PE97198A1 - Preparacion de capsula suave que contiene ciclosporina - Google Patents
Preparacion de capsula suave que contiene ciclosporinaInfo
- Publication number
- PE97198A1 PE97198A1 PE1997000521A PE00052197A PE97198A1 PE 97198 A1 PE97198 A1 PE 97198A1 PE 1997000521 A PE1997000521 A PE 1997000521A PE 00052197 A PE00052197 A PE 00052197A PE 97198 A1 PE97198 A1 PE 97198A1
- Authority
- PE
- Peru
- Prior art keywords
- mixture
- fatty acid
- cyclosporin
- peg
- polyethylene glycol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE REFIERE A UNA COMPOSICION CONTENIDA EN UNA CUBIERTA DE GELATINA QUE CONTIENE POLIETILENGLICOL Y PROPILENGLICOL COMO PLASTIFICANTE, QUE COMPRENDE: (1) CICLOSPORINA, DE PREFERENCIA CICLOSPORINA A; (2) UN COTENSIOACTIVO; (3) UN COMPONENTE OLEOSO; (4) UN TENSIOACTIVO CON UN VALOR HLB DE 8 A 17; EN DONDE: LA PROPORCION EN PESO DE (1):(2):(3):(4) ES DE 1:0,1-10:1,1-10:0,1-10 O DE 1:0,5-8:2-6:2-8; Y EN DONDE: (2) ES POLIETILENGLICOL (PEG DE 200 O 600) O ES CARBONATO DE PROPILENO O ES UNA MEZCLA DE AMBOS EN UNA PROPORCION PEG:CARBONATO DE PROPILENO DE 1:0,1-5 O DE 1:0,2-2; (3) ES UNA MEZCLA DE: (i) UN ESTER DE ACIDO GRASO Y ALCOHOL PRIMARIO, DE PREFERENCIA ES LINOLEATO DE ETILO; (ii) UN MONOGLICERIDO DE ACIDO GRASO COMO ACIDO OLEICO; Y OPCIONALMENTE, (iii) UN TRIGLICERIDO DE ACIDO GRASO DE CADENA MEDIA COMO ACIDO CAPRILICO O CAPRICO; (4) ES DE PREFERENCIA UNA MEZCLA DE ACEITE DE RICINO HIDROGENADO Y POLIOXIETILENO (50):MONOLAURATO DE POLIOXIETILENO (20) Y SORBITAN CUYA PROPORCION ES 1:0,1-5. ESTA COMPOSICION DE ACCION INMUNOSUPRESORA Y ANTIINFLAMATORIA TIENE MAYOR BIODISPONIBILIDAD Y ESTABILIDAD EN EL ALMACENAMIENTO CON RESPECTO AL TIEMPO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019960022417A KR0183449B1 (ko) | 1996-06-19 | 1996-06-19 | 사이클로스포린-함유 연질캅셀제 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE97198A1 true PE97198A1 (es) | 1999-01-13 |
Family
ID=19462548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000521A PE97198A1 (es) | 1996-06-19 | 1997-06-19 | Preparacion de capsula suave que contiene ciclosporina |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0813876B1 (es) |
| JP (2) | JP2855135B2 (es) |
| KR (1) | KR0183449B1 (es) |
| CN (1) | CN1180840C (es) |
| AR (1) | AR013586A1 (es) |
| AT (1) | ATE214937T1 (es) |
| CO (1) | CO4970826A1 (es) |
| DE (1) | DE69711267T2 (es) |
| DK (1) | DK0813876T3 (es) |
| ES (1) | ES2175217T3 (es) |
| HK (1) | HK1006780A1 (es) |
| ID (1) | ID18517A (es) |
| PE (1) | PE97198A1 (es) |
| PL (1) | PL188986B1 (es) |
| PT (1) | PT813876E (es) |
| SI (1) | SI0813876T1 (es) |
| ZA (1) | ZA975448B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR19980073479A (ko) * | 1997-03-14 | 1998-11-05 | 한스루돌프하우스, 니콜케르커 | 사이클로스포린-함유 연질캅셀제 |
| KR19990047897A (ko) * | 1997-12-05 | 1999-07-05 | 김충환 | 사이클로스포린 함유 약학적 조성물 |
| PL348193A1 (en) | 1998-12-11 | 2002-05-06 | Pharmasolutions | Self-emulsifying compositions for drugs poorly soluble in water |
| US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
| KR100533460B1 (ko) * | 2002-07-20 | 2005-12-08 | 대화제약 주식회사 | 난용성 약물의 가용화용 점막흡착성 조성물, 이를 이용한난용성 약물의 가용화용 제형 및 이들의 제조 방법 |
| GB2391473B (en) * | 2002-08-02 | 2004-07-07 | Satishchandra Punambhai Patel | Pharmaceutical compositions |
| GB2391472B (en) * | 2002-08-02 | 2004-12-08 | Satishchandra Punambhai Patel | Pharmaceutical compositions |
| KR100525234B1 (ko) * | 2003-02-19 | 2005-10-28 | 한국유나이티드제약 주식회사 | 사이클로스포린 함유 연질캅셀제 및 그 제조방법 |
