to phase angle between voltages or between currents involving comparison of the voltage or current values at corresponding points in different conductors of a single system, e.g. of currents in go and return conductors using summation current transformers
Landscapes
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- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nanotechnology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
EP1712639B1 (de) | 2005-04-06 | 2008-08-27 | Maurice Stroun | Methode zur Krebsdiagnose mittels Nachweis von DNA und RNA im Kreislauf |
ATE536420T1 (de) * | 2005-10-24 | 2011-12-15 | Univ Johns Hopkins | Verbesserte verfahren für beaming |
EP3913375A1 (de) | 2006-01-11 | 2021-11-24 | Bio-Rad Laboratories, Inc. | Mikrofluidische vorrichtungen und verfahren zur verwendung bei der bildung und steuerung von nanoreaktoren |
EP2530167A1 (de) | 2006-05-11 | 2012-12-05 | Raindance Technologies, Inc. | Mikrofluidische Vorrichtungen |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
GB2453173A (en) * | 2007-09-28 | 2009-04-01 | Dxs Ltd | Polynucleotide primers |
EP2315629B1 (de) | 2008-07-18 | 2021-12-15 | Bio-Rad Laboratories, Inc. | Tröpfchenbibliotheken |
US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
US20100041048A1 (en) | 2008-07-31 | 2010-02-18 | The Johns Hopkins University | Circulating Mutant DNA to Assess Tumor Dynamics |
US8583380B2 (en) | 2008-09-05 | 2013-11-12 | Aueon, Inc. | Methods for stratifying and annotating cancer drug treatment options |
EP4484577A3 (de) | 2010-02-12 | 2025-03-26 | Bio-Rad Laboratories, Inc. | Digitale analytanalyse |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
CA2810931C (en) | 2010-09-24 | 2018-04-17 | The Board Of Trustees Of The Leland Stanford Junior University | Direct capture, amplification and sequencing of target dna using immobilized primers |
EP3859011A1 (de) | 2011-02-11 | 2021-08-04 | Bio-Rad Laboratories, Inc. | Verfahren zur bildung gemischter tröpfchen |
EP3736281A1 (de) | 2011-02-18 | 2020-11-11 | Bio-Rad Laboratories, Inc. | Zusammensetzungen und verfahren für molekulare etikettierung |
DE202012013668U1 (de) | 2011-06-02 | 2019-04-18 | Raindance Technologies, Inc. | Enzymquantifizierung |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
EP2788500A1 (de) * | 2011-12-09 | 2014-10-15 | F.Hoffmann-La Roche Ag | Identifizierung von non-respondern auf her2-inhibitoren |
US20130309667A1 (en) * | 2012-05-15 | 2013-11-21 | Anthony P. Shuber | Primers for analyzing methylated sequences and methods of use thereof |
US10119134B2 (en) | 2013-03-15 | 2018-11-06 | Abvitro Llc | Single cell bar-coding for antibody discovery |
DE102013211113A1 (de) * | 2013-06-14 | 2014-12-18 | Siemens Aktiengesellschaft | Verfahren zur kombinierten Quantifizierung und Sequenzierung von mindestens einer Ziel-Nukleinsäure |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
ES2895750T3 (es) | 2014-09-15 | 2022-02-22 | Abvitro Llc | Secuenciación de alto rendimiento de colecciones de nucleótidos |
CN107427823B (zh) * | 2015-03-24 | 2020-07-14 | 日立金属株式会社 | 陶瓷蜂窝结构体 |
WO2016170179A1 (en) * | 2015-04-24 | 2016-10-27 | Qiagen Gmbh | Method for immobilizing a nucleic acid molecule on solid support |
US11085073B2 (en) | 2015-04-24 | 2021-08-10 | Qiagen Gmbh | Method for immobilizing a nucleic acid molecule on a solid support |
