PH24199A - Derivatives of quinoline carboxylic acid,pharmaceutical composition containing same and process of preparing same - Google Patents

Derivatives of quinoline carboxylic acid,pharmaceutical composition containing same and process of preparing same

Info

Publication number: PH24199A
Authority: PH; Philippines
Prior art keywords: same; pharmaceutical composition; derivatives; carboxylic acid; composition containing
Prior art date: 1986-10-20

Application number

PH35962A

Other languages

English (en)

Inventor

John Michael Domagala

Joseph Peter Sanchez

Thomas Frederick Mich

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-10-20

Filing date

1987-10-20

Publication date

1990-04-10

1987-10-20 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1989-04-03 Priority to PH38419A priority Critical patent/PH26729A/en

1990-04-10 Publication of PH24199A publication Critical patent/PH24199A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PH35962A 1986-10-20 1987-10-20 Derivatives of quinoline carboxylic acid,pharmaceutical composition containing same and process of preparing same PH24199A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
PH38419A PH26729A (en)	1986-10-20	1989-04-03	Benzoxazines useful as antibacterial preparation thereof and pharmaceutical composition containing them

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/920,536 US4822801A (en)	1984-07-20	1986-10-20	4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents

Publications (1)

Publication Number	Publication Date
PH24199A true PH24199A (en)	1990-04-10

Family

ID=25443916

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PH35962A PH24199A (en)	1986-10-20	1987-10-20	Derivatives of quinoline carboxylic acid,pharmaceutical composition containing same and process of preparing same
PH38421A PH25423A (en)	1986-10-20	1989-04-03	Method of treating bacterial infections using benzoxazine carboxylic acid
PH38420A PH25459A (en)	1986-10-20	1989-04-03	Compound useful in the production of quinoline, naphthyridine carboxylic acids useful as antibacterials

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
PH38421A PH25423A (en)	1986-10-20	1989-04-03	Method of treating bacterial infections using benzoxazine carboxylic acid
PH38420A PH25459A (en)	1986-10-20	1989-04-03	Compound useful in the production of quinoline, naphthyridine carboxylic acids useful as antibacterials

Country Status (17)

