[go: up one dir, main page]

PL1888604T3 - Sposób wytwarzania (alfa S, beta R)-6-bromo-alfa-[2-(dimetyloamino)etylo]-2-metoksy-alfa-1-naftalenylo-beta-fenylo-3-chinolinetanolu - Google Patents

Sposób wytwarzania (alfa S, beta R)-6-bromo-alfa-[2-(dimetyloamino)etylo]-2-metoksy-alfa-1-naftalenylo-beta-fenylo-3-chinolinetanolu

Info

Publication number
PL1888604T3
PL1888604T3 PL06755275T PL06755275T PL1888604T3 PL 1888604 T3 PL1888604 T3 PL 1888604T3 PL 06755275 T PL06755275 T PL 06755275T PL 06755275 T PL06755275 T PL 06755275T PL 1888604 T3 PL1888604 T3 PL 1888604T3
Authority
PL
Poland
Prior art keywords
alpha
beta
quinolineethanol
naphthalenyl
dimethylamino
Prior art date
Application number
PL06755275T
Other languages
English (en)
Inventor
Frank Ralf Porstmann
Stefan Horns
Thomas Bader
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PL1888604T3 publication Critical patent/PL1888604T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
PL06755275T 2005-05-25 2006-05-22 Sposób wytwarzania (alfa S, beta R)-6-bromo-alfa-[2-(dimetyloamino)etylo]-2-metoksy-alfa-1-naftalenylo-beta-fenylo-3-chinolinetanolu PL1888604T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05104482 2005-05-25
EP06755275A EP1888604B1 (en) 2005-05-25 2006-05-22 Process for preparing (alpha s, beta r)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol
PCT/EP2006/062502 WO2006125769A1 (en) 2005-05-25 2006-05-22 Process for preparing (alpha s, beta r)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol

Publications (1)

Publication Number Publication Date
PL1888604T3 true PL1888604T3 (pl) 2012-08-31

Family

ID=36013279

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06755275T PL1888604T3 (pl) 2005-05-25 2006-05-22 Sposób wytwarzania (alfa S, beta R)-6-bromo-alfa-[2-(dimetyloamino)etylo]-2-metoksy-alfa-1-naftalenylo-beta-fenylo-3-chinolinetanolu

Country Status (28)

