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PE20110574A1 - Derivados de fenilamida y de piridilamida como agonistas de gpbar1 - Google Patents

Derivados de fenilamida y de piridilamida como agonistas de gpbar1

Info

Publication number
PE20110574A1
PE20110574A1 PE2011000923A PE2011000923A PE20110574A1 PE 20110574 A1 PE20110574 A1 PE 20110574A1 PE 2011000923 A PE2011000923 A PE 2011000923A PE 2011000923 A PE2011000923 A PE 2011000923A PE 20110574 A1 PE20110574 A1 PE 20110574A1
Authority
PE
Peru
Prior art keywords
alcoxy
halogen
alkyl
pyridylamide
phenylamide
Prior art date
Application number
PE2011000923A
Other languages
English (en)
Inventor
Caterina Bissantz
Henrietta Dehmlow
Rainer E Martin
Sander Ulrike Obst
Hans Richter
Christoph Ullmer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41426925&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110574(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20110574A1 publication Critical patent/PE20110574A1/es

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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE FENILAMIDA O DE PIRIDILAMIDA DE FORMULA (I) DONDE A1 ES CR12 O N; A2 ES CR13 O N, EN DONDE R12 Y R13 SON CADA UNO H, ALQUILO(C1-C7), HALOGENO, CN, ENTRE OTROS; R1 Y R2 SON CADA UNO H, ALQUILO(C1-C7), CN, ENTRE OTROS; R3 ES H, ALQUILO(C1-C7), ALCOXI(C1-C7), ENTRE OTROS; R4 ES METILO, ETILO, ISOPROPILO, ENTRE OTROS; B1 ES N O CR19; B2 ES N O CR20, EN DONDE R19 Y R20 SON CADA UNO H, HALOGENO, ALCOXI(C1-C7), CN, ENTRE OTROS; R5 Y R6 SON CADA UNO H, HALOGENO, ALQUILO(C1-C7), HALOGENO-ALCOXI(C1-C7), ENTRE OTROS; R7, R8, R9, R10 Y R11 SON CADA UNO H, ALCOXI(C1-C7), HIDROXI-ALQUENILO(C3-C7), FENILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (3,4-DIHIDRO-2H-QUINOLIN-1-IL)-[2-(3-TRIFLUORMETIL-FENOXI)-PIRIDIN-3-IL]-METANONA; [2-(2-CLORO-FENOXI)-PIRIDIN-3-IL]-(3,4-DIHIDRO-2H-QUINOLIN-1-IL)-METANONA; [2-(3-CLORO-FENOXI)-PIRIDIN-3-IL]-(3,4-DIHIDRO-2H-QUINOLIN-1-IL)-METANONA; ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DE GPBAR1 SIENDO UTILES EN EL TRATAMIENTO DE DIABETES, OBESIDAD, SINDROME METABOLICO, INFARTO DE MIOCARDIO
PE2011000923A 2008-10-29 2009-10-19 Derivados de fenilamida y de piridilamida como agonistas de gpbar1 PE20110574A1 (es)

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CL2011000978A1 (es) 2011-09-23
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