[go: up one dir, main page]

PL444394A1 - 1-aryl-6-hydroxyimino-5(1H)oxo-2,3-dihydroimidazo[1,2-a]imidazoles and method of their preparation and use - Google Patents

1-aryl-6-hydroxyimino-5(1H)oxo-2,3-dihydroimidazo[1,2-a]imidazoles and method of their preparation and use

Info

Publication number
PL444394A1
PL444394A1 PL444394A PL44439423A PL444394A1 PL 444394 A1 PL444394 A1 PL 444394A1 PL 444394 A PL444394 A PL 444394A PL 44439423 A PL44439423 A PL 44439423A PL 444394 A1 PL444394 A1 PL 444394A1
Authority
PL
Poland
Prior art keywords
dihydroimidazo
aryl
hydroxyimino
imidazoles
oxo
Prior art date
Application number
PL444394A
Other languages
Polish (pl)
Inventor
Dariusz Matosiuk
Dominik Straszak
Sylwia Woźniak
Original Assignee
Uniwersytet Medyczny W Lublinie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Medyczny W Lublinie filed Critical Uniwersytet Medyczny W Lublinie
Priority to PL444394A priority Critical patent/PL444394A1/en
Publication of PL444394A1 publication Critical patent/PL444394A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia są 1-Arylo-6-hydroksyimino-5(1H)okso-2,3-dihydroimidazo[1,2-a]imidazole o wzorze ogólnym 1, gdzie R oznacza podstawnik w pierścieniu fenylowym taki jak wodór 3-metyl, 4-metyl, 3-chloro, 4-chloro, 2-metoksy, 4-metoksy oraz sposób ich otrzymywania charakteryzujący się tym, że pochodne 1-arylo-5,6(1H)diokso-2,3-dihydroimidazo[1,2-a]imidazole o wzorze ogólnym 2, gdzie R ma wyżej podane znaczenie poddaje się kondensacji z chlorowodorkiem hydroksyloaminy o wzorze ogólnym 3, przy czym reakcję prowadzi się w polarnym, protonowym rozpuszczalniku, korzystnie alkoholu. Zgłoszenie obejmuje również zastosowanie przedmiotowych związków w leczeniu bólu neuropatycznego i przewlekłego.The subject of the application are 1-aryl-6-hydroxyimino-5(1H)oxo-2,3-dihydroimidazo[1,2-a]imidazoles of general formula 1, where R denotes a substituent in the phenyl ring such as hydrogen 3-methyl, 4-methyl, 3-chloro, 4-chloro, 2-methoxy, 4-methoxy and a method for their preparation characterized in that 1-aryl-5,6(1H)dioxo-2,3-dihydroimidazo[1,2-a]imidazole derivatives of general formula 2, where R has the meaning given above are condensed with hydroxylamine hydrochloride of general formula 3, wherein the reaction is carried out in a polar, protic solvent, preferably an alcohol. The application also covers the use of the subject compounds in the treatment of neuropathic and chronic pain.

PL444394A 2023-04-13 2023-04-13 1-aryl-6-hydroxyimino-5(1H)oxo-2,3-dihydroimidazo[1,2-a]imidazoles and method of their preparation and use PL444394A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL444394A PL444394A1 (en) 2023-04-13 2023-04-13 1-aryl-6-hydroxyimino-5(1H)oxo-2,3-dihydroimidazo[1,2-a]imidazoles and method of their preparation and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL444394A PL444394A1 (en) 2023-04-13 2023-04-13 1-aryl-6-hydroxyimino-5(1H)oxo-2,3-dihydroimidazo[1,2-a]imidazoles and method of their preparation and use

Publications (1)

Publication Number Publication Date
PL444394A1 true PL444394A1 (en) 2024-10-14

Family

ID=93062636

Family Applications (1)

Application Number Title Priority Date Filing Date
PL444394A PL444394A1 (en) 2023-04-13 2023-04-13 1-aryl-6-hydroxyimino-5(1H)oxo-2,3-dihydroimidazo[1,2-a]imidazoles and method of their preparation and use

Country Status (1)

