PL1603566T3 - Zastosowanie pochodnych izochinoliny do leczenia raka i chorób związanych z kinezą MAP - Google Patents

Zastosowanie pochodnych izochinoliny do leczenia raka i chorób związanych z kinezą MAP

Info

Publication number: PL1603566T3
Authority: PL; Poland
Prior art keywords: map kinase; treating cancer; related diseases; isoquinoline derivatives; kinase related
Prior art date: 2003-03-11

Application number

PL04718960T

Other languages

English (en)

Inventor

David Bryant Batt

Guido Bold

Sunkyu Kim

Timothy Michael Ramsey

Michael Lloyd Sabio

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-11

Filing date

2004-03-10

Publication date

2009-07-31

2004-03-10 Application filed by Novartis Ag filed Critical Novartis Ag

2009-07-31 Publication of PL1603566T3 publication Critical patent/PL1603566T3/pl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Quinoline Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

PL04718960T 2003-03-11 2004-03-10 Zastosowanie pochodnych izochinoliny do leczenia raka i chorób związanych z kinezą MAP PL1603566T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US45362403P	2003-03-11	2003-03-11
EP04718960A EP1603566B1 (en)	2003-03-11	2004-03-10	Use of isoquinoline derivatives for treating cancer and map kinase related diseases
PCT/EP2004/002460 WO2004080464A1 (en)	2003-03-11	2004-03-10	Use of isoquinoline derivatives for treating cancer and map kinase related diseases

Publications (1)

Publication Number	Publication Date
PL1603566T3 true PL1603566T3 (pl)	2009-07-31

Family

ID=32990797

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04718960T PL1603566T3 (pl)	2003-03-11	2004-03-10	Zastosowanie pochodnych izochinoliny do leczenia raka i chorób związanych z kinezą MAP

Country Status (22)

Country	Link
EP (1)	EP1603566B1 (pl)
JP (1)	JP2006519807A (pl)
KR (1)	KR20050108383A (pl)
CN (1)	CN1758910A (pl)
AT (1)	ATE421324T1 (pl)
AU (1)	AU2004218914A1 (pl)
BR (1)	BRPI0408257A (pl)
CA (1)	CA2518530A1 (pl)
DE (1)	DE602004019193D1 (pl)
ES (1)	ES2318276T3 (pl)
HR (1)	HRP20050788A2 (pl)
IS (1)	IS8064A (pl)
MA (1)	MA27724A1 (pl)
MX (1)	MXPA05009687A (pl)
NO (1)	NO20054647L (pl)
PL (1)	PL1603566T3 (pl)
PT (1)	PT1603566E (pl)
RU (1)	RU2325159C2 (pl)
TN (1)	TNSN05223A1 (pl)
TW (1)	TW200501955A (pl)
WO (1)	WO2004080464A1 (pl)
ZA (1)	ZA200506571B (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20060025141A (ko)	2003-05-15	2006-03-20	아르퀼 인코포레이티드	Ｐ38의 억제제 및 이를 사용하는 방법
PE20050952A1 (es) *	2003-09-24	2005-12-19	Novartis Ag	Derivados de isoquinolina como inhibidores de b-raf
US7829560B2 (en)	2004-07-08	2010-11-09	Arqule, Inc.	1,4-disubstituted naphthalenes as inhibitors of P38 MAP kinase
EP2258704A1 (en)	2004-10-19	2010-12-08	ArQule, Inc.	Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase
CN101160131A (zh) *	2005-02-25	2008-04-09	诺瓦提斯公司	Bcr-abl和raf抑制剂的药物组合产品
SI1912949T1 (sl) *	2005-07-26	2011-12-30	Sanofi Sa	Cikloheksilamin izokinolonski derivati kot inhibitorji Rho-kinaze
US8318941B2 (en)	2006-07-06	2012-11-27	Bristol-Myers Squibb Company	Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
CA2639416C (en) *	2007-09-11	2019-12-31	F. Hoffmann-La Roche Ag	Diagnostic test for susceptibility to b-raf kinase inhibitors
AU2010278894B2 (en)	2009-07-30	2014-01-30	Tandem Diabetes Care, Inc.	Infusion pump system with disposable cartridge having pressure venting and pressure feedback
CA2791247C (en) *	2010-03-09	2019-05-14	Dana-Farber Cancer Institute, Inc.	Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy
JP5921560B2 (ja) *	2010-10-28	2016-05-24	イノクリンファーマシューティカルズ，インコーポレイテッド	金属酵素阻害化合物
CN103435430B (zh) *	2013-08-08	2015-02-18	四川大学	一种还原酰胺类化合物的方法
KR102119943B1 (ko)	2018-05-23	2020-06-05	주식회사 포스코	시편배치유닛 및 이를 포함하는 도장밀착성 실험장치
CN112384503A (zh) *	2018-07-02	2021-02-19	洛桑联邦理工学院(Epfl)	乳酸增强化合物及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2339961C (en) *	1998-08-11	2009-01-20	Novartis Ag	Isoquinoline derivatives with angiogenesis inhibiting activity
AR025752A1 (es) *	1999-09-28	2002-12-11	Bayer Corp	Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis
PT1254138E (pt) *	2000-02-09	2005-09-30	Novartis Ag	Derivados de piridina que inibem a angiogenese e/ou o receptor de tirosina cinase do vegf
WO2002060392A2 (en) *	2001-01-31	2002-08-08	Synaptic Pharmaceutical Corporation	Use of gal3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
EP1975620A3 (en) *	2001-03-02	2008-12-24	GPC Biotech AG	Three hybrid assay system
EP1467736A2 (en) *	2001-12-21	2004-10-20	Bayer Pharmaceuticals Corporation	Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives
US7220775B2 (en) *	2002-08-07	2007-05-22	H. Lundbeck A/S	Compound useful for the treatment of neuropathic pain

