PL2566972T3 - Kompozycje do wiązania modułów z motywem palca cynkowego - Google Patents
Kompozycje do wiązania modułów z motywem palca cynkowegoInfo
- Publication number
- PL2566972T3 PL2566972T3 PL11777690T PL11777690T PL2566972T3 PL 2566972 T3 PL2566972 T3 PL 2566972T3 PL 11777690 T PL11777690 T PL 11777690T PL 11777690 T PL11777690 T PL 11777690T PL 2566972 T3 PL2566972 T3 PL 2566972T3
- Authority
- PL
- Poland
- Prior art keywords
- compositions
- zinc finger
- finger modules
- linking zinc
- linking
- Prior art date
Links
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000011701 zinc Substances 0.000 title 1
- 229910052725 zinc Inorganic materials 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Contacts (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34372910P | 2010-05-03 | 2010-05-03 | |
| PCT/US2011/000758 WO2011139349A1 (en) | 2010-05-03 | 2011-05-02 | Compositions for linking zinc finger modules |
| EP11777690.6A EP2566972B1 (en) | 2010-05-03 | 2011-05-02 | Compositions for linking zinc finger modules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2566972T3 true PL2566972T3 (pl) | 2020-06-29 |
Family
ID=44903931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11777690T PL2566972T3 (pl) | 2010-05-03 | 2011-05-02 | Kompozycje do wiązania modułów z motywem palca cynkowego |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8772453B2 (pl) |
| EP (2) | EP3636766A1 (pl) |
| JP (1) | JP5898179B2 (pl) |
| KR (2) | KR20130073887A (pl) |
| CN (1) | CN102959087B (pl) |
| AU (1) | AU2011249019B2 (pl) |
| CA (1) | CA2797189C (pl) |
| CY (1) | CY1122636T1 (pl) |
| DK (1) | DK2566972T3 (pl) |
| ES (1) | ES2773052T3 (pl) |
| HR (1) | HRP20200254T1 (pl) |
| HU (1) | HUE048072T2 (pl) |
| IL (1) | IL222632B (pl) |
| LT (1) | LT2566972T (pl) |
| PL (1) | PL2566972T3 (pl) |
| PT (1) | PT2566972T (pl) |
| SI (1) | SI2566972T1 (pl) |
| WO (1) | WO2011139349A1 (pl) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120196370A1 (en) | 2010-12-03 | 2012-08-02 | Fyodor Urnov | Methods and compositions for targeted genomic deletion |
| CA2805442C (en) | 2010-07-21 | 2020-05-12 | Sangamo Biosciences, Inc. | Methods and compositions for modification of an hla locus |
| WO2012094132A1 (en) | 2011-01-05 | 2012-07-12 | Sangamo Biosciences, Inc. | Methods and compositions for gene correction |
| WO2013016446A2 (en) | 2011-07-25 | 2013-01-31 | Sangamo Biosciences, Inc. | Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (cftr) gene |
| US9222105B2 (en) | 2011-10-27 | 2015-12-29 | Sangamo Biosciences, Inc. | Methods and compositions for modification of the HPRT locus |
| US9528107B2 (en) | 2012-01-31 | 2016-12-27 | Pacific Biosciences Of California, Inc. | Compositions and methods for selection of nucleic acids |
| BR112014021104B1 (pt) | 2012-02-29 | 2023-03-28 | Sangamo Biosciences, Inc | Proteína de fusão de ocorrência não natural compreendendo um domínio de ligação de dna de dedo de zinco manipulado que se liga a um gene htt, seu uso, método in vitro de modificação da expressão de um gene htt em uma célula, e método de geração de um sistema modelo para o estudo da doença de huntington |
