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DK1159279T3 - 4-Oxo-4,7-dihydro-thieno[2,3-b]pyridin-5-carboxamider som antivirale midler - Google Patents

4-Oxo-4,7-dihydro-thieno[2,3-b]pyridin-5-carboxamider som antivirale midler

Info

Publication number
DK1159279T3
DK1159279T3 DK00913786T DK00913786T DK1159279T3 DK 1159279 T3 DK1159279 T3 DK 1159279T3 DK 00913786 T DK00913786 T DK 00913786T DK 00913786 T DK00913786 T DK 00913786T DK 1159279 T3 DK1159279 T3 DK 1159279T3
Authority
DK
Denmark
Prior art keywords
antivirals
carboxamides
thieno
dihydro
oxo
Prior art date
Application number
DK00913786T
Other languages
English (en)
Inventor
Mark E Schnute
Allen Scott
Michele M Cudahy
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DK1159279T3 publication Critical patent/DK1159279T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
DK00913786T 1999-03-09 2000-03-07 4-Oxo-4,7-dihydro-thieno[2,3-b]pyridin-5-carboxamider som antivirale midler DK1159279T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12366099P 1999-03-09 1999-03-09
PCT/US2000/005937 WO2000053610A2 (en) 1999-03-09 2000-03-07 4-OXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS

Publications (1)

Publication Number Publication Date
DK1159279T3 true DK1159279T3 (da) 2003-02-17

Family

ID=22410054

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00913786T DK1159279T3 (da) 1999-03-09 2000-03-07 4-Oxo-4,7-dihydro-thieno[2,3-b]pyridin-5-carboxamider som antivirale midler

Country Status (25)

