PH20256A - Novel 5-acyl-2-(1h) pyridinones - Google Patents

Novel 5-acyl-2-(1h) pyridinones

Info

Publication number: PH20256A
Authority: PH; Philippines
Prior art keywords: pyridinones; acyl; novel
Prior art date: 1983-04-29

Application number

PH30602A

Other languages

English (en)

Inventor

Winton D Jones

Richard A Schnettler

Richard C Dage

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-04-29

Filing date

1984-04-26

Publication date

1986-11-14

1984-04-26 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1986-11-14 Publication of PH20256A publication Critical patent/PH20256A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PH30602A 1983-04-29 1984-04-26 Novel 5-acyl-2-(1h) pyridinones PH20256A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/490,081 US4568751A (en)	1983-04-29	1983-04-29	5-Acyl-2-(1H)-pyridinones

Publications (1)

Publication Number	Publication Date
PH20256A true PH20256A (en)	1986-11-14

Family

ID=23946554

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH30602A PH20256A (en)	1983-04-29	1984-04-26	Novel 5-acyl-2-(1h) pyridinones

Country Status (22)

Country	Link
US (1)	US4568751A (ru)
EP (2)	EP0124090B1 (ru)
JP (2)	JPS59206355A (ru)
KR (2)	KR900005011B1 (ru)
AR (1)	AR240313A1 (ru)
AT (2)	ATE26262T1 (ru)
AU (2)	AU571219B2 (ru)
CA (2)	CA1242443A (ru)
DD (1)	DD223444A5 (ru)
DE (2)	DE3462503D1 (ru)
DK (2)	DK159424C (ru)
ES (2)	ES531911A0 (ru)
GR (2)	GR81967B (ru)
HU (2)	HU191928B (ru)
IE (2)	IE57285B1 (ru)
IL (2)	IL71649A (ru)
NO (2)	NO164416C (ru)
NZ (2)	NZ207960A (ru)
PH (1)	PH20256A (ru)
PT (2)	PT78491B (ru)
SU (1)	SU1299505A3 (ru)
ZA (2)	ZA843033B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4853395A (en) *	1983-04-29	1989-08-01	Merrell Dow Pharmaceuticals Inc.	Certain 3-carboxylate or 3-carbamyl-5-acyl-2-(1H)-pyridinones having cardiotonic properties
US4992452A (en) *	1983-04-29	1991-02-12	Merrell Dow Pharmaceuticals Inc.	Certain 5-acyl-2-(1H)-pyridinones useful in treating cardiac failure
US4731371A (en) *	1984-03-29	1988-03-15	Merrell Dow Pharmaceuticals Inc.	Certain 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles which are useful as cardiotonic agents
US5118696A (en) *	1983-04-29	1992-06-02	Merrell Dow Pharmaceuticals Inc.	5-Acyl-2-(1H)-pyridinones useful for treating cardiac failure
US4568751A (en) *	1983-04-29	1986-02-04	Merrell Dow Pharmaceuticals Inc.	5-Acyl-2-(1H)-pyridinones
US5428045A (en) *	1983-04-29	1995-06-27	Merrell Dow Pharmaceuticals Inc.	5-acyl-2-(1H)-pyridinoes
US4732982A (en) *	1983-11-03	1988-03-22	Merrell Dow Pharmaceuticals Inc.	Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
US5212314A (en) *	1983-11-03	1993-05-18	Merrell Dow Pharmaceuticals Inc.	Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
US4657919A (en) *	1984-08-03	1987-04-14	E. I. Du Pont De Nemours & Co.	Pyridone esters as inotropic agents
US4650806A (en) *	1985-01-14	1987-03-17	Sterling Drug Inc.	Cardiotonic 5-(heterylcarbonyl)-pyridones