| US10648001B2 (en) | 2012-07-11 | 2020-05-12 | Sangamo Therapeutics, Inc. | Method of treating mucopolysaccharidosis type I or II |
| WO2014011901A2 (en) | 2012-07-11 | 2014-01-16 | Sangamo Biosciences, Inc. | Methods and compositions for delivery of biologics |
| US9650648B2 (en) | 2012-08-29 | 2017-05-16 | Sangamo Biosciences, Inc. | Methods and compositions for treatment of a genetic condition |
| US9290800B2 (en) | 2013-03-15 | 2016-03-22 | Pacific Biosciences Of California, Inc. | Targeted rolling circle amplification |
| US10501748B2 (en) | 2013-04-05 | 2019-12-10 | Dow Agrosciences Llc | Methods and compositions for integration of an exogenous sequence within the genome of plants |
| CA2920899C (en) | 2013-08-28 | 2023-02-28 | Sangamo Biosciences, Inc. | Compositions for linking dna-binding domains and cleavage domains |
| CN116836957A (zh) | 2013-10-17 | 2023-10-03 | 桑格摩生物科学股份有限公司 | 用于核酸酶介导的基因组工程改造的递送方法和组合物 |
| EP3057432B1 (en) | 2013-10-17 | 2018-11-21 | Sangamo Therapeutics, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells |
| NZ719477A (en) | 2013-11-11 | 2022-05-27 | Sangamo Therapeutics Inc | Methods and compositions for treating huntington’s disease |
| ES2721936T3 (es) | 2013-11-13 | 2019-08-06 | Childrens Medical Center | Regulación de la expresión genética mediada por las nucleasas |
| DK3102673T3 (da) | 2014-02-03 | 2020-07-06 | Sangamo Therapeutics Inc | Fremgangsmåder og sammensætninger til behandling af beta-talassæmi |
| JP6594891B2 (ja) | 2014-03-18 | 2019-10-23 | サンガモ セラピューティクス， インコーポレイテッド | ジンクフィンガータンパク質発現を調節するための方法および組成物 |
| US10435685B2 (en) | 2014-08-19 | 2019-10-08 | Pacific Biosciences Of California, Inc. | Compositions and methods for enrichment of nucleic acids |
| MX382223B (es) | 2015-05-12 | 2025-03-13 | Sangamo Therapeutics Inc | Regulacion de expresion genica mediada por nucleasa. |
| US9957501B2 (en) | 2015-06-18 | 2018-05-01 | Sangamo Therapeutics, Inc. | Nuclease-mediated regulation of gene expression |
| CA2991301A1 (en) | 2015-07-13 | 2017-01-19 | Sangamo Therapeutics, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering |
| EA201891212A1 (ru) | 2015-12-18 | 2019-01-31 | Сангамо Терапьютикс, Инк. | Адресная дезорганизация клеточного рецептора гкгс |
| JP7128741B2 (ja) | 2015-12-18 | 2022-08-31 | サンガモ セラピューティクス， インコーポレイテッド | Ｔ細胞受容体の標的化破壊 |
| SG11201805680SA (en) | 2016-01-15 | 2018-07-30 | Sangamo Therapeutics Inc | Methods and compositions for the treatment of neurologic disease |
| US10724020B2 (en) | 2016-02-02 | 2020-07-28 | Sangamo Therapeutics, Inc. | Compositions for linking DNA-binding domains and cleavage domains |
| PE20190568A1 (es) | 2016-08-24 | 2019-04-22 | Sangamo Therapeutics Inc | Regulacion de la expresion genica usando nucleasas modificadas |
| ES2901989T3 (es) | 2016-08-24 | 2022-03-24 | Sangamo Therapeutics Inc | Nucleasas específicas de objetivo modificadas |
| CN110022904B (zh) | 2016-10-20 | 2024-04-19 | 桑格摩生物治疗股份有限公司 | 用于治疗法布里病的方法和组合物 |
| AU2017347928A1 (en) | 2016-10-31 | 2019-05-09 | Sangamo Therapeutics, Inc. | Gene correction of scid-related genes in hematopoietic stem and progenitor cells |