Country Link
US (2) US6239142B1 (da)
EP (1) EP1159279B1 (da)
JP (1) JP2002539130A (da)
KR (1) KR20010102543A (da)
CN (1) CN1347417A (da)
AT (1) ATE226208T1 (da)
AU (1) AU759875B2 (da)
BR (1) BR0008804A (da)
CA (1) CA2366609A1 (da)
CZ (1) CZ20013028A3 (da)
DE (1) DE60000611T2 (da)
DK (1) DK1159279T3 (da)
EA (1) EA003607B1 (da)
ES (1) ES2184705T3 (da)
HK (1) HK1045518A1 (da)
HU (1) HUP0200324A3 (da)
IL (1) IL145005A0 (da)
NO (1) NO20014363L (da)
NZ (1) NZ513758A (da)
PL (1) PL350651A1 (da)
PT (1) PT1159279E (da)
SK (1) SK12582001A3 (da)
TW (1) TWI222451B (da)
WO (1) WO2000053610A2 (da)
ZA (1) ZA200107255B (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
WO2003020728A1 (en) * 2001-08-30 2003-03-13 Pharmacia & Upjohn Company 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS
BR0211214A (pt) 2001-08-30 2004-07-13 Upjohn Co 4-tioxo-4,7-dihidro-tieno [2,3-b]piridina-5-carboxamidas como agentes antivirais
JP4668536B2 (ja) * 2001-12-20 2011-04-13 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド 膵臓リパーゼ阻害化合物、その合成および使用
AR038118A1 (es) * 2002-01-14 2004-12-29 Upjohn Co Compuestos derivados de la bencinamida del acido 7-oxo-4,7-dihidrotien[2,3-b[piridin-6-carboxilico 3-sustituido que son utiles como antivirales
AR038117A1 (es) * 2002-01-14 2004-12-29 Upjohn Co Agentes antivirales derivados de la 4- oxo-4,7 -dihidrofuro [2,3-b]piridin-5-carboxamida
AR038294A1 (es) * 2002-01-14 2005-01-12 Upjohn Co Oxotieno(3,2-b)piridincarboxamidas como agentes antivirales
AU2003222077A1 (en) * 2002-04-22 2003-11-03 Pharmacia And Upjohn Company A trifluoroacetic acid process to prepare (2,3-b)pyridine intermediates
HRP20050104B1 (hr) 2002-08-09 2014-02-14 Janssen Pharmaceutica N.V. Postupci za pripremu 4-[[4-[[4-(2-cijanoetenil)-2,6-dimetilfenil]amino]-2-pirimidinil]amino]benzonitrila
WO2004019940A1 (en) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Method of preventing or treating atherosclerosis or restenosis
WO2004019933A1 (en) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Method of preventing or treating atherosclerosis or restenosis
AU2003262947A1 (en) * 2002-08-30 2004-03-19 Pharmacia And Upjohn Company Method of preventing or treating atherosclerosis or restenosis
US20040102473A1 (en) * 2002-08-30 2004-05-27 Wathen Michael W. Method of preventing or treating atherosclerosis or restenosis
AU2003269950A1 (en) * 2002-09-04 2004-03-29 Pharmacia & Upjohn Company Llc Heteroaryl-ethanolamine derivatives as antiviral agents
US20050049245A1 (en) * 2002-09-04 2005-03-03 Schnute Mark E. Heteroaryl-ethanolamine derivatives as antiviral agents
WO2004022566A1 (en) * 2002-09-04 2004-03-18 Pharmacia & Upjohn Company Llc 4-OXO-4,7-DIHYDROTHIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS
AU2003304151A1 (en) * 2002-09-04 2005-01-21 Pharmacia And Upjohn Company Heteroaryl-ethanolamine derivatives as antiviral agents
WO2005003140A1 (en) * 2003-07-02 2005-01-13 Pharmacia & Upjohn Company Llc 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents
WO2005100338A1 (en) * 2004-04-13 2005-10-27 Astex Therapeutics Limited 5-morpholinylmethylthiophenyl pharmaceutial compounds as p38 map kinase modulators
SE0401578D0 (sv) 2004-06-18 2004-06-18 Active Biotech Ab Novel compounds
WO2006093518A2 (en) * 2004-06-25 2006-09-08 Apath, Llc Thienyl compounds for treating virus-related conditions
BRPI1005828A2 (pt) * 2009-02-27 2017-07-18 Siga Tech Inc composição farmacêutica; método para o tratamento ou a profilaxia de uma infecção viral ou doença associada com a mesma; composto; método para a preparação de uma mistura de terc-butil(4e)-4-(hidroximetileno)-5-oxoazepano-1-carboxilato e terc-butil (3e)-3-(hidroximetileno)-4-oxoazepano-1-carboxilato; método para a preparação de uma mistura de terc-butil 3-ciano-2-tioxo-1,2,5,6,8,9-hexaidro-1h-pirido [2,3-d] azepina-7-carboxilato e terc-butil 3-ciano-2-tioxo-1,2,5,7,8,9-hexaidro-6h-pirido [3,2-c] azepina-6-carboxilato; método para a preparação de ácido 3-amino-7-terc-butiloxicarbonil-6,7,8,9-tetraidro-5h-1-tia-7,10-diaza-ciclohepta [f] indeno-2-carboxílico (5-fenil-[1,3,4]tiazol-2-il)-amida; método para a preparação de ácido 3-amino-6,7,8,9-tetraidro-5h-1-tia-7,10-diaza-ciclohepta [f] indeno-2-carboxílico (5-fenil-[1,3,4] tiadiazol-2-il)-amida; método para a preparação de ácido 3-amino-6-tercbutiloxicarbonil-6,7,8,9-tetraidro-5h-1-tia-6,10-diaza-ciclohepta [f] indeno-2-carboxílico (5-fenil-[1,3,4] tiadiazol-2-il)-amida e método para a preparação de ácido 3-amino-6,7,8,9-tetraidro-5h-1-tia-6,10-diaza-ciclohepta [f] indeno-2-carboxílico (5-fenil-[1,3,4] tiadiazol-2-il)-amida
EP3416639B1 (en) 2016-02-16 2022-06-08 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m1
US10899759B2 (en) 2016-09-30 2021-01-26 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor M1
CA3112326A1 (en) 2018-09-12 2020-03-19 Novartis Ag Antiviral pyridopyrazinedione compounds
CN120842223A (zh) 2019-09-26 2025-10-28 诺华股份有限公司 抗病毒吡唑并吡啶酮化合物
CN115073489B (zh) * 2021-03-15 2023-11-28 同济大学 一种噻吩骈吡啶酮类化合物、制备方法及一种抗真菌药物
EP4313995A4 (en) * 2021-04-14 2025-02-26 University of Virginia Patent Foundation COMPOSITIONS AND METHODS FOR TREATING AND/OR PREVENTING LUNG INJURY

