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PL3546458T3 - ((pirydyn-2-ylo)amino)pirydo[3,4-d]pirymidynowe i ((pirydazyn-3-ylo)amino)pirydo[3,4-d]pirymidynowe pochodne jako inhibitory cdk4/6 w leczeniu np. reumatoidalnego zapalenia stawów, miażdżycy tętnic, zwłóknienia płuc, zawału mózgu lub raka - Google Patents

((pirydyn-2-ylo)amino)pirydo[3,4-d]pirymidynowe i ((pirydazyn-3-ylo)amino)pirydo[3,4-d]pirymidynowe pochodne jako inhibitory cdk4/6 w leczeniu np. reumatoidalnego zapalenia stawów, miażdżycy tętnic, zwłóknienia płuc, zawału mózgu lub raka

Info

Publication number
PL3546458T3
PL3546458T3 PL17874165T PL17874165T PL3546458T3 PL 3546458 T3 PL3546458 T3 PL 3546458T3 PL 17874165 T PL17874165 T PL 17874165T PL 17874165 T PL17874165 T PL 17874165T PL 3546458 T3 PL3546458 T3 PL 3546458T3
Authority
PL
Poland
Prior art keywords
pyrido
amino
pyrimidine
cdk4
pyridazin
Prior art date
Application number
PL17874165T
Other languages
English (en)
Inventor
Tsuyoshi Mizuno
Tomohiro Shimada
Gen Unoki
Akinobu MARUYAMA
Kosuke Sasaki
Takuya YOKOSAKA
Hiroshi Takahashi
Kyohei HORIE
Yuri Sakai
Original Assignee
Teijin Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Pharma Limited filed Critical Teijin Pharma Limited
Publication of PL3546458T3 publication Critical patent/PL3546458T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL17874165T 2016-11-28 2017-11-27 ((pirydyn-2-ylo)amino)pirydo[3,4-d]pirymidynowe i ((pirydazyn-3-ylo)amino)pirydo[3,4-d]pirymidynowe pochodne jako inhibitory cdk4/6 w leczeniu np. reumatoidalnego zapalenia stawów, miażdżycy tętnic, zwłóknienia płuc, zawału mózgu lub raka PL3546458T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016229969 2016-11-28
EP17874165.8A EP3546458B1 (en) 2016-11-28 2017-11-27 ((pyridin-2-yl)-amino)pyrido[3,4-d]pyrimidine and ((pyridazin-3-yl)-amino)pyrido[3,4-d]pyrimidine derivatives as cdk4/6 inhibitors for treating e.g. rheumatoid arthritis, arteriosclerosis, pulmonary fibrosis, cerebral infarction or cancer
PCT/JP2017/042443 WO2018097297A1 (ja) 2016-11-28 2017-11-27 ピリド［３，４－ｄ］ピリミジン誘導体及びその薬学的に許容される塩

Publications (1)

Publication Number Publication Date
PL3546458T3 true PL3546458T3 (pl) 2021-06-14

Family

ID=62194988

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17874165T PL3546458T3 (pl) 2016-11-28 2017-11-27 ((pirydyn-2-ylo)amino)pirydo[3,4-d]pirymidynowe i ((pirydazyn-3-ylo)amino)pirydo[3,4-d]pirymidynowe pochodne jako inhibitory cdk4/6 w leczeniu np. reumatoidalnego zapalenia stawów, miażdżycy tętnic, zwłóknienia płuc, zawału mózgu lub raka

Country Status (28)

