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PE20100149A1 - Composiciones farmaceuticas a base de agonistas del receptor s1p - Google Patents

Composiciones farmaceuticas a base de agonistas del receptor s1p

Info

Publication number
PE20100149A1
PE20100149A1 PE2009001335A PE2009001335A PE20100149A1 PE 20100149 A1 PE20100149 A1 PE 20100149A1 PE 2009001335 A PE2009001335 A PE 2009001335A PE 2009001335 A PE2009001335 A PE 2009001335A PE 20100149 A1 PE20100149 A1 PE 20100149A1
Authority
PE
Peru
Prior art keywords
receptor
agonists
pharmaceutical compositions
weight
composition
Prior art date
Application number
PE2009001335A
Other languages
English (en)
Inventor
Vivian Christine Georgousis
Wei-Qin Tong
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37734410&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20100149(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20100149A1 publication Critical patent/PE20100149A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/141—Esters of phosphorous acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • AIDS & HIV (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

REFERIDA A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE DE 5% A 20% POR PESO DE UN PRIMER COMPUESTO AGONISTA DEL RECEPTOR S1P Y DE 65% A 99,999% POR PESO DE PROPILENGLICOL, BASADO EN EL PESO TOTAL DE LA COMPOSICION, DONDE EL PRIMER COMPUESTO ES 2-AMINO-2-[2-(4-OCTILFENILETIL)PROPANO-1,3-DIOL, ACIDO 1-{4-[1-(4-CICLOHEXIL-3-TRIFLUOROMETIL-BENCILOXIMINO)-ETIL]-2-ETIL-BENCIL}-AZETIDIN-3-CARBOXILICO, ENTRE OTROS; TAMBIEN PUEDE CONTENER GLICERINA EN UNA PROPORCION CON RESPECTO AL PROPILENGLICOL DE 5:95 a 25:75. DICHA COMPOSICION SE DILUYE CON AGUA, JUGO DE FRUTA, REFRESCO DE SODA O UNA MEZCLA DE LOS MISMOS, EN UNA PROPORCION DE 1:1 A 1:10, ANTES DE SU ADMINISTRACION
PE2009001335A 2005-08-09 2006-08-07 Composiciones farmaceuticas a base de agonistas del receptor s1p PE20100149A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70682005P 2005-08-09 2005-08-09

Publications (1)

Publication Number Publication Date
PE20100149A1 true PE20100149A1 (es) 2010-03-24

Family

ID=37734410

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2006000957A PE20070337A1 (es) 2005-08-09 2006-08-07 Formulaciones liquidas que comprenden un modulador o agonista del receptor s1p
PE2009001335A PE20100149A1 (es) 2005-08-09 2006-08-07 Composiciones farmaceuticas a base de agonistas del receptor s1p

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2006000957A PE20070337A1 (es) 2005-08-09 2006-08-07 Formulaciones liquidas que comprenden un modulador o agonista del receptor s1p

Country Status (24)

Country Link
US (4) US20080194526A1 (es)
EP (1) EP1915130B1 (es)
JP (1) JP5068755B2 (es)
KR (1) KR101473494B1 (es)
CN (1) CN101237852B (es)
AR (1) AR056020A1 (es)
AU (1) AU2006280138B2 (es)
BR (1) BRPI0615009A2 (es)
CA (1) CA2618018C (es)
EC (1) ECSP088165A (es)
GT (1) GT200600350A (es)
HK (1) HK1123188A1 (es)
IL (1) IL188915A0 (es)
MA (1) MA29736B1 (es)
MX (1) MX2008001967A (es)
MY (1) MY145111A (es)
NO (1) NO20081218L (es)
NZ (2) NZ593121A (es)
PE (2) PE20070337A1 (es)
RU (2) RU2428180C2 (es)
TN (1) TNSN08061A1 (es)
TW (1) TWI317289B (es)
WO (1) WO2007021666A2 (es)
ZA (1) ZA200800640B (es)

