PE20130813A1 - Nueva asociacion entre la 4-{3-[cis-hexahidrociclopenta[c]pirrol-2(1h)-il]propoxi}benzamida y un antagonista de los receptores nmda y las composiciones farmaceuticas que la contienen - Google Patents
Nueva asociacion entre la 4-{3-[cis-hexahidrociclopenta[c]pirrol-2(1h)-il]propoxi}benzamida y un antagonista de los receptores nmda y las composiciones farmaceuticas que la contienenInfo
- Publication number
- PE20130813A1 PE20130813A1 PE2012002234A PE2012002234A PE20130813A1 PE 20130813 A1 PE20130813 A1 PE 20130813A1 PE 2012002234 A PE2012002234 A PE 2012002234A PE 2012002234 A PE2012002234 A PE 2012002234A PE 20130813 A1 PE20130813 A1 PE 20130813A1
- Authority
- PE
- Peru
- Prior art keywords
- propoxi
- hexahydrocyclopenta
- benzamide
- antagonist
- cis
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 title 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000848 glutamatergic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003891 oxalate salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE CONTIENE: A) EL COMPUESTO 4-{3-[CIS-HEXAHIDROCICLOPENTA[c]PIRROL-2(1H)-IL]PROPOXI}BENZAMIDA DE FORMULA (I) EN LA FORMA DE UN OXALATO O UN HIDROCLORURO Y EN UNA CANTIDAD DE 2MG, 5MG O 20MG; Y B) UN ANTAGONISTA DE LOS RECEPTORES GLUTAMATERGICOS NMDA TAL COMO MEMANTINA EN FORMA DE HIDROCLORURO Y EN UNA CANTIDAD DE 10MG O 20MG. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE LOS TRASTORNOS COGNITIVOS ASOCIADOS A LA ENFERMEDAD DE ALZHEIMER
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161568831P | 2011-12-09 | 2011-12-09 | |
| FR1103777A FR2983732B1 (fr) | 2011-12-09 | 2011-12-09 | Nouvelle association entre le 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}pharmaceutiques qui la contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20130813A1 true PE20130813A1 (es) | 2013-07-28 |
Family
ID=47682151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012002234A PE20130813A1 (es) | 2011-12-09 | 2012-11-28 | Nueva asociacion entre la 4-{3-[cis-hexahidrociclopenta[c]pirrol-2(1h)-il]propoxi}benzamida y un antagonista de los receptores nmda y las composiciones farmaceuticas que la contienen |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US8921409B2 (es) |
| EP (1) | EP2601942A1 (es) |
| JP (1) | JP5591310B2 (es) |
| KR (1) | KR101489670B1 (es) |
| CN (1) | CN103157111B (es) |
| AP (1) | AP3225A (es) |
| AR (1) | AR089112A1 (es) |
| AU (1) | AU2012258339A1 (es) |
| BR (1) | BR102012031031A2 (es) |
| CA (1) | CA2798549A1 (es) |
| CL (1) | CL2012003437A1 (es) |
| CO (2) | CO6660080A1 (es) |
| CR (1) | CR20120608A (es) |
| EA (1) | EA201201530A1 (es) |
| EC (1) | ECSP12012329A (es) |
| FR (1) | FR2983732B1 (es) |
| GT (1) | GT201200329A (es) |
| MA (1) | MA34867B1 (es) |
| MD (1) | MD4348B1 (es) |
| MX (1) | MX2012014184A (es) |
| NI (1) | NI201200178A (es) |
| PE (1) | PE20130813A1 (es) |
| PH (1) | PH12012000378A1 (es) |
| SG (1) | SG191494A1 (es) |
| TN (1) | TN2012000563A1 (es) |
| TW (1) | TWI457123B (es) |
| UY (1) | UY34475A (es) |
| WO (1) | WO2013083887A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3003466B1 (fr) * | 2013-03-22 | 2015-08-07 | Servier Lab | Utilisation du 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide pour le traitement des douleurs neuropathiques |
| KR101484405B1 (ko) * | 2013-08-14 | 2015-01-19 | 서울대학교산학협력단 | Ｎｉｎｊｕｒｉｎ１ 결핍 유래의 강박증 예방 또는 치료용 약학적 조성물 |
| GB201509134D0 (en) * | 2015-05-28 | 2015-07-15 | Electrophoretics Ltd | Biomolecules involved in Alzheimer's disease |
| CN107708687A (zh) * | 2015-07-22 | 2018-02-16 | 阿纳韦克斯生命科学公司 | 四氢‑N,N‑二甲基‑2,2‑二苯基‑3‑呋喃甲胺的对映体（ANAVEX2‑73）及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0311375A (pt) * | 2002-05-31 | 2005-03-15 | Lundbeck & Co As H | Composição farmacêutica, uso da mesma, e, método para o tratamento de demência ou dano cognitivo suave em um mamìfero |