2004
- 2004-03-10 EP EP04718960A patent/EP1603566B1/en not_active Expired - Lifetime
- 2004-03-10 WO PCT/EP2004/002460 patent/WO2004080464A1/en active Application Filing
- 2004-03-10 CN CNA2004800065706A patent/CN1758910A/zh active Pending
- 2004-03-10 CA CA002518530A patent/CA2518530A1/en not_active Abandoned
- 2004-03-10 TW TW093106341A patent/TW200501955A/zh unknown
- 2004-03-10 BR BRPI0408257-5A patent/BRPI0408257A/pt not_active IP Right Cessation
- 2004-03-10 PT PT04718960T patent/PT1603566E/pt unknown
- 2004-03-10 ES ES04718960T patent/ES2318276T3/es not_active Expired - Lifetime
- 2004-03-10 DE DE602004019193T patent/DE602004019193D1/de not_active Expired - Lifetime
- 2004-03-10 RU RU2005131168/04A patent/RU2325159C2/ru not_active IP Right Cessation
- 2004-03-10 AU AU2004218914A patent/AU2004218914A1/en not_active Abandoned
- 2004-03-10 KR KR1020057016936A patent/KR20050108383A/ko not_active Application Discontinuation
- 2004-03-10 AT AT04718960T patent/ATE421324T1/de active
- 2004-03-10 PL PL04718960T patent/PL1603566T3/pl unknown
- 2004-03-10 MX MXPA05009687A patent/MXPA05009687A/es active IP Right Grant
- 2004-03-10 JP JP2006504625A patent/JP2006519807A/ja active Pending
2005
- 2005-08-17 ZA ZA200506571A patent/ZA200506571B/en unknown
- 2005-09-08 HR HR20050788A patent/HRP20050788A2/xx not_active Application Discontinuation
- 2005-09-09 TN TNP2005000223A patent/TNSN05223A1/en unknown
- 2005-09-23 MA MA28511A patent/MA27724A1/fr unknown
- 2005-10-10 IS IS8064A patent/IS8064A/is unknown
- 2005-10-10 NO NO20054647A patent/NO20054647L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
DE602004019193D1 (de)	2009-03-12
CA2518530A1 (en)	2004-09-23
AU2004218914A1 (en)	2004-09-23
TW200501955A (en)	2005-01-16
BRPI0408257A (pt)	2006-03-07
CN1758910A (zh)	2006-04-12
WO2004080464A1 (en)	2004-09-23
RU2005131168A (ru)	2006-05-27
ATE421324T1 (de)	2009-02-15
NO20054647D0 (no)	2005-10-10
JP2006519807A (ja)	2006-08-31
ZA200506571B (en)	2006-07-26
IS8064A (is)	2005-10-10
HRP20050788A2 (en)	2006-12-31
TNSN05223A1 (en)	2007-06-11
PT1603566E (pt)	2009-04-27
EP1603566A1 (en)	2005-12-14
NO20054647L (no)	2005-12-09
RU2325159C2 (ru)	2008-05-27
EP1603566B1 (en)	2009-01-21
KR20050108383A (ko)	2005-11-16
MXPA05009687A (es)	2005-10-20
MA27724A1 (fr)	2006-01-02
ES2318276T3 (es)	2009-05-01

