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PL3039123T3 - Sposób wytwarzania komórek progenitorowych dorosłej wątroby - Google Patents

Sposób wytwarzania komórek progenitorowych dorosłej wątroby

Info

Publication number
PL3039123T3
PL3039123T3 PL14780421T PL14780421T PL3039123T3 PL 3039123 T3 PL3039123 T3 PL 3039123T3 PL 14780421 T PL14780421 T PL 14780421T PL 14780421 T PL14780421 T PL 14780421T PL 3039123 T3 PL3039123 T3 PL 3039123T3
Authority
PL
Poland
Prior art keywords
progenitor cells
adult liver
liver progenitor
producing adult
producing
Prior art date
Application number
PL14780421T
Other languages
English (en)
Inventor
Etienne Sokal
Sarah Snykers
Tuba BARAN
Kris GELLYNCK
Original Assignee
Promethera Biosciences S.A. / N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promethera Biosciences S.A. / N.V. filed Critical Promethera Biosciences S.A. / N.V.
Publication of PL3039123T3 publication Critical patent/PL3039123T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37Digestive system
    • A61K35/407Liver; Hepatocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/067Hepatocytes
    • C12N5/0672Stem cells; Progenitor cells; Precursor cells; Oval cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067Liver cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/11Epidermal growth factor [EGF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/12Hepatocyte growth factor [HGF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70Enzymes
    • C12N2501/73Hydrolases (EC 3.)
    • C12N2501/734Proteases (EC 3.4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/54Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
PL14780421T 2013-08-28 2014-08-28 Sposób wytwarzania komórek progenitorowych dorosłej wątroby PL3039123T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361870983P 2013-08-28 2013-08-28
PCT/EP2014/068317 WO2015028577A1 (en) 2013-08-28 2014-08-28 Method for producing adult liver progenitor cells
EP14780421.5A EP3039123B1 (en) 2013-08-28 2014-08-28 Method for producing adult liver progenitor cells

Publications (1)

Publication Number Publication Date
PL3039123T3 true PL3039123T3 (pl) 2021-07-19

Family

ID=51659609

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14780421T PL3039123T3 (pl) 2013-08-28 2014-08-28 Sposób wytwarzania komórek progenitorowych dorosłej wątroby

Country Status (16)

Country Link
US (2) US10172889B2 (pl)
EP (2) EP3039123B1 (pl)
JP (2) JP6974941B2 (pl)
KR (2) KR101954743B1 (pl)
CN (1) CN105658786B (pl)
AU (1) AU2014314152B2 (pl)
CA (1) CA2922247C (pl)
DK (1) DK3039123T3 (pl)
EA (1) EA034878B1 (pl)
ES (1) ES2764408T3 (pl)
IL (1) IL244205B (pl)
MX (1) MX369514B (pl)
PL (1) PL3039123T3 (pl)
PT (1) PT3039123T (pl)
SG (1) SG11201601485UA (pl)
WO (1) WO2015028577A1 (pl)

