PE20191152A1 - Anticuerpos y polipeptidos dirigidos contra cd127 - Google Patents
Anticuerpos y polipeptidos dirigidos contra cd127Info
- Publication number
- PE20191152A1 PE20191152A1 PE2019001201A PE2019001201A PE20191152A1 PE 20191152 A1 PE20191152 A1 PE 20191152A1 PE 2019001201 A PE2019001201 A PE 2019001201A PE 2019001201 A PE2019001201 A PE 2019001201A PE 20191152 A1 PE20191152 A1 PE 20191152A1
- Authority
- PE
- Peru
- Prior art keywords
- antibody
- seq
- antigen
- refers
- variable domain
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
Abstract
Referido a un anticuerpo o un fragmento del mismo de union a antigeno, que se une especificamente a CD127, en particular a CD127 humano, que comprende: una cadena liviana del anticuerpo que comprende, o un dominio variable de la cadena liviana del anticuerpo que consiste en, una secuencia seleccionada del grupo que consiste de las SEQ ID NOs: 9, 10, 11, 12 y en particular SEQ ID NO: 12; un dominio variable de la cadena pesada del anticuerpo que consiste en la secuencia establecida en la SEQ ID NO: 7. Este anticuerpo o fragmento del mismo de union a antigeno, antagonista de la senalizacion de IL7-R inducida por IL-7 no induce la activacion de la fosfatidilinositol 3-quinasa y/o de la via de senalizacion de ERK. Tambien se refiere a una composicion farmaceutica que comprende el anticuerpo o fragmento del mismo, y/o combinacion de moleculas de acido nucleico aisladas y un vehiculo farmaceutico; de administracion local subcutanea, enterica u oral, o para el suministro en el colon. Y sus usos terapeuticos y aplicaciones de tipo diagnostico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16306655 | 2016-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20191152A1 true PE20191152A1 (es) | 2019-09-05 |
Family
ID=57796143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019001201A PE20191152A1 (es) | 2016-12-09 | 2017-12-07 | Anticuerpos y polipeptidos dirigidos contra cd127 |
Country Status (38)
| Country | Link |
|---|---|
| US (3) | US11098128B2 (es) |
| EP (1) | EP3551664B1 (es) |
| JP (1) | JP6986559B2 (es) |
| KR (1) | KR102306366B1 (es) |
| CN (1) | CN110392695B (es) |
| AR (1) | AR110326A1 (es) |
| AU (1) | AU2017373819B2 (es) |
| BR (1) | BR112019010595A2 (es) |
| CA (1) | CA3042582C (es) |
| CL (1) | CL2019001530A1 (es) |
| CO (1) | CO2019005909A2 (es) |
| CR (1) | CR20190273A (es) |
| CY (1) | CY1124153T1 (es) |
| DK (1) | DK3551664T3 (es) |
| EA (1) | EA201991005A1 (es) |
| ES (1) | ES2867900T3 (es) |
| HR (1) | HRP20210697T1 (es) |
| HU (1) | HUE054206T2 (es) |
| IL (1) | IL266837B (es) |
| LT (1) | LT3551664T (es) |
| MA (1) | MA49727B1 (es) |
| MD (1) | MD3551664T2 (es) |
| MX (1) | MX2019006577A (es) |
| MY (1) | MY190770A (es) |
| NZ (1) | NZ753213A (es) |
| PE (1) | PE20191152A1 (es) |
| PH (1) | PH12019501285B1 (es) |
| PL (1) | PL3551664T3 (es) |
| PT (1) | PT3551664T (es) |
| RS (1) | RS61808B1 (es) |
| RU (1) | RU2769352C2 (es) |
| SA (1) | SA519401906B1 (es) |
| SI (1) | SI3551664T1 (es) |
