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PT1159279E - 4-oxo-4,7-di-hidrotieno¬2,3-b|piridino-5-carboxamidas como agentes antivirais - Google Patents

4-oxo-4,7-di-hidrotieno¬2,3-b|piridino-5-carboxamidas como agentes antivirais

Info

Publication number
PT1159279E
PT1159279E PT00913786T PT00913786T PT1159279E PT 1159279 E PT1159279 E PT 1159279E PT 00913786 T PT00913786 T PT 00913786T PT 00913786 T PT00913786 T PT 00913786T PT 1159279 E PT1159279 E PT 1159279E
Authority
PT
Portugal
Prior art keywords
dihydrotiene
carboxamides
oxo
pyridine
antiviral agents
Prior art date
Application number
PT00913786T
Other languages
English (en)
Inventor
Mark E Schnute
Michele M Cudahy
Allen Scott
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PT1159279E publication Critical patent/PT1159279E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
PT00913786T 1999-03-09 2000-03-07 4-oxo-4,7-di-hidrotieno¬2,3-b|piridino-5-carboxamidas como agentes antivirais PT1159279E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12366099P 1999-03-09 1999-03-09

Publications (1)

Publication Number Publication Date
PT1159279E true PT1159279E (pt) 2003-02-28

Family

ID=22410054

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00913786T PT1159279E (pt) 1999-03-09 2000-03-07 4-oxo-4,7-di-hidrotieno¬2,3-b|piridino-5-carboxamidas como agentes antivirais

Country Status (25)

Country Link
US (2) US6239142B1 (pt)
EP (1) EP1159279B1 (pt)
JP (1) JP2002539130A (pt)
KR (1) KR20010102543A (pt)
CN (1) CN1347417A (pt)
AT (1) ATE226208T1 (pt)
AU (1) AU759875B2 (pt)
BR (1) BR0008804A (pt)
CA (1) CA2366609A1 (pt)
CZ (1) CZ20013028A3 (pt)
DE (1) DE60000611T2 (pt)
DK (1) DK1159279T3 (pt)
EA (1) EA003607B1 (pt)
ES (1) ES2184705T3 (pt)
HK (1) HK1045518A1 (pt)
HU (1) HUP0200324A3 (pt)
IL (1) IL145005A0 (pt)
NO (1) NO20014363L (pt)
NZ (1) NZ513758A (pt)
PL (1) PL350651A1 (pt)
PT (1) PT1159279E (pt)
SK (1) SK12582001A3 (pt)
TW (1) TWI222451B (pt)
WO (1) WO2000053610A2 (pt)
ZA (1) ZA200107255B (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
WO2003020729A1 (en) * 2001-08-30 2003-03-13 Pharmacia & Upjohn Company 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANT IVIRAL AGENTS
WO2003020728A1 (en) 2001-08-30 2003-03-13 Pharmacia & Upjohn Company 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS
EA009368B1 (ru) * 2001-12-20 2007-12-28 Оси Фармасьютикалз, Инк. Соединения-ингибиторы липазы поджелудочной железы, их синтез и применение
AR038117A1 (es) * 2002-01-14 2004-12-29 Upjohn Co Agentes antivirales derivados de la 4- oxo-4,7 -dihidrofuro [2,3-b]piridin-5-carboxamida
AR038294A1 (es) * 2002-01-14 2005-01-12 Upjohn Co Oxotieno(3,2-b)piridincarboxamidas como agentes antivirales
AR038118A1 (es) * 2002-01-14 2004-12-29 Upjohn Co Compuestos derivados de la bencinamida del acido 7-oxo-4,7-dihidrotien[2,3-b[piridin-6-carboxilico 3-sustituido que son utiles como antivirales
US20030212271A1 (en) * 2002-04-22 2003-11-13 Allen Scott Trifluoroacetic acid process to prepare [2,3-B]pyridine intermediates
WO2004016581A1 (en) 2002-08-09 2004-02-26 Janssen Pharmaceutica N.V. Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
US20040186131A1 (en) * 2002-08-30 2004-09-23 Wathen Michael W Method of preventing or treating atherosclerosis or restenosis
AU2003270032A1 (en) * 2002-08-30 2004-03-19 Pharmacia And Upjohn Company Method of preventing or treating atherosclerosis or restenosis
US20040176366A1 (en) * 2002-08-30 2004-09-09 Wathen Michael W Method of preventing or treating atherosclerosis or restenosis
US20040067947A1 (en) * 2002-08-30 2004-04-08 Wathen Michael W Method of preventing or treating atherosclerosis or restenosis
US20040116464A1 (en) * 2002-09-04 2004-06-17 Schnute Mark E. Aryl-ethanolamine derivatives as antiviral agents
WO2004022567A1 (en) * 2002-09-04 2004-03-18 Pharmacia & Upjohn Company Llc Heteroaryl-ethanolamine derivatives as antiviral agents
WO2004106345A2 (en) * 2002-09-04 2004-12-09 Pharmacia & Upjohn Company Heteroaryl-ethanolamine derivatives as antiviral agents
US6831081B2 (en) * 2002-09-04 2004-12-14 Pharmacia & Upjohn 4-Oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents
WO2005003140A1 (en) * 2003-07-02 2005-01-13 Pharmacia & Upjohn Company Llc 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents
US20070208015A1 (en) * 2004-04-13 2007-09-06 Astex Therapeutics, Ltd. 5-Morpholinylmethylthiophenyl Pharmaceutical Compounds As P38 MAP Kinase Modulators
SE0401578D0 (sv) 2004-06-18 2004-06-18 Active Biotech Ab Novel compounds
WO2006093518A2 (en) * 2004-06-25 2006-09-08 Apath, Llc Thienyl compounds for treating virus-related conditions
CA2753421A1 (en) * 2009-02-27 2010-09-02 Siga Technologies, Inc. Thienopyridine derivatives for the treatment and prevention of dengue virus infections
KR20180110132A (ko) 2016-02-16 2018-10-08 반더빌트유니버시티 무스카린성 아세틸콜린 수용체 m1의 양성 알로스테릭 조절제
US10899759B2 (en) 2016-09-30 2021-01-26 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor M1
EP3849979A1 (en) 2018-09-12 2021-07-21 Novartis AG Antiviral pyridopyrazinedione compounds
TWI867053B (zh) 2019-09-26 2024-12-21 瑞士商諾華公司 抗病毒吡唑并吡啶酮化合物
CN115073489B (zh) * 2021-03-15 2023-11-28 同济大学 一种噻吩骈吡啶酮类化合物、制备方法及一种抗真菌药物
WO2022221602A2 (en) * 2021-04-14 2022-10-20 University Of Virginia Patent Foundation Compositions and methods for treating and/or preventing lung injury

