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DE60026155D1 - Einige alkylendiamin-substituierte heterocyclen - Google Patents

Einige alkylendiamin-substituierte heterocyclen

Info

Publication number
DE60026155D1
DE60026155D1 DE60026155T DE60026155T DE60026155D1 DE 60026155 D1 DE60026155 D1 DE 60026155D1 DE 60026155 T DE60026155 T DE 60026155T DE 60026155 T DE60026155 T DE 60026155T DE 60026155 D1 DE60026155 D1 DE 60026155D1
Authority
DE
Germany
Prior art keywords
alkylendiamine
substituted heterocycles
novel compounds
neuropeptide
vii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60026155T
Other languages
English (en)
Other versions
DE60026155T2 (de
Inventor
F Horvath
Jennifer Tran
Lombaert Stephane De
Julian Hodgetts
A Carpino
A Griffith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Neurogen Corp
Pfizer Inc
Original Assignee
Pfizer Corp Belgium
Neurogen Corp
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Neurogen Corp, Pfizer Inc filed Critical Pfizer Corp Belgium
Publication of DE60026155D1 publication Critical patent/DE60026155D1/de
Application granted granted Critical
Publication of DE60026155T2 publication Critical patent/DE60026155T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
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    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/5755—Neuropeptide Y
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

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  • Organic Chemistry (AREA)
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  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Psychiatry (AREA)
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  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
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  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE60026155T 1999-09-30 2000-09-29 Einige alkylendiamin-substituierte heterocyclen Expired - Fee Related DE60026155T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15687099P 1999-09-30 1999-09-30
US156870P 1999-09-30
PCT/US2000/026886 WO2001023389A2 (en) 1999-09-30 2000-09-29 Certain alkylene diamine-substituted heterocycles

Publications (2)

Publication Number Publication Date
DE60026155D1 true DE60026155D1 (de) 2006-04-27
DE60026155T2 DE60026155T2 (de) 2006-08-10

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DE60026155T Expired - Fee Related DE60026155T2 (de) 1999-09-30 2000-09-29 Einige alkylendiamin-substituierte heterocyclen

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US (3) US6506762B1 (de)
EP (1) EP1224187B1 (de)
JP (2) JP2003510327A (de)
KR (1) KR20020043223A (de)
CN (1) CN1377356A (de)
AT (1) ATE318267T1 (de)
AU (1) AU7738000A (de)
BG (1) BG106508A (de)
CA (1) CA2379640C (de)
CZ (1) CZ20021086A3 (de)
DE (1) DE60026155T2 (de)
EA (1) EA200200424A1 (de)
ES (1) ES2258476T3 (de)
HU (1) HUP0202636A3 (de)
IL (1) IL148903A0 (de)
NO (1) NO20021358L (de)
NZ (1) NZ517575A (de)
OA (1) OA12050A (de)
PL (1) PL354784A1 (de)
WO (1) WO2001023389A2 (de)
ZA (1) ZA200202518B (de)

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DE60034783T2 (de) * 1999-04-22 2008-01-31 H. Lundbeck A/S, Valby Selektive npy(y5)-antagonisten
US6989379B1 (en) 1999-04-22 2006-01-24 H. Lundbick A/S Selective NPY (Y5) antagonists
US7273880B2 (en) 1999-06-30 2007-09-25 H. Lunbeck A/S Selective NPY (Y5) antagonists
EP1224187B1 (de) * 1999-09-30 2006-02-22 Neurogen Corporation Einige alkylendiamin-substituierte heterocyclen
PL354675A1 (en) * 1999-09-30 2004-02-09 Neurogen Corporation Certain alkylene diamine-substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines
US20010031474A1 (en) * 2000-01-28 2001-10-18 Neurogen Corporation Chimeric neuropeptide Y receptors
CN100351253C (zh) * 2000-06-26 2007-11-28 辉瑞产品公司 作为免疫抑制剂的吡咯并[2,3－d]嘧啶化合物
MXPA03004245A (es) * 2000-12-12 2003-09-22 Neurogen Corp Espiro[isobenzofuran-1,4'piperidin]-3-onas y 3h-espiroisobenzofuran-1,4'-piperidinas.
CN100343258C (zh) * 2001-04-30 2007-10-17 美国拜尔公司 新的4－氨基－5,6－取代的噻吩并[2,3－d]嘧啶化合物
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AU7738000A (en) 2001-04-30
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US7074929B2 (en) 2006-07-11
JP2003510327A (ja) 2003-03-18
EA200200424A1 (ru) 2002-12-26
US20030158197A1 (en) 2003-08-21
US6696445B2 (en) 2004-02-24
IL148903A0 (en) 2002-09-12
DE60026155T2 (de) 2006-08-10
JP2008007515A (ja) 2008-01-17
US20040229870A1 (en) 2004-11-18
OA12050A (en) 2006-05-02
EP1224187B1 (de) 2006-02-22
CA2379640C (en) 2006-11-28
PL354784A1 (en) 2004-02-23
ATE318267T1 (de) 2006-03-15
NO20021358D0 (no) 2002-03-19
US6506762B1 (en) 2003-01-14
HUP0202636A2 (hu) 2002-12-28
NZ517575A (en) 2004-04-30
CZ20021086A3 (cs) 2002-10-16
CA2379640A1 (en) 2001-04-05
NO20021358L (no) 2002-05-27
EP1224187A2 (de) 2002-07-24
ES2258476T3 (es) 2006-09-01
CN1377356A (zh) 2002-10-30
WO2001023389A2 (en) 2001-04-05
WO2001023389A3 (en) 2002-05-10
BG106508A (en) 2003-02-28
KR20020043223A (ko) 2002-06-08

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