Country Link
PL (1) PL444394A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0051809A1 (en) * 1980-11-12 1982-05-19 C.H. Boehringer Sohn 7-(2,6-Dibromo-4-methylphenyl)-2,3-dihydroimidazo(1,2-a) imidazoles, their acid addition salts, medicines containing them and processes for their preparation
EP1216247B1 (en) * 1999-07-21 2008-11-05 Boehringer Ingelheim Pharmaceuticals Inc. Imidazoimidazoles and triazoles as anti-inflammatory agents
EP3221318A1 (en) * 2014-11-21 2017-09-27 Rigel Pharmaceuticals, Inc. Fused imidazole derivatives as tgf-beta inhibitors
EP3668873A1 (en) * 2017-08-17 2020-06-24 H. Hoffnabb-La Roche Ag Imidazo[1,2-a]imidazol-2-one derivatives for the treatment of diseases such as parkinson's disease

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0051809A1 (en) * 1980-11-12 1982-05-19 C.H. Boehringer Sohn 7-(2,6-Dibromo-4-methylphenyl)-2,3-dihydroimidazo(1,2-a) imidazoles, their acid addition salts, medicines containing them and processes for their preparation
EP1216247B1 (en) * 1999-07-21 2008-11-05 Boehringer Ingelheim Pharmaceuticals Inc. Imidazoimidazoles and triazoles as anti-inflammatory agents
EP3221318A1 (en) * 2014-11-21 2017-09-27 Rigel Pharmaceuticals, Inc. Fused imidazole derivatives as tgf-beta inhibitors
EP3668873A1 (en) * 2017-08-17 2020-06-24 H. Hoffnabb-La Roche Ag Imidazo[1,2-a]imidazol-2-one derivatives for the treatment of diseases such as parkinson's disease

Similar Documents

Publication Publication Date Title
EP1592686B1 (en) Gyrase inhibitors and uses thereof
US6667335B2 (en) Imidazole derivatives
DK2146963T3 (en) Double-acting antihypertensive agents
DE69408750T2 (en) 4-aminopyrimidine derivatives
CA2433197C (en) Gyrase inhibitors and uses thereof
EP2129375B1 (en) Imidazo[1,2-a]pyridines and their use as pharmaceuticals
JP4722851B2 (en) Quinoline potassium channel inhibitor
JP5400032B2 (en) Benzimidazole and pharmaceutical composition thereof
JP2018525426A5 (en)
CA2316223A1 (en) Hydrophilic coating for an intracorporeal medical device
SK1932003A3 (en) Acridin derivatives and the use thereof as pharmaceuticals
RU2008125055A (en) 2- (phenyl or heterocyclo) -1H-phenanthro [9.10-D] imidazoles as MPGES-1 inhibitors
FI97804B (en) Process for the preparation of therapeutically active (substituted aralkyl) triazole, imidazole, pyridine and pyrimidine compounds
IL148313A (en) N - heterocyclic derivatives, pharmaceutical compositions comprising them and uses of said derivatives
EP2129676A1 (en) Imidazo[1,2-a]azines and their use as pharmaceuticals
KR20070030162A (en) Benzimidazole derivatives, preparation method thereof and pharmaceutical application
KR20070048762A (en) Zyrase Inhibitors and Uses thereof
EP1143959A2 (en) Antifungal activity of dicationic molecules
JP2018525427A5 (en)
RU2284326C2 (en) 2-thio-substituted derivatives of imidazole, their using and pharmaceutical agent based on thereof
PL444394A1 (en) 1-aryl-6-hydroxyimino-5(1H)oxo-2,3-dihydroimidazo[1,2-a]imidazoles and method of their preparation and use
CN111848600B (en) 2,4, 4-trisubstituted dihydrooxazole derivative and application thereof
AU2018337138B2 (en) 2-substituted pyrazole amino-4-substituted amino-5-pyrimidine formamide compound, composition, and application thereof
MX2007010496A (en) 2-sulfinyl- and 2-sulfonyl-substituted imidazole derivatives and their use as cytokine inhibitors.
HUT72063A (en) Acylized amino-alkyl-imidazoles and -triazoles, pharmaceutical compositions containing them and process for producing them