| US20050014743A1 (en) * | 2003-05-27 | 2005-01-20 | Forest Laboratories, Inc. | Combination of an NMDA receptor antagonist and a selective serotonin reuptake inhibitor for the treatment of depression and other mood disorders |
| EP1638560A1 (en) * | 2003-06-20 | 2006-03-29 | Eli Lilly And Company | 3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake |
| CA2551689A1 (en) * | 2004-01-05 | 2005-07-28 | Merz Pharma Gmbh & Co. Kgaa | Memantine for the treatment of mild and mild-to-moderate alzheimer's disease |
| FR2866647B1 (fr) * | 2004-02-20 | 2006-10-27 | Servier Lab | Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| TW200531680A (en) * | 2004-03-03 | 2005-10-01 | Merz Pharma Gmbh & Co Kgaa | Therapy using 1-aminocyclohexane derivatives for the treatment of behavioral disorders associated with alzheimer's disease |
| JP2007529556A (ja) * | 2004-03-19 | 2007-10-25 | アクソニクス インコーポレイテッド | 認知障害の処置に有用なアセチルコリンエステラーゼ阻害剤およびｎ−メチル−ｄ−アスパラギン酸拮抗剤 |
| FR2937119B1 (fr) | 2008-10-15 | 2010-12-17 | Air Liquide | Procede de production d'energie et capture de co2 |
| FR2937251B1 (fr) * | 2008-10-16 | 2011-03-18 | Servier Lab | Utilisation du 4-{3-°hexahydrocyclopenta°c!pyrrol-2(1h)-yl! propoxy}benzamide pour l'obtention de medicaments destines au traitement des troubles du sommeil |
| FR2953515B1 (fr) * | 2009-12-09 | 2011-12-23 | Servier Lab | Nouveaux derives du type hexahydrocyclopenta[b]pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2011
- 2011-12-09 FR FR1103777A patent/FR2983732B1/fr not_active Expired - Fee Related
-
2012
- 2012-04-27 CO CO12069442A patent/CO6660080A1/es unknown
- 2012-11-28 AU AU2012258339A patent/AU2012258339A1/en not_active Abandoned
- 2012-11-28 PE PE2012002234A patent/PE20130813A1/es not_active Application Discontinuation
- 2012-11-28 PH PH1/2012/000378A patent/PH12012000378A1/en unknown
- 2012-11-28 UY UY0001034475A patent/UY34475A/es unknown
- 2012-11-29 SG SG2012087771A patent/SG191494A1/en unknown
- 2012-11-29 TN TNP2012000563A patent/TN2012000563A1/fr unknown
- 2012-12-03 MD MDA20120119A patent/MD4348B1/ro not_active IP Right Cessation
- 2012-12-03 MA MA35425A patent/MA34867B1/fr unknown
- 2012-12-03 CR CR20120608A patent/CR20120608A/es unknown
- 2012-12-03 NI NI201200178A patent/NI201200178A/es unknown
- 2012-12-05 AP AP2012006607A patent/AP3225A/xx active
- 2012-12-05 MX MX2012014184A patent/MX2012014184A/es not_active Application Discontinuation
- 2012-12-05 BR BR102012031031-7A patent/BR102012031031A2/pt not_active Application Discontinuation
- 2012-12-06 KR KR20120141338A patent/KR101489670B1/ko not_active Expired - Fee Related
- 2012-12-06 CO CO12221472A patent/CO6690116A1/es unknown
- 2012-12-06 JP JP2012267342A patent/JP5591310B2/ja not_active Expired - Fee Related
- 2012-12-06 TW TW101145875A patent/TWI457123B/zh not_active IP Right Cessation
- 2012-12-06 CL CL2012003437A patent/CL2012003437A1/es unknown
- 2012-12-06 CA CA2798549A patent/CA2798549A1/fr not_active Abandoned
- 2012-12-06 US US13/706,828 patent/US8921409B2/en not_active Expired - Fee Related
- 2012-12-07 GT GT201200329A patent/GT201200329A/es unknown
- 2012-12-07 EA EA201201530A patent/EA201201530A1/ru unknown
- 2012-12-07 AR ARP120104595A patent/AR089112A1/es unknown
- 2012-12-07 EP EP12195997.7A patent/EP2601942A1/fr not_active Withdrawn
- 2012-12-07 EC ECSP12012329 patent/ECSP12012329A/es unknown
- 2012-12-07 WO PCT/FR2012/000505 patent/WO2013083887A1/fr active Application Filing
- 2012-12-10 CN CN201210530112.9A patent/CN103157111B/zh not_active Expired - Fee Related
-
2014
- 2014-11-25 US US14/553,206 patent/US20150080448A1/en not_active Abandoned
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