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* Cited by examiner, † Cited by third party
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SG158096A1 (en) * 2004-11-29 2010-01-29 Novartis Ag Dosage regimen of an s1p receptor agonist
PT2623113T (pt) 2005-11-09 2017-07-14 Onyx Therapeutics Inc Compostos para inibição de enzimas
MY147832A (en) 2006-06-19 2013-01-31 Onyx Therapeutics Inc Compounds for enzyme inhibition
JP5734656B2 (ja) 2007-10-04 2015-06-17 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． ペプチドエポキシケトンプロテアーゼ阻害剤結晶及びアミノ酸ケトエポキシドの調製
PL2465492T3 (pl) * 2007-10-12 2015-11-30 Novartis Ag Mieszaniny zawierające modulatory receptora 1-fosforanu sfingozyny (S1P)
KR20170081755A (ko) * 2008-06-20 2017-07-12 노파르티스 아게 다발성 경화증을 치료하기 위한 소아용 조성물
AU2009308516B2 (en) 2008-10-21 2016-08-25 Onyx Therapeutics, Inc. Combination therapy with peptide epoxyketones
EP2358660A2 (en) 2008-11-11 2011-08-24 Novartis AG Salts of fingolimod
EP2379499B1 (en) * 2008-12-18 2014-04-09 Novartis AG Hydrochloride salt of 1-(4-(1-((E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl)-2-ethyl-benzyl)-azetidine-3-carboxylic acid
WO2010071794A1 (en) * 2008-12-18 2010-06-24 Novartis Ag New polymorphic form of 1- (4- { l- [ (e) -4-cyclohexyl--3-trifluoromethyl-benzyloxyimino] -ethyl) -2-ethyl-benzy l) -azetidine-3-carboxylic
CN102256943A (zh) * 2008-12-18 2011-11-23 诺瓦提斯公司 1-(4-{1-[(e)-4-环己基-3-三氟甲基-苄氧基亚氨基]-乙基}-2-乙基-苄基)-氮杂环丁烷-3-甲酸的半富马酸盐
PL2400960T3 (pl) * 2009-02-24 2013-08-30 Novartis Ag Metabolity będące analogami ceramidowymi
US20100243087A1 (en) * 2009-03-03 2010-09-30 Millipore Corporation System and pump apparatus for processing fluid samples
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
US8853147B2 (en) 2009-11-13 2014-10-07 Onyx Therapeutics, Inc. Use of peptide epoxyketones for metastasis suppression
MA34133B1 (fr) 2010-03-01 2013-04-03 Onyx Therapeutics Inc Composes pour inhibiteurs de l'immunoproteasome
UA114283C2 (uk) 2011-01-07 2017-05-25 Новартіс Аг Композиції імуносупресантів
WO2012095853A1 (en) 2011-01-10 2012-07-19 Novartis Pharma Ag Modified release formulations comprising sip receptor modulators
JO3177B1 (ar) 2011-04-01 2018-03-08 Novartis Ag تركيبات تتالف من 2-أمينو-2- [ 2- ( 4- أكتيل فينيل ) إثيل ] بروبان - 3, 1- ديول
EP2869820A4 (en) 2012-07-09 2016-02-17 Onyx Therapeutics Inc PRODRUGS OF PEPTIDEPOXIDE KETONE PROTEASE INHIBITORS
RU2496486C1 (ru) 2012-07-11 2013-10-27 Александр Васильевич Иващенко Фармацевтическая композиция с улучшенной сыпучестью, лекарственное средство, способ получения и применение
EP3027174B1 (en) 2013-07-29 2019-07-24 Aizant Drug Research Solutions Private Limited Pharmaceutical compositions of fingolimod
WO2016042493A1 (en) 2014-09-19 2016-03-24 Aizant Drug Research Pvt. Ltd Pharmaceutical compositions of fingolimod
US20180042895A1 (en) 2015-02-26 2018-02-15 Novartis Ag Treatment of autoimmune disease in a patient receiving additionally a beta-blocker
US11434200B2 (en) 2017-03-09 2022-09-06 Novartis Ag Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof
US11629124B2 (en) 2017-03-09 2023-04-18 Novartis Ag Solid forms comprising an oxime ether compound, compositions and methods of use thereof
US11628137B2 (en) 2017-09-27 2023-04-18 Novartis Ag Parenteral formulation comprising siponimod
CA3073910A1 (en) 2017-09-29 2019-04-04 Novartis Ag Dosing regimen of siponimod
KR20200062240A (ko) 2017-09-29 2020-06-03 노파르티스 아게 시포니모드의 투여 요법
WO2021214717A1 (en) 2020-04-23 2021-10-28 Novartis Ag Dosing regimen for the use of siponimod for the treatment of acute respiratory distress syndrome

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Also Published As

Publication number Publication date
RU2008108887A (ru) 2009-09-20
CA2618018C (en) 2016-05-31
PE20070337A1 (es) 2007-04-18
MA29736B1 (fr) 2008-09-01
NZ593121A (en) 2012-09-28
AU2006280138A1 (en) 2007-02-22
BRPI0615009A2 (pt) 2011-05-03
RU2470631C2 (ru) 2012-12-27
NZ565696A (en) 2011-06-30
TWI317289B (en) 2009-11-21
ECSP088165A (es) 2008-03-26
US20140179636A1 (en) 2014-06-26
CN101237852A (zh) 2008-08-06
US20120328664A1 (en) 2012-12-27
NO20081218L (no) 2008-04-29
RU2011106364A (ru) 2012-08-27
CA2618018A1 (en) 2007-02-22
WO2007021666A3 (en) 2007-05-31
HK1123188A1 (en) 2009-06-12
US20080194526A1 (en) 2008-08-14
EP1915130B1 (en) 2016-07-13
GT200600350A (es) 2007-03-28
EP1915130A2 (en) 2008-04-30
ZA200800640B (en) 2008-12-31
WO2007021666A2 (en) 2007-02-22
TW200738277A (en) 2007-10-16
CN101237852B (zh) 2011-01-26
KR101473494B1 (ko) 2014-12-16
MX2008001967A (es) 2008-03-26
KR20080035608A (ko) 2008-04-23
JP2009504653A (ja) 2009-02-05
AR056020A1 (es) 2007-09-12
JP5068755B2 (ja) 2012-11-07
US20150080347A9 (en) 2015-03-19
RU2428180C2 (ru) 2011-09-10
TNSN08061A1 (en) 2009-07-14
US20160030572A1 (en) 2016-02-04
MY145111A (en) 2011-12-30
AU2006280138B2 (en) 2010-03-04
IL188915A0 (en) 2008-04-13

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