| BR112019010014A2 (pt) | 2016-12-01 | 2019-08-20 | Sangamo Therapeutics Inc | moduladores de tau e métodos e composições para entrega dos mesmos |
| MA71412A (fr) | 2017-04-03 | 2025-04-30 | Encoded Therapeutics, Inc. | Expression de transgène sélective d'un tissu |
| CA3061612A1 (en) | 2017-04-28 | 2018-11-01 | Acuitas Therapeutics, Inc. | Novel carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| WO2018204469A2 (en) | 2017-05-03 | 2018-11-08 | Sangamo Therapeutics, Inc. | Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (cftr) gene |
| US11512287B2 (en) | 2017-06-16 | 2022-11-29 | Sangamo Therapeutics, Inc. | Targeted disruption of T cell and/or HLA receptors |
| CN111565730B (zh) | 2017-11-09 | 2024-09-17 | 桑格摩生物治疗股份有限公司 | 细胞因子诱导型含sh2蛋白（cish）基因的遗传修饰 |
| MA50942A (fr) | 2017-12-01 | 2020-10-07 | Encoded Therapeutics Inc | Protéines de liaison à l'adn modifiées |
| US11401512B2 (en) | 2018-02-08 | 2022-08-02 | Sangamo Therapeutics, Inc. | Engineered target specific nucleases |
| EP3781587A4 (en) * | 2018-04-18 | 2022-03-30 | Sangamo Therapeutics, Inc. | ZINC FINGER PROTEIN COMPOSITIONS FOR THE MODULATION OF HUNTINGTINE (HTT) |
| US11690921B2 (en) | 2018-05-18 | 2023-07-04 | Sangamo Therapeutics, Inc. | Delivery of target specific nucleases |
| KR102712986B1 (ko) | 2018-08-23 | 2024-10-07 | 상가모 테라퓨틱스, 인코포레이티드 | 조작된 표적 특이적 염기 편집기 |
| EP4234570A3 (en) | 2018-09-18 | 2023-12-13 | Sangamo Therapeutics, Inc. | Programmed cell death 1 (pd1) specific nucleases |
| EP3852911B1 (en) | 2018-09-21 | 2025-01-22 | Acuitas Therapeutics, Inc. | Systems and methods for manufacturing lipid nanoparticles and liposomes |
| CN113195002A (zh) * | 2018-10-02 | 2021-07-30 | 桑格摩生物治疗股份有限公司 | 工程化的遗传调节物 |
| CA3115156A1 (en) | 2018-10-02 | 2020-04-09 | Sangamo Therapeutics, Inc. | Methods and compositions for modulation of tau proteins |
| EP3908568B1 (en) | 2019-01-11 | 2024-06-26 | Acuitas Therapeutics, Inc. | Lipids for lipid nanoparticle delivery of active agents |
| WO2020162978A1 (en) | 2019-02-06 | 2020-08-13 | Sangamo Therapeutics, Inc. | Method for the treatment of mucopolysaccharidosis type i |
| MA55531A (fr) | 2019-04-02 | 2022-02-09 | Sangamo Therapeutics Inc | Procédés pour le traitement de béta-thalassémie |
| PE20212332A1 (es) | 2019-04-23 | 2021-12-14 | Sangamo Therapeutics Inc | Moduladores de la expresioon del gen de marco de lectura abierto 72 del cromosoma 9 y usos de los mismos |
| WO2021028359A1 (en) | 2019-08-09 | 2021-02-18 | Sangamo Therapeutics France | Controlled expression of chimeric antigen receptors in t cells |
| EP4041754A1 (en) | 2019-10-02 | 2022-08-17 | Sangamo Therapeutics, Inc. | Zinc finger protein transcription factors for repressing alpha-synuclein expression |
| US20230002459A1 (en) | 2019-10-02 | 2023-01-05 | Sangamo Therapeutics, Inc. | Zinc Finger Protein Transcription Factors for Treatment of Prion Disease |
| EP4051322A1 (en) | 2019-11-01 | 2022-09-07 | Sangamo Therapeutics, Inc. | Compositions and methods for genome engineering |
| AU2021209699A1 (en) | 2020-01-22 | 2022-07-21 | Sangamo Therapeutics, Inc. | Zinc finger protein transcription factors for repressing tau expression |
| KR20230051172A (ko) | 2020-07-16 | 2023-04-17 | 아퀴타스 테라퓨틱스 인크. | 지질 나노 입자에 사용하기 위한 양이온성 지질 |
