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PE20142312A1 - THERAPEUTIC COMBINATIONS AND METHODS TO TREAT MELANOMA - Google Patents

THERAPEUTIC COMBINATIONS AND METHODS TO TREAT MELANOMA

Info

Publication number
PE20142312A1
PE20142312A1 PE2014000603A PE2014000603A PE20142312A1 PE 20142312 A1 PE20142312 A1 PE 20142312A1 PE 2014000603 A PE2014000603 A PE 2014000603A PE 2014000603 A PE2014000603 A PE 2014000603A PE 20142312 A1 PE20142312 A1 PE 20142312A1
Authority
PE
Peru
Prior art keywords
inhibitor
methods
cytotoxin
combination
etbr
Prior art date
Application number
PE2014000603A
Other languages
Spanish (es)
Inventor
Paul Polakis
Jyoti Asundi
Suzanna Clark
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20142312A1 publication Critical patent/PE20142312A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

REFERIDA A UNA COMBINACION DE UN ANTICUERPO DEL RECEPTOR ANTI-ENDOTELIAL TIPO B (ETBR) Y UN INHIBIDOR DE LA MAP QUINASA, DONDE EL ANTICUERPO ANTI-ETBR SE CONJUGA CON UNA CITOTOXINA Y EL INHIBIDOR DE LA MAP QUINASA ES UN INHIBIDOR DEL GEN BRAF. LA CITOTOXINA ES UN AGENTE CITOTOXICO SELECCIONADO DE TOXINAS TALES COMO MAITANSINOIDE, CALIQUEAMICINA Y AURISTATINA, ANTIBIOTICOS, ISOTOPOS RADIOACTIVOS Y ENZIMAS NUCLEOLITICAS; EL INHIBIDOR DEL GEN BRAF ES ACIDO PROPANO-1-SULFONICO{3-[5-(4-CLOROFENIL)-1H-PIRROLO{2,3-b]PIRIDINA-3-CARBONIL]-2,4-DIFLUORO-FENIL}-AMIDA. DICHA COMBINACION ES UTIL EN LA INHIBICION DEL CRECIMIENTO TUMORAL (TGI) EN UN SUJETO QUE SUFRE DE MELANOMAREFERRED TO A COMBINATION OF AN ANTI-ENDOTELIAL TYPE B RECEPTOR ANTIBODY (ETBR) AND A MAP KINASE INHIBITOR, WHERE THE ANTI-ETBR ANTIBODY IS CONJUGATED WITH A CYTOTOXIN AND THE INHIBITOR OF THE MAP KINASA GENE IS AN INHIBITOR. CYTOTOXIN IS A CYTOTOXIC AGENT SELECTED FROM TOXINS SUCH AS MAITANSINOID, CALIQUEAMICIN AND AURISTATIN, ANTIBIOTICS, RADIOACTIVE ISOTOPES AND NUCLEOLYTIC ENZYMES; THE INHIBITOR OF THE BRAF GENE IS PROPANE-1-SULPHONIC ACID {3- [5- (4-CHLOROPHENYL) -1H-PYRROLO {2,3-b] PYRIDINE-3-CARBONYL] -2,4-DIFLUORO-PHENYL} - AMIDE. SUCH COMBINATION IS USEFUL IN THE INHIBITION OF TUMOR GROWTH (GIT) IN A SUBJECT SUFFERING FROM MELANOMA

PE2014000603A 2011-10-28 2012-10-24 THERAPEUTIC COMBINATIONS AND METHODS TO TREAT MELANOMA PE20142312A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161552893P 2011-10-28 2011-10-28
US201261678978P 2012-08-02 2012-08-02

Publications (1)

Publication Number Publication Date
PE20142312A1 true PE20142312A1 (en) 2015-01-25

Family

ID=48168400

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014000603A PE20142312A1 (en) 2011-10-28 2012-10-24 THERAPEUTIC COMBINATIONS AND METHODS TO TREAT MELANOMA

Country Status (19)

Country Link
EP (1) EP2776051A4 (en)
JP (2) JP6251682B2 (en)
KR (1) KR20140097205A (en)
CN (1) CN104039340B (en)
AR (1) AR088509A1 (en)
AU (1) AU2012328980A1 (en)
BR (1) BR112014009953A2 (en)
CA (1) CA2850034A1 (en)
CL (1) CL2014001092A1 (en)
CO (1) CO7151543A2 (en)
EA (1) EA201490879A1 (en)
IL (1) IL232135A0 (en)
IN (1) IN2014CN03062A (en)
MX (1) MX2014004991A (en)
PE (1) PE20142312A1 (en)
PH (1) PH12014500925A1 (en)
SG (1) SG11201401815XA (en)
TW (1) TW201325613A (en)
WO (1) WO2013063001A1 (en)

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US9216170B2 (en) 2012-03-19 2015-12-22 Hoffmann-La Roche Inc. Combination therapy for proliferative disorders
ES2742500T3 (en) 2014-07-15 2020-02-14 Federal Express Corp Compositions for cancer treatment using pd-1 axis binding antagonists and MEK inhibitors
KR20170058432A (en) 2014-10-10 2017-05-26 화이자 인코포레이티드 Synergistic auristatin combinations
WO2017024032A2 (en) * 2015-08-03 2017-02-09 Enb Therapeutics, Llc Compositions and methods for treating cancers associated with etbr activation
FR3053042B1 (en) * 2016-06-24 2018-08-10 Commissariat A L'energie Atomique Et Aux Energies Alternatives ANTIBODIES AGAINST ENDOTHELIN RECEPTOR B SUBTYPE B AND USES THEREOF
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WO2024209089A1 (en) 2023-04-07 2024-10-10 Commissariat A L'energie Atomique Et Aux Energies Alternatives Use of antibody against the endothelin receptor b for diagnostic and therapeutic applications

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IL232135A0 (en) 2014-05-28
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