PE38197A1 - Procedimiento para preparar solvatos de 2-metil-tieno-benzodiacepina (olanzapina) - Google Patents
Procedimiento para preparar solvatos de 2-metil-tieno-benzodiacepina (olanzapina)Info
- Publication number
- PE38197A1 PE38197A1 PE1996000202A PE00020296A PE38197A1 PE 38197 A1 PE38197 A1 PE 38197A1 PE 1996000202 A PE1996000202 A PE 1996000202A PE 00020296 A PE00020296 A PE 00020296A PE 38197 A1 PE38197 A1 PE 38197A1
- Authority
- PE
- Peru
- Prior art keywords
- solvate
- methyl
- less
- benzodiacepine
- theno
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A LOS SOLVATOS DEL ANTIPSICOTICO 2-METIL-4-(4-METIL-1-PIPERACINIL)-1-OH-TIENO[2,3-b][1,5]BENZODIACEPINA, CARACTERIZADOS POR SUS ESPACIOS INTERPLANARES EN EL DIFRACTOMETRO DE RAYOS X, QUE COMPRENDE VALORES PARA: a) EL SOLVATO MONOMETANOLICO DE 10,2932(A) A 2,7412(A); b) EL SOLVATO MONOETANOLICO DE 10,2672(A) A 2,5791(A) Y c) EL SOLVATO MONO-1-PROPANOLICO DE 10,2736(A) A 2,5683(A). TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE LA OLANZAPINA CON MENOS DE 5%, INCLUSIVE MENOS DE 1% DE SUSTANCIAS RELACIONADAS INDESEABLES, QUE COMPRENDE: 1) LA CRISTALIZACION DEL SOLVATO, AL AGREGAR EL ALCOHOL A UNA TEMPERATURA DE 25�C A 50�C Y POR UN TIEMPO DE AGITACION DE HASTA 30 MINUTOS;Y 2) EL SECADO A UNA TEMPERATURA MENOR DE 50�C. EL PROCEDIMIENTO PROPORCIONA MENOS RECRISTALIZACIONES, MAYOR RENDIMIENTO TOTAL Y MAYOR INOCUIDAD (AL DISMINUIR LAS SUSTANCIAS INDESEABLES), LO QUE FACILITA SU MANIPULACION PARA FINES DE PRODUCCION
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40956695A | 1995-03-24 | 1995-03-24 | |
| US08/410,474 US5631250A (en) | 1995-03-24 | 1995-03-24 | Process and solvate of 2-methyl-thieno-benzodiazepine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE38197A1 true PE38197A1 (es) | 1997-10-16 |
Family
ID=27020696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1996000202A PE38197A1 (es) | 1995-03-24 | 1996-03-22 | Procedimiento para preparar solvatos de 2-metil-tieno-benzodiacepina (olanzapina) |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0733634B1 (es) |
| AR (2) | AR002721A1 (es) |
| AT (1) | ATE197711T1 (es) |
| AU (1) | AU5257896A (es) |
| CO (1) | CO4700300A1 (es) |
| DE (1) | DE69611003T2 (es) |
| DK (1) | DK0733634T3 (es) |
| EG (1) | EG24221A (es) |
| ES (1) | ES2151991T3 (es) |
| GR (1) | GR3035355T3 (es) |
| IL (1) | IL117613A (es) |
| MY (1) | MY116503A (es) |
| PE (1) | PE38197A1 (es) |
| PT (1) | PT733634E (es) |
| SI (1) | SI0733634T1 (es) |
| WO (1) | WO1996030374A1 (es) |
| YU (1) | YU49276B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA978515B (en) * | 1996-09-23 | 1999-03-23 | Lilly Co Eli | Intermediates and process for preparing olanzapine |
| BR9711541A (pt) * | 1996-09-23 | 1999-08-24 | Lilly Co Eli | Dihidrato d de olanzapina |
| FR2802101B1 (fr) | 1999-12-10 | 2003-02-28 | Aventis Pharma Sa | Association de cymemazine et d'un neuroleptique atypique |
| EP1513846B1 (en) | 2002-05-31 | 2011-03-02 | Sandoz Ag | Process of preparation of olanzapine form i |
| SI21270A (sl) | 2002-07-15 | 2004-02-29 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Kristalne oblike olanzapina in postopki za njihovo pripravo |
| US7323459B2 (en) | 2002-12-24 | 2008-01-29 | Teva Pharmaceutical Industries Ltd. | Crystal forms, methods for their preparation and method for preparation of olanzapine |
| ATE397611T1 (de) | 2003-12-22 | 2008-06-15 | Teva Pharma | Verfahren zur herstellung von olanzapin |
