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PL3448364T3 - Celowanie we wrodzony układ immunologiczny dla wywołania długotrwałej tolerancji i wyeliminowania akumulacji makrofagów w miażdżycy naczyń - Google Patents

Celowanie we wrodzony układ immunologiczny dla wywołania długotrwałej tolerancji i wyeliminowania akumulacji makrofagów w miażdżycy naczyń

Info

Publication number
PL3448364T3
PL3448364T3 PL17790646.8T PL17790646T PL3448364T3 PL 3448364 T3 PL3448364 T3 PL 3448364T3 PL 17790646 T PL17790646 T PL 17790646T PL 3448364 T3 PL3448364 T3 PL 3448364T3
Authority
PL
Poland
Prior art keywords
atherosclerosis
resolve
targeting
immune system
innate immune
Prior art date
Application number
PL17790646.8T
Other languages
English (en)
Inventor
Willem Mulder
Jordi OCHANDO
Zahi Fayad
Mounia BRAZA
Raphael DUIVENVOORDEN
Francois Fay
Original Assignee
Icahn School Of Medicine At Mount Sinai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icahn School Of Medicine At Mount Sinai filed Critical Icahn School Of Medicine At Mount Sinai
Publication of PL3448364T3 publication Critical patent/PL3448364T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5169Proteins, e.g. albumin, gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A61K51/1224Lipoprotein vesicles, e.g. HDL and LDL proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1275Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5123Organic compounds, e.g. fats, sugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL17790646.8T 2016-04-29 2017-05-01 Celowanie we wrodzony układ immunologiczny dla wywołania długotrwałej tolerancji i wyeliminowania akumulacji makrofagów w miażdżycy naczyń PL3448364T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662329676P 2016-04-29 2016-04-29
PCT/US2017/030444 WO2017190145A1 (en) 2016-04-29 2017-05-01 Targeting the innate immune system to induce long-term tolerance and to resolve macrophage accumulation in atherosclerosis

Publications (1)

Publication Number Publication Date
PL3448364T3 true PL3448364T3 (pl) 2022-08-16

Family

ID=60161161

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17790646.8T PL3448364T3 (pl) 2016-04-29 2017-05-01 Celowanie we wrodzony układ immunologiczny dla wywołania długotrwałej tolerancji i wyeliminowania akumulacji makrofagów w miażdżycy naczyń

Country Status (11)

Country Link
US (2) US20190290593A1 (pl)
EP (2) EP4014967A1 (pl)
JP (2) JP7262100B2 (pl)
CN (2) CN116077439A (pl)
AU (2) AU2017257189B2 (pl)
CA (1) CA3021645A1 (pl)
DK (1) DK3448364T3 (pl)
ES (1) ES2913073T3 (pl)
PL (1) PL3448364T3 (pl)
PT (1) PT3448364T (pl)
WO (1) WO2017190145A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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EP3713547A4 (en) * 2017-11-20 2023-07-19 Icahn School of Medicine at Mount Sinai TRAINED IMMUNITY INHIBITION USING A THERAPEUTIC BIOLOGICAL NANO-COMPOSITION
CA3144710A1 (en) * 2019-07-19 2021-01-28 James J. MOON Compositions and methods for treating autoimmune disorders
CA3162617A1 (en) * 2019-11-22 2021-05-27 The Research Foundation For The State University Of New York Compositions and methods for use in type 1 diabetes
CN111494320A (zh) * 2020-04-24 2020-08-07 上海交通大学医学院附属仁济医院 一种载糖皮质激素的纳米载体及其制备和应用
CA3212571A1 (en) * 2021-03-19 2022-09-22 Trained Therapeutix Discovery, Inc. Compounds for regulating trained immunity, and their methods of use
CN114788835B (zh) * 2022-04-07 2024-01-23 中山大学附属第三医院 Foxp3阳性巨噬细胞在制备治疗急性脑梗死药物中的应用

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US5549910A (en) 1989-03-31 1996-08-27 The Regents Of The University Of California Preparation of liposome and lipid complex compositions
JP3218637B2 (ja) 1990-07-26 2001-10-15 大正製薬株式会社 安定なリポソーム水懸濁液
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Also Published As

Publication number Publication date
EP3448364A4 (en) 2019-12-25
DK3448364T3 (da) 2022-05-02
PT3448364T (pt) 2022-05-04
CN116077439A (zh) 2023-05-09
EP4014967A1 (en) 2022-06-22
CN109640959A (zh) 2019-04-16
JP2019515926A (ja) 2019-06-13
WO2017190145A1 (en) 2017-11-02
CA3021645A1 (en) 2017-11-02
US20230218537A1 (en) 2023-07-13
US20190290593A1 (en) 2019-09-26
JP7262100B2 (ja) 2023-04-21
AU2017257189B2 (en) 2022-03-31
ES2913073T3 (es) 2022-05-31
EP3448364B1 (en) 2022-02-09
EP3448364A1 (en) 2019-03-06
CN109640959B (zh) 2023-03-17
AU2017257189A1 (en) 2018-11-15
AU2022204675A1 (en) 2022-09-15
JP2023085437A (ja) 2023-06-20

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