Country	Link
US (1)	US4822801A (no)
EP (1)	EP0265230B1 (no)
JP (2)	JP2750117B2 (no)
KR (1)	KR880005137A (no)
AT (1)	ATE71375T1 (no)
AU (1)	AU643489B2 (no)
CA (1)	CA1336089C (no)
DE (1)	DE3775882D1 (no)
DK (1)	DK543787A (no)
ES (1)	ES2040261T3 (no)
FI (1)	FI874570A (no)
GR (1)	GR3003548T3 (no)
IE (1)	IE64492B1 (no)
NO (1)	NO874350L (no)
PH (3)	PH24199A (no)
PT (1)	PT85943B (no)
ZA (1)	ZA877887B (no)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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JPH089597B2 (ja) *	1986-01-21	1996-01-31	杏林製薬株式会社	選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
US5173484A (en) *	1988-02-05	1992-12-22	Bayer Aktiengesellschaft	Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
JPH0228178A (ja) *	1988-04-23	1990-01-30	Toyama Chem Co Ltd	新規なピリドンカルボン酸誘導体およびその塩並びにそれらの製造法
KR910003630B1 (ko) *	1988-06-17	1991-06-07	한국과학기술원	벤조일 아세틱 에스테르 유도체 및 그 제조방법
JPH0674261B2 (ja) *	1988-06-21	1994-09-21	塩野義製薬株式会社	キノロンカルボン酸誘導体
AU618823B2 (en) *	1988-07-20	1992-01-09	Sankyo Company Limited	4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use
ES2147721T3 (es)	1990-04-18	2000-10-01	Procter & Gamble Pharma	Quinolonil lactamas antimicrobianas.
ATE207479T1 (de) *	1992-01-31	2001-11-15	Chugai Pharmaceutical Co Ltd	Kristalle von derivaten von chinozon carbonsäure- hydraten
US5646163A (en) *	1992-10-30	1997-07-08	The Procter & Gamble Company	Quinolone 5-(N-heterosubstituted amino) antimicrobials
WO1996002512A1 (fr) *	1994-07-18	1996-02-01	Ube Industries, Ltd.	Acide du type trifluoromethylquinoleinecarboxylique
US5602254A (en) *	1995-05-26	1997-02-11	Warner-Lambert Company	Method for making quinoline carboxylic acids or naphthyridine carboxylic acids in free base form
DE19652239A1 (de) *	1996-12-16	1998-06-18	Bayer Ag	Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
MY138335A (en)	1997-09-15	2009-05-29	Procter & Gamble	Antimicrobial quinolones, their compositions and uses
US6387928B1 (en)	1997-09-15	2002-05-14	The Procter & Gamble Co.	Antimicrobial quinolones, their compositions and uses
US7098219B2 (en)	2000-08-01	2006-08-29	Wockhart Limited	Inhibitors of cellular efflux pumps of microbes
US6878713B2 (en)	2001-04-25	2005-04-12	Wockhardt Limited	Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6964966B2 (en)	2001-04-25	2005-11-15	Wockhardt Limited	Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
WO2003078439A1 (fr) *	2002-03-18	2003-09-25	Kyorin Pharmaceutical Co., Ltd.	Derive d'acide 10-(3-cyclopropylaminomethyl-1-pyrrolidinyl)pyridobenzoxazinecarboxylique efficace contre les bacteries resistantes
US6664267B1 (en)	2002-05-28	2003-12-16	Wockhardt Limited	Crystalline fluoroquinolone arginine salt form
BR0318460A (pt)	2003-09-04	2006-09-12	Wockhardt Ltd	sal de arginina de ácido benzoquinolizina-2-carboxìlico tetrahidratado
SG144936A1 (en) *	2003-09-10	2008-08-28	Kyorin Seiyaku Kk	7-(4-substituted-3-cyclopropylaminomethyl-1- pyrrolidinyl)quinolonecarboxylic acid derivative
WO2005111030A1 (en) *	2004-05-12	2005-11-24	Warner-Lambert Company Llc	Quinolone antibacterial agents
US20090156577A1 (en) *	2004-09-09	2009-06-18	Benjamin Davis	7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US7563805B2 (en) *	2005-05-19	2009-07-21	Daiichi Pharmaceutical Co., Ltd.	Tri-, tetra-substituted-3-aminopyrrolidine derivative
DK2383271T3 (da)	2006-03-13	2013-10-07	Kyorin Seiyaku Kk	Aminoquinoloner som GSK-3-inhibitorer
MX2008012488A (es) *	2006-03-28	2008-10-10	Procter & Gamble	Un proceso de acoplamiento para preparar intermedios de quinolona.
BRPI0709772B8 (pt) *	2006-03-28	2021-05-25	The Protecter & Gamble Company	sais de malato e polimorfos do ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-diidro-8-metóxi-4-oxo-3-quinolinocarboxílico
CA2647457C (en) *	2006-03-28	2011-05-24	The Procter & Gamble Company	A hydride reduction process for preparing quinolone intermediates
EP2149571A4 (en) *	2007-05-24	2010-09-01	Kyorin Seiyaku Kk	MUTILINE DERIVATIVE WITH A RINGED, HETEROCYCLIC AND AROMATIC CARBOXYLIC ACID STRUCTURE IN A SUBSTITUTE AT POSITION 14
US7902227B2 (en) *	2007-07-27	2011-03-08	Janssen Pharmaceutica Nv.	C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
KR101563018B1 (ko)	2007-09-11	2015-10-23	교린 세이야꾸 가부시키 가이샤	Ｇｓｋ-３ 억제제로서의 시아노아미노퀴놀론 및 테트라졸로아미노퀴놀론
CN102344457B (zh)	2007-09-12	2015-07-22	杏林制药株式会社	作为 gsk-3 抑制剂的螺环状氨基喹诺酮
US20100273787A1 (en) *	2007-11-15	2010-10-28	Robert Schwarcz	Kynurenine-aminotransferase inhibitors
KR101748891B1 (ko)	2009-03-11	2017-06-19	교린 세이야꾸 가부시키 가이샤	Ｇｓｋ-3 억제제로서의 7-시클로알킬아미노퀴놀론
WO2014125506A2 (en) *	2013-02-15	2014-08-21	Laurus Labs Private Limited	A process for the preparation of ivacaftor and its intermediates
KR102213991B1 (ko) *	2014-05-20	2021-02-09	동화약품주식회사	개선된 자보플록사신의 제조방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4049811A (en) *	1968-07-23	1977-09-20	Boehringer Mannheim G.M.B.H.	Compositions using cycloalkano-quinolone derivatives and their method of use
JPS5746986A (en) *	1980-09-02	1982-03-17	Dai Ichi Seiyaku Co Ltd	Pyrido(1,2,3-de)(1,4)benzoxazine derivative
US4665079A (en) *	1984-02-17	1987-05-12	Warner-Lambert Company	Antibacterial agents
US4571396A (en) *	1984-04-16	1986-02-18	Warner-Lambert Company	Antibacterial agents
US4604401A (en) *	1984-07-20	1986-08-05	Warner-Lambert Company	Antibacterial agents III
IE58742B1 (en) *	1984-07-20	1993-11-05	Warner Lambert Co	Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
AU576272B2 (en) *	1984-11-13	1988-08-18	Kyorin Pharmaceutical Co. Ltd.	Quinolone carboxylic acid derivates
AU578793B2 (en) *	1985-02-15	1988-11-03	Dainippon Pharmaceutical Co. Ltd.	Novel 1,8-naphthyridine derivatives and processes for preparation thereof
JPH089597B2 (ja) *	1986-01-21	1996-01-31	杏林製薬株式会社	選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
JPH0720940B2 (ja) *	1986-02-28	1995-03-08	大日本製薬株式会社	キノリン誘導体の製造法
US4780408A (en) *	1986-03-26	1988-10-25	Colorado State University Research Foundation	Antibody for detection and quantification of trifluralin
JPH0720941B2 (ja) *	1986-03-28	1995-03-08	大日本製薬株式会社	新規キノロン誘導体、そのエステルおよびその塩
EP0242789A3 (en) *	1986-04-25	1990-09-05	Dainippon Pharmaceutical Co., Ltd.	Novel quinoline derivates and processes for preparation thereof
US4771055A (en) *	1986-07-28	1988-09-13	Warner-Lambert Company	7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids
JPS63152318A (ja) *	1986-08-07	1988-06-24	Dainippon Pharmaceut Co Ltd	抗マイコプラズマ剤