Country Link
US (1) US11084814B2 (pl)
EP (1) EP3546458B1 (pl)
JP (1) JP6785876B2 (pl)
KR (1) KR102290815B1 (pl)
CN (1) CN110036012B (pl)
AR (1) AR110238A1 (pl)
AU (1) AU2017364807B2 (pl)
BR (1) BR112019010674A2 (pl)
CA (1) CA3043561A1 (pl)
CL (1) CL2019001419A1 (pl)
CO (1) CO2019005514A2 (pl)
CY (1) CY1123850T1 (pl)
DK (1) DK3546458T3 (pl)
ES (1) ES2852123T3 (pl)
HR (1) HRP20210285T1 (pl)
HU (1) HUE053220T2 (pl)
IL (1) IL266312B (pl)
LT (1) LT3546458T (pl)
MX (1) MX2019005803A (pl)
MY (1) MY196497A (pl)
PH (1) PH12019501171A1 (pl)
PL (1) PL3546458T3 (pl)
PT (1) PT3546458T (pl)
SA (1) SA519401827B1 (pl)
SI (1) SI3546458T1 (pl)
TW (1) TWI799399B (pl)
WO (1) WO2018097297A1 (pl)
ZA (1) ZA201902893B (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022037592A1 (zh) * 2020-08-17 2022-02-24 南京明德新药研发有限公司 嘧啶并环类化合物
CN113636973B (zh) * 2021-09-07 2023-04-07 山东铂源药业股份有限公司 一种4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯的工业化制备方法
WO2023155841A1 (zh) * 2022-02-16 2023-08-24 南京明德新药研发有限公司 嘧啶并环类化合物的盐型、晶型
TW202412784A (zh) * 2022-07-18 2024-04-01 美商依安彼克醫療有限公司 氮-喹唑啉化合物及使用方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP1767A (en) 2002-01-22 2007-08-13 Warner Lambert Co 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones.
BRPI0917791B1 (pt) 2008-08-22 2022-03-22 Novartis Ag Compostos de pirrolopirimidina como inibidores de cdk, bem como composição farmacêutica e combinação
AU2009298367A1 (en) 2008-10-01 2010-04-08 The University Of North Carolina At Chapel Hill Hematopoietic protection against chemotherapeutic compounds using selective cyclin-dependent kinase 4/6 inhibitors
JO2885B1 (en) 2008-12-22 2015-03-15 ايلي ليلي اند كومباني Protein kinase inhibitors
CN103189369B (zh) 2010-09-01 2016-08-24 吉利德康涅狄格有限公司 吡啶酮/吡嗪酮、其制备方法及使用方法
GB201216017D0 (en) * 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Inhibitor compounds
WO2014183520A1 (zh) * 2013-05-17 2014-11-20 上海恒瑞医药有限公司 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用
NZ718190A (en) 2013-08-23 2017-10-27 Neupharma Inc Substituted quinazolines for inhibiting kinase activity
US9914839B2 (en) * 2013-09-30 2018-03-13 Certainteed Corporation Stain repellent and VOC eliminating coatings and use thereof
GB201403536D0 (en) * 2014-02-28 2014-04-16 Cancer Rec Tech Ltd Inhibitor compounds
US9828373B2 (en) 2014-07-26 2017-11-28 Sunshine Lake Pharma Co., Ltd. 2-amino-pyrido[2,3-D]pyrimidin-7(8H)-one derivatives as CDK inhibitors and uses thereof
EP3305785B1 (en) * 2015-05-29 2021-08-25 Teijin Pharma Limited Pyrido[3,4-d]pyrimidine derivative and pharmaceutically acceptable salt thereof

Also Published As

Publication number Publication date
SA519401827B1 (ar) 2022-07-28
LT3546458T (lt) 2021-05-10
WO2018097297A1 (ja) 2018-05-31
EP3546458A4 (en) 2019-10-09
EP3546458B1 (en) 2021-01-06
JPWO2018097297A1 (ja) 2019-06-24
CY1123850T1 (el) 2022-05-27
TW201831476A (zh) 2018-09-01
BR112019010674A2 (pt) 2019-10-01
CL2019001419A1 (es) 2019-08-30
PT3546458T (pt) 2021-02-25
KR20190066631A (ko) 2019-06-13
TWI799399B (zh) 2023-04-21
CN110036012B (zh) 2022-05-10
HRP20210285T1 (hr) 2021-04-02
AR110238A1 (es) 2019-03-13
RU2019116137A3 (pl) 2021-08-13
ES2852123T3 (es) 2021-09-13
MX2019005803A (es) 2019-09-10
CN110036012A (zh) 2019-07-19
JP6785876B2 (ja) 2020-11-18
DK3546458T3 (da) 2021-02-22
SI3546458T1 (sl) 2021-03-31
CO2019005514A2 (es) 2019-07-31
PH12019501171A1 (en) 2021-02-08
EP3546458A1 (en) 2019-10-02
MY196497A (en) 2023-04-17
US11084814B2 (en) 2021-08-10
AU2017364807A1 (en) 2019-05-16
IL266312B (en) 2021-08-31
KR102290815B1 (ko) 2021-08-18
ZA201902893B (en) 2020-01-29
IL266312A (en) 2019-06-30
HUE053220T2 (hu) 2021-06-28
US20190367510A1 (en) 2019-12-05
RU2019116137A (ru) 2020-11-27
AU2017364807B2 (en) 2021-05-13
CA3043561A1 (en) 2018-05-31

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