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PL2089371T3 - Sposoby wytwarzania heksahydrofuro[2,3-b]furan-3-olu - Google Patents

Sposoby wytwarzania heksahydrofuro[2,3-b]furan-3-olu

Info

Publication number
PL2089371T3
PL2089371T3 PL07822416T PL07822416T PL2089371T3 PL 2089371 T3 PL2089371 T3 PL 2089371T3 PL 07822416 T PL07822416 T PL 07822416T PL 07822416 T PL07822416 T PL 07822416T PL 2089371 T3 PL2089371 T3 PL 2089371T3
Authority
PL
Poland
Prior art keywords
hexahydrofuro
furan
methods
preparation
enantiomer
Prior art date
Application number
PL07822416T
Other languages
English (en)
Inventor
Sébastien François Emmanuel LEMAIRE
Andras Horvath
Wim Albert Alex Aelterman
Thomas Joachim Landewald Rammeloo
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37692659&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2089371(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of PL2089371T3 publication Critical patent/PL2089371T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL07822416T 2006-11-09 2007-11-09 Sposoby wytwarzania heksahydrofuro[2,3-b]furan-3-olu PL2089371T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06123752 2006-11-09
PCT/EP2007/062119 WO2008055970A2 (en) 2006-11-09 2007-11-09 Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol
EP07822416A EP2089371B1 (en) 2006-11-09 2007-11-09 Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol

Publications (1)

Publication Number Publication Date
PL2089371T3 true PL2089371T3 (pl) 2011-06-30

Family

ID=37692659

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07822416T PL2089371T3 (pl) 2006-11-09 2007-11-09 Sposoby wytwarzania heksahydrofuro[2,3-b]furan-3-olu

Country Status (22)

