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PE20110924A1 - Derivados de 2, 4-diamino-pirimidina n2, n4-disustituidos como inhibidores de jak3 - Google Patents

Derivados de 2, 4-diamino-pirimidina n2, n4-disustituidos como inhibidores de jak3

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Publication number
PE20110924A1
PE20110924A1 PE2011001374A PE2011001374A PE20110924A1 PE 20110924 A1 PE20110924 A1 PE 20110924A1 PE 2011001374 A PE2011001374 A PE 2011001374A PE 2011001374 A PE2011001374 A PE 2011001374A PE 20110924 A1 PE20110924 A1 PE 20110924A1
Authority
PE
Peru
Prior art keywords
alkyl
pyrimidine
diamine
disustituted
derivatives
Prior art date
Application number
PE2011001374A
Other languages
English (en)
Inventor
Hui Li
Thilo J Heckrodt
Yan Chen
Darren John Mcmurtrie
Vanessa Taylor
Rajinder Singh
Pingyu Ding
Sambaiah Thota
Rose Yen
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42091548&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110924(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of PE20110924A1 publication Critical patent/PE20110924A1/es

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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE PIRIMIDINA DE FORMULA (I) DONDE X E Y SON CADA UNO O, S, S(O), ENTRE OTROS; EL ANILLO A ES ARILO(C6-C10) O HETEROARILO DE 5 A 10 MIEMBROS; R2 ES H, Re, Rb, ENTRE OTROS, EN DONDE Re ES ALQUILO(C1-C6), CICLOALQUILO(C3-C8), ARILO(C6-C10), ENTRE OTROS; Ra ES H, ALQUILO(C1-C6), HETEROARILO DE 5 A 15 MIEMBROS; p ES DE 0 A 4; Z1 Y Z2 SON CADA UNO CH, CR2 O N; R3 Y R4 SON CADA UNO H, ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO, ENTRE OTROS; R5 ES HALO, CN, ALQUILO(C1-C6), NITRO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N4-(1,3-DIMETILBENZIMIDAZOLIN-2-ON-5-IL)-N2-((4-METILSULFONILAMINO)FENIL)-5-FLUOROPIRIMIDINA-2,4-DIAMINA; 5-[2-(2,4-DIFLUORO-5-METOXI-FENILAMINO)-5-METIL-PIRIMIDIN-4-ILAMINO]-3H-BENZOXAZOL-2-ONA; 5-(2-(4-(1-(CICLOPROPILAMINO)ETIL)FENILAMINO)-5-METILPIRIMIDIN-4-ILAMINO)BENZO[d]OXAZOL-2(3H)-ONA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE JAK QUINASAS SIENDO UTILES EN EL TRATAMIENTO DE UNA ENFERMEDAD AUTOINMUNE MEDIADA POR CELULAS T, RECHAZO AL TRANSPLANTE DE ALOINJERTO
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