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PE20141307A1 - Aril dihidropiridinona y piperidinona como inhibidores de monoacilglicerol aciltransferasa (mgat2) - Google Patents

Aril dihidropiridinona y piperidinona como inhibidores de monoacilglicerol aciltransferasa (mgat2)

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Publication number
PE20141307A1
PE20141307A1 PE2014000853A PE2014000853A PE20141307A1 PE 20141307 A1 PE20141307 A1 PE 20141307A1 PE 2014000853 A PE2014000853 A PE 2014000853A PE 2014000853 A PE2014000853 A PE 2014000853A PE 20141307 A1 PE20141307 A1 PE 20141307A1
Authority
PE
Peru
Prior art keywords
alkyl
aciltransferase
mgat2
piperidinone
inhibitors
Prior art date
Application number
PE2014000853A
Other languages
English (en)
Inventor
Huji Turdi
Jon J Hangeland
Dong Cheng
Saleem Ahmad
Wei Meng
Robert Paul Brigance
Guohua Zhao
R Michael Lawrence
Pratik Devasthale
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20141307A1 publication Critical patent/PE20141307A1/es

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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE ARIL DIHIDROPIRIDINONA Y PIPERIDINONA DE FORMULA (I) DONDE x E y SON UN ENLACE SIMPLE O DOBLE; R1 ES -CONH(ALQUILO C4-C8), -CONHCH2CO-ALQUILO(C2-C8), ENTRE OTROS; R2 ES ALQUILO(C1-C4), CICLOALQUILO(C3-C4) O HALOALQUILO(C1-C4); R3 ES H, F, Cl, CN, ENTRE OTROS; R4 Y R5 SON CADA UNO H, F, Cl O ALQUILO(C1-C4); R6 ES H, HALO, CN, NO2, ENTRE OTROS; R11, R12, R13, R14 Y R15 SON CADA UNO H, HALO, ALCOXI(C1-C4), HALOALQUILO(C1-C4), ENTRE OTROS; R16 ES H O ALQUILO(C1-C4). SON COMPUESTOS PREFERIDOS: (S)-3-(1H-TETRAZOL-5-IL)-4-(p-TOLIL)-6-(4-(4,4,4-TRIFLUOROBUTOXI)FENIL)-6-(TRIFLUOROMETIL)-5,6-DIHIDROPIRIDIN-2(1H)-ONA; (S)-N-(4-METOXIFENIL)-2-OXO-4-(p-TOLIL)-6-(4-(4,4,4-TRIFLUOROBUTOXI)FENIL)-6-(TRIFLUOROMETIL)-1,2,5,6-TETRAHIDROPIRIDIN-3-CARBOXAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE MONOACILGLICEROL ACILTRANSFERASA (MGAT2) SIENDO UTILES EN EL TRATAMIENTO DE DIABETES, RESISTENCIA A LA INSULINA, NEFROPATIA
PE2014000853A 2011-12-02 2012-11-30 Aril dihidropiridinona y piperidinona como inhibidores de monoacilglicerol aciltransferasa (mgat2) PE20141307A1 (es)

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