Country Link
US (1) US8153829B2 (pl)
EP (1) EP2089371B1 (pl)
JP (1) JP5491862B2 (pl)
CN (2) CN102432621B (pl)
AT (1) ATE497499T1 (pl)
AU (1) AU2007316562B2 (pl)
BR (1) BRPI0718706B8 (pl)
CA (1) CA2669014C (pl)
CY (1) CY1111407T1 (pl)
DE (1) DE602007012365D1 (pl)
DK (1) DK2089371T3 (pl)
ES (1) ES2359949T3 (pl)
HR (1) HRP20110258T1 (pl)
IL (1) IL198270A (pl)
ME (1) ME01232B (pl)
MX (1) MX2009004957A (pl)
PL (1) PL2089371T3 (pl)
PT (1) PT2089371E (pl)
RS (1) RS51675B (pl)
RU (1) RU2464266C2 (pl)
SI (1) SI2089371T1 (pl)
WO (1) WO2008055970A2 (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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WO2010075887A1 (en) * 2008-12-30 2010-07-08 Oxyrane (Uk) Limited Methods and intermediates useful in the synthesis of hexahydrofuro[2,3-b]furan-3-ol
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
AU2010313085A1 (en) 2009-10-30 2012-05-31 Lupin Limited A novel process for preparation of darunavir and darunavir ethanolate of fine particle size
US20110313035A1 (en) 2009-12-16 2011-12-22 Hetero Research Foundation Polymorphs of darunavir
JP2013518096A (ja) 2010-01-28 2013-05-20 マピ ファーマ リミテッド ダルナビル及びダルナビル中間体の調製方法
US8853430B2 (en) 2010-05-20 2014-10-07 Hetero Research Foundation Crystalline hydrochloride salt of darunavir
CN102617586B (zh) * 2011-01-26 2016-04-06 浙江九洲药业股份有限公司 地瑞那韦中间体的制备方法
EP2887807B1 (en) 2012-08-22 2019-09-18 Merck Sharp & Dohme Corp. Benzimidazole hexahydrofuro[3,2-b]furan derivatives useful as amp-activated protein kinase activators
CN103864813B (zh) * 2012-12-18 2017-02-22 上海迪赛诺化学制药有限公司 一种合成六氢呋喃并[2,3‑b]呋喃‑3‑醇及其对映体的方法
CN103896886A (zh) * 2012-12-31 2014-07-02 上海迪赛诺化学制药有限公司 一种达鲁那韦中间体及其制备方法和应用
TW201514188A (zh) * 2013-03-13 2015-04-16 Lantheus Medical Imaging Inc 製備釓磷維塞三鈉單水合物之方法
CN103664976B (zh) * 2013-12-12 2015-11-04 惠州市莱佛士制药技术有限公司 一种顺式六氢呋喃并[2,3-b]呋喃-3-醇的制备方法
CN113307783B (zh) * 2016-05-07 2023-04-07 成都博腾药业有限公司 一种制备地瑞那韦中间体的方法
CN112300186B (zh) * 2019-08-01 2024-04-30 浙江九洲药业股份有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0715618T3 (da) 1993-08-24 1999-08-23 Searle & Co Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser
JPH10500938A (ja) 1994-03-07 1998-01-27 バーテックス ファーマシューティカルズ インコーポレイテッド アスパラチルプロテアーゼインヒビターとしてのスルホンアミド誘導体
EP0754669B1 (en) 1995-02-03 2001-10-31 Kaneka Corporation Processes for producing alpha-halo ketones, alpha-halohydrins and epoxides
US5753660A (en) 1995-11-15 1998-05-19 G. D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5856531A (en) * 1996-10-21 1999-01-05 Eastman Chemical Company Preparation of 3-methytetra-hydrofuran from 2,3-dihydrofuran
JP2002515888A (ja) * 1996-10-21 2002-05-28 イーストマン ケミカル カンパニー ３―アルキルテトラヒドロフランの製造方法
US5990313A (en) * 1996-10-21 1999-11-23 Eastman Chemical Company Preparation of 3-alkyltetrahydrofurans
BR9912169A (pt) 1998-06-19 2001-04-10 Vertex Pharma Inibidores de sulfonamida de protease de aspartil
WO1999067254A2 (en) 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
DK1088098T4 (en) 1998-06-23 2015-09-14 Us Of America Represented By The Secretary Dept Of Health And Human Services Fitnessassay and methods for reducing HIV resistance to therapy
DE69918050T2 (de) 1998-08-25 2005-06-30 Kaneka Corp. Verfahren zur herstellung von (2r,3s)-3-amino-1,2-oxiran
ATE334121T1 (de) 1999-01-29 2006-08-15 Kaneka Corp Verfahren zur herstellung von threo-1,2-epoxy-3- amino-4-phenylbutan-derivaten
DK1159278T3 (da) 1999-02-12 2006-04-10 Vertex Pharma Inhibitorer af aspartylprotease
AR031520A1 (es) 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
KR100708221B1 (ko) 1999-08-31 2007-04-17 아지노모토 가부시키가이샤 에폭사이드 결정의 제조방법
WO2001025240A1 (en) 1999-10-06 2001-04-12 Tibotec Pharmaceuticals Ltd. HEXAHYDROFURO'2,3-B!FURAN-3-YL-N- {3'(1,3-BENZODIOXOL -5- YLSULFONYL) (ISOBUTYL) AMINO! -1-BENZYL-2-HYDROXYPROPYL} CARBAMATE AS RETROVIRAL PROTEASE INHIBITOR
WO2002067239A2 (en) 2000-10-24 2002-08-29 Glaxo Group Limited Process for preparing intermediates of hiv protease inhibitors
KR20020046948A (ko) 2000-12-12 2002-06-21 에가시라 구니오 에폭사이드 결정의 제조방법
CA2459168C (en) * 2001-09-10 2014-01-28 Tibotec Pharmaceuticals Ltd. Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol
US7145024B2 (en) 2001-09-20 2006-12-05 Smithkline Beecham Corporation Process for preparing protease inhibitor intermediates
SI1567529T2 (sl) * 2002-05-16 2021-08-31 Janssen Sciences Ireland Unlimited Company Psevdopolimorfne oblike zaviralca HIV proteaze
EP1532127B1 (en) * 2002-06-27 2006-09-27 SmithKline Beecham Corporation PREPARATION OF STEREOISOMERS OF (3ALPHA, 3ALPHA/BETA, 6ALPHA/BETA) HEXAHYDROFURO(2,3-b) FURAN-3-OL
US6919465B2 (en) 2002-10-09 2005-07-19 The Board Of Trustees Of The University Of Illinois Method of preparing (3R, 3aS, 6aR)-3-hydroxyhexahydrofuro[2,3,-b] furan and related compounds
AU2003275675A1 (en) 2002-12-27 2004-07-29 Sumitomo Chemical Company, Limited Process for producing hexahydrofurofuranol derivative, intermediate thereof and process for producing the same
BRPI0417272B8 (pt) * 2003-12-23 2021-05-25 Janssen R&D Ireland processo para a preparação de (3r, 3as, 6ar)-hexahidrofuro [2,3-b] furan-3-il (1s, 2r)-3-[[(4-aminofenil) sulfonil] (isobutil) amino]-1-benzil-2-hidroxipropilcarbamato
TWI383975B (zh) 2004-03-31 2013-02-01 Tibotec Pharm Ltd 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法

Also Published As

Publication number Publication date
IL198270A0 (en) 2009-12-24
EP2089371B1 (en) 2011-02-02
HRP20110258T1 (hr) 2011-05-31
CN102432621A (zh) 2012-05-02
WO2008055970A2 (en) 2008-05-15
IL198270A (en) 2014-02-27
MX2009004957A (es) 2009-05-19
PT2089371E (pt) 2011-04-18
BRPI0718706B1 (pt) 2021-03-23
DE602007012365D1 (de) 2011-03-17
CN102432621B (zh) 2016-02-17
RU2464266C2 (ru) 2012-10-20
CA2669014A1 (en) 2008-05-15
CN101541775B (zh) 2011-12-28
CA2669014C (en) 2016-01-26
JP5491862B2 (ja) 2014-05-14
ES2359949T3 (es) 2011-05-30
CY1111407T1 (el) 2015-08-05
ATE497499T1 (de) 2011-02-15
CN101541775A (zh) 2009-09-23
WO2008055970A3 (en) 2008-06-26
ME01232B (me) 2013-06-20
BRPI0718706A2 (pt) 2014-01-07
RU2009121792A (ru) 2010-12-20
SI2089371T1 (sl) 2011-05-31
DK2089371T3 (da) 2011-05-16
US20100094028A1 (en) 2010-04-15
RS51675B (en) 2011-10-31
JP2010509290A (ja) 2010-03-25
BRPI0718706B8 (pt) 2021-05-25
AU2007316562A1 (en) 2008-05-15
US8153829B2 (en) 2012-04-10
EP2089371A2 (en) 2009-08-19
AU2007316562B2 (en) 2013-02-21

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