Publication	Publication Date	Title
TNSN05223A1 (en)	2007-06-11	Use of isoquinoline derivatives for treating cancer and map kinase related diseases
TNSN05045A1 (en)	2007-05-14	Indole or benzimidazole derivatives for modulating ikappab kinase
ES2176251T3 (es)	2002-12-01	Compuestos utilizados como inhibidores de pde iv y del factor de necrosis tumoral(tnf).
GB0112348D0 (en)	2001-07-11	Compounds
TW200621751A (en)	2006-07-01	Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors
RS48804A (en)	2006-12-15	Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers
BRPI0411365A (pt)	2006-07-25	derivados de aminopiridina
MXPA05009595A (es)	2005-11-04	Compuestos 7-amino-isoindolilo y sus usos farmaceuticos.
PT1353672E (pt)	2008-01-11	Síntese da 4-amino talidomida enantiómeros
TNSN05044A1 (en)	2007-05-14	Use of ikappab kinase inhibitors for the treatment of pain
EA200701930A1 (ru)	2008-02-28	Производные пиримидина для лечения гиперпролиферативных нарушений
EA200500377A1 (ru)	2005-08-25	Пиразольные производные как ингибиторы трансформирующего фактора роста (tgf)
MY141197A (en)	2010-03-31	Substituted thiazole-benzoisothiazole dioxide derivatives, process for their preparation and their use
EA200800516A1 (ru)	2008-08-29	Производные n-фенил-2-пиримидинамина и процесс их получения
TNSN07294A1 (en)	2008-12-31	Treatment of metastasized tumors
WO2003106384A3 (en)	2004-06-17	NOVEL BORIC CHALCONE DERIVATIVES AND USES THEREOF
PT1390371E (pt)	2006-07-31	Oxazolo- e furopirimidinas e sua utilizacao em medicamentos contra tumores
UA83821C2 (ru)	2008-08-26	Производные бензолсульфонамидов, способ их получения и их применение для лечения воспалительных заболеваний и утоления боли
NO20050640L (no)	2005-03-22	Rutenium anticancer komplekser
DE60131968D1 (de)	2008-01-31	PYRANOÄ2,3-cÜIMIDAZOÄ1,2-aÜPYRIDIN-DERIVATE ZUR BEHANDLUNG VON GASTROINTESTINALEN ERKRANKUNGEN
ATE386029T1 (de)	2008-03-15	Urokinase-inhibitoren
DE502004007950D1 (en)	2008-10-09	Antitumor wirksame 2-substituierte d-homoestra-1,3,5(10)-trien-3-yl sulfamate
NO20055650D0 (no)	2005-11-30	Ruteinum (II)-komplekser for behandling av tumorer
ATE423780T1 (de)	2009-03-15	Makrozyclen zur behandlung von krebserkrankungen