| EP4204545A2 (en) | 2020-08-25 | 2023-07-05 | Kite Pharma, Inc. | T cells with improved functionality |
| CN116261594A (zh) | 2020-09-25 | 2023-06-13 | 桑格摩生物治疗股份有限公司 | 用于核碱基编辑的锌指融合蛋白 |
| UY39450A (es) | 2020-10-02 | 2022-04-29 | Sangamo Therapeutics Inc | Nuevos factores de transcripción de la proteína de dedo de zinc para reprimir la expresión de alfa- sinucleina |
| WO2022140577A2 (en) | 2020-12-22 | 2022-06-30 | Chroma Medicine, Inc. | Compositions and methods for epigenetic editing |
| EP4426832A1 (en) | 2021-11-03 | 2024-09-11 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Precise genome editing using retrons |
| JP2024546952A (ja) | 2021-12-16 | 2024-12-26 | アクイタス セラピューティクス インコーポレイテッド | 脂質ナノ粒子製剤に用いるための脂質 |
| CN118591626A (zh) | 2021-12-22 | 2024-09-03 | 桑格摩生物治疗股份有限公司 | 用于核碱基编辑的新型锌指融合蛋白 |
| WO2023141602A2 (en) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| IL316722A (en) | 2022-05-01 | 2024-12-01 | Chroma Medicine Inc | Compositions and methods for epigenetic regulation of PCSK9 expression |
| WO2023250490A1 (en) | 2022-06-23 | 2023-12-28 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of trac expression |
| IL317913A (en) | 2022-06-23 | 2025-02-01 | Chroma Medicine Inc | Compositions and methods for epigenetic regulation of B2M expression |
| EP4544058A1 (en) | 2022-06-23 | 2025-04-30 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of ciita expression |
| WO2024044723A1 (en) | 2022-08-25 | 2024-02-29 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| EP4590822A1 (en) | 2022-09-23 | 2025-07-30 | nChroma Bio, Inc. | Compositions and methods for epigenetic regulation of hbv gene expression |
| WO2024081879A1 (en) | 2022-10-14 | 2024-04-18 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of cd247 expression |
| WO2024238700A1 (en) | 2023-05-15 | 2024-11-21 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of hbv gene expression |
| WO2025049959A2 (en) | 2023-09-01 | 2025-03-06 | Renagade Therapeutics Management Inc. | Gene editing systems, compositions, and methods for treatment of vexas syndrome |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4512110A (en) | 1981-12-10 | 1985-04-23 | Timesavers, Inc. | Endless abrasive belts |
| US5422251A (en) | 1986-11-26 | 1995-06-06 | Princeton University | Triple-stranded nucleic acids |
| US5176996A (en) | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| US5420032A (en) | 1991-12-23 | 1995-05-30 | Universitge Laval | Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence |
| US5487994A (en) | 1992-04-03 | 1996-01-30 | The Johns Hopkins University | Insertion and deletion mutants of FokI restriction endonuclease |
| US5356802A (en) | 1992-04-03 | 1994-10-18 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease |
| US5436150A (en) | 1992-04-03 | 1995-07-25 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease |
| US5792632A (en) | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US6242568B1 (en) | 1994-01-18 | 2001-06-05 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| AU704601B2 (en) | 1994-01-18 | 1999-04-29 | Scripps Research Institute, The | Zinc finger protein derivatives and methods therefor |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US5585245A (en) | 1994-04-22 | 1996-12-17 | California Institute Of Technology | Ubiquitin-based split protein sensor |