US9938572B1 (en) | 2015-09-08 | 2018-04-10 | Raindance Technologies, Inc. | System and method for forming an emulsion |
CN106929598B (zh) * | 2017-05-04 | 2019-07-05 | 湖南融健基因生物科技有限公司 | 一种乳液中进行滚环扩增的数字核酸分析方法 |
US11701391B2 (en) | 2017-10-24 | 2023-07-18 | Dalia ELANI | Methods of treating an ischemic disease |
EP3853373A4 (de) | 2018-09-17 | 2022-06-22 | The University of North Carolina at Chapel Hill | Verfahren zur quantifizierung von dns-fragmenten in einer probe nach grösse |
US11474109B2 (en) | 2018-11-16 | 2022-10-18 | Scintimetrics, Inc. | Compositions and methods for controllably merging emulsion droplets and sample analysis |
EP3725894A1 (de) | 2019-04-16 | 2020-10-21 | Blod Diagnostik GmbH | Vorrichtung und verfahren zur nukleinsäurezielanreicherung, -suspension und -quantifizierung |
CN114902024A (zh) * | 2019-11-15 | 2022-08-12 | 闪璨迈璀公司 | 基于荧光团扩散的组合物和方法 |
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US5888778A (en) * | 1997-06-16 | 1999-03-30 | Exact Laboratories, Inc. | High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers |
GB9900298D0 (en) * | 1999-01-07 | 1999-02-24 | Medical Res Council | Optical sorting method |
US6355431B1 (en) * | 1999-04-20 | 2002-03-12 | Illumina, Inc. | Detection of nucleic acid amplification reactions using bead arrays |
DE10048797A1 (de) * | 2000-10-02 | 2002-04-18 | Bayer Ag | Wirkstoffhaltige Emulsionen |
AUPS298102A0 (en) | 2002-06-13 | 2002-07-04 | Nucleics Pty Ltd | Method for performing chemical reactions |
ES2380893T3 (es) * | 2003-01-29 | 2012-05-21 | 454 Life Sciences Corporation | Amplificación de ácidos nucleicos en emulsión en perlas |
EP2918595B1 (de) * | 2003-07-05 | 2019-12-11 | The Johns-Hopkins University | Verfahren und Zusammensetzungen zur Detektion und Zählung von genetischen Variationen |
WO2005073410A2 (en) * | 2004-01-28 | 2005-08-11 | 454 Corporation | Nucleic acid amplification with continuous flow emulsion |
CA2566538C (en) * | 2004-05-13 | 2023-03-14 | Anita Goel | Nano-pcr: methods and devices for nucleic acid amplification and detection |
US20060228721A1 (en) * | 2005-04-12 | 2006-10-12 | Leamon John H | Methods for determining sequence variants using ultra-deep sequencing |
ATE536420T1 (de) | 2005-10-24 | 2011-12-15 | Univ Johns Hopkins | Verbesserte verfahren für beaming |
US20080242560A1 (en) * | 2006-11-21 | 2008-10-02 | Gunderson Kevin L | Methods for generating amplified nucleic acid arrays |
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SI1948816T1 (sl) | 2012-04-30 |
ES2426031T3 (es) | 2013-10-18 |
WO2007050465A2 (en) | 2007-05-03 |
DK1948816T3 (da) | 2012-04-02 |
WO2007050465A3 (en) | 2007-10-25 |
EP1948816A4 (de) | 2009-11-04 |
US20110059435A1 (en) | 2011-03-10 |
ES2381204T3 (es) | 2012-05-24 |
EP2428579B1 (de) | 2013-05-29 |
US20130040300A9 (en) | 2013-02-14 |
EP2428579A1 (de) | 2012-03-14 |
US20200123600A1 (en) | 2020-04-23 |
CY1112525T1 (el) | 2015-12-09 |
US10150991B2 (en) | 2018-12-11 |
US10837050B2 (en) | 2020-11-17 |
ATE536420T1 (de) | 2011-12-15 |
US20160376645A1 (en) | 2016-12-29 |
EP1948816B1 (de) | 2011-12-07 |
HK1121193A1 (en) | 2009-04-17 |
EP1948816A2 (de) | 2008-07-30 |
US9360526B2 (en) | 2016-06-07 |
US20120014879A1 (en) | 2012-01-19 |
PL1948816T3 (pl) | 2012-07-31 |
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