| ES2496102T3 (es) * | 2003-03-28 | 2014-09-18 | Sigmoid Pharma Limited | Forma de dosificación oral sólida que contiene microcápsulas sin fisuras |
| CN100342856C (zh) * | 2003-04-10 | 2007-10-17 | 上海医药工业研究院 | 达那唑半固体骨架制剂的组合物 |
| DK2079456T3 (da) | 2007-04-04 | 2013-03-18 | Sigmoid Pharma Ltd | Farmaceutiske cyclosporinsammensætninger |
| EP2061587A1 (en) | 2007-04-26 | 2009-05-27 | Sigmoid Pharma Limited | Manufacture of multiple minicapsules |
| TW200932240A (en) * | 2007-10-25 | 2009-08-01 | Astellas Pharma Inc | Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production |
| BRPI1012196B1 (pt) | 2009-05-18 | 2021-11-30 | Sublimity Therapeutics Limited | Composição compreendendo gotas de óleo |
| EP2464341B1 (en) | 2009-08-12 | 2022-07-06 | Sublimity Therapeutics Limited | Immunomodulatory compositions comprising a polymer matrix and an oil phase |
| GB201020032D0 (en) * | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| AU2015258840B2 (en) * | 2014-05-15 | 2018-03-15 | Enzychem Lifesciences Corporation | Methods for treating leukopenia and thrombocytopenia |
| KR20170102223A (ko) | 2014-11-07 | 2017-09-08 | 시그모이드 파마 리미티드 | 사이클로스포린을 포함하는 조성물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU215966B (hu) * | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum |
| KR0167613B1 (ko) * | 1994-12-28 | 1999-01-15 | 한스 루돌프 하우스, 니콜 케르커 | 사이클로스포린-함유 연질캅셀제 조성물 |
-
1996
- 1996-06-19 KR KR1019960022417A patent/KR0183449B1/ko not_active IP Right Cessation
- 1996-08-28 JP JP8227156A patent/JP2855135B2/ja not_active Expired - Fee Related
-
1997
- 1997-06-05 AT AT97109152T patent/ATE214937T1/de not_active IP Right Cessation
- 1997-06-05 DE DE69711267T patent/DE69711267T2/de not_active Expired - Fee Related
- 1997-06-05 PT PT97109152T patent/PT813876E/pt unknown
- 1997-06-05 EP EP97109152A patent/EP0813876B1/en not_active Expired - Lifetime
- 1997-06-05 ES ES97109152T patent/ES2175217T3/es not_active Expired - Lifetime
- 1997-06-05 SI SI9730334T patent/SI0813876T1/xx unknown
- 1997-06-05 DK DK97109152T patent/DK0813876T3/da active
- 1997-06-16 CN CNB971127964A patent/CN1180840C/zh not_active Expired - Fee Related
- 1997-06-18 CO CO97033896A patent/CO4970826A1/es unknown
- 1997-06-19 PE PE1997000521A patent/PE97198A1/es not_active Application Discontinuation
- 1997-06-19 ZA ZA975448A patent/ZA975448B/xx unknown
- 1997-06-19 AR ARP970102686A patent/AR013586A1/es active IP Right Grant
- 1997-06-19 ID IDP972100A patent/ID18517A/id unknown
- 1997-06-19 PL PL97326169A patent/PL188986B1/pl not_active IP Right Cessation
-
1998
- 1998-06-22 HK HK98105860A patent/HK1006780A1/xx not_active IP Right Cessation
- 1998-07-09 JP JP10194739A patent/JP2923503B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CO4970826A1 (es) | 2000-11-07 |
| DK0813876T3 (da) | 2002-07-22 |
| DE69711267D1 (de) | 2002-05-02 |
| PL188986B1 (pl) | 2005-05-31 |
| JPH107550A (ja) | 1998-01-13 |
| PT813876E (pt) | 2002-07-31 |
| EP0813876B1 (en) | 2002-03-27 |
| ZA975448B (en) | 1999-03-19 |
| ES2175217T3 (es) | 2002-11-16 |
| CN1180840C (zh) | 2004-12-22 |
| HK1006780A1 (en) | 1999-03-19 |
| AR013586A1 (es) | 2001-01-10 |
| ID18517A (id) | 1998-04-16 |
| SI0813876T1 (en) | 2002-10-31 |
| JP2923503B2 (ja) | 1999-07-26 |
| KR980000466A (ko) | 1998-03-30 |
| JP2855135B2 (ja) | 1999-02-10 |
| CN1178106A (zh) | 1998-04-08 |
| DE69711267T2 (de) | 2002-11-21 |
| KR0183449B1 (ko) | 1999-05-01 |
| ATE214937T1 (de) | 2002-04-15 |
| JPH11100326A (ja) | 1999-04-13 |
| EP0813876A1 (en) | 1997-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |