PE20121722A1 - Polipeptido de fusion contra tumor inducido por virus eb y mutante de colicina ia - Google Patents
Polipeptido de fusion contra tumor inducido por virus eb y mutante de colicina iaInfo
- Publication number
- PE20121722A1 PE20121722A1 PE2012000834A PE2012000834A PE20121722A1 PE 20121722 A1 PE20121722 A1 PE 20121722A1 PE 2012000834 A PE2012000834 A PE 2012000834A PE 2012000834 A PE2012000834 A PE 2012000834A PE 20121722 A1 PE20121722 A1 PE 20121722A1
- Authority
- PE
- Peru
- Prior art keywords
- virus
- colicin
- polypeptide
- mutant
- amino acid
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 108010073254 Colicins Proteins 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 241000700605 Viruses Species 0.000 title abstract 3
- 230000004927 fusion Effects 0.000 title 1
- 230000002155 anti-virotic effect Effects 0.000 abstract 4
- 150000001413 amino acids Chemical group 0.000 abstract 3
- 102220471284 Guanine nucleotide exchange factor subunit RIC1_H40D_mutation Human genes 0.000 abstract 1
- 102000004310 Ion Channels Human genes 0.000 abstract 1
- 108090000862 Ion Channels Proteins 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102200051800 rs121434525 Human genes 0.000 abstract 1
- 102200142793 rs35418374 Human genes 0.000 abstract 1
- 102220059797 rs786203763 Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
SE REFIERE A UN POLIPEPTIDO CONTRA UN TUMOR CAUSADO POR EL VIRUS DE EPSTEIN-BARR (EB) QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID Nº 29 QUE SE FORMA MEDIANTE UNION OPERATIVA DE UN POLIPEPTIDO MUTANTE DE COLICINA QUE SE OBTIENE MEDIANTE MUTACION DE RESIDUOS DE AMINOACIDO DE G11A, H22G, A26G, V31L Y H40D EN LA CADENA PEPTIDICA DE COLICINA DE TIPO NATURAL Y QUE PUEDE FORMAR CANALES IONICOS CON UN POLIPEPTIDO DE ANTICUERPO ANTI-VIRUS EB CUYA SECUENCIA DE AMINOACIDOS ES LA MISMA QUE LA DEL POLIPEPTIDO DE ANTICUERPO MONOCLONAL SECRETADO POR EL HIBRIDOMA DE ATCC HB-168 O UN POLIPEPTIDO DE MIMETICOS DE ANTICUERPO ANTI-VIRUS EB. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA UTIL EN EL TRATAMIENTO DE TUMOR CAUSADO POR EL VIRUS EB
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102428380A CN102101888B (zh) | 2009-12-17 | 2009-12-17 | 一种新型抗eb病毒所致肿瘤多肽及其应用与制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20121722A1 true PE20121722A1 (es) | 2012-12-15 |
Family
ID=44154977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012000834A PE20121722A1 (es) | 2009-12-17 | 2010-02-26 | Polipeptido de fusion contra tumor inducido por virus eb y mutante de colicina ia |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8883161B2 (es) |
| EP (1) | EP2514768B1 (es) |
| JP (1) | JP5683603B2 (es) |
| KR (1) | KR101464842B1 (es) |
| CN (1) | CN102101888B (es) |
| AP (1) | AP3535A (es) |
| AU (1) | AU2010333588B2 (es) |
| BR (1) | BR112012017350A2 (es) |
| CA (1) | CA2784784C (es) |
| CL (1) | CL2012001609A1 (es) |
| CO (1) | CO6541633A2 (es) |
| CR (1) | CR20120329A (es) |
| CU (1) | CU20120096A7 (es) |
| DK (1) | DK2514768T3 (es) |
| DO (1) | DOP2012000164A (es) |
| EA (1) | EA030638B1 (es) |
| ES (1) | ES2634944T3 (es) |
| GE (1) | GEP20156228B (es) |
| HU (1) | HUE033298T2 (es) |
| IL (1) | IL220296A (es) |
| MA (1) | MA33921B1 (es) |
| MX (1) | MX2012006952A (es) |
| NZ (1) | NZ600729A (es) |
| PE (1) | PE20121722A1 (es) |
| PH (1) | PH12012501134A1 (es) |
| SG (1) | SG181553A1 (es) |
| TN (1) | TN2012000253A1 (es) |
| UA (1) | UA104933C2 (es) |
| WO (1) | WO2011072501A1 (es) |
| ZA (1) | ZA201205217B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9200251B1 (en) | 2011-03-31 | 2015-12-01 | David Gordon Bermudes | Bacterial methionine analogue and methionine synthesis inhibitor anticancer, antiinfective and coronary heart disease protective microcins and methods of treatment therewith |