| SM (1) | SMT202100267T1 (es) |
| TW (1) | TWI777996B (es) |
| UA (1) | UA126386C2 (es) |
| UY (1) | UY37511A (es) |
| WO (1) | WO2018104483A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170132749A (ko) | 2015-03-31 | 2017-12-04 | 브이에이치스퀘어드 리미티드 | 폴리펩티드 |
| AU2016239949A1 (en) | 2015-03-31 | 2017-09-07 | Sorriso Pharmaceuticals, Inc. | Peptide construct having a protease-cleavable linker |
| EP3405491A1 (en) | 2016-01-21 | 2018-11-28 | VHsquared Limited | Polypeptides |
| JP7604099B2 (ja) | 2017-06-04 | 2024-12-23 | ラパポート・ファミリー・インスティテュート・フォー・リサーチ・イン・ザ・メディカル・サイエンシーズ | 免疫チェックポイント阻害薬によるがん治療に対する個別化応答の予測方法およびそのためのキット |
| US12016900B2 (en) | 2017-06-04 | 2024-06-25 | Rappaport Family Institute For Research In The Medical Sciences | Method of treating cancer with an immune checkpoint inhibitor in combination with another therapeutic agent |
| US12070489B2 (en) | 2018-12-12 | 2024-08-27 | Rappaport Family Institute For Research In The Medical Sciences | Method of treating cancer with a cancer therapy in combination with another therapeutic agent |
| AU2020210635B2 (en) | 2019-01-22 | 2024-12-12 | Bristol Myers Squibb Company | Antibodies against IL-7R alpha subunit and uses thereof |
| CN119684455A (zh) | 2019-06-21 | 2025-03-25 | 索瑞索制药公司 | 多肽 |
| CA3144567A1 (en) | 2019-06-21 | 2020-12-24 | Scott Crowe | Polypeptides |
| BR112022008744A2 (pt) | 2019-11-05 | 2022-07-19 | Medikine Inc | Ligante de il-2rss, ligante de il-2r¿c, composto de ligação a il-2r¿¿c, composição farmacêutica, método para tratar uma doença em um paciente, método para expandir células imunes, método de uma terapia celular, método para reforçar uma vacina, método para modificar a resposta imune e ácido nucleico |
| CN110894237B (zh) * | 2019-12-05 | 2021-08-03 | 山东省分析测试中心 | 抗cd127的抗体、分泌该抗体的细胞株及其制备方法和应用 |
| WO2021158623A1 (en) * | 2020-02-03 | 2021-08-12 | Medikine, Inc. | IL-7Rαγc BINDING COMPOUNDS |
| US20220389104A1 (en) | 2021-05-28 | 2022-12-08 | Ose Immunotherapeutics | Method for Treating CD127-Positive Cancers by Administering an Anti-CD127 Agent |
| CN113501499A (zh) * | 2021-08-11 | 2021-10-15 | 无锡贝塔医药科技有限公司 | 一种高纯无水溴化氘气体的制备方法及其应用 |
| US11999771B2 (en) | 2022-04-07 | 2024-06-04 | Medikine, Inc. | IL-7Rαγc ligand immunoglobulin fusion proteins |
| WO2023232826A1 (en) | 2022-05-30 | 2023-12-07 | Ose Immunotherapeutics | Biomarkers of il7r modulator activity |
| EP4455308A1 (en) | 2023-04-24 | 2024-10-30 | Les Laboratoires Servier | Il-7r gene signatures |
| WO2025029859A2 (en) * | 2023-07-31 | 2025-02-06 | Q32 Bio Inc. | Treatment of atopic dermatitis |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY32038A (es) * | 2008-08-08 | 2010-03-26 | Glaxo Wellcome Mfg Pte Ltd | Inmunoblobulinas anti-cd127 y sus usos |
| UY33202A (es) * | 2010-01-28 | 2011-08-31 | Glaxo Group Ltd | Proteínas de unión a cd127 |
| AR080291A1 (es) * | 2010-02-24 | 2012-03-28 | Rinat Neuroscience Corp | Anticuerpos antagonistas anti receptor de il-7 y procedimientos |