| WO2005080401A1 (en) * | 2004-02-19 | 2005-09-01 | Neuland Laboratories Limited | Process for the preparation of olanzapine form 1 useful as antipsychotic drug |
| ES2253091B1 (es) * | 2004-07-27 | 2007-02-01 | Inke, S.A. | Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo. |
| ES2363364T3 (es) | 2005-01-05 | 2011-08-02 | Eli Lilly And Company | Dihidrato de pamoato de olanzapina. |
| CA2593407A1 (en) * | 2007-06-22 | 2008-12-22 | Apotex Pharmachem Inc. | Improved processes for the synthesis of olanzapine |
| CU20090172A6 (es) | 2009-10-09 | 2011-10-05 | Facultad De Quimica Universidad De La Habana | Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular |
| EP2486913A1 (en) | 2011-02-14 | 2012-08-15 | Labtec GmbH | Rapidly disintegrating oral film formulation for Olanzapin |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4237279A (en) * | 1979-07-27 | 1980-12-02 | Eli Lilly And Company | Crystalline 3-hydroxycephalosporin solvates |
| GB9009229D0 (en) * | 1990-04-25 | 1990-06-20 | Lilly Industries Ltd | Pharmaceutical compounds |
| US5229382A (en) * | 1990-04-25 | 1993-07-20 | Lilly Industries Limited | 2-methyl-thieno-benzodiazepine |
| NO305125B1 (no) * | 1992-05-29 | 1999-04-06 | Lilly Industries Ltd | Farmas°ytiske forbindelser |
| US5439888A (en) * | 1994-03-04 | 1995-08-08 | Eli Lilly And Company | Antithrombotic agents |
| US5457101A (en) * | 1994-06-03 | 1995-10-10 | Eli Lilly And Company | Thieno[1,5]benzoidiazepine use |
-
1996
- 1996-03-12 EG EG25396A patent/EG24221A/xx active
- 1996-03-22 DE DE69611003T patent/DE69611003T2/de not_active Expired - Lifetime
- 1996-03-22 EP EP96301999A patent/EP0733634B1/en not_active Expired - Lifetime
- 1996-03-22 IL IL11761396A patent/IL117613A/xx not_active IP Right Cessation
- 1996-03-22 AT AT96301999T patent/ATE197711T1/de active
- 1996-03-22 PT PT96301999T patent/PT733634E/pt unknown
- 1996-03-22 SI SI9630280T patent/SI0733634T1/xx unknown
- 1996-03-22 AR ARP960101881A patent/AR002721A1/es not_active Application Discontinuation
- 1996-03-22 YU YU17696A patent/YU49276B/sh unknown
- 1996-03-22 MY MYPI96001068A patent/MY116503A/en unknown
- 1996-03-22 AU AU52578/96A patent/AU5257896A/en not_active Abandoned
- 1996-03-22 AR ARP960101882A patent/AR004169A1/es active IP Right Grant
- 1996-03-22 PE PE1996000202A patent/PE38197A1/es not_active IP Right Cessation
- 1996-03-22 DK DK96301999T patent/DK0733634T3/da active
- 1996-03-22 WO PCT/US1996/003854 patent/WO1996030374A1/en unknown
- 1996-03-22 CO CO96014565A patent/CO4700300A1/es unknown
- 1996-03-22 ES ES96301999T patent/ES2151991T3/es not_active Expired - Lifetime
-
2001
- 2001-02-02 GR GR20010400180T patent/GR3035355T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI0733634T1 (en) | 2001-06-30 |
| AR004169A1 (es) | 1998-11-04 |
| GR3035355T3 (en) | 2001-05-31 |
| EP0733634A1 (en) | 1996-09-25 |
| DK0733634T3 (da) | 2000-12-11 |
| AU5257896A (en) | 1996-10-16 |
| WO1996030374A1 (en) | 1996-10-03 |
| YU49276B (sh) | 2005-03-15 |
| DE69611003D1 (de) | 2000-12-28 |
| EG24221A (en) | 2008-11-10 |
| CO4700300A1 (es) | 1998-12-29 |
| ES2151991T3 (es) | 2001-01-16 |
| IL117613A0 (en) | 1996-07-23 |
| ATE197711T1 (de) | 2000-12-15 |
| IL117613A (en) | 2000-07-16 |
| MY116503A (en) | 2004-02-28 |
| YU17696A (sh) | 1998-07-10 |
| EP0733634B1 (en) | 2000-11-22 |
| AR002721A1 (es) | 1998-04-29 |
| DE69611003T2 (de) | 2001-05-10 |
| PT733634E (pt) | 2001-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| MK | Expiration of term |