1986
- 1986-10-20 US US06/920,536 patent/US4822801A/en not_active Expired - Lifetime
1987
- 1987-09-18 CA CA000547233A patent/CA1336089C/en not_active Expired - Fee Related
- 1987-09-25 IE IE259087A patent/IE64492B1/en not_active IP Right Cessation
- 1987-10-16 FI FI874570A patent/FI874570A/fi not_active Application Discontinuation
- 1987-10-16 DK DK543787A patent/DK543787A/da not_active Application Discontinuation
- 1987-10-19 PT PT85943A patent/PT85943B/pt not_active IP Right Cessation
- 1987-10-19 JP JP62261929A patent/JP2750117B2/ja not_active Expired - Fee Related
- 1987-10-19 NO NO874350A patent/NO874350L/no unknown
- 1987-10-20 EP EP87309267A patent/EP0265230B1/en not_active Expired - Lifetime
- 1987-10-20 DE DE8787309267T patent/DE3775882D1/de not_active Expired - Fee Related
- 1987-10-20 AT AT87309267T patent/ATE71375T1/de not_active IP Right Cessation
- 1987-10-20 ES ES198787309267T patent/ES2040261T3/es not_active Expired - Lifetime
- 1987-10-20 ZA ZA877887A patent/ZA877887B/xx unknown
- 1987-10-20 KR KR870011656A patent/KR880005137A/ko not_active Application Discontinuation
- 1987-10-20 PH PH35962A patent/PH24199A/en unknown
1989
- 1989-04-03 PH PH38421A patent/PH25423A/en unknown
- 1989-04-03 PH PH38420A patent/PH25459A/en unknown
1991
- 1991-01-07 AU AU69205/91A patent/AU643489B2/en not_active Ceased
1992
- 1992-01-09 GR GR910402252T patent/GR3003548T3/el unknown
1997
- 1997-10-08 JP JP27539997A patent/JP3235539B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT85943B (pt)	1990-07-31
CA1336089C (en)	1995-06-27
DK543787A (da)	1988-04-21
JP2750117B2 (ja)	1998-05-13
GR3003548T3 (no)	1993-03-16
JPS63104974A (ja)	1988-05-10
ES2040261T3 (es)	1993-10-16
JP3235539B2 (ja)	2001-12-04
US4822801A (en)	1989-04-18
AU643489B2 (en)	1993-11-18
IE64492B1 (en)	1995-08-09
DK543787D0 (da)	1987-10-16
AU6920591A (en)	1991-03-28
IE872590L (en)	1988-04-20
PT85943A (en)	1987-11-01
EP0265230A1 (en)	1988-04-27
KR880005137A (ko)	1988-06-28
FI874570A (fi)	1988-04-21
JPH10114779A (ja)	1998-05-06
NO874350D0 (no)	1987-10-19
PH25459A (en)	1991-07-01
DE3775882D1 (de)	1992-02-20
AU7987987A (en)	1988-04-21
ZA877887B (en)	1989-05-30
AU606618B2 (en)	1991-02-14
EP0265230B1 (en)	1992-01-08
NO874350L (no)	1988-04-21
PH25423A (en)	1991-07-01
FI874570A0 (fi)	1987-10-16
ATE71375T1 (de)	1992-01-15

