PL397821A1 - Związek1-acetylo-6-fluoro-2-indolinon - Google Patents
Związek1-acetylo-6-fluoro-2-indolinonInfo
- Publication number
- PL397821A1 PL397821A1 PL397821A PL39782103A PL397821A1 PL 397821 A1 PL397821 A1 PL 397821A1 PL 397821 A PL397821 A PL 397821A PL 39782103 A PL39782103 A PL 39782103A PL 397821 A1 PL397821 A1 PL 397821A1
- Authority
- PL
- Poland
- Prior art keywords
- fluoro
- acetyl
- indolinone compound
- indolinone
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10233366A DE10233366A1 (de) | 2002-07-23 | 2002-07-23 | In 6-Stellung substituierte Indolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
DE10328533A DE10328533A1 (de) | 2003-06-24 | 2003-06-24 | In 6-Stellung substituierte Indolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
PL397821A1 true PL397821A1 (pl) | 2012-03-12 |
Family
ID=30771725
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL03374879A PL374879A1 (pl) | 2002-07-23 | 2003-07-22 | Pochodne indolinonu podstawione w pozycji 6, sposób ich wytwarzania i ich zastosowanie jako leki |
PL397821A PL397821A1 (pl) | 2002-07-23 | 2003-07-22 | Związek1-acetylo-6-fluoro-2-indolinon |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL03374879A PL374879A1 (pl) | 2002-07-23 | 2003-07-22 | Pochodne indolinonu podstawione w pozycji 6, sposób ich wytwarzania i ich zastosowanie jako leki |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1523473B1 (pl) |
JP (1) | JP4401291B2 (pl) |
KR (2) | KR20120003025A (pl) |
CN (1) | CN1318403C (pl) |
AR (1) | AR041188A1 (pl) |
AU (2) | AU2003254557B2 (pl) |
BR (1) | BR0312799A (pl) |
CA (1) | CA2493436C (pl) |
DK (1) | DK1523473T3 (pl) |
EA (1) | EA008623B1 (pl) |
EC (1) | ECSP055567A (pl) |
ES (1) | ES2409062T3 (pl) |
HK (1) | HK1081554A1 (pl) |
HR (1) | HRP20050069A2 (pl) |
IL (1) | IL166404A0 (pl) |
MX (1) | MXPA04012937A (pl) |
MY (1) | MY138141A (pl) |
NO (1) | NO20050937L (pl) |
PE (1) | PE20040701A1 (pl) |
PL (2) | PL374879A1 (pl) |
RS (1) | RS20050047A (pl) |
SA (1) | SA03240430B1 (pl) |
TW (1) | TWI343375B (pl) |
UY (1) | UY27903A1 (pl) |
WO (1) | WO2004009547A1 (pl) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7514468B2 (en) | 2002-07-23 | 2009-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions |
US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
US20060058311A1 (en) * | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
PE20061155A1 (es) * | 2004-12-24 | 2006-12-16 | Boehringer Ingelheim Int | Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas |
BRPI0609899A2 (pt) * | 2005-04-28 | 2010-05-11 | Boehringer Ingelheim International Gmbh | compostos para o tratamento de doenças inflamatórias, uso dos mesmos, formulações farmacêuticas, combinações medicamentosas e produtos intermediários |
WO2007057399A2 (en) * | 2005-11-15 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Treatment of cancer with indole derivatives |
MX2010007949A (es) * | 2008-01-25 | 2010-08-04 | Boehringer Ingelheim Int | Procedimiento para la fabricacion de un derivado de 6-fluoro-1,2-dihidro-2-oxo-3h-indol-3-ilideno. |
JP2011510032A (ja) * | 2008-01-25 | 2011-03-31 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 6−フルオロ−1,2−ジヒドロ−2−オキソ−3h−インドール−3−イリデン誘導体の塩形態、それらの製造方法及びそれらを含有する医薬組成物 |