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5268193A (en) 1975-11-28 1977-06-06 Sumitomo Chem Co Ltd Synthesis of novel cephalosporin derivatives
US4145418A (en) 1976-01-06 1979-03-20 Takeda Chemical Industries, Ltd. Thienopyridine substituted cephalosporins
US4568649A (en) 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4767766A (en) 1987-01-30 1988-08-30 Merck & Co., Inc. Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US4959363A (en) 1989-06-23 1990-09-25 Sterling Drug Inc. Quinolonecarboxamide compounds, their preparation and use as antivirals.
CA2036618C (en) 1990-02-22 2002-10-29 Akira Morimoto Fused thiophene derivatives, their production and use
WO1992003427A1 (fr) 1990-08-17 1992-03-05 Yoshitomi Pharmaceutical Industries, Ltd. Compose de cetone et remede pour l'osteoporose
US5219864A (en) 1991-03-12 1993-06-15 Kyowa Hakko Kogyo Co., Ltd. Thienopyridine derivatives
DE4227747A1 (de) 1992-08-21 1994-02-24 Basf Ag Heteroaromatisch kondensierte Hydroxypyridoncarbonsäureamide, deren Herstellung und Verwendung
JPH0776586A (ja) 1993-07-16 1995-03-20 Yoshitomi Pharmaceut Ind Ltd ピリジン化合物
TW449600B (en) * 1994-04-19 2001-08-11 Takeda Chemical Industries Ltd Condensed-ring thiophene derivatives, their production and use
WO1996018617A1 (en) 1994-12-12 1996-06-20 Merck & Co., Inc. Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase
AU4515696A (en) 1994-12-12 1996-07-03 Merck & Co., Inc. Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
JPH08301849A (ja) 1995-05-01 1996-11-19 Takeda Chem Ind Ltd ヘテロ環化合物およびその製造法
JPH09208496A (ja) 1996-01-30 1997-08-12 Takeda Chem Ind Ltd Ｌｈ−ｒｈ拮抗物質含有組成物
WO1997040846A1 (en) 1996-04-30 1997-11-06 Takeda Chemical Industries, Ltd. COMBINED USE OF GnRH AGONIST AND ANTAGONIST
EP0927164A1 (en) * 1996-09-10 1999-07-07 PHARMACIA & UPJOHN COMPANY 8-hydroxy-7-substituted quinolines as anti-viral agents
KR20010052570A (ko) 1998-06-04 2001-06-25 스티븐 에프. 웨인스톡 세포 유착을 억제하는 소염성 화합물

Also Published As

Publication number Publication date
NO20014363L (no) 2001-11-08
KR20010102543A (ko) 2001-11-15
CA2366609A1 (en) 2000-09-14
ZA200107255B (en) 2002-12-02
AU759875B2 (en) 2003-05-01
WO2000053610A2 (en) 2000-09-14
EP1159279B1 (en) 2002-10-16
EA003607B1 (ru) 2003-06-26
HUP0200324A3 (en) 2003-07-28
DE60000611D1 (en) 2002-11-21
CN1347417A (zh) 2002-05-01
ATE226208T1 (de) 2002-11-15
IL145005A0 (en) 2002-06-30
EA200100955A1 (ru) 2002-02-28
HUP0200324A2 (en) 2002-06-29
NO20014363D0 (no) 2001-09-07
US6239142B1 (en) 2001-05-29
ES2184705T3 (es) 2003-04-16
US20020006937A1 (en) 2002-01-17
BR0008804A (pt) 2002-04-16
NZ513758A (en) 2001-09-28
TWI222451B (en) 2004-10-21
CZ20013028A3 (cs) 2002-03-13
EP1159279A2 (en) 2001-12-05
HK1045518A1 (zh) 2002-11-29
US6495683B2 (en) 2002-12-17
WO2000053610A3 (en) 2001-01-25
JP2002539130A (ja) 2002-11-19
DE60000611T2 (de) 2003-06-26
SK12582001A3 (sk) 2002-02-05
PT1159279E (pt) 2003-02-28
PL350651A1 (en) 2003-01-27
AU3516200A (en) 2000-09-28

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