Country Link
US (2) US8039628B2 (pl)
EP (1) EP1888604B1 (pl)
JP (1) JP5410749B2 (pl)
KR (2) KR101534021B1 (pl)
CN (1) CN101180302B (pl)
AT (1) ATE549343T1 (pl)
AU (1) AU2006251208B2 (pl)
BR (1) BRPI0611166B1 (pl)
CA (1) CA2606675C (pl)
CY (1) CY1113383T1 (pl)
DK (1) DK1888604T3 (pl)
EA (1) EA011770B1 (pl)
ES (1) ES2383908T3 (pl)
HK (1) HK1118061A1 (pl)
HR (1) HRP20120429T1 (pl)
IL (1) IL186913A (pl)
ME (1) ME01445B (pl)
MX (1) MX2007014874A (pl)
NO (1) NO341633B1 (pl)
NZ (1) NZ563819A (pl)
PL (1) PL1888604T3 (pl)
PT (1) PT1888604E (pl)
RS (1) RS52316B (pl)
SG (1) SG162724A1 (pl)
SI (1) SI1888604T1 (pl)
UA (1) UA92484C2 (pl)
WO (1) WO2006125769A1 (pl)
ZA (1) ZA200710150B (pl)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1835115B1 (de) 2006-03-17 2013-05-29 Peter Villiger Schutzverfahren und Schutzsystem für Wertsachen
RU2486175C2 (ru) * 2011-09-12 2013-06-27 Закрытое Акционерное Общество "Фарм-Синтез" Производные хинолина, в частности 5,6,7-замещенные 1-(2-хлорхинолин-3-ил)-4-диметиламино-2-(нафталин-1-ил)-1-фенилбутан-2-олы, способ получения и применение соединений
US9572809B2 (en) 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases
CN105017147B (zh) * 2014-04-30 2019-02-01 中国医学科学院药物研究所 一种回收和利用Bedaquiline立体化学异构体的方法
CN105085396B (zh) * 2014-05-07 2017-08-08 国药集团国瑞药业有限公司 用于制备贝达喹啉的中间体及其制备方法和应用
CN105085395B (zh) * 2014-05-07 2017-09-26 国药集团国瑞药业有限公司 贝达喹啉的制备方法
CN105198808B (zh) * 2014-05-27 2017-08-25 北京万生药业有限责任公司 一种高效生产贝达喹啉的方法
CN105175329B (zh) * 2014-06-10 2017-09-19 重庆圣华曦药业股份有限公司 一种贝达喹啉消旋体的合成路线及方法
CZ2014708A3 (cs) 2014-10-16 2016-04-27 Zentiva, K.S. Soli Bedaquilinu
CZ201534A3 (cs) 2015-01-21 2016-08-03 Zentiva, K.S. Nové možnosti chirální resoluce bedaquilinu
CZ201533A3 (cs) 2015-01-21 2016-08-03 Zentiva, K.S. Způsob izolace směsi enantiomerů
CZ201535A3 (cs) 2015-01-21 2016-08-03 Zentiva, K.S. Nové možnosti chirální resoluce bedaquilinu
US20180000810A1 (en) * 2015-01-27 2018-01-04 Janssen Pharmaceutica Nv Dispersible compositions
CZ2015391A3 (cs) 2015-06-09 2016-12-21 Zentiva, K.S. Sůl bedaquilinu s kyselinou citronovou
CN107848978B (zh) * 2015-07-24 2021-04-02 浙江海正药业股份有限公司 一种分离贝达喹啉非对映异构体a的方法
EP3426255B1 (en) * 2016-03-07 2022-11-30 The Global Alliance for TB Drug Development, Inc. Antibacterial compounds and uses thereof
CN107602464B (zh) * 2016-07-12 2020-02-18 宜昌人福药业有限责任公司 利用光学拆分制备双芳基喹啉类抗生素的方法
CN106866525B (zh) * 2017-03-24 2019-04-19 福建省微生物研究所 用于合成(1r,2s)-贝达喹啉的手性诱导剂
LT3943070T (lt) 2017-07-14 2024-02-12 Janssen Pharmaceutica Nv Ilgo veikimo bedakvilino preparatai
CN109422679B (zh) * 2017-08-30 2021-06-25 武汉武药科技有限公司 一种贝达喹啉的纯化及稳定晶型的制备方法
CN107857727B (zh) * 2017-10-26 2019-10-18 江苏天和制药有限公司 一种（1r，2s）和（1s，2r）-贝达喹啉的制备方法
CN110759885B (zh) * 2018-07-27 2021-10-22 中国医学科学院药物研究所 制备光活依格鲁特的方法
WO2020161743A1 (en) 2019-02-08 2020-08-13 Mylan Laboratories Limited Process for the preparation of bedaquiline fumarate
KR102303635B1 (ko) * 2020-07-01 2021-09-17 동아에스티 주식회사 (1r,2s)-1-(6-브로모-2-메톡시퀴놀린-3-일)-4-디메틸아미노-2-(1-나프틸)-1-페닐-부탄-2-올 및 이의 약제학적으로 허용 가능한 염의 제조방법
MX2023000439A (es) 2020-07-09 2023-02-09 Janssen Pharmaceutica Nv Formulaciones a largo plazo.
JP2023532981A (ja) 2020-07-09 2023-08-01 ヤンセン ファーマシューティカ エヌ．ベー． 長時間作用型配合物
JP2023532982A (ja) 2020-07-09 2023-08-01 ヤンセン ファーマシューティカ エヌ．ベー． 長時間作用型配合物
WO2024068693A1 (en) 2022-09-28 2024-04-04 Janssen Pharmaceutica Nv Long-acting formulations
TW202423427A (zh) 2022-09-28 2024-06-16 比利時商健生藥品公司 長效配方
US12116345B2 (en) 2023-08-01 2024-10-15 Shanghai Jiaotong University Low-temperature continuous-flow preparation method of bedaquiline

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2111138A1 (en) * 1993-01-15 1994-07-16 Thierry Godel Octahydrophenanthrene derivatives
US5319084A (en) * 1993-08-16 1994-06-07 Research Triangle Institute Hexahydroindenopyridine compounds having antispermatogenic activity
PT1527050E (pt) * 2002-07-25 2010-06-22 Janssen Pharmaceutica Nv Derivados de quinolina e sua utilização como inibidores de micobactérias
WO2004060889A1 (en) * 2003-01-07 2004-07-22 Glaxo Group Limited 5-thiazole substituted 2-pyrrolidine-carboxylic acids

