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PE20110844A1 - Composicion farmaceutica solida - Google Patents

Composicion farmaceutica solida

Info

Publication number
PE20110844A1
PE20110844A1 PE2011000787A PE2011000787A PE20110844A1 PE 20110844 A1 PE20110844 A1 PE 20110844A1 PE 2011000787 A PE2011000787 A PE 2011000787A PE 2011000787 A PE2011000787 A PE 2011000787A PE 20110844 A1 PE20110844 A1 PE 20110844A1
Authority
PE
Peru
Prior art keywords
methyl
oxo
solid preparation
pharmaceutical composition
solid pharmaceutical
Prior art date
Application number
PE2011000787A
Other languages
English (en)
Inventor
Kazuhiro Hirata
Junya Nomura
Yutaka Tanoue
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42059801&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110844(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20110844A1 publication Critical patent/PE20110844A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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Abstract

SE REFIERE A UNA PREPARACION SOLIDA QUE COMPRENDE: A) UN COMPUESTO DE FORMULA (I) DONDE: R1 ES UN GRUPO HETEROCICLICO QUE COMPRENDE N MONOCICLICO QUE CONTIENE H QUE PUEDE SER DESPROTONADO; R2 ES UN GRUPO CARBOXILO ESTERIFICADO; R3 ES UN ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO. UN COMPUESTO PREFERIDO ES: 2-ETOXI-1-{[2'-(5-OXO-4,5-DIHIDRO-1,2,4-OXODIAZOL-3-IL)BIFENIL-4-IL]METIL}-1H-BENCIMIDAZOL-7-CARBOXILATO DE (5-METIL-2-OXO-1,3-DIOXOL-4-IL)METILO; B) UN AGENTE CONTROL DE PH TAL COMO FUMARATO MONOSODICO QUE TIENE PH DE 2 A 5 Y QUE ESTA CONTENIDO EN LA PROPORCION DE 0.01 A 20% EN PESO Y C) UN ANTAGONISTA DE CALCIO TAL COMO BESILATO DE AMLODIPINA. DICHA PREPARACION SOLIDA MEJORA LAS PROPIEDADES DE DISOLUCION Y ESTABILIDAD Y ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES CIRCULATORIAS
PE2011000787A 2008-09-25 2009-09-25 Composicion farmaceutica solida PE20110844A1 (es)

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NZ592225A (en) 2012-06-29
EP2332535A4 (en) 2013-11-27
UY32126A (es) 2010-04-30
ECSP11011001A (es) 2011-05-31
CR20110209A (es) 2011-05-27
EP2332535A1 (en) 2011-06-15
MX2011003261A (es) 2011-04-21
AU2009297522A1 (en) 2010-04-01
WO2010035806A1 (ja) 2010-04-01
CN104306975A (zh) 2015-01-28
GEP20146063B (en) 2014-03-25
KR20110063557A (ko) 2011-06-10
TW201014850A (en) 2010-04-16
CL2011000625A1 (es) 2011-07-08
CN102223884A (zh) 2011-10-19
CN102223884B (zh) 2015-05-06
ZA201102715B (en) 2012-07-25
CA2738147C (en) 2016-10-11
BRPI0918955A2 (pt) 2015-12-01
JP5570426B2 (ja) 2014-08-13
US20110229567A1 (en) 2011-09-22
CA2738147A1 (en) 2010-04-01
US9173849B2 (en) 2015-11-03
JPWO2010035806A1 (ja) 2012-02-23
MA32721B1 (fr) 2011-10-02
CO6361934A2 (es) 2012-01-20
EA201170483A1 (ru) 2011-10-31
IL211886A0 (en) 2011-06-30
AR073380A1 (es) 2010-11-03

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