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US10174289B2 (en) 2014-05-28 2019-01-08 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
LT3140393T (lt) * 2014-08-28 2023-09-11 Cellaïon SA Suaugusiųjų kepenų ląstelių pradininkių produkavimo metodas
US11584916B2 (en) 2014-10-17 2023-02-21 Children's Hospital Medical Center Method of making in vivo human small intestine organoids from pluripotent stem cells
US10179896B2 (en) 2015-05-12 2019-01-15 Baker Group, LLP Method and system for a bioartificial organ
AU2017205801A1 (en) 2016-01-08 2018-08-16 Cynity Co., Ltd. Method for producing hepatic stem/precursor cells from mature hepatic cells using low-molecular-weight compound
MA45274A (fr) * 2016-03-02 2019-01-09 Univ Catholique Louvain Préparations améliorées de cellules progénitrices hépatiques adultes
CA3016641A1 (en) 2016-05-05 2017-11-09 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
US11506652B2 (en) * 2016-07-12 2022-11-22 EMULATE, Inc. Compositions and methods of cell attachment
KR102546194B1 (ko) 2016-11-04 2023-06-21 칠드런즈 호스피탈 메디칼 센터 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법
US11492595B2 (en) * 2016-11-23 2022-11-08 Morphocell Technologies Inc. Encapsulated liver tissue
WO2018106628A1 (en) 2016-12-05 2018-06-14 Children's Hospital Medical Center Colonic organoids and methods of making and using same
WO2018191673A1 (en) 2017-04-14 2018-10-18 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
KR102107602B1 (ko) * 2017-05-29 2020-05-08 한양대학교 산학협력단 인간 성체 간세포 리프로그래밍 배지 조성물
WO2018231726A1 (en) 2017-06-12 2018-12-20 The University Of North Carolina At Chapel Hill Patch graft compositions for cell engraftment
EP3694603A4 (en) 2017-10-10 2021-07-14 Children's Hospital Medical Center ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF
WO2019126626A1 (en) 2017-12-21 2019-06-27 Children's Hospital Medical Center Digitalized human organoids and methods of using same
WO2019219828A1 (en) * 2018-05-16 2019-11-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Method of culturing proliferative hepatocytes
WO2020023245A1 (en) 2018-07-26 2020-01-30 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
SG11202102431YA (en) 2018-09-12 2021-04-29 Childrens Hospital Med Ct Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
CA3122715A1 (en) 2018-12-14 2020-06-18 Promethera Therapeutics Sa Cell composition comprising liver progenitor cells expressing hla-e
WO2020120666A1 (en) 2018-12-14 2020-06-18 Promethera Biosciences S.A./N.V. Liver progenitor cells expressing hla-g, and method for obtaining these cells compositions comprising said cells and their use
TW202100171A (zh) 2019-03-26 2021-01-01 比利時商普羅米修亞生物科技股份有限公司 用於治療非酒精性脂肪肝疾病的成人肝臟前驅細胞
TW202100170A (zh) 2019-03-26 2021-01-01 比利時商普羅米修亞生物科技股份有限公司 用於治療慢性肝衰竭之急性發作的成人肝先驅細胞
TW202106874A (zh) 2019-04-30 2021-02-16 比利時商普羅米修亞生物科技股份有限公司 人類同種異體肝衍生前驅細胞的製備(一)
JP2022530620A (ja) * 2019-04-30 2022-06-30 プロメセラ セラピューティクス エスエイ ヒト同種肝臓由来前駆細胞の調製
CA3141814A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
EP3976066A4 (en) 2019-05-31 2023-06-28 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
CN111394391B (zh) * 2019-07-11 2022-12-06 上海赛立维生物科技有限公司 肝祖细胞样细胞库的构建方法及其制备的细胞株与应用
EP4041261A1 (en) 2019-10-09 2022-08-17 Cellaion SA Use of liver progenitor or stem cells, lysates thereof, and/or conditioned medium in disorders characterized by vascular hyperpermeability
EP3881853A1 (en) 2020-03-20 2021-09-22 Promethera Therapeutics Sa Human allogeneic liver-derived progenitor cells for use in the treatment of inflammatory and infectious lung diseases and systemic inflammation
CN111778268B (zh) * 2020-06-03 2022-06-21 武汉仝干医疗科技股份有限公司 增强解毒功能基因片段及改造的HepG2细胞
WO2022035287A1 (ko) * 2020-08-14 2022-02-17 한양대학교 산학협력단 체외에서 유전자 교정된 세포 및 이의 용도
CN113380343B (zh) * 2021-06-11 2023-10-31 中国食品药品检定研究院 基于oatp1b1和oatp1b3的何首乌中肝毒性化合物的快速筛选方法
WO2023180122A1 (en) 2022-03-24 2023-09-28 Université Catholique de Louvain Use of human allogenic liver-derived progenitor cells for treating and/or preventing cellular senescence
US11898127B1 (en) * 2022-09-26 2024-02-13 Upside Foods, Inc. Harvesting cell-based meat
WO2024200809A1 (en) 2023-03-31 2024-10-03 Université Catholique de Louvain Use of human allogenic liver-derived progenitor cells for treating and/or preventing hepatocellular carcinoma

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US6129911A (en) * 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
US6872389B1 (en) * 1999-07-08 2005-03-29 Rhode Island Hospital Liver stem cell
SE527491C2 (sv) 2003-12-19 2006-03-21 Cmc Contrast Ab Kontraktsmedelskomposition för magnetisk resonanstomografi för oral administration
JP5250423B2 (ja) 2005-12-21 2013-07-31 ユニヴァルシテ カソリック デ ルーバン 単離肝幹細胞
CN101356264B (zh) * 2005-12-21 2014-05-14 鲁汶大学 分离的肝脏干细胞
LT3140393T (lt) 2014-08-28 2023-09-11 Cellaïon SA Suaugusiųjų kepenų ląstelių pradininkių produkavimo metodas

Also Published As

Publication number Publication date
EP3039123B1 (en) 2019-11-06
JP6974941B2 (ja) 2021-12-01
SG11201601485UA (en) 2016-03-30
KR101954743B1 (ko) 2019-03-06
MX2016002582A (es) 2016-10-26
US20160206664A1 (en) 2016-07-21
AU2014314152B2 (en) 2020-02-06
DK3039123T3 (da) 2020-01-20
PT3039123T (pt) 2020-01-16
KR20190022939A (ko) 2019-03-06
JP2020127429A (ja) 2020-08-27
ES2764408T3 (es) 2020-06-03
KR20160047523A (ko) 2016-05-02
EA034878B1 (ru) 2020-04-01
IL244205B (en) 2020-03-31
CN105658786A (zh) 2016-06-08
US10172889B2 (en) 2019-01-08
IL244205A0 (en) 2016-04-21
WO2015028577A1 (en) 2015-03-05
EP3039123A1 (en) 2016-07-06
CA2922247A1 (en) 2015-03-05
EP3620514A1 (en) 2020-03-11
JP6884908B2 (ja) 2021-06-09
CN105658786B (zh) 2020-07-03
JP2016530884A (ja) 2016-10-06
CA2922247C (en) 2023-03-07
AU2014314152A1 (en) 2016-03-17
US20190134098A1 (en) 2019-05-09
EA201690398A1 (ru) 2016-08-31
MX369514B (es) 2019-11-11

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