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DE4227747A1 (de) 1992-08-21 1994-02-24 Basf Ag Heteroaromatisch kondensierte Hydroxypyridoncarbonsäureamide, deren Herstellung und Verwendung
JPH0776586A (ja) 1993-07-16 1995-03-20 Yoshitomi Pharmaceut Ind Ltd ピリジン化合物
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WO1996018617A1 (en) 1994-12-12 1996-06-20 Merck & Co., Inc. Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase
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Also Published As

Publication number Publication date
DE60000611T2 (de) 2003-06-26
EP1159279A2 (en) 2001-12-05
NO20014363L (no) 2001-11-08
KR20010102543A (ko) 2001-11-15
DK1159279T3 (da) 2003-02-17
ATE226208T1 (de) 2002-11-15
SK12582001A3 (sk) 2002-02-05
ZA200107255B (en) 2002-12-02
AU3516200A (en) 2000-09-28
BR0008804A (pt) 2002-04-16
HUP0200324A2 (en) 2002-06-29
HK1045518A1 (zh) 2002-11-29
NO20014363D0 (no) 2001-09-07
CN1347417A (zh) 2002-05-01
NZ513758A (en) 2001-09-28
TWI222451B (en) 2004-10-21
EA003607B1 (ru) 2003-06-26
PL350651A1 (en) 2003-01-27
JP2002539130A (ja) 2002-11-19
HUP0200324A3 (en) 2003-07-28
ES2184705T3 (es) 2003-04-16
CZ20013028A3 (cs) 2002-03-13
WO2000053610A3 (en) 2001-01-25
CA2366609A1 (en) 2000-09-14
WO2000053610A2 (en) 2000-09-14
US20020006937A1 (en) 2002-01-17
IL145005A0 (en) 2002-06-30
EA200100955A1 (ru) 2002-02-28
AU759875B2 (en) 2003-05-01
EP1159279B1 (en) 2002-10-16
US6239142B1 (en) 2001-05-29
DE60000611D1 (en) 2002-11-21
US6495683B2 (en) 2002-12-17

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