| EP2583980A1 (en) | 2011-10-19 | 2013-04-24 | Effimune | Antibodies directed against the alpha chain of IL7 receptor - their use for the preparation of drug candidates |
| EP2955196A1 (en) | 2014-06-10 | 2015-12-16 | Effimune | Antibodies directed against CD127 |
| GB201506869D0 (en) * | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
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2017
- 2017-12-07 RS RS20210520A patent/RS61808B1/sr unknown
- 2017-12-07 LT LTEP17835592.1T patent/LT3551664T/lt unknown
- 2017-12-07 PL PL17835592T patent/PL3551664T3/pl unknown
- 2017-12-07 HU HUE17835592A patent/HUE054206T2/hu unknown
- 2017-12-07 PE PE2019001201A patent/PE20191152A1/es unknown
- 2017-12-07 NZ NZ753213A patent/NZ753213A/en unknown
- 2017-12-07 BR BR112019010595A patent/BR112019010595A2/pt unknown
- 2017-12-07 CR CR20190273A patent/CR20190273A/es unknown
- 2017-12-07 SM SM20210267T patent/SMT202100267T1/it unknown
- 2017-12-07 JP JP2019530803A patent/JP6986559B2/ja active Active
- 2017-12-07 EA EA201991005A patent/EA201991005A1/ru unknown
- 2017-12-07 DK DK17835592.1T patent/DK3551664T3/da active
- 2017-12-07 ES ES17835592T patent/ES2867900T3/es active Active
- 2017-12-07 KR KR1020197019889A patent/KR102306366B1/ko active Active
- 2017-12-07 EP EP17835592.1A patent/EP3551664B1/en active Active
- 2017-12-07 US US16/467,284 patent/US11098128B2/en active Active
- 2017-12-07 MX MX2019006577A patent/MX2019006577A/es unknown
- 2017-12-07 UY UY0001037511A patent/UY37511A/es active IP Right Grant
- 2017-12-07 PH PH1/2019/501285A patent/PH12019501285B1/en unknown
- 2017-12-07 MD MDE20191173T patent/MD3551664T2/ro unknown
- 2017-12-07 UA UAA201905605A patent/UA126386C2/uk unknown
- 2017-12-07 CA CA3042582A patent/CA3042582C/en active Active
- 2017-12-07 CN CN201780076086.8A patent/CN110392695B/zh active Active
- 2017-12-07 AR ARP170103427A patent/AR110326A1/es unknown
- 2017-12-07 MY MYPI2019003245A patent/MY190770A/en unknown
- 2017-12-07 AU AU2017373819A patent/AU2017373819B2/en active Active
- 2017-12-07 MA MA49727A patent/MA49727B1/fr unknown
- 2017-12-07 RU RU2019115610A patent/RU2769352C2/ru active
- 2017-12-07 WO PCT/EP2017/081911 patent/WO2018104483A1/en active Application Filing
- 2017-12-07 SI SI201730717T patent/SI3551664T1/sl unknown
- 2017-12-07 TW TW106142933A patent/TWI777996B/zh active
- 2017-12-07 PT PT178355921T patent/PT3551664T/pt unknown
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2019
- 2019-05-23 IL IL266837A patent/IL266837B/en active IP Right Grant
- 2019-05-30 SA SA519401906A patent/SA519401906B1/ar unknown
- 2019-06-05 CO CONC2019/0005909A patent/CO2019005909A2/es unknown
- 2019-06-05 CL CL2019001530A patent/CL2019001530A1/es unknown
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2021
- 2021-05-05 HR HRP20210697TT patent/HRP20210697T1/hr unknown
- 2021-05-07 CY CY20211100394T patent/CY1124153T1/el unknown
- 2021-06-30 US US17/363,260 patent/US11926671B2/en active Active
-
2024
- 2024-03-09 US US18/600,697 patent/US20240352135A1/en active Pending
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