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PE73599A1 - Moduladores de receptores de aminoacidos excitadores - Google Patents

Moduladores de receptores de aminoacidos excitadores

Info

Publication number
PE73599A1
PE73599A1 PE1998000370A PE00037098A PE73599A1 PE 73599 A1 PE73599 A1 PE 73599A1 PE 1998000370 A PE1998000370 A PE 1998000370A PE 00037098 A PE00037098 A PE 00037098A PE 73599 A1 PE73599 A1 PE 73599A1
Authority
PE
Peru
Prior art keywords
excitors
amino acid
receptor modulators
refers
acid receptor
Prior art date
Application number
PE1998000370A
Other languages
English (en)
Inventor
James Allen Monn
Matthew John Valli
Steven Marc Massey
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE73599A1 publication Critical patent/PE73599A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/14—Compounds containing azido groups with azido groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/07—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/383—Cycloaliphatic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I), SU ESTER O AMIDA O SAL, DONDE R1 ES FLUOR, XOR3, XNR4R5, SO3H, ENTRE OTROS; R2 ES H o R1 Y R2 SON FLUOR o =O, =NOR7 o =CR8R9 o UNO ES AMINO Y EL OTRO ES CARBOXILO, ENTRE OTROS; R3 ES H, ALQUILO C1-C6, ALQUENILO C3-C6, ALQUINILO C3-C6, ENTRE OTROS; X ES UN ENLACE, CH2, CO; m ES 1-3; R4 ES COR10 o ES R3, R4, R5, R7, R8, R9, R10 SON IGUAL A R3, R6 ES H o ALQUILO C1-C6. UN COMPUESTO PREFERIDO ES ACIDO (1S*,2S*,5R*,6R*)-2-AMINO-4-OXOBICICLO[3.1.0]HEXANO-2,6-DICARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A COMPUESTOS DE FORMULA (II), DONDE R11 ES H, ACILO; R12 ES UN GRUPO CARBOXILO TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA SU PREPARACION. EL COMPUESTO (I) MODULA LA FUNCION DE RECEPTORES METABOTROPICOS DE GLUTAMATO
PE1998000370A 1997-05-14 1998-05-14 Moduladores de receptores de aminoacidos excitadores PE73599A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4701197P 1997-05-14 1997-05-14

Publications (1)

Publication Number Publication Date
PE73599A1 true PE73599A1 (es) 1999-08-14

Family

ID=21946570

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000370A PE73599A1 (es) 1997-05-14 1998-05-14 Moduladores de receptores de aminoacidos excitadores

Country Status (30)

Country Link
US (3) US5958960A (es)
EP (1) EP0878463B1 (es)
JP (1) JP4191263B2 (es)
KR (1) KR20010012489A (es)
CN (1) CN1125807C (es)
AR (1) AR015664A1 (es)
AT (1) ATE198190T1 (es)
AU (1) AU729632B2 (es)
BR (1) BR9808787A (es)
CA (1) CA2289472C (es)
CO (1) CO4950558A1 (es)
DE (1) DE69800430T2 (es)
DK (1) DK0878463T3 (es)
EA (1) EA199901029A1 (es)
ES (1) ES2152738T3 (es)
GR (1) GR3035156T3 (es)
HU (1) HUP0001404A3 (es)
ID (1) ID23183A (es)
IL (1) IL132894A0 (es)
NO (1) NO995480D0 (es)
NZ (1) NZ500954A (es)
PE (1) PE73599A1 (es)
PL (1) PL336793A1 (es)
PT (1) PT878463E (es)
SI (1) SI0878463T1 (es)
SV (1) SV1998000056A (es)
TR (1) TR199902777T2 (es)
TW (1) TW505623B (es)
WO (1) WO1998051655A1 (es)
ZA (1) ZA983930B (es)

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Also Published As

Publication number Publication date
JP2001525825A (ja) 2001-12-11
DE69800430D1 (de) 2001-01-25
TR199902777T2 (xx) 2000-07-21
IL132894A0 (en) 2001-03-19
ZA983930B (en) 1999-11-08
CA2289472A1 (en) 1998-11-19
CA2289472C (en) 2007-04-24
HUP0001404A3 (en) 2000-09-28
TW505623B (en) 2002-10-11
ES2152738T3 (es) 2001-02-01
SI0878463T1 (en) 2001-06-30
AR015664A1 (es) 2001-05-16
US6160009A (en) 2000-12-12
DE69800430T2 (de) 2001-06-13
US6268507B1 (en) 2001-07-31
AU7386998A (en) 1998-12-08
DK0878463T3 (da) 2001-02-19
AU729632B2 (en) 2001-02-08
WO1998051655A1 (en) 1998-11-19
NO995480L (no) 1999-11-09
ATE198190T1 (de) 2001-01-15
JP4191263B2 (ja) 2008-12-03
CO4950558A1 (es) 2000-09-01
KR20010012489A (ko) 2001-02-15
PL336793A1 (en) 2000-07-17
BR9808787A (pt) 2000-07-11
PT878463E (pt) 2001-04-30
HUP0001404A2 (hu) 2000-08-28
SV1998000056A (es) 1999-01-18
ID23183A (id) 2000-03-23
EP0878463A1 (en) 1998-11-18
CN1125807C (zh) 2003-10-29
NZ500954A (en) 2001-06-29
US5958960A (en) 1999-09-28
EP0878463B1 (en) 2000-12-20
GR3035156T3 (en) 2001-04-30
CN1255117A (zh) 2000-05-31
EA199901029A1 (ru) 2000-06-26
NO995480D0 (no) 1999-11-09

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