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PT1261613E - Pro-farmacos gastro especificos - Google Patents

Pro-farmacos gastro especificos

Info

Publication number
PT1261613E
PT1261613E PT01909258T PT01909258T PT1261613E PT 1261613 E PT1261613 E PT 1261613E PT 01909258 T PT01909258 T PT 01909258T PT 01909258 T PT01909258 T PT 01909258T PT 1261613 E PT1261613 E PT 1261613E
Authority
PT
Portugal
Prior art keywords
disclosed
pro
drugs
hydrophilic group
awh
Prior art date
Application number
PT01909258T
Other languages
English (en)
Inventor
Samuel J Tremont
Paul W Collins
Ricky L Fenton
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of PT1261613E publication Critical patent/PT1261613E/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT01909258T 2000-02-28 2001-02-16 Pro-farmacos gastro especificos PT1261613E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/514,819 US6413945B1 (en) 1997-04-04 2000-02-28 Gastro-specific prodrugs

Publications (1)

Publication Number Publication Date
PT1261613E true PT1261613E (pt) 2004-08-31

Family

ID=24048822

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01909258T PT1261613E (pt) 2000-02-28 2001-02-16 Pro-farmacos gastro especificos

Country Status (11)

Country Link
US (1) US6413945B1 (pt)
EP (1) EP1261613B1 (pt)
JP (1) JP2003525301A (pt)
AT (1) ATE266034T1 (pt)
AU (1) AU2001237033A1 (pt)
DE (1) DE60103134T2 (pt)
DK (1) DK1261613T3 (pt)
ES (1) ES2215880T3 (pt)
PT (1) PT1261613E (pt)
TR (1) TR200401012T4 (pt)
WO (1) WO2001064690A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1744785A1 (en) * 2004-04-30 2007-01-24 Kopran Research Laboratories Limited Hydroxyalkyl derivatives of biologically active compounds
WO2009132265A2 (en) * 2008-04-25 2009-10-29 The University Of North Carolina At Chapel Hill Degradable compounds and methods of use thereof, particularly with particle replication in non-wetting templates
US20110212986A1 (en) * 2008-08-21 2011-09-01 Health Research, Inc. Anti-flavivirus therapeutic
WO2012037358A1 (en) 2010-09-16 2012-03-22 The University Of North Carolina At Chapel Hill Asymmetric bifunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents
ES2746105T3 (es) 2014-10-08 2020-03-04 Epigenetics Pharma Llc Profármacos de 5-aza-pirimidina sililada útiles para tratar el cáncer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055604A (en) * 1990-04-17 1991-10-08 G. D. Searle & Co. Process for preparing prostaglandin analogs using organozirconium compounds
EP0540580B1 (en) * 1990-07-26 1994-04-13 G.D. Searle & Co. Polymeric drug delivery system
JPH08165301A (ja) * 1994-12-15 1996-06-25 Mitsubishi Chem Corp 環状イヌロオリゴ糖のシリル化誘導体およびその製造方法
US5618959A (en) * 1995-03-10 1997-04-08 Vivus Incorporated Process for preparing prostaglandin E1, E2 and analogs thereof using furylcopper reagents
US6030959A (en) * 1997-04-04 2000-02-29 Monsanto Company Gastro-specific prodrugs

Also Published As

Publication number Publication date
EP1261613B1 (en) 2004-05-06
EP1261613A1 (en) 2002-12-04
AU2001237033A1 (en) 2001-09-12
ATE266034T1 (de) 2004-05-15
WO2001064690A1 (en) 2001-09-07
DE60103134T2 (de) 2005-04-28
US6413945B1 (en) 2002-07-02
ES2215880T3 (es) 2004-10-16
DK1261613T3 (da) 2004-08-09
DE60103134D1 (de) 2004-06-09
TR200401012T4 (tr) 2004-10-21
JP2003525301A (ja) 2003-08-26

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