Also Published As

Publication number Publication date
ES2383908T3 (es) 2012-06-27
CA2606675C (en) 2013-02-19
US8039628B2 (en) 2011-10-18
EA200702611A1 (ru) 2008-04-28
AU2006251208A1 (en) 2006-11-30
HK1118061A1 (en) 2009-01-30
EA011770B1 (ru) 2009-06-30
DK1888604T3 (da) 2012-06-18
SG162724A1 (en) 2010-07-29
PT1888604E (pt) 2012-05-28
CA2606675A1 (en) 2006-11-30
ATE549343T1 (de) 2012-03-15
CY1113383T1 (el) 2016-06-22
CN101180302B (zh) 2013-06-19
US8350040B2 (en) 2013-01-08
KR20080010453A (ko) 2008-01-30
AU2006251208B2 (en) 2012-11-29
KR101712835B1 (ko) 2017-03-07
KR20150008196A (ko) 2015-01-21
ME01445B (me) 2013-12-20
SI1888604T1 (sl) 2012-08-31
MX2007014874A (es) 2008-02-15
NO341633B1 (no) 2017-12-11
CN101180302A (zh) 2008-05-14
BRPI0611166B1 (pt) 2022-01-25
NO20076542L (no) 2007-12-19
HRP20120429T1 (hr) 2012-06-30
US20110319623A1 (en) 2011-12-29
UA92484C2 (en) 2010-11-10
EP1888604B1 (en) 2012-03-14
NZ563819A (en) 2011-01-28
US20080200683A1 (en) 2008-08-21
KR101534021B1 (ko) 2015-07-06
IL186913A0 (en) 2008-02-09
JP2008545675A (ja) 2008-12-18
BRPI0611166A2 (pt) 2010-08-17
EP1888604A1 (en) 2008-02-20
WO2006125769A1 (en) 2006-11-30
IL186913A (en) 2013-12-31
ZA200710150B (en) 2012-06-27
RS52316B (en) 2012-12-31
JP5410749B2 (ja) 2014-02-05

Similar Documents

Publication Publication Date Title
IL186913A0 (en) Process for preparing (alpha s, beta r)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol
MY148253A (en) Azaadamantane derivatives and methods of use
WO2001028996A3 (en) Pyrrolidine derivatives, their preparation and their use as inhibitors of neuraminidases
BRPI0520870B8 (pt) compostos intermediários para a preparação de alfa-mercaptoacetanilidas de s-triazolila
WO2007031548A3 (en) Processes for preparing of glucopyranosyl-substituted (ethynyl-benzyl)-benzene derivatives and intermediates thereof
CA2665931C (en) Hydrobenzamide derivatives as inhibitors of hsp90
BRPI0407282A (pt) Processo para preparação de inibidores de pirrolotriazina cinase
MX2010004546A (es) Nuevos intermedios de pregabalina y procedimiento para prepararlos y para preparar pregabalina.
TW200720221A (en) Cyclobutane and spiro[3.3]heptane compounds
WO2007074477A3 (en) Metaxalone polymorphs
TW200738713A (en) Diazepinoquinolines, synthesis thereof, and intermediates thereto
TW200740729A (en) Methods for preparing glutamic acid derivatives
SG160353A1 (en) Process for the preparation of substituted benzoxazole compounds
TW200612959A (en) Method for preparing hydroxamic acids
MY143324A (en) Process for preparing phosphorus compounds having phosphate-phosphonate bond
BRPI0517390B8 (pt) processo para a preparação de derivados de [1,4,5]-oxadiazepam
WO2007054970A3 (en) Novel polymorphic forms of (s)-(-)-2-amino-6-(n- propylamino) 4,5,6,7- tetrahydrobenzothiazole
MX2022002533A (es) Ácidos nucleicos modificados con ligandos 2', síntesis de estos y compuestos intermedios de estos.
TW200624435A (en) Process for preparing iridium(Ⅲ) ketoketonates
WO2007062058A3 (en) Carbamate compounds as 5-ht4 receptor agonists
WO2008075380A3 (en) Process for the preparation of thiazolidine derivatives
WO2007029082A3 (en) An improved fermentation process for preparing ascomycin
MX2009004371A (es) Proceso para la preparacion de 5-alquil-7h-pirrolo[2,3-d]piri-midi n-2-oles.
WO2003106399A3 (en) PROCESS FOR THE PREPARATION OF DOLLAR G (B) -AMINO N-PROTECTED ALDEHYDE COMPOUNDS
WO2008010764A3 (en) A process for the preparation of substituted 2-acetylamino-alkoxyphenyl