| EA201400634A1 (ru) * | 2011-12-08 | 2014-12-30 | Протеин Дизайн Лаб, Лтд. | Способ получения новых антибиотиков и основанная на нём рамочная система |
| WO2016023491A1 (en) * | 2014-08-12 | 2016-02-18 | The University Of Hong Kong | Biophosphonate compounds and gamma delta t cell-mediated therapy for treating epstein-barr virus-associated disorders |
| CN104604799B (zh) * | 2015-02-05 | 2017-11-21 | 南华大学 | 一种鉴定eb病毒对淋巴瘤的诱发性的方法 |
| EP3957995A1 (en) * | 2018-11-19 | 2022-02-23 | Bioaster | Methods and reagents for multiplex binding experiments |
| CN111333724B (zh) * | 2018-12-19 | 2022-03-15 | 中国人民解放军军事科学院军事医学研究院 | 一种抗金黄色葡萄球菌肠毒素b的单克隆抗体yg11-1及其应用 |
| CN111848817B (zh) * | 2020-07-28 | 2021-11-09 | 中国农业大学 | 一种兼具抗菌、抗病毒、免疫调节和抗炎活性的多功能杂合肽及其制备方法和应用 |
| CN112125959B (zh) * | 2020-10-10 | 2022-07-29 | 中山大学肿瘤防治中心 | 一种抑制eb病毒的肽和编码该肽的dna及其应用 |
| CN113880914B (zh) * | 2021-04-25 | 2023-11-21 | 内蒙古农业大学 | 一种抗肿瘤多肽及其衍生物 |
| CN114369158B (zh) * | 2021-09-28 | 2024-04-19 | 北京亦科信息菌素研究院有限公司 | 一种抗新冠病毒的信息菌素及其应用 |
| CN113999304B (zh) * | 2021-10-13 | 2023-10-24 | 北京市农林科学院 | 抗肠菌素单克隆抗体mAb4及其在肠菌素检测中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1164612C (zh) | 2001-09-11 | 2004-09-01 | 四川新泰克控股有限责任公司 | 人工组合的抗菌工程多肽及其制备方法 |
| CN1274829C (zh) | 2004-12-10 | 2006-09-13 | 四川大学华西医院 | 抗eb病毒所致肿瘤多肽及其应用与制备方法 |
| CN1314806C (zh) * | 2005-01-14 | 2007-05-09 | 四川大学 | 小型化抗eb病毒肿瘤多肽及其应用与制备方法 |
| WO2007083175A1 (en) * | 2006-01-17 | 2007-07-26 | West China Hospital, Sichuan University | Antiviral bifunctional molecules, methods of construction and methods of treating virus-induced cancer therewith |
| CN101643501B (zh) | 2008-11-07 | 2012-06-20 | 畿晋庆三联（北京）生物技术有限公司 | 一种新型抗生素及其核苷酸序列、制备方法与应用 |
| CN101633699B (zh) * | 2009-09-02 | 2012-02-15 | 畿晋庆堂国际生物技术有限公司 | 一种含抗体模拟物的新型抗生素及其制备方法与应用 |
-
2009
- 2009-12-17 CN CN2009102428380A patent/CN102101888B/zh not_active Expired - Fee Related
-
2010
- 2010-02-26 JP JP2012543448A patent/JP5683603B2/ja not_active Expired - Fee Related
- 2010-02-26 BR BR112012017350-2A patent/BR112012017350A2/pt not_active Application Discontinuation
- 2010-02-26 DK DK10836940.6T patent/DK2514768T3/en active
- 2010-02-26 CA CA2784784A patent/CA2784784C/en not_active Expired - Fee Related
- 2010-02-26 NZ NZ600729A patent/NZ600729A/en not_active IP Right Cessation
- 2010-02-26 SG SG2012041786A patent/SG181553A1/en unknown
- 2010-02-26 AU AU2010333588A patent/AU2010333588B2/en not_active Ceased
- 2010-02-26 US US13/516,605 patent/US8883161B2/en not_active Expired - Fee Related
- 2010-02-26 HU HUE10836940A patent/HUE033298T2/en unknown
- 2010-02-26 MX MX2012006952A patent/MX2012006952A/es active IP Right Grant
- 2010-02-26 PE PE2012000834A patent/PE20121722A1/es active IP Right Grant
- 2010-02-26 UA UAA201208633A patent/UA104933C2/uk unknown
- 2010-02-26 KR KR1020127018638A patent/KR101464842B1/ko not_active Expired - Fee Related
- 2010-02-26 ES ES10836940.6T patent/ES2634944T3/es active Active
- 2010-02-26 MA MA35062A patent/MA33921B1/fr unknown
- 2010-02-26 EP EP10836940.6A patent/EP2514768B1/en active Active
- 2010-02-26 GE GEAP201012791A patent/GEP20156228B/en unknown
- 2010-02-26 AP AP2012006327A patent/AP3535A/xx active
- 2010-02-26 WO PCT/CN2010/070762 patent/WO2011072501A1/zh active Application Filing
- 2010-02-26 PH PH1/2012/501134A patent/PH12012501134A1/en unknown
- 2010-02-26 EA EA201270655A patent/EA030638B1/ru not_active IP Right Cessation
-
2012
- 2012-05-24 TN TNP2012000253A patent/TN2012000253A1/en unknown
- 2012-06-11 IL IL220296A patent/IL220296A/en not_active IP Right Cessation
- 2012-06-12 CO CO12098450A patent/CO6541633A2/es unknown
- 2012-06-12 CU CU2012000096A patent/CU20120096A7/es active IP Right Grant
- 2012-06-13 DO DO2012000164A patent/DOP2012000164A/es unknown
- 2012-06-14 CL CL2012001609A patent/CL2012001609A1/es unknown
- 2012-06-15 CR CR20120329A patent/CR20120329A/es unknown
- 2012-07-13 ZA ZA2012/05217A patent/ZA201205217B/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |