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PE20221569A1 - Compuestos tetraciclicos para el tratamiento de infecciones por vih - Google Patents

Compuestos tetraciclicos para el tratamiento de infecciones por vih

Info

Publication number
PE20221569A1
PE20221569A1 PE2022001814A PE2022001814A PE20221569A1 PE 20221569 A1 PE20221569 A1 PE 20221569A1 PE 2022001814 A PE2022001814 A PE 2022001814A PE 2022001814 A PE2022001814 A PE 2022001814A PE 20221569 A1 PE20221569 A1 PE 20221569A1
Authority
PE
Peru
Prior art keywords
treatment
hiv infections
tetracyclic compounds
compounds
alkyl
Prior art date
Application number
PE2022001814A
Other languages
English (en)
Inventor
Lan Jiang
David W Lin
Michael L Mitchell
Ezra Roberts
Gregg M Schwarzwalder
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of PE20221569A1 publication Critical patent/PE20221569A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invencion se refiere a un compuesto de formula I, o una sal farmaceuticamente aceptable del mismo, en donde: R1 es H, arilo C6-C10, entre otros; Y es -CONH-, entre otros; L es -CO-, -SO2-, entre otros; W1 es un enlace o -CR4aR4b-; W2 es -O-, entre otros; X es un enlace o -CR8aR8b; Z es -CR9aR9b, entre otros; T es -CR2aR2b-, entre otros; U es -CO-, -O-, entre otros; R2a y R2b son H, alquilo C1-C6, entre otros; R4a, R4b, R8a, R8b, R9a y R9b son H, alquilo C1-C6, cicloalquilo C3-C6, entre otros. Son compuestos especificos i), ii), entre otros. Tambien se refiere a una composicion farmaceutica. Dichos compuestos son utiles en el tratamiento o prevencion de la infeccion por el virus de la inmunodeficiencia humana (VIH).
PE2022001814A 2020-02-24 2021-02-23 Compuestos tetraciclicos para el tratamiento de infecciones por vih PE20221569A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202062980857P 2020-02-24 2020-02-24
US202063036268P 2020-06-08 2020-06-08
US202063128670P 2020-12-21 2020-12-21
PCT/US2021/019179 WO2021173522A1 (en) 2020-02-24 2021-02-23 Tetracyclic compounds for treating hiv infection

Publications (1)

Publication Number Publication Date
PE20221569A1 true PE20221569A1 (es) 2022-10-06

Family

ID=74885056

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2022001814A PE20221569A1 (es) 2020-02-24 2021-02-23 Compuestos tetraciclicos para el tratamiento de infecciones por vih

Country Status (15)

Country Link
US (2) US11697652B2 (es)
EP (1) EP4110783A1 (es)
JP (2) JP7453399B2 (es)
CN (1) CN115151545B (es)
AU (2) AU2021225809B2 (es)
BR (1) BR112022015771A2 (es)
CA (1) CA3166480A1 (es)
CO (1) CO2022011947A2 (es)
CR (1) CR20220418A (es)
DO (1) DOP2022000171A (es)
IL (1) IL295677A (es)
MX (1) MX2022009871A (es)
PE (1) PE20221569A1 (es)
TW (2) TW202248199A (es)
WO (1) WO2021173522A1 (es)

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TW202227445A (zh) 2020-10-30 2022-07-16 大陸商上海拓界生物醫藥科技有限公司 抑制基因缺陷的ｈｉｖ病毒的用途
EP4321217A3 (en) 2021-01-19 2024-04-10 Gilead Sciences, Inc. Substituted pyridotriazine compounds and uses thereof
AR124868A1 (es) 2021-02-16 2023-05-10 Merck Sharp & Dohme Llc Compuestos de heterociclo tetracíclicos útiles como inhibidores de la integrasa del vih
TW202446773A (zh) 2022-04-06 2024-12-01 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途

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