Publication	Publication Date	Title
PH24199A (en)	1990-04-10	Derivatives of quinoline carboxylic acid,pharmaceutical composition containing same and process of preparing same
HU908495D0 (en)	1991-07-29	Process for the production of a-nor-steroid-3-carbonic acid derivatives
EP0614913A3 (en)	1997-06-04	Dynorphin derivatives.
HU913760D0 (en)	1992-02-28	Process for the production of new dihydro-iso-kynoline derivatives
GR3004902T3 (no)	1993-04-28
EP0255908A3 (en)	1989-10-25	7-ûû3-(aminomethyl)-3-alkyl¨-1-pyrrolidinyl¨-quinoline-carboxylic acid-derivatives and pharmaceutical compositions containing them
HUT40101A (en)	1986-11-28	Process for producing quinolin-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents
HUT40126A (en)	1986-11-28	Process for producing 6,7-disubstituted-1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtiridine-3-carboxylic acid derivatives and pharmaceutical compositions and food additives containing them
HUT46664A (en)	1988-11-28	Process for producing new dihydropyridineamide derivatives and pharmaceutical compositions comprising these compounds
IL93161A0 (en)	1990-11-05	3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
HUT53643A (en)	1990-11-28	Process for producing substituted azetidinye-pyridon-carboxylic acid derivatives and pharmaceutical compositions containing them
GR3003126T3 (en)	1993-02-17	Quinolinecarboxylic acid derivatives, a composition comprising the same, process for preparing the same, and the use of the same for the manufacture of medicaments
HUT47923A (en)	1989-04-28	Process for production of new derivatives of naphtotiazephin and medical compositions containing these substances
HU9302546D0 (en)	1993-11-29	Heteroarenyl-piperazine derivatives, method for producing them and medical preparatives containing said compounds
GR880100409A (en)	1990-05-11	Method for the synthesis of 1-cyclopropyl-6-fluoro-1,4 dihydro-4-oxo-7-chloro-quinoline-3-carboxylic acid as basis for the preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quinoline-3-carboxylic acids
GR3019381T3 (en)	1996-06-30	3-Anilino-2-hydroxycarbonyl-4-thiophen-acetic acids
GR3022259T3 (en)	1997-04-30	Tetrahydro-4-phenylimino-3-thiophen-acetic acids