| US7285416B2 (en) * | 2000-01-24 | 2007-10-23 | Gendaq Limited | Regulated gene expression in plants |
| ATE407205T1 (de) | 1994-08-20 | 2008-09-15 | Gendaq Ltd | Verbesserung in bezug auf bindungsproteine bei der erkennung von dna |
| GB9824544D0 (en) | 1998-11-09 | 1999-01-06 | Medical Res Council | Screening system |
| US5789538A (en) | 1995-02-03 | 1998-08-04 | Massachusetts Institute Of Technology | Zinc finger proteins with high affinity new DNA binding specificities |
| US5925523A (en) | 1996-08-23 | 1999-07-20 | President & Fellows Of Harvard College | Intraction trap assay, reagents and uses thereof |
| GB2338237B (en) | 1997-02-18 | 2001-02-28 | Actinova Ltd | In vitro peptide or protein expression library |
| GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| US6342345B1 (en) | 1997-04-02 | 2002-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by reporter subunit complementation |
| GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| GB9710807D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| US6410248B1 (en) | 1998-01-30 | 2002-06-25 | Massachusetts Institute Of Technology | General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites |
| ATE466952T1 (de) * | 1998-03-02 | 2010-05-15 | Massachusetts Inst Technology | Poly-zinkfinger-proteine mit verbesserten linkern |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US6794136B1 (en) | 2000-11-20 | 2004-09-21 | Sangamo Biosciences, Inc. | Iterative optimization in the design of binding proteins |
| US7151201B2 (en) | 2000-01-21 | 2006-12-19 | The Scripps Research Institute | Methods and compositions to modulate expression in plants |
| EP1250424B1 (en) | 2000-01-24 | 2007-02-28 | Gendaq, Ltd. | Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules |
| AU2001250774B2 (en) | 2000-02-08 | 2005-01-27 | Sangamo Biosciences, Inc. | Cells expressing zinc finger proteins for drug discovery |
| US20020061512A1 (en) | 2000-02-18 | 2002-05-23 | Kim Jin-Soo | Zinc finger domains and methods of identifying same |
| US20030044787A1 (en) | 2000-05-16 | 2003-03-06 | Joung J. Keith | Methods and compositions for interaction trap assays |
| US20060268407A1 (en) | 2000-07-07 | 2006-11-30 | Fergason James L | Display system using two displays and polarization direction rotation for showing high-resolution and three-dimensional images and method and use of a DBEF beam splitter |
| JP2002060786A (ja) | 2000-08-23 | 2002-02-26 | Kao Corp | 硬質表面用殺菌防汚剤 |
| US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| US20040197892A1 (en) * | 2001-04-04 | 2004-10-07 | Michael Moore | Composition binding polypeptides |
| GB0108491D0 (en) | 2001-04-04 | 2001-05-23 | Gendaq Ltd | Engineering zinc fingers |
| AU2002336373A1 (en) | 2001-08-20 | 2003-03-03 | The Scripps Research Institute | Zinc finger binding domains for cnn |
| US7262054B2 (en) | 2002-01-22 | 2007-08-28 | Sangamo Biosciences, Inc. | Zinc finger proteins for DNA binding and gene regulation in plants |