EP2471787A1 (en) | 2008-07-29 | 2012-07-04 | Boehringer Ingelheim International GmbH | New compounds |
WO2014061752A1 (ja) * | 2012-10-17 | 2014-04-24 | 国立大学法人岡山大学 | 化合物、その互変異性体、幾何異性体、乃至それらの塩、及びそれらの製造方法、抗菌剤、並びに感染症治療薬 |
CN104936944B (zh) * | 2012-12-06 | 2017-09-12 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的吲哚满酮衍生物 |
CN105461609B (zh) * | 2015-12-25 | 2019-08-23 | 杭州新博思生物医药有限公司 | 一种尼达尼布的制备方法 |
CN114213396B (zh) * | 2022-01-27 | 2023-03-24 | 深圳市乐土生物医药有限公司 | 一种吲哚-2-酮类化合物及其制备方法与用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1115704T1 (en) * | 1998-09-25 | 2003-12-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes |
GB9904933D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
US6559173B1 (en) * | 2001-09-27 | 2003-05-06 | Allergan, Inc. | 3-(heteroarylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors |
CA2461812C (en) * | 2001-09-27 | 2011-09-20 | Allergan, Inc. | 3-(arylamino)methylene-1,3-dihydro-2h-indol-2-ones as kinase inhibitors |
-
2003
- 2003-07-21 PE PE2003000724A patent/PE20040701A1/es not_active Application Discontinuation
- 2003-07-22 PL PL03374879A patent/PL374879A1/pl unknown
- 2003-07-22 ES ES03765079T patent/ES2409062T3/es not_active Expired - Lifetime
- 2003-07-22 BR BR0312799-0A patent/BR0312799A/pt not_active Expired - Fee Related
- 2003-07-22 JP JP2004522540A patent/JP4401291B2/ja not_active Expired - Fee Related
- 2003-07-22 DK DK03765079.3T patent/DK1523473T3/da active
- 2003-07-22 KR KR1020117030702A patent/KR20120003025A/ko not_active Application Discontinuation
- 2003-07-22 MY MYPI20032755A patent/MY138141A/en unknown
- 2003-07-22 PL PL397821A patent/PL397821A1/pl unknown
- 2003-07-22 KR KR1020057001222A patent/KR20050052456A/ko active IP Right Grant
- 2003-07-22 WO PCT/EP2003/007961 patent/WO2004009547A1/de active Application Filing
- 2003-07-22 EA EA200500148A patent/EA008623B1/ru not_active IP Right Cessation
- 2003-07-22 CA CA2493436A patent/CA2493436C/en not_active Expired - Fee Related
- 2003-07-22 MX MXPA04012937A patent/MXPA04012937A/es active IP Right Grant
- 2003-07-22 EP EP03765079A patent/EP1523473B1/de not_active Expired - Lifetime
- 2003-07-22 RS YUP-2005/0047A patent/RS20050047A/sr unknown
- 2003-07-22 CN CNB038173174A patent/CN1318403C/zh not_active Expired - Fee Related
- 2003-07-22 TW TW092119987A patent/TWI343375B/zh not_active IP Right Cessation
- 2003-07-22 AU AU2003254557A patent/AU2003254557B2/en not_active Ceased
- 2003-07-23 UY UY27903A patent/UY27903A1/es not_active Application Discontinuation
- 2003-07-23 AR ARP030102634A patent/AR041188A1/es not_active Suspension/Interruption
- 2003-12-07 SA SA3240430A patent/SA03240430B1/ar unknown
-
2005
- 2005-01-20 IL IL16640405A patent/IL166404A0/xx not_active IP Right Cessation
- 2005-01-21 HR HR20050069A patent/HRP20050069A2/hr not_active Application Discontinuation
- 2005-01-24 EC EC2005005567A patent/ECSP055567A/es unknown
- 2005-02-21 NO NO20050937A patent/NO20050937L/no not_active Application Discontinuation
-
2006
- 2006-02-16 HK HK06101988A patent/HK1081554A1/xx not_active IP Right Cessation
-
2010
- 2010-07-06 AU AU2010202845A patent/AU2010202845A1/en not_active Ceased
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
DISC | Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications) |