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PE20230179A1 - Metodos y composiciones para el tratamiento de un trastorno asociado con angiotensinogeno (agt) - Google Patents

Metodos y composiciones para el tratamiento de un trastorno asociado con angiotensinogeno (agt)

Info

Publication number
PE20230179A1
PE20230179A1 PE2022000781A PE2022000781A PE20230179A1 PE 20230179 A1 PE20230179 A1 PE 20230179A1 PE 2022000781 A PE2022000781 A PE 2022000781A PE 2022000781 A PE2022000781 A PE 2022000781A PE 20230179 A1 PE20230179 A1 PE 20230179A1
Authority
PE
Peru
Prior art keywords
angiotensinogen
agt
nucleotide sequence
treatment
agent
Prior art date
Application number
PE2022000781A
Other languages
English (en)
Inventor
Donald Foster
Sagar Agarwal
Stephen Albert Huang
Jae Kim
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of PE20230179A1 publication Critical patent/PE20230179A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/52—Methods for regulating/modulating their activity modulating the physical stability, e.g. GC-content

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Referido a un agente de acido ribonucleico de hebra doble (ARNi), o de una sal del mismo; que comprende una dosis fija de aproximadamente entre 50 mg y 800 mg; donde la hebra doble del agente de RNAi o su sal comprende una hebra sentido y una hebra antisentido. En donde la hebra antisentido comprende una secuencia de nucleotidos que comprende por lo menos 19 nucleotidos contiguos de la secuencia de nucleotidos UGUACUCUCAUUGUGGAUGACGA (SEQ ID NO: 9) y la hebra sentido comprende una secuencia de nucleotidos que comprende por lo menos 19 nucleotidos contiguos de la secuencia de nucleotidos GUCAUCCACAAUGAGAGUACA (SEQ ID NO: 10). Este agente de ARNi inhibe la expresion de un gen de angiotensinogeno (AGT). Tambien se refiere a la via de administracion de dicho agente subcutanea o intravenosa, y su uso para el tratamiento de un trastorno asociado con angiotensinogeno (AGT), tales como hipertension.
PE2022000781A 2019-11-13 2020-11-06 Metodos y composiciones para el tratamiento de un trastorno asociado con angiotensinogeno (agt) PE20230179A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962934695P 2019-11-13 2019-11-13
US202063017854P 2020-04-30 2020-04-30
PCT/US2020/059265 WO2021096763A1 (en) 2019-11-13 2020-11-06 Methods and compositions for treating an angiotensinogen- (agt-) associated disorder

Publications (1)

Publication Number Publication Date
PE20230179A1 true PE20230179A1 (es) 2023-02-01

Family

ID=73643353

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2022000781A PE20230179A1 (es) 2019-11-13 2020-11-06 Metodos y composiciones para el tratamiento de un trastorno asociado con angiotensinogeno (agt)

Country Status (16)

Country Link
US (1) US20230002765A1 (es)
EP (1) EP4058577A1 (es)
JP (1) JP7707164B2 (es)
KR (1) KR20220115946A (es)
CN (1) CN114981431A (es)
AU (1) AU2020382478A1 (es)
BR (1) BR112022009216A2 (es)
CA (1) CA3161703A1 (es)
CL (1) CL2022001256A1 (es)
CO (1) CO2022006092A2 (es)
IL (1) IL292865A (es)
MX (1) MX2022005692A (es)
PE (1) PE20230179A1 (es)
PH (1) PH12022551158A1 (es)
TW (1) TWI877247B (es)
WO (1) WO2021096763A1 (es)

Families Citing this family (12)

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Publication number Priority date Publication date Assignee Title
TWI851574B (zh) 2018-05-14 2024-08-11 美商阿尼拉製藥公司 血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法
EP4363580A1 (en) * 2021-06-30 2024-05-08 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating an angiotensinogen- (agt-) associated disorder
US20250197853A1 (en) * 2021-11-19 2025-06-19 Tuojie Biotech (Shanghai) Co., Ltd. Sirna targeting angiotensinogen and pharmaceutical use of sirna
TW202339773A (zh) * 2022-01-20 2023-10-16 大陸商上海拓界生物醫藥科技有限公司 一種ｄｓＲＮＡ、其應用及製備方法
JP2025514400A (ja) * 2022-04-29 2025-05-02 ベースキュア セラピューティクス ヌクレオチドアナログ含有二重鎖ＲＮＡｉアナログのコンジュゲート
WO2024032679A1 (zh) * 2022-08-11 2024-02-15 益杰立科(上海)生物科技有限公司 一种表观编辑靶点的方法及用途
CN117568350B (zh) * 2024-01-15 2024-04-30 苏州时安生物技术有限公司 一种用于调节血管紧张素原基因表达的双链rna、其缀合物、药物组合物及用途
WO2024234831A1 (zh) * 2023-05-15 2024-11-21 苏州时安生物技术有限公司 一种用于调节血管紧张素原基因表达的双链rna、其缀合物、药物组合物及用途
CN119585433A (zh) * 2023-07-06 2025-03-07 石药集团中奇制药技术（石家庄）有限公司 一种抑制AGT基因表达的RNAi剂及其应用
WO2025007961A1 (zh) * 2023-07-06 2025-01-09 大睿生物 调控AGT表达的dsRNA分子
TW202509216A (zh) * 2023-07-14 2025-03-01 大陸商北京安龍生物醫藥有限公司 靶向血管收縮素原的寡核苷酸及其用途
WO2025128614A1 (en) * 2023-12-12 2025-06-19 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating an angiotensinogen- (agt-) associated disorder

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