| JP2006513694A (ja) * | 2002-06-11 | 2006-04-27 | ザ スクリップス リサーチ インスティテュート | 人工転写因子 |
| US8409861B2 (en) | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
| US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| WO2005028630A2 (en) | 2003-09-19 | 2005-03-31 | Sangamo Biosciences, Inc. | Engineered zinc finger proteins for regulation of gene expression |
| KR20060123382A (ko) * | 2003-12-23 | 2006-12-01 | 주식회사 툴젠 | 징크 핑거 단백질을 이용한 원핵세포의 유전자 발현 조절 |
| US7972854B2 (en) | 2004-02-05 | 2011-07-05 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| WO2005100392A2 (en) | 2004-04-08 | 2005-10-27 | Sangamo Biosciences, Inc. | Treatment of neuropathic pain with zinc finger proteins |
| AU2005287278B2 (en) | 2004-09-16 | 2011-08-04 | Sangamo Biosciences, Inc. | Compositions and methods for protein production |
| WO2006121866A2 (en) | 2005-05-05 | 2006-11-16 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Sequence enabled reassembly (seer) - a novel method for visualizing specific dna sequences |
| CN101273141B (zh) | 2005-07-26 | 2013-03-27 | 桑格摩生物科学股份有限公司 | 外源核酸序列的靶向整合和表达 |
| US8021867B2 (en) | 2005-10-18 | 2011-09-20 | Duke University | Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity |
| EP2018424A2 (en) | 2006-05-19 | 2009-01-28 | Sangamo BioSciences, Inc. | Methods and compositions for inactivation of dihydrofolate reductase |
| EP2206782A1 (en) | 2006-05-25 | 2010-07-14 | Sangamo BioSciences, Inc. | Methods and compositions for gene inactivation |
| ATE462783T1 (de) | 2006-05-25 | 2010-04-15 | Sangamo Biosciences Inc | Variante foki-spaltungshälften-domänen |
| JP5188504B2 (ja) | 2006-11-13 | 2013-04-24 | サンガモ バイオサイエンシズ インコーポレイテッド | ヒトグルココルチコイド受容体遺伝子座の修飾のための方法および組成物 |
| US8110379B2 (en) | 2007-04-26 | 2012-02-07 | Sangamo Biosciences, Inc. | Targeted integration into the PPP1R12C locus |
| US9506120B2 (en) | 2007-09-27 | 2016-11-29 | Sangamo Biosciences, Inc. | Rapid in vivo identification of biologically active nucleases |
| CA2767377A1 (en) * | 2009-07-24 | 2011-01-27 | Sigma-Aldrich Co. Llc | Method for genome editing |
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|---|---|
| EP2566972A1 (en) | 2013-03-13 |
| SI2566972T1 (sl) | 2020-04-30 |
| EP2566972B1 (en) | 2020-01-15 |
| EP3636766A1 (en) | 2020-04-15 |
| HUE048072T2 (hu) | 2020-05-28 |
| EP2566972A4 (en) | 2014-01-01 |
| CA2797189A1 (en) | 2011-11-10 |
| JP5898179B2 (ja) | 2016-04-06 |
| LT2566972T (lt) | 2020-03-10 |
| AU2011249019B2 (en) | 2015-01-22 |
| KR20180077284A (ko) | 2018-07-06 |
| DK2566972T3 (da) | 2020-02-17 |
| CA2797189C (en) | 2020-05-26 |
| KR20130073887A (ko) | 2013-07-03 |
| US20110287512A1 (en) | 2011-11-24 |
| WO2011139349A1 (en) | 2011-11-10 |
| ES2773052T3 (es) | 2020-07-09 |
| US8772453B2 (en) | 2014-07-08 |
| CN102959087A (zh) | 2013-03-06 |
| CY1122636T1 (el) | 2021-03-12 |
| US20140287500A1 (en) | 2014-09-25 |
| CN102959087B (zh) | 2015-04-29 |
| KR101974036B1 (ko) | 2019-04-30 |
| US9163245B2 (en) | 2015-10-20 |
| IL222632B (en) | 2018-12-31 |
| JP2013527765A (ja) | 2013-07-04 |
| HRP20200254T1 (hr) | 2020-05-29 |
| IL222632A0 (en) | 2012-12-31 |
| PT2566972T (pt) | 2020-03-02 |
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