PL334318A1 - Method of obtaining intermediate products for use in synthesising antagonists of endotheline by dissymmetrical addition employing a chiral additive - Google Patents
Method of obtaining intermediate products for use in synthesising antagonists of endotheline by dissymmetrical addition employing a chiral additiveInfo
- Publication number
- PL334318A1 PL334318A1 PL98334318A PL33431898A PL334318A1 PL 334318 A1 PL334318 A1 PL 334318A1 PL 98334318 A PL98334318 A PL 98334318A PL 33431898 A PL33431898 A PL 33431898A PL 334318 A1 PL334318 A1 PL 334318A1
- Authority
- PL
- Poland
- Prior art keywords
- endotheline
- dissymmetrical
- synthesising
- antagonists
- intermediate products
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/48—Aldehydo radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Steroid Compounds (AREA)
- Length Measuring Devices By Optical Means (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3546297P | 1997-01-14 | 1997-01-14 | |
GBGB9705858.0A GB9705858D0 (en) | 1997-03-21 | 1997-03-21 | Asymmetric conjugate addition reaction using a chiral additive |
PCT/US1998/000263 WO1998030543A1 (en) | 1997-01-14 | 1998-01-09 | Endothelin intermediates by asymmetric conjugate addition reaction using a chiral additive |
Publications (1)
Publication Number | Publication Date |
---|---|
PL334318A1 true PL334318A1 (en) | 2000-02-14 |
Family
ID=26311228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL98334318A PL334318A1 (en) | 1997-01-14 | 1998-01-09 | Method of obtaining intermediate products for use in synthesising antagonists of endotheline by dissymmetrical addition employing a chiral additive |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0973742A1 (en) |
JP (1) | JP2000507969A (en) |
KR (1) | KR20000070085A (en) |
CN (1) | CN1243509A (en) |
AU (1) | AU728441B2 (en) |
BR (1) | BR9806875A (en) |
CA (1) | CA2277161A1 (en) |
EA (1) | EA002056B1 (en) |
HR (1) | HRP980001A2 (en) |
NZ (1) | NZ336220A (en) |
PL (1) | PL334318A1 (en) |
SK (1) | SK93499A3 (en) |
TW (1) | TW432028B (en) |
WO (1) | WO1998030543A1 (en) |
YU (1) | YU30499A (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010014352A1 (en) | 1998-05-27 | 2001-08-16 | Udit Batra | Compressed tablet formulation |
US6465664B1 (en) | 1999-09-15 | 2002-10-15 | Massachusetts Institute Of Technology | Asymmetric 1,4-reductions of and 1,4-additions to enoates and related systems |
GB2355988A (en) | 1999-10-28 | 2001-05-09 | Merck & Co Inc | Synthesis of cyclopropylacetylene in a one-pot process using a diazo-keto-phos phonate |
GB2355724A (en) | 1999-10-28 | 2001-05-02 | Merck & Co Inc | Synthesis of cyclopropylacetylene from propiolic acid (2-propynoic acid) |
US8115032B2 (en) | 2009-04-09 | 2012-02-14 | Lonza Ltd. | Process for the synthesis of a propargylic alcohol |
EP2417097A2 (en) | 2009-04-09 | 2012-02-15 | Lonza Ltd. | Autocatalytic process for the synthesis of chiral propargylic alcohols |
EP2447255A1 (en) | 2010-10-14 | 2012-05-02 | Lonza Ltd. | Process for the synthesis of cyclic carbamates |
EP2447247A1 (en) | 2010-10-14 | 2012-05-02 | Lonza Ltd. | Process for the synthesis of chiral propargylic alcohols |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2086544C1 (en) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Benzenesulfonamide derivatives of pyrimidine or their salts, pharmaceutical composition for treatment of diseases associated with endothelin activity |
DK0612244T3 (en) * | 1991-11-05 | 2002-01-14 | Smithkline Beecham Corp | endothelin receptor antagonists |
-
1998
- 1998-01-05 TW TW087100082A patent/TW432028B/en not_active IP Right Cessation
- 1998-01-05 HR HR9705858.0A patent/HRP980001A2/en not_active Application Discontinuation
- 1998-01-09 CN CN98801833A patent/CN1243509A/en active Pending
- 1998-01-09 KR KR1019997006306A patent/KR20000070085A/en not_active Application Discontinuation
- 1998-01-09 YU YU30499A patent/YU30499A/en unknown
- 1998-01-09 NZ NZ336220A patent/NZ336220A/en unknown
- 1998-01-09 SK SK934-99A patent/SK93499A3/en unknown
- 1998-01-09 JP JP10531063A patent/JP2000507969A/en active Pending
- 1998-01-09 PL PL98334318A patent/PL334318A1/en unknown
- 1998-01-09 AU AU59089/98A patent/AU728441B2/en not_active Ceased
- 1998-01-09 WO PCT/US1998/000263 patent/WO1998030543A1/en not_active Application Discontinuation
- 1998-01-09 EP EP98902416A patent/EP0973742A1/en not_active Withdrawn
- 1998-01-09 BR BR9806875-0A patent/BR9806875A/en not_active IP Right Cessation
- 1998-01-09 EA EA199900661A patent/EA002056B1/en not_active IP Right Cessation
- 1998-01-09 CA CA002277161A patent/CA2277161A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EA002056B1 (en) | 2001-12-24 |
TW432028B (en) | 2001-05-01 |
YU30499A (en) | 2002-06-19 |
CN1243509A (en) | 2000-02-02 |
WO1998030543A1 (en) | 1998-07-16 |
JP2000507969A (en) | 2000-06-27 |
EP0973742A1 (en) | 2000-01-26 |
EA199900661A1 (en) | 2000-02-28 |
NZ336220A (en) | 2000-12-22 |
HRP980001A2 (en) | 1998-10-31 |
BR9806875A (en) | 2000-04-18 |
SK93499A3 (en) | 2000-05-16 |
KR20000070085A (en) | 2000-11-25 |
AU728441B2 (en) | 2001-01-11 |
CA2277161A1 (en) | 1998-07-16 |
AU5908998A (en) | 1998-08-03 |
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