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2531035A1 (de) *	1975-07-11	1977-01-27	Basf Ag	Verfahren zur herstellung von 5-cyanpyridonen-(6)
US4072746A (en) *	1975-10-14	1978-02-07	Sterling Drug Inc.	3-Amino-5-(pyridinyl)-2(1H)-pyridinones
GB1596887A (en) *	1977-07-15	1981-09-03	Rohm & Haas	2-pyridone derivatives and their use as plant growth regulators
DE3005069A1 (de) *	1980-02-11	1981-08-20	Cassella Ag, 6000 Frankfurt	Pyridonderivate, ihre herstellung und ihre verwendung
DE3106460A1 (de) *	1980-03-03	1982-01-28	Sandoz-Patent-GmbH, 7850 Lörrach	2(1h)-pyridinon-derivate, ihre herstellung und sie enthaltende pharmazeutische zubereitungen
US4524149A (en) *	1982-03-15	1985-06-18	Sterling Drug Inc.	5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and their cardiotonic use
US4412077A (en) *	1982-03-15	1983-10-25	Sterling Drug Inc.	Process for preparing 5-(lower-alkanoyl)-6-(lower-alkyl)-2(1H)-pyridinone
US4568751A (en) *	1983-04-29	1986-02-04	Merrell Dow Pharmaceuticals Inc.	5-Acyl-2-(1H)-pyridinones
DE3406329A1 (de) *	1984-02-22	1985-08-22	Merck Patent Gmbh, 6100 Darmstadt	Pyridone

1983
- 1983-04-29 US US06/490,081 patent/US4568751A/en not_active Expired - Lifetime
1984
- 1984-04-19 AU AU27141/84A patent/AU571219B2/en not_active Ceased
- 1984-04-19 AU AU27131/84A patent/AU557543B2/en not_active Ceased
- 1984-04-24 ZA ZA843033A patent/ZA843033B/xx unknown
- 1984-04-24 AR AR296404A patent/AR240313A1/es active
- 1984-04-24 ZA ZA843034A patent/ZA843034B/xx unknown
- 1984-04-25 ES ES531911A patent/ES531911A0/es active Granted
- 1984-04-25 ES ES531910A patent/ES8505955A1/es not_active Expired
- 1984-04-26 CA CA000452888A patent/CA1242443A/en not_active Expired
- 1984-04-26 NZ NZ207960A patent/NZ207960A/en unknown
- 1984-04-26 HU HU841618A patent/HU191928B/hu not_active IP Right Cessation
- 1984-04-26 PT PT78491A patent/PT78491B/pt not_active IP Right Cessation
- 1984-04-26 IL IL71649A patent/IL71649A/xx unknown
- 1984-04-26 IL IL71648A patent/IL71648A/xx unknown
- 1984-04-26 AT AT84104704T patent/ATE26262T1/de not_active IP Right Cessation
- 1984-04-26 PH PH30602A patent/PH20256A/en unknown
- 1984-04-26 DE DE8484104703T patent/DE3462503D1/de not_active Expired
- 1984-04-26 DE DE8484104704T patent/DE3462889D1/de not_active Expired
- 1984-04-26 PT PT78493A patent/PT78493B/pt not_active IP Right Cessation
- 1984-04-26 CA CA000452889A patent/CA1256880A/en not_active Expired
- 1984-04-26 NZ NZ207961A patent/NZ207961A/en unknown
- 1984-04-26 AT AT84104703T patent/ATE25678T1/de active
- 1984-04-26 EP EP84104704A patent/EP0124090B1/en not_active Expired
- 1984-04-26 HU HU841619A patent/HU191753B/hu not_active IP Right Cessation
- 1984-04-26 EP EP84104703A patent/EP0124089B1/en not_active Expired
- 1984-04-27 IE IE1047/84A patent/IE57285B1/en not_active IP Right Cessation
- 1984-04-27 GR GR74536A patent/GR81967B/el unknown
- 1984-04-27 JP JP59084234A patent/JPS59206355A/ja active Granted
- 1984-04-27 DD DD84262415A patent/DD223444A5/de not_active IP Right Cessation
- 1984-04-27 DK DK213284A patent/DK159424C/da not_active IP Right Cessation
- 1984-04-27 JP JP59084235A patent/JPS59206356A/ja active Granted
- 1984-04-27 GR GR74535A patent/GR81990B/el unknown
- 1984-04-27 NO NO841690A patent/NO164416C/no unknown
- 1984-04-27 NO NO841691A patent/NO164415C/no unknown
- 1984-04-27 DK DK213584A patent/DK159425C/da not_active IP Right Cessation
- 1984-04-27 IE IE1046/84A patent/IE57273B1/en not_active IP Right Cessation
- 1984-04-28 SU SU843732701A patent/SU1299505A3/ru active
- 1984-04-28 KR KR1019840002298A patent/KR900005011B1/ko not_active IP Right Cessation
- 1984-04-28 KR KR1019840002297A patent/KR900005010B1/ko not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO164416B (no)	1990-06-25
AU571219B2 (en)	1988-04-14
PT78491B (en)	1986-05-22
ES8505956A1 (es)	1985-06-01
DK159425B (da)	1990-10-15
KR900005011B1 (ko)	1990-07-16
DK159425C (da)	1991-03-18
CA1242443A (en)	1988-09-27
EP0124089B1 (en)	1987-03-04
HUT34007A (en)	1985-01-28
JPH058192B2 (ru)	1993-02-01
DK213284D0 (da)	1984-04-27
NO164415B (no)	1990-06-25
JPS59206355A (ja)	1984-11-22
AR240313A1 (es)	1990-03-30
DK159424C (da)	1991-03-18
IL71648A0 (en)	1984-07-31
IL71648A (en)	1987-11-30
CA1256880A (en)	1989-07-04
ATE25678T1 (de)	1987-03-15
KR900005010B1 (ko)	1990-07-16
ES531911A0 (es)	1985-06-01
DE3462503D1 (en)	1987-04-09
PT78493B (en)	1986-05-20
NO164416C (no)	1990-10-03
NO841690L (no)	1984-10-30
AU2713184A (en)	1984-11-01
DE3462889D1 (de)	1987-05-07
ZA843034B (en)	1984-11-28
HU191928B (en)	1987-04-28
ATE26262T1 (de)	1987-04-15
JPS59206356A (ja)	1984-11-22
NZ207960A (en)	1987-05-29
SU1299505A3 (ru)	1987-03-23
JPH0579668B2 (ru)	1993-11-04
IE57285B1 (en)	1992-07-15
IL71649A (en)	1987-10-30
IE841046L (en)	1984-10-29
ZA843033B (en)	1984-11-28
ES531910A0 (es)	1985-06-01
EP0124090B1 (en)	1987-04-01
DK213584A (da)	1984-10-30
DD223444A5 (de)	1985-06-12
KR840008322A (ko)	1984-12-14
KR840008323A (ko)	1984-12-14
IL71649A0 (en)	1984-07-31
IE57273B1 (en)	1992-07-01
DK213284A (da)	1984-10-30
DK159424B (da)	1990-10-15
US4568751A (en)	1986-02-04
AU2714184A (en)	1984-11-01
NZ207961A (en)	1986-09-10
IE841047L (en)	1984-10-29
EP0124089A1 (en)	1984-11-07
HUT34006A (en)	1985-01-28
NO841691L (no)	1984-10-30
EP0124090A1 (en)	1984-11-07
NO164415C (no)	1990-10-03
AU557543B2 (en)	1986-12-24
GR81990B (ru)	1984-12-12
GR81967B (ru)	1984-12-12
ES8505955A1 (es)	1985-06-01
HU191753B (en)	1987-04-28
PT78491A (en)	1984-05-01
PT78493A (en)	1984-05-01
DK213584D0 (da)	1984-04-27

Publication	Publication Date	Title
GB8411627D0 (en)	1984-06-13	Buttons
GB8403579D0 (en)	1984-03-14	Erythropoietin
GB8626464D0 (en)	1986-12-03	Intermediates
ZA847779B (en)	1985-05-29	Novel pipelock
PH20256A (en)	1986-11-14	Novel 5-acyl-2-(1h) pyridinones
GB2137867B (en)	1986-12-03	Buttons
GB8313408D0 (en)	1983-06-22	2(1h)-pyridinone derivatives
GB8427320D0 (en)	1984-12-05	Pyridine mixtures
DE3278856D1 (en)	1988-09-08	Substituted pyridines
ZA844435B (en)	1985-02-27	High-velocity msfb process
GB2146025B (en)	1987-01-28	Novel phenoxyalkylphosphinates and -phosphonates
DE3472556D1 (en)	1988-08-11	Novel aroylimidazolones
GB8403336D0 (en)	1984-03-14	Buttons
PH17742A (en)	1984-11-27	Novel immunoregulatory pyridines
JPS56166174A (en)	1981-12-21	Nicotinamide manufacture
GB8524110D0 (en)	1985-11-06	Pyridine
GB8527541D0 (en)	1985-12-11	Pyridine carboxamide compounds
IE832930L (en)	1984-06-14	Pyridines
IE830567L (en)	1983-09-17	Pyridines
IE830661L (en)	1983-09-27	Pyridones
IE842815L (en)	1985-05-03	Pyridinones
IE820276L (en)	1982-08-09	Pyridines
KR850000222Y1 (en)	1985-02-25	Earring
IL69949A0 (en)	1984-01-31	Structural member
ZA845841B (en)	1986-03-26	Novel